| Compound ID |
Compound Name |
Compound Formula |
|
CP0904291
|
(5R)-N5-(2-(2,4-Dichlorophenyl)ethyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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|
C27H35Cl2N3O2
|
1
|
| 1 |
EC50 = 3.8 nM
|
|
|
|
CP0857654
|
(5R*)-N5-(2-(4-Bromophenyl)ethyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt
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|
C28H38BrN3O4
|
1
|
| 1 |
EC50 = 6.6 nM
|
|
|
|
CP0900486
|
(5R*)-N5-(2-(4,5-Dimethyl -1H-imidazol-2-yl)-ethyl)-(6R*)-N6-(4-bromophenyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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|
C24H27BrN4O2
|
1
|
| 1 |
EC50 = 7.4 nM
|
|
|
|
CP0900932
|
(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-(4-methyl-1,4-diazepan-1-yl)butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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|
C27H37BrN4O2
|
1
|
| 1 |
EC50 = 12 nM
|
|
|
|
CP0900476
|
(5R)-N5-(4-Bromo-3-trifluoromethyl phenyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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|
C26H31BrF3N3O2
|
1
|
| 1 |
EC50 = 13 nM
|
|
|
|
CP0861849
|
(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-(4-ethyl-piperazin-1-yl)-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C27H37BrN4O2
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0864728
|
(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
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|
C25H34BrN3O2
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0952742
|
(5R)-N5-(4-Bromo-3-fluorophenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H33BrFN3O2
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0858048
|
(5R)-N5-(4-Bromo-3,5-difluorophenyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C27H34BrF2N3O2
|
1
|
| 1 |
EC50 = 16 nM
|
|
|
|
CP0891842
|
(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-(4-methyl-piperazin-1-yl)butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H35BrN4O2
|
1
|
| 1 |
EC50 = 16 nM
|
|
|
|
CP0946873
|
(5R)-N5-(4-Bromo-2-fluorophenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H35BrFN3O2
|
1
|
| 1 |
EC50 = 18 nM
|
|
|
|
CP0935546
|
(5R)-N5-(2-(4-Chlorophenyl)ethyl)-(6R)-N6-(N-isopentyl-piperidin-4-yl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C29H40ClN3O2
|
1
|
| 1 |
EC50 = 20 nM
|
|
|
|
CP0904328
|
(5R)-N5-(2-(4-Chlorophenyl)ethyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C27H36ClN3O2
|
1
|
| 1 |
EC50 = 26 nM
|
|
|
|
CP0850498
|
(5R)-N5-(4-Bromo-2,3-difluorophenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H32BrF2N3O2
|
1
|
| 1 |
EC50 = 27 nM
|
|
|
|
CP0946856
|
(5R*)-N5-(2-(2,4-Dimethyl phenyl)ethyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt
Show/Hide
|
C30H43N3O4
|
1
|
| 1 |
EC50 = 27 nM
|
|
|
|
CP0850625
|
(5R)-N5-(4-Bromo-3-chlorophenyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H31BrClN3O2
|
1
|
| 1 |
EC50 = 28 nM
|
|
|
|
CP0894566
|
(5R*)-N5-(2-(Benzo[d][1,3]dioxol-5-yl)ethyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt
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|
C29H39N3O6
|
1
|
| 1 |
EC50 = 29 nM
|
|
|
|
CP0951739
|
(5R*)-N5-(2-(4-Methylphenyl)ethyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt
Show/Hide
|
C29H41N3O4
|
1
|
| 1 |
EC50 = 30 nM
|
|
|
|
CP0952117
|
(5R)-N5-(4-Bromo-3-fluorophenyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H31BrFN3O2
|
1
|
| 1 |
EC50 = 33 nM
|
|
|
|
CP0864304
|
(5R)-N5-(4-Bromophenyl)-(6R)-N6-(5-pyrrolidino-pentyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H34BrN3O2
|
1
|
| 1 |
EC50 = 41 nM
|
|
|
|
CP0963532
|
(5R)-N5-(4-Bromo-2,6-difluorophenyl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H32BrF2N3O2
|
1
|
| 1 |
EC50 = 44 nM
|
|
|
|
CP0866449
|
(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H32BrN3O2
|
1
|
| 1 |
EC50 = 46 nM
|
|
|
|
CP0868020
|
(5R*)-N5-(4-Bromo-phenyl-methyl)-(6R*)-N6-(3-(1H-benzoimidazol-2-yl)-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C28H29BrN4O2
|
1
|
| 1 |
EC50 = 47 nM
|
|
|
|
CP0873901
|
(5R*)-N5-(2-(4-Fluorophenyl)ethyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt
Show/Hide
|
C28H38FN3O4
|
1
|
| 1 |
EC50 = 52 nM
|
|
|
|
CP0868959
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-(4,5-dimethyl-1H-imidazol-2-yl)-ethyl)-(4S*,7R*)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C24H29BrN4O2
|
1
|
| 1 |
EC50 = 57 nM
|
|
|
|
CP0859201
|
(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-piperidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H34BrN3O2
|
1
|
| 1 |
EC50 = 58 nM
|
|
|
|
CP0866054
|
(5R)-N5-(4-Bromo-3,5-difluorophenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H32BrF2N3O2
|
1
|
| 1 |
EC50 = 60 nM
|
|
|
|
CP0877220
|
(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-(4-acetyl-piperazin-1-yl)butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C27H35BrN4O3
|
1
|
| 1 |
EC50 = 61 nM
|
|
|
|
CP0861400
|
(5R)-N5-(2-Bromopyrid-5-yl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H35BrN4O2
|
1
|
| 1 |
EC50 = 62 nM
|
|
|
|
CP0864609
|
(5R)-N5-(4-Bromo-2,5-difluorophenyl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H32BrF2N3O2
|
1
|
| 1 |
EC50 = 64 nM
|
|
|
|
CP0959585
|
(5R*)-N5-(4-Chloro-phenyl-methyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt
Show/Hide
|
C27H36ClN3O4
|
1
|
| 1 |
EC50 = 65 nM
|
|
|
|
CP0904289
|
(5R)-N5-(2-Bromo-3-fluoro-pyridin-5-yl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H34BrFN4O4
|
1
|
| 1 |
EC50 = 66 nM
|
|
|
|
CP0867111
|
(5R*)-N5-(3,5-Difluoro-4-methoxy-phenyl-methyl)-(6R*)-N6-(4-pyrrolidin-1-yl -butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt
Show/Hide
|
C28H37F2N3O5
|
1
|
| 1 |
EC50 = 67 nM
|
|
|
|
CP0954131
|
(5R*)-N5-(Benzo[d]oxazol-6-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide hydrochloride
Show/Hide
|
C26H33ClN4O3
|
1
|
| 1 |
EC50 = 67 nM
|
|
|
|
CP0877235
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-(4,5-dimethyl-1H-imidazol-2-yl)-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C24H27BrN4O2
|
1
|
| 1 |
EC50 = 68 nM
|
|
|
|
CP0877229
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-(4-methyl-piperazin-1-yl)-propyl)-(4S*,7R*)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H35BrN4O2
|
1
|
| 1 |
EC50 = 71 nM
|
|
|
|
CP0911525
|
(5R*)-N5-(2-(3-Bromo-4-methoxyphenyl)ethyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt
Show/Hide
|
C29H40BrN3O5
|
1
|
| 1 |
EC50 = 72 nM
|
|
|
|
CP0873899
|
(5R*)-N5-(2-(4-Methoxyphenyl)ethyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt
Show/Hide
|
C29H41N3O5
|
1
|
| 1 |
EC50 = 74 nM
|
|
|
|
CP0946603
|
(5R*)-N5-(2-Bromo-thiophen-4-yl-methyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C24H32BrN3O2S
|
1
|
| 1 |
EC50 = 75 nM
|
|
|
|
CP0868025
|
(5R*)-N5-(1-(4-Bromophenyl)-ethyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C27H36BrN3O2
|
1
|
| 1 |
EC50 = 79 nM
|
|
|
|
CP0902302
|
(5R*)-N5-(2,3-Difluoro-4-methoxy-phenyl-methyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt
Show/Hide
|
C28H37F2N3O5
|
1
|
| 1 |
EC50 = 89 nM
|
|
|
|
CP0903336
|
(5R*)-N5-(3-(2-Methyl-1H-indol-1-yl)-propyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C31H42N4O2
|
1
|
| 1 |
EC50 = 91 nM
|
|
|
|
CP0946604
|
(5R*)-N5-(3-Phenyl-[1,2,4]thiadiazol-5-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C27H33N5O2S
|
1
|
| 1 |
EC50 = 91 nM
|
|
|
|
CP0859932
|
(5R*)-N5-(3-Bromophenyl-methyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H34BrN3O2
|
1
|
| 1 |
EC50 = 94 nM
|
|
|
|
CP0902253
|
(5R*)-N5-[(5-Acetyl-thiazol-2-yl)methyl]-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H34N4O3S
|
1
|
| 1 |
EC50 = 94 nM
|
|
|
|
CP0924093
|
(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-(2-(pyrrolidin-1-yl)ethoxy)ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H32BrN3O3
|
1
|
| 1 |
EC50 = 95 nM
|
|
|
|
CP0940780
|
(5R*)-N5-(2-Trifluoromethyl-pyridin-5-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide hydrochloride
Show/Hide
|
C25H32ClF3N4O2
|
1
|
| 1 |
EC50 = 99 nM
|
|
|
|
CP0857658
|
(5R*)-N5-(4-tert-Butyl-cyclohexyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C29H47N3O2
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
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CP0873900
|
(5R*)-N5-(2-(3,4-Dimethylphenyl)ethyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt
Show/Hide
|
C30H43N3O4
|
1
|
| 1 |
EC50 = 103 nM
|
|
|
|
CP0952720
|
(5R*)-N5-(4-Trifluoromethyl-phenyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H34F3N3O2
|
1
|
| 1 |
EC50 = 105 nM
|
|
|
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CP0946859
|
(5R*)-N5-(4-Acetyl-thiazol-2-yl-methyl)-(6R*)-N6-(4-diethylamino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H36N4O3S
|
1
|
| 1 |
EC50 = 106 nM
|
|
|
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CP0937373
|
(5R*)-N5-(4-(4-Chlorophenyl)-thiazol-2-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C28H33ClN4O2S
|
1
|
| 1 |
EC50 = 110 nM
|
|
|
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CP0935344
|
(5R*)-N5-(4-Trifluoromethoxy-phenyl-methyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate saltc
Show/Hide
|
C28H36F3N3O5
|
1
|
| 1 |
EC50 = 112 nM
|
|
|
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CP0861399
|
(5R)-N5-(4-Bromo-2-fluorophenyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H31BrFN3O2
|
1
|
| 1 |
EC50 = 116 nM
|
|
|
|
CP0859194
|
(5R*)-N5-(4-Trifluoromethoxyphenyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H32F3N3O3
|
1
|
| 1 |
EC50 = 122 nM
|
|
|
|
CP0932454
|
(5R)-N5-(4-Bromo-2,3-difluorophenyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H30BrF2N3O2
|
1
|
| 1 |
EC50 = 122 nM
|
|
|
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CP0952723
|
(5R*)-N5-(2-(1H-Indol-1-yl)-ethyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C29H38N4O2
|
1
|
| 1 |
EC50 = 136 nM
|
|
|
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CP0891844
|
(5R*)-N5-(4-Acetyl-phenyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C27H35N3O3
|
1
|
| 1 |
EC50 = 139 nM
|
|
|
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CP0952459
|
(5R)-N5-(2-Bromo-3-fluoro-pyridin-5-yl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C24H30BrFN4O2
|
1
|
| 1 |
EC50 = 139 nM
|
|
|
|
CP0947058
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(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C22H31BrN4O2S
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1
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| 1 |
EC50 = 142 nM
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CP0903237
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(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-(2,5-dimethylpyrrolidin-1-yl)butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C27H36BrN3O2
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1
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| 1 |
EC50 = 149 nM
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CP0934294
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(5R*)-N5-(4-tert-Butyl-thiazol-2-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C26H38N4O2S
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1
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| 1 |
EC50 = 150 nM
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CP0947060
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(5R*)-N5-(2-Phenyl-ethyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C27H37N3O2
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1
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| 1 |
EC50 = 152 nM
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CP0924083
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(5R*)-N5-(4-Fluoro-phenyl -methyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt
Show/Hide
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C27H36FN3O4
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1
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| 1 |
EC50 = 159 nM
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CP0903240
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(5R*)-N5-(2-(Cyclohexen-1-yl)ethyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C27H41N3O2
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1
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| 1 |
EC50 = 165 nM
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CP0935732
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(5R)-N5-(4-Bromo-thiazol-2-yl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C22H29BrN4O2S
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1
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| 1 |
EC50 = 166 nM
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CP0953506
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(5R*)-N5-(5-Trifluoromethyl -1,3,4-thiadiazol-2-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide hydrochloride
Show/Hide
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C22H29ClF3N5O2S
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1
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| 1 |
EC50 = 167 nM
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CP0940775
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(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4((3R)-fluoropyrrolidino)butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C25H31BrFN3O2
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1
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| 1 |
EC50 = 174 nM
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CP0850628
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(5R*)-N5-(3,5-Dimethylphenyl-methyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C28H39N3O2
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1
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| 1 |
EC50 = 176 nM
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CP0892127
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(5R*)-N5-(4-Bromo-thiazol-2-yl-methyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C23H31BrN4O2S
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1
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| 1 |
EC50 = 176 nM
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CP0900470
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(5R*)-N5-(2-Methoxy-5-methylphenyl-methyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C28H39N3O3
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1
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| 1 |
EC50 = 180 nM
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CP0863202
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(5R*)-N5-(2-Acetyl-oxazol-4-yl-methyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C25H34N4O4
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1
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| 1 |
EC50 = 181 nM
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CP0946605
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(5R*)-N5-(2-Chloro-pyrimidin-5-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C23H30ClN5O2
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1
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| 1 |
EC50 = 182 nM
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CP0904445
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(5R*)-N5-(5-Methyl-furan-2-yl-methyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C25H35N3O3
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1
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| 1 |
EC50 = 192 nM
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CP0946858
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(5R)-N5-(4-Bromo-2-methylphenyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C26H34BrN3O2
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1
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| 1 |
EC50 = 193 nM
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CP0903265
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(5R*)-N5-(4-Isopropoxy-phenyl-methyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt
Show/Hide
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C30H43N3O5
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1
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| 1 |
EC50 = 197 nM
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CP0861393
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(5R*)-N5-(3-Chloro-2-fluorophenyl-methyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C26H33ClFN3O2
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1
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| 1 |
EC50 = 200 nM
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CP0900933
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(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-(azetidin-1-yl)butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C24H30BrN3O2
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1
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| 1 |
EC50 = 200 nM
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CP0872923
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(5R)-N5-(4-Bromo-2,5-difluorophenyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C25H30BrF2N3O2
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1
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| 1 |
EC50 = 204 nM
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CP0896560
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(5R*)-N5-(2-(2-Methoxy-phenyl)-ethyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C28H39N3O3
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1
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| 1 |
EC50 = 204 nM
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CP0935342
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(5R*)-N5-(4,5-Dimethyl-thiazol-2-yl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C24H34N4O2S
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1
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| 1 |
EC50 = 204 nM
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CP0902188
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(5R)-N5-(2-Bromo-thiazol-5-yl-methyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C23H31BrN4O2S
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1
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| 1 |
EC50 = 208 nM
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CP0894112
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(5R*)-N5-(5-Trifluoromethyl-pyridin-2-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide hydrochloride
Show/Hide
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C26H33ClF3N3O2
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1
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| 1 |
EC50 = 210 nM
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CP0895804
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(5R*)-N5-(6-Chloro-benzothiazol-2-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C26H31ClN4O2S
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1
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| 1 |
EC50 = 214 nM
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CP0859937
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(5R*)-N5-[(2-Acetyl-thiazol-4-yl)methyl]-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C25H34N4O3S
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1
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| 1 |
EC50 = 219 nM
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CP0864612
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(5R*)-N5-(3-Bromo-4-fluorophenyl-methyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C26H33BrFN3O2
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1
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| 1 |
EC50 = 223 nM
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CP0871280
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(5R*)-N5-(3-Methyl-butyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C24H39N3O2
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1
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| 1 |
EC50 = 224 nM
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CP0902899
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(5R*)-N5-(6-Fluoro-benzothiazol-2-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C26H31FN4O2S
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1
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| 1 |
EC50 = 226 nM
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CP0850626
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(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(5-amino-pentyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C19H27BrN4O2S
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1
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| 1 |
EC50 = 230 nM
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CP0900930
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(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-((3S)-fluoropyrrolidino)butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C25H31BrFN3O2
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1
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| 1 |
EC50 = 235 nM
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CP0850495
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(5R*)-N5-(4-Iodophenyl-methyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C26H34IN3O2
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1
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| 1 |
EC50 = 236 nM
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CP0848744
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(5R*)-N5-(3-Chloro-4-methoxyphenyl-methyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt
Show/Hide
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C28H38ClN3O5
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1
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| 1 |
EC50 = 237 nM
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CP0911526
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(5R*)-N5-(4-Ethoxyphenyl-methyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt
Show/Hide
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C29H41N3O5
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1
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| 1 |
EC50 = 254 nM
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CP0904292
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(5R*)-N5-(2,5-Dimethylphenyl-methyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C28H39N3O2
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1
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| 1 |
EC50 = 255 nM
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CP0952745
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(5R*)-N5-(5-Aminopentyl)-(6R*)-N6-(4-bromophenyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C22H28BrN3O2
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1
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| 1 |
EC50 = 255 nM
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CP0852698
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(5R*)-N5-(2-Bromo-4-fluorophenyl-methyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C26H33BrFN3O2
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1
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| 1 |
EC50 = 256 nM
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CP0935551
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(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-[(piperidin-2-yl)-methyl]-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C20H27BrN4O2S
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1
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| 1 |
EC50 = 262 nM
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CP0900484
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(5R*)-N5-(Cyclohexyl-methyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C26H41N3O2
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1
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| 1 |
EC50 = 268 nM
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CP0935725
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(5R*)-N5-(2-Chloro-3,6-difluorophenyl-methyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C26H32ClF2N3O2
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1
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| 1 |
EC50 = 271 nM
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CP0931094
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(5R*)-N5-(2-Fluoro-3-trifluoromethyl phenyl -methyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C27H33F4N3O2
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1
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| 1 |
EC50 = 290 nM
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CP0867750
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(5R*)-N5-(4-Bromo-phenyl-methyl)-(6R*)-N6-(3-pyrrolidin-1-yl-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C25H32BrN3O2
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1
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| 1 |
EC50 = 292 nM
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CP0866713
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(5R)-N5-(4-Bromo-2,6-difluorophenyl)-(6R)-N6-(4-pyrrolidino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C25H30BrF2N3O2
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1
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| 1 |
EC50 = 296 nM
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CP0953577
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(5R)-N5-(4-Bromophenyl)-(6R)-N6-((3R,6S)-6-(pyrrolidin-1-ylmethyl)tetrahydro-2H-pyran-3-yl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C27H34BrN3O3
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1
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| 1 |
EC50 = 297 nM
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CP0861883
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(5R*)-N5-(4-Bromophenyl-methyl)-(6R*)-N6-(4-diethylamino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C26H36BrN3O2
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1
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| 1 |
EC50 = 299 nM
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CP0903796
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(5R*)-N5-(3-Fluoro-5-trifluoromethylphenyl-methyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C27H33F4N3O2
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1
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| 1 |
EC50 = 306 nM
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CP0946871
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-pyrrolidin-1-yl-propyl)-(4S*,7R*)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C24H32BrN3O2
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1
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| 1 |
EC50 = 307 nM
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CP0859298
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(5R*)-N5-(3-Fluoro-4-methoxy-phenyl-methyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt
Show/Hide
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C28H38FN3O5
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1
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| 1 |
EC50 = 308 nM
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CP0952967
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(5R*)-N5-(Benzothiazol-2-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C26H32N4O2S
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1
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| 1 |
EC50 = 324 nM
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CP0850384
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(4-(N,N-diethyl-amino)-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C25H34BrN3O2
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1
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| 1 |
EC50 = 329 nM
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CP0864613
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(5R*)-N5-[(2-Methoxypyridin-4-yl)methyl]-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C26H36N4O3
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1
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| 1 |
EC50 = 330 nM
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CP0865014
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(5R)-N5-(4-Bromo-2-fluorophenyl-methyl)-(6R)-N6-(5-amino-pentyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C23H29BrFN3O2
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1
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| 1 |
EC50 = 331 nM
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CP0850374
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(5R*)-N5-[(4-Methyl-phenyl)-methyl]-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C27H37N3O2
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1
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| 1 |
EC50 = 332 nM
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CP0859193
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(5R*)-N5-(2-Methyl-benzothiazol-5-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C27H34N4O2S
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1
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| 1 |
EC50 = 332 nM
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CP0848742
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(5R*)-N5-(2,4-Dimethoxyphenyl-methyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt
Show/Hide
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C29H41N3O6
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1
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| 1 |
EC50 = 334 nM
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CP0900816
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(5R*)-N5-(3-Methyl-benzo[d]isothiazol-5-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C27H34N4O2S
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1
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| 1 |
EC50 = 337 nM
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CP0895805
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(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-pyrrolidino-4-oxobutyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C25H30BrN3O3
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1
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| 1 |
EC50 = 338 nM
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CP0935552
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(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-[(piperidin-3-yl)-methyl]-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C20H27BrN4O2S
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1
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| 1 |
EC50 = 339 nM
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CP0852678
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(5R*)-N5-(4-Methyl-thiazol-2-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide hydrochloride
Show/Hide
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C23H33ClN4O2S
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1
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| 1 |
EC50 = 348 nM
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CP0902254
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(5R*)-N5-(2-Fluoro-5-trifluoromethyl phenyl -methyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C27H33F4N3O2
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1
|
| 1 |
EC50 = 350 nM
|
|
|
|
CP0896564
|
(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(piperidin-3-yl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C19H25BrN4O2S
|
1
|
| 1 |
EC50 = 354 nM
|
|
|
|
CP0899832
|
(5R*)-N5-(5-Methyl-thiazol-2-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C23H32N4O2S
|
1
|
| 1 |
EC50 = 355 nM
|
|
|
|
CP0850388
|
(5R*)-N5-(2,6-Difluoro-4-methoxy-phenyl-methyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt
Show/Hide
|
C28H37F2N3O5
|
1
|
| 1 |
EC50 = 356 nM
|
|
|
|
CP0900931
|
(5R)-N5-(4-Bromophenyl)-(6R)-N6-(cis-4-(pyrrolidin-1-yl-methyl)-cyclohexyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C28H36BrN3O2
|
1
|
| 1 |
EC50 = 356 nM
|
|
|
|
CP0935341
|
(5R*)-N5-(Furan-2-yl-methyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C24H33N3O3
|
1
|
| 1 |
EC50 = 358 nM
|
|
|
|
CP0867983
|
(5R*)-N5-(4-Acetyl-thiazol-2-yl-methyl)-(6R*)-N6-(3-amino-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C20H26N4O3S
|
1
|
| 1 |
EC50 = 359 nM
|
|
|
|
CP0877228
|
(5R*)-N5-(Benzothiazol-5-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H32N4O2S
|
1
|
| 1 |
EC50 = 359 nM
|
|
|
|
CP0899822
|
(5R*)-N5-(3-Acetylphenyl-methyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C28H37N3O3
|
1
|
| 1 |
EC50 = 359 nM
|
|
|
|
CP0864632
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-(1-ethyl-5-methyl-1H-pyrazol-3-yl)-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H29BrN4O2
|
1
|
| 1 |
EC50 = 363 nM
|
|
|
|
CP0866467
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(5-(N,N-diethyl-amino)-pent-2-yl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H36BrN3O2
|
1
|
| 1 |
EC50 = 365 nM
|
|
|
|
CP0911530
|
(5R*)-N5-(4-Fluoro-3-trifluoromethylphenyl-methyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C27H33F4N3O2
|
1
|
| 1 |
EC50 = 366 nM
|
|
|
|
CP0852699
|
(5R*)-N5-(2-Chloro-5-trifluoromethylphenyl-methyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C27H33ClF3N3O2
|
1
|
| 1 |
EC50 = 372 nM
|
|
|
|
CP0904327
|
(5R*)-N5-(2-Isopropoxyphenyl-methyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C29H41N3O3
|
1
|
| 1 |
EC50 = 389 nM
|
|
|
|
CP0846042
|
(5R*)-N5-(5-Bromothiazol-2-yl)-(6R*)-N6-(4-diethylamino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C22H31BrN4O2S
|
1
|
| 1 |
EC50 = 396 nM
|
|
|
|
CP0859200
|
(5R)-N5-(4-Bromophenyl)-(6R)-N6-(trans-4-(pyrrolidin-1-yl-methyl)-cyclohexyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C28H36BrN3O2
|
1
|
| 1 |
EC50 = 398 nM
|
|
|
|
CP0867762
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-pyrrolidin-1-yl-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C24H30BrN3O2
|
1
|
| 1 |
EC50 = 405 nM
|
|
|
|
CP0850383
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-((3-aminomethyl-phenyl)-methyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H26BrN3O2
|
1
|
| 1 |
EC50 = 413 nM
|
|
|
|
CP0864610
|
(5R*)-N5-(4-Acetyl-thiazol-2-yl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C24H32N4O3S
|
1
|
| 1 |
EC50 = 414 nM
|
|
|
|
CP0852697
|
(5R*)-N5-(2,4-Dimethylphenyl-methyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C28H39N3O2
|
1
|
| 1 |
EC50 = 417 nM
|
|
|
|
CP0911524
|
(5R*)-N5-(2-(3,4-Dimethoxyphenyl)ethyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C29H41N3O4
|
1
|
| 1 |
EC50 = 417 nM
|
|
|
|
CP0861882
|
(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-morpholino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H32BrN3O3
|
1
|
| 1 |
EC50 = 423 nM
|
|
|
|
CP0940771
|
(5R*)-N5-(4-Bromophenyl-methyl)-(6R*)-N6-(3-(4-methylpiperazin-1-yl)-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H35BrN4O2
|
1
|
| 1 |
EC50 = 432 nM
|
|
|
|
CP0866444
|
(5R*)-N5-(5-Acetyl-thiophen-2-yl-methyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H35N3O3S
|
1
|
| 1 |
EC50 = 436 nM
|
|
|
|
CP0911523
|
(5R*)-N5-(3,4-Dimethoxyphenyl-methyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt
Show/Hide
|
C29H41N3O6
|
1
|
| 1 |
EC50 = 443 nM
|
|
|
|
CP0864611
|
(5R*)-N5-(4-Methyl-oxazol-2-yl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C23H32N4O3
|
1
|
| 1 |
EC50 = 444 nM
|
|
|
|
CP0871281
|
(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-[(4-pyrrolidin-1-yl-butanoylamino)-methyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
|
C25H32BrN3O2
|
1
|
| 1 |
EC50 = 446 nM
|
|
|
|
CP0867714
|
(5R*)-N5-(5-Methyl-pyridin-2-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H34N4O2
|
1
|
| 1 |
EC50 = 454 nM
|
|
|
|
CP0867716
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-[(5-methyl-3-phenyl-isoxazol-4-yl)-methyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C28H26BrN3O3
|
1
|
| 1 |
EC50 = 457 nM
|
|
|
|
CP0904331
|
(5R*)-N5-(2-Acetyl-oxazol-5-yl-methyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H34N4O4
|
1
|
| 1 |
EC50 = 462 nM
|
|
|
|
CP0961783
|
(5R*)-N5-(5-Bromothiazol-2-yl)-(6R*)-N6-(3-(4-methyl piperazin-1-yl)-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C22H30BrN5O2S
|
1
|
| 1 |
EC50 = 462 nM
|
|
|
|
CP0940770
|
(5R*)-N5-(4-Bromophenyl-methyl)-(6R*)-N6-(2,2-dimethyl-3-amino-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C23H30BrN3O2
|
1
|
| 1 |
EC50 = 466 nM
|
|
|
|
CP0873894
|
(5R)-N5-(4-Bromo-2-fluorophenyl-methyl)-(6R)-N6-(4-amino-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C22H27BrFN3O2
|
1
|
| 1 |
EC50 = 472 nM
|
|
|
|
CP0903795
|
(5R*)-N5-(2,3,5-Trifluorophenyl-methyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H32F3N3O2
|
1
|
| 1 |
EC50 = 477 nM
|
|
|
|
CP0857656
|
(5R*)-N5-(2-Chloro-6-fluoro-3-methyl phenyl -methyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C27H35ClFN3O2
|
1
|
| 1 |
EC50 = 478 nM
|
|
|
|
CP0937310
|
(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-[(pyrrolidin-2-yl)-methyl]-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C19H25BrN4O2S
|
1
|
| 1 |
EC50 = 479 nM
|
|
|
|
CP0866498
|
(5R*)-N5-(5-Methyl -isoxazol-3-yl-methyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide hydrochloride
Show/Hide
|
C24H35ClN4O3
|
1
|
| 1 |
EC50 = 489 nM
|
|
|
|
CP0952737
|
(5R*)-N5-(4-Bromophenyl-methyl)-(6R*)-N6-(3-(aminomethyl)phenyl-methyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H28BrN3O2
|
1
|
| 1 |
EC50 = 493 nM
|
|
|
|
CP0911532
|
(5R*)-N5-Pentyl-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C24H39N3O2
|
1
|
| 1 |
EC50 = 496 nM
|
|
|
|
CP0952750
|
(5R*)-N5-(2,4,6-Trifluorophenyl-methyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H32F3N3O2
|
1
|
| 1 |
EC50 = 508 nM
|
|
|
|
CP0858047
|
(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-(3,3-difluoropyrrolidin-1-yl)butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt
Show/Hide
|
C26H32BrF2N3O4
|
1
|
| 1 |
EC50 = 516 nM
|
|
|
|
CP0866053
|
(5R*)-N5-(3-Difluoromethoxyphenyl-methyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C27H35F2N3O3
|
1
|
| 1 |
EC50 = 530 nM
|
|
|
|
CP0934305
|
(5R*)-N5-(5-Bromo-thiazol-2-yl)-(6R*)-N6-(3-pyrrolidin-1-yl -propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C21H27BrN4O2S
|
1
|
| 1 |
EC50 = 542 nM
|
|
|
|
CP0850382
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-pyrrolidinyl-methyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C22H26BrN3O2
|
1
|
| 1 |
EC50 = 551 nM
|
|
|
|
CP0904366
|
(5R)-N5-(2-(4-Chlorophenyl)ethyl)-(6R)-N6-(2-(pyridin-2-yl)ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H28ClN3O2
|
1
|
| 1 |
EC50 = 554 nM
|
|
|
|
CP0958526
|
(5R*)-N5-(2-Bromo-pyrazin-5-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide hydrochloride
Show/Hide
|
C23H31BrClN5O2
|
1
|
| 1 |
EC50 = 558 nM
|
|
|
|
CP0931093
|
(5R*)-N5-(4-Acetylphenyl-methyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C28H37N3O3
|
1
|
| 1 |
EC50 = 570 nM
|
|
|
|
CP0949170
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(5-amino-pentyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C22H28BrN3O2
|
1
|
| 1 |
EC50 = 571 nM
|
|
|
|
CP0868772
|
(5R)-N5-(2-(4-Chlorophenyl)ethyl)-(6R)-N6-(2-(4-aminosulfonyl-phenyl)-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C27H30ClN3O4S
|
1
|
| 1 |
EC50 = 576 nM
|
|
|
|
CP0877230
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(N-tert-butoxycarbonyl-azetidin-3-yl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H30BrN3O4
|
1
|
| 1 |
EC50 = 582 nM
|
|
|
|
CP0868960
|
(5R*)-N5-(2-Phenoxy-ethyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C27H37N3O3
|
1
|
| 1 |
EC50 = 612 nM
|
|
|
|
CP0867754
|
(5R*)-N5-(4-Methyl-cyclohex-1-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H41N3O2
|
1
|
| 1 |
EC50 = 613 nM
|
|
|
|
CP0900471
|
(5R)-N5-(2-(4-Chlorophenyl)ethyl)-(6R)-N6-(2-dimethylamino-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C23H30ClN3O2
|
1
|
| 1 |
EC50 = 623 nM
|
|
|
|
CP0958529
|
(5R*)-N5-(2-(1-Methyl-1H-benzoimidazol-2-yl)-ethyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C29H39N5O2
|
1
|
| 1 |
EC50 = 623 nM
|
|
|
|
CP0903238
|
(5R*)-N5-[(2,6-Dichloropyridin-4-yl)methyl]-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H32Cl2N4O2
|
1
|
| 1 |
EC50 = 644 nM
|
|
|
|
CP0954150
|
(5R)-N5-(5-Acetyl-furan-2-yl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H35N3O4
|
1
|
| 1 |
EC50 = 647 nM
|
|
|
|
CP0954711
|
(5R*)-N5-(5-tert-Butyl-isoxazol-3-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H38N4O3
|
1
|
| 1 |
EC50 = 647 nM
|
|
|
|
CP0863222
|
(5R)-N5-(4-Bromo-2-fluorophenyl-methyl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C21H25BrFN3O3
|
1
|
| 1 |
EC50 = 661 nM
|
|
|
|
CP0867715
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(5-(dimethyl-amino)-pentyl)-(4S*,7R*)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C24H34BrN3O2
|
1
|
| 1 |
EC50 = 666 nM
|
|
|
|
CP0873844
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(N-benzyl -piperidin-4-yl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C29H32BrN3O2
|
1
|
| 1 |
EC50 = 678 nM
|
|
|
|
CP0859191
|
(5R*)-N5-(2-Ethyl-butyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H41N3O2
|
1
|
| 1 |
EC50 = 691 nM
|
|
|
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CP0896531
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(N-(3-methyl-butyl)-piperidin-4-yl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C27H36BrN3O2
|
1
|
| 1 |
EC50 = 708 nM
|
|
|
|
CP0902293
|
(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-[(3-(1-methyl-1H-benzoimidazol-2-yl)-propionylamino)-methyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
|
C28H29BrN4O2
|
1
|
| 1 |
EC50 = 709 nM
|
|
|
|
CP0954194
|
(5R*)-N5-(Benzo[2,1,3]oxadiazol-4-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H31N5O3
|
1
|
| 1 |
EC50 = 714 nM
|
|
|
|
CP0867726
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2,2-dimethyl-3-amino-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C22H28BrN3O2
|
1
|
| 1 |
EC50 = 726 nM
|
|
|
|
CP0857657
|
(5R*)-N5-(4-Trifluoromethyl-thiazol-2-yl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C23H29F3N4O2S
|
1
|
| 1 |
EC50 = 734 nM
|
|
|
|
CP0949165
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(piperidin-3-yl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C22H26BrN3O2
|
1
|
| 1 |
EC50 = 744 nM
|
|
|
|
CP0866403
|
(5R*)-N5-(2-Methoxy-pyrid-5-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide hydrochloride
Show/Hide
|
C25H35ClN4O3
|
1
|
| 1 |
EC50 = 746 nM
|
|
|
|
CP0935550
|
(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(3-(N-methylamino)-propyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C18H25BrN4O2S
|
1
|
| 1 |
EC50 = 773 nM
|
|
|
|
CP0867030
|
(5R*)-N5-(4-Acetyl-thiazol-2-yl-methyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H34N4O3S
|
1
|
| 1 |
EC50 = 826 nM
|
|
|
|
CP0940776
|
(5R*)-N5-(4-Acetyl-thiazol-2-yl-methyl)-(6R*)-N6-(3-pyrrolidino-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C24H32N4O3S
|
1
|
| 1 |
EC50 = 835 nM
|
|
|
|
CP0867210
|
(5R*)-N5-(1H-Indol-5-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C27H34N4O2
|
1
|
| 1 |
EC50 = 837 nM
|
|
|
|
CP0867722
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-1H-imidazol-1-yl-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C23H25BrN4O2
|
1
|
| 1 |
EC50 = 848 nM
|
|
|
|
CP0859934
|
(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-[(2-(2,5-dimethyl-thiazol-4-yl)-acetylamino)-methyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
|
C24H26BrN3O2S
|
1
|
| 1 |
EC50 = 862 nM
|
|
|
|
CP0904290
|
(5R*)-N5-[(4-Acetyl-thiazol-2-yl)methyl]-(6R*)-N6-(2-methylamino-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C20H26N4O3S
|
1
|
| 1 |
EC50 = 872 nM
|
|
|
|
CP0951413
|
(5R*)-N5-(2-(Pyridin-2-yl)ethyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H36N4O2
|
1
|
| 1 |
EC50 = 885 nM
|
|
|
|
CP0952722
|
(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-[(2-(2-methyl-thiazol-4-yl)-acetylamino)-methyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
|
C23H24BrN3O2S
|
1
|
| 1 |
EC50 = 888 nM
|
|
|
|
CP0867760
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-(4-methyl-piperazin-1-yl)-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H33BrN4O2
|
1
|
| 1 |
EC50 = 925 nM
|
|
|
|
CP0857659
|
(5R)-N5-(4-Bromo-2-fluorophenyl-methyl)-(6R)-N6-(5-amino-pentyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C23H31BrFN3O2
|
1
|
| 1 |
EC50 = 930 nM
|
|
|
|
CP0850627
|
(5R*)-N5-[(4-Methyl-1,2,5-oxadiazol-3-yl)methyl]-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C23H33N5O3
|
1
|
| 1 |
EC50 = 948 nM
|
|
|
|
CP0861852
|
(5R*)-N5-(3-Acetylphenyl)-(6R*)-N6-(4-pyrrolidino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C27H35N3O3
|
1
|
| 1 |
EC50 = 958 nM
|
|
|
|
CP0900478
|
(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(pyrrolidin-3-yl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C18H23BrN4O2S
|
1
|
| 1 |
EC50 = 1020 nM
|
|
|
|
CP0850389
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(N-tert-butoxycarbonyl-piperidin-4-yl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C27H34BrN3O4
|
1
|
| 1 |
EC50 = 1040 nM
|
|
|
|
CP0866443
|
(5R)-N5-(5-Acetyl-furan-2-yl-methyl)-(6R)-N6-(4-pyrrolidin-1-yl-butyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H37N3O4
|
1
|
| 1 |
EC50 = 1080 nM
|
|
|
|
CP0866465
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(furan-3-yl-methyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C22H21BrN2O3
|
1
|
| 1 |
EC50 = 1080 nM
|
|
|
|
CP0900929
|
(5R*)-N5-(4-Acetyl-thiazol-2-yl-methyl)-(6R*)-N6-(3-(1H-benzoimidazol-2-yl)-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C27H29N5O3S
|
1
|
| 1 |
EC50 = 1080 nM
|
|
|
|
CP0866094
|
(5R)-N5-(4-Bromophenyl)-(6R)-N6-(cis-4-(aminomethyl)-cyclohexyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C24H30BrN3O2
|
1
|
| 1 |
EC50 = 1150 nM
|
|
|
|
CP0904446
|
(5R*)-N5-(2-Methoxycarbonyl-ethyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C23H35N3O4
|
1
|
| 1 |
EC50 = 1150 nM
|
|
|
|
CP0949169
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(4-amino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C21H26BrN3O2
|
1
|
| 1 |
EC50 = 1160 nM
|
|
|
|
CP0850497
|
(5R*)-N5-(4-Bromophenyl-methyl)-(6R*)-N6-(piperidin-4-yl-methyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C24H30BrN3O2
|
1
|
| 1 |
EC50 = 1170 nM
|
|
|
|
CP0859935
|
(5R*)-N5-(4-Bromophenyl-methyl)-(6R*)-N6-(2-dimethylamino-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C22H28BrN3O2
|
1
|
| 1 |
EC50 = 1170 nM
|
|
|
|
CP0867733
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-(methyl-tert-butoxycarbonyl-amino)-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H32BrN3O4
|
1
|
| 1 |
EC50 = 1170 nM
|
|
|
|
CP0867209
|
(5R*)-N5-Butyl-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C23H37N3O2
|
1
|
| 1 |
EC50 = 1180 nM
|
|
|
|
CP0867753
|
(5R*)-N5-(5-Chloro-thiazol-2-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C22H29ClN4O2S
|
1
|
| 1 |
EC50 = 1190 nM
|
|
|
|
CP0861394
|
(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(piperidin-4-yl -methyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C20H27BrN4O2S
|
1
|
| 1 |
EC50 = 1210 nM
|
|
|
|
CP0863259
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-methylamino-3-oxopropyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C21H24BrN3O3
|
1
|
| 1 |
EC50 = 1210 nM
|
|
|
|
CP0873891
|
(5R*)-N5-(4-Acetyl-thiazol-2-yl-methyl)-(6R*)-N6-(2-dimethylamino-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C21H28N4O3S
|
1
|
| 1 |
EC50 = 1210 nM
|
|
|
|
CP0951741
|
(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(5-tert-butoxycarbonyl-amino-pentyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C24H35BrN4O4S
|
1
|
| 1 |
EC50 = 1240 nM
|
|
|
|
CP0949168
|
(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-N,N-dimethyl-amino-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C21H26BrN3O2
|
1
|
| 1 |
EC50 = 1260 nM
|
|
|
|
CP0861885
|
(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(4-amino-butyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C18H25BrN4O2S
|
1
|
| 1 |
EC50 = 1300 nM
|
|
|
|
CP0873889
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(N-tert-butoxycarbonyl-pyrrolidin-2-yl-methyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C27H34BrN3O4
|
1
|
| 1 |
EC50 = 1300 nM
|
|
|
|
CP0903388
|
(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-hydroxy-propyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C20H23BrN2O3
|
1
|
| 1 |
EC50 = 1300 nM
|
|
|
|
CP0859192
|
(5R*)-N5-(4-oxo-pentyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C24H37N3O3
|
1
|
| 1 |
EC50 = 1310 nM
|
|
|
|
CP0863312
|
(5R*)-N5-(4-Bromophenyl-methyl)-(6R*)-N6-(4-(aminomethyl)phenyl-methyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C26H28BrN3O2
|
1
|
| 1 |
EC50 = 1340 nM
|
|
|
|
CP0877377
|
(5R*)-N5-(5-Bromo-thiazol-2-yl)-(6R*)-N6-(4-(aminomethyl)phenyl-methyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C22H23BrN4O2S
|
1
|
| 1 |
EC50 = 1340 nM
|
|
|
|
CP0850623
|
(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-{[(cyclopentyl-carbonyl)-amino]-methyl}-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
|
C23H27BrN2O2
|
1
|
| 1 |
EC50 = 1380 nM
|
|
|
|
CP0863158
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-pyrrolidin-1-yl-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C23H28BrN3O2
|
1
|
| 1 |
EC50 = 1380 nM
|
|
|
|
CP0850379
|
(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-methoxy-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C20H23BrN2O3
|
1
|
| 1 |
EC50 = 1410 nM
|
|
|
|
CP0867717
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-[(4-N-tert-butoxycarbonyl-aminomethyl-phenyl)-methyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C30H34BrN3O4
|
1
|
| 1 |
EC50 = 1430 nM
|
|
|
|
CP0850496
|
(5R*)-N5-(5-(iso-Butyl)-isoxazol-3-yl-methyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C27H40N4O3
|
1
|
| 1 |
EC50 = 1440 nM
|
|
|
|
CP0873892
|
(5R)-N5-(4-Methoxyphenyl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C21H25N3O4
|
1
|
| 1 |
EC50 = 1440 nM
|
|
|
|
CP0864727
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-(1H-imidazol-1-yl)-propyl)-(4S*,7R*)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C23H27BrN4O2
|
1
|
| 1 |
EC50 = 1480 nM
|
|
|
|
CP0866714
|
(5R*)-N5-(4-Aminobutyl)-(6R*)-N6-(4-bromophenyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C21H26BrN3O2
|
1
|
| 1 |
EC50 = 1480 nM
|
|
|
|
CP0867756
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-(methoxy-carbonyl)-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C21H23BrN2O4
|
1
|
| 1 |
EC50 = 1481 nM
|
|
|
|
CP0867758
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(5-dimethyl-amino-pentyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C24H32BrN3O2
|
1
|
| 1 |
EC50 = 1487 nM
|
|
|
|
CP0903802
|
(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6,N6-(3-(aminomethyl)pentane-1,5-diyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C20H27BrN4O2S
|
1
|
| 1 |
EC50 = 1490 nM
|
|
|
|
CP0877238
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(pyrrolidin-3-yl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C21H24BrN3O2
|
1
|
| 1 |
EC50 = 1510 nM
|
|
|
|
CP0891848
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-1H-[1,2,4]-triazol-1-yl-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C21H22BrN5O2
|
1
|
| 1 |
EC50 = 1510 nM
|
|
|
|
CP0867723
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-ethyl-N6-(2-diethylamino-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamid
Show/Hide
|
C25H34BrN3O2
|
1
|
| 1 |
EC50 = 1540 nM
|
|
|
|
CP0931095
|
(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(piperidin-4-yl-methyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C20H25BrN4O2S
|
1
|
| 1 |
EC50 = 1545 nM
|
|
|
|
CP0867730
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-[(4-aminomethyl -phenyl)-methyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H26BrN3O2
|
1
|
| 1 |
EC50 = 1550 nM
|
|
|
|
CP0867759
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(4-tert-butoxycarbonyl-amino-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C26H34BrN3O4
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1
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| 1 |
EC50 = 1600 nM
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CP0930474
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(5R*)-N5-(3-(1H-Imidazol-1-yl)-propyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C25H37N5O2
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1
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| 1 |
EC50 = 1600 nM
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CP0852681
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(5R*)-N5-(5-Bromo-thiazol-2-yl)-(6R*)-N6-(2,2-dimethyl-3-amino-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C19H25BrN4O2S
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1
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| 1 |
EC50 = 1630 nM
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CP0867734
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-(N-tert-butoxycarbonyl-amino)-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C25H32BrN3O4
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1
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| 1 |
EC50 = 1660 nM
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CP0863156
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(N-tert-butoxycarbonyl-pyrrolidin-3-yl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C26H32BrN3O4
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1
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| 1 |
EC50 = 1690 nM
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CP0866448
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-(N-methyl-amino)-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C20H24BrN3O2
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1
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| 1 |
EC50 = 1690 nM
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CP0904288
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(5R)-N5-(4-Bromophenyl)-(6R)-N6-(trans-4-(aminomethyl)-cyclohexyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C24H30BrN3O2
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1
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| 1 |
EC50 = 1700 nM
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CP0868962
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-{[(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)-amino]-methyl}-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
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C23H24BrClN4O2
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1
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| 1 |
EC50 = 1705 nM
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CP0866466
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-1H-pyrazol-1-yl-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C23H25BrN4O2
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1
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| 1 |
EC50 = 1710 nM
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CP0859190
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-[(2-(2-chloro-phenyl)-acetylamino)-methyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
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C25H24BrClN2O2
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1
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| 1 |
EC50 = 1730 nM
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CP0867757
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(N-tert-butoxycarbonyl -piperidin-3-yl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C27H34BrN3O4
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1
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| 1 |
EC50 = 1750 nM
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CP0901903
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(5R*)-N5-(2-Methyl-pyridin-5-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide hydrochloride
Show/Hide
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C25H35ClN4O2
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1
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| 1 |
EC50 = 1770 nM
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CP0867751
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-{[(1-phenyl-1H-pyrazole-5-carbonyl)-amino]-methyl}-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
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C27H25BrN4O2
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1
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| 1 |
EC50 = 1790 nM
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CP0947057
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-{[(N-ethyl -piperidine-4-carbonyl)-amino]-methyl}-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
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C25H32BrN3O2
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1
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| 1 |
EC50 = 1820 nM
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CP0951744
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(5R*)-N5-(4-Acetyl-thiazol-2-yl-methyl)-(6R*)-N6-(piperidin-4-yl-methyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C23H30N4O3S
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1
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| 1 |
EC50 = 1820 nM
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CP0867719
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-[(1S)-1-carbamoyl-2-phenyl-ethyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C26H26BrN3O3
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1
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| 1 |
EC50 = 1846 nM
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CP0850865
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(1-phenyl-1H-pyrazol-5-yl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C26H23BrN4O2
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1
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| 1 |
EC50 = 1850 nM
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CP0958527
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(5R*)-N5-(2-Acetyl-thiazol-5-yl-methyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C25H34N4O3S
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1
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| 1 |
EC50 = 1860 nM
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CP0903386
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-[(3-(4-fluoro-phenyl)-propionylamino)-methyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
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C26H26BrFN2O2
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1
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| 1 |
EC50 = 1920 nM
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CP0850380
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-tert-butoxycarbonyl-amino-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C24H30BrN3O4
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1
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| 1 |
EC50 = 1960 nM
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CP0866468
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(piperidin-4-yl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C22H26BrN3O2
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1
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| 1 |
EC50 = 2000 nM
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CP0850624
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(5R*)-N5-(5-Bromothiazol-2-yl)-(6R*)-N6-(3-dimethylamino-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C19H25BrN4O2S
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1
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| 1 |
EC50 = 2010 nM
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CP0863182
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-ethoxy-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C22H27BrN2O3
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1
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| 1 |
EC50 = 2010 nM
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CP0871332
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-{[N-(2-(2-chloro-phenyl)-acetyl)-N-methyl-amino]-methyl}-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
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C26H26BrClN2O2
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1
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| 1 |
EC50 = 2020 nM
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CP0866055
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(5R*)-N5-(4-Bromophenyl-methyl)-(6R*)-N6-(2-methylamino-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C21H26BrN3O2
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1
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| 1 |
EC50 = 2050 nM
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CP0952719
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-[(2-(N,N-dimethyl-amino)-acetylamino)-methyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
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C21H26BrN3O2
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1
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| 1 |
EC50 = 2050 nM
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CP0864306
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-dimethylamino-3-oxopropyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C22H26BrN3O3
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1
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| 1 |
EC50 = 2080 nM
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CP0935549
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(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(2-(N-methyl amino)-ethyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C17H23BrN4O2S
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1
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| 1 |
EC50 = 2110 nM
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CP0952721
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(5-tert-butoxycarbonyl-amino-pentyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C27H36BrN3O4
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1
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| 1 |
EC50 = 2170 nM
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CP0850390
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-morpholino-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C24H30BrN3O3
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1
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| 1 |
EC50 = 2205 nM
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CP0864633
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-diethyl-amino-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C23H30BrN3O2
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1
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| 1 |
EC50 = 2219 nM
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CP0866710
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-{[(2-chloro-3-fluoro-phenyl-carbonyl)-amino]-methyl}-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
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C24H21BrClFN2O2
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1
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| 1 |
EC50 = 2230 nM
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CP0873845
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-{[(3-N-tert-butoxycarbonyl-aminomethyl)-phenyl]-methyl}-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C30H34BrN3O4
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1
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| 1 |
EC50 = 2260 nM
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CP0904416
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-(4-aminosulfonyl-phenyl)-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C25H26BrN3O4S
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1
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| 1 |
EC50 = 2267 nM
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CP0859415
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-hydroxy-propyl)-(4S*,7R*)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C20H25BrN2O3
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1
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| 1 |
EC50 = 2270 nM
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CP0860085
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-phenyl-2-morpholino-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C29H32BrN3O3
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1
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| 1 |
EC50 = 2277 nM
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CP0873852
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(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(azetidin-3-yl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C17H21BrN4O2S
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1
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| 1 |
EC50 = 2290 nM
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CP0873890
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(5R*)-N5-(4-Acetyl-oxazol-2-yl-methyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C25H34N4O4
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1
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| 1 |
EC50 = 2300 nM
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CP0952732
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(5R)-N5-(4-Methoxyphenyl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C21H27N3O4
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1
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| 1 |
EC50 = 2370 nM
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CP0958528
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-[(3-(3,5-dimethyl-pyrazol-1-yl)-propionylamino)-methyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
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C25H29BrN4O2
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1
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| 1 |
EC50 = 2370 nM
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CP0903262
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-(1-ethyl-3-methyl-1H-pyrazol-5-yl)-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C25H29BrN4O2
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1
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| 1 |
EC50 = 2432 nM
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CP0868023
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-tert-butoxycarbonyl-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C25H31BrN2O4
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1
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| 1 |
EC50 = 2467 nM
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CP0850381
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2,2,2-trifluoro-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C19H18BrF3N2O2
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1
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| 1 |
EC50 = 2480 nM
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CP0850378
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-[(1-ethyl-pyrrolidin-2-yl)-methyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C24H30BrN3O2
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1
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| 1 |
EC50 = 2587 nM
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CP0859188
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-{[(2,2-dichloro-1-methyl-cyclopropylcarbonyl)-amino]-methyl}-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
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C22H23BrCl2N2O2
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1
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| 1 |
EC50 = 2600 nM
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CP0894644
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(4-piperidinyl-methyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C23H28BrN3O2
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1
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| 1 |
EC50 = 2600 nM
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CP0911533
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(5R*)-N5-(4-Bromophenyl-methyl)-(6R*)-N6-(3-amino-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C21H26BrN3O2
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1
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| 1 |
EC50 = 2640 nM
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CP0894655
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(N-tert-butoxycarbonyl-piperidin-4-yl-methyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C28H36BrN3O4
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1
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| 1 |
EC50 = 2670 nM
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CP0934295
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(5R*)-N5-(5-Bromo-thiazol-2-yl)-(6R*)-N6-(2-methylamino-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C17H21BrN4O2S
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1
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| 1 |
EC50 = 2700 nM
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CP0868024
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(5R*)-N5-(5-oxo-hexyl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C25H39N3O3
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1
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| 1 |
EC50 = 2740 nM
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CP0861398
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(5R*)-N5-(4-Bromophenyl-methyl)-(6R*)-N6-(piperidin-4-yl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C23H28BrN3O2
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1
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| 1 |
EC50 = 2760 nM
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CP0867727
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-fluoro-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C19H20BrFN2O2
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1
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| 1 |
EC50 = 2860 nM
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CP0954196
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(cyclopropyl)-(4S*,7R*)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C20H23BrN2O2
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1
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| 1 |
EC50 = 2935 nM
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CP0868026
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-pyrrolidino-3-oxopropyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C24H28BrN3O3
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1
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| 1 |
EC50 = 2980 nM
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CP0904429
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-propyl-N6-(cyclopropylmethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C24H29BrN2O2
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1
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| 1 |
EC50 = 2980 nM
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CP0871313
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(5R*)-N5-(5-Bromo-thiazol-2-yl)-(6R*)-N6-(3-(1H-benzoimidazol-2-yl)-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C24H24BrN5O2S
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1
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| 1 |
EC50 = 3060 nM
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CP0868961
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-{[(4-methyl -pyridine-3-carbonyl)-amino]-methyl}-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
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C24H24BrN3O2
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1
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| 1 |
EC50 = 3220 nM
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CP0871282
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-[(3-phenyl-acryloylamino)-methyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
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C26H25BrN2O2
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1
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| 1 |
EC50 = 3240 nM
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CP0866450
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-(1H-benzoimidazol-2-yl)-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C27H27BrN4O2
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1
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| 1 |
EC50 = 3280 nM
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CP0859195
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(5R*)-N5-(5-Nitro-thiazol-2-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C22H29N5O4S
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1
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| 1 |
EC50 = 3440 nM
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CP0901904
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(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(4-tert-butoxycarbonyl-amino-butyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C23H33BrN4O4S
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1
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| 1 |
EC50 = 3540 nM
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CP0866057
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(5R*)-N5-(4-Acetyl-thiazol-2-yl-methyl)-(6R*)-N6-((2-imidazolidin-2-on)-1-yl-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C22H27N5O4S
|
1
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| 1 |
EC50 = 3550 nM
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CP0867752
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-(pentanoylamino-methyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
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C22H27BrN2O2
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1
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| 1 |
EC50 = 3690 nM
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CP0900483
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-[(2-imidazolidin-2-on-1-yl)-ethyl]-(4S*,7R*)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C22H27BrN4O3
|
1
|
| 1 |
EC50 = 3730 nM
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CP0891849
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-amino-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C20H24BrN3O2
|
1
|
| 1 |
EC50 = 3920 nM
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CP0852680
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(5R)-N5-(2-Chloro-pyridin-5-yl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C19H23ClN4O3
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1
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| 1 |
EC50 = 4070 nM
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CP0891845
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-{[(1,5-dimethyl -1H-pyrazole-3-carbonyl)-amino]-methyl}-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
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C23H25BrN4O2
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1
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| 1 |
EC50 = 4070 nM
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CP0866451
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-(1-methyl-pyrrolidin-2-yl)-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C24H30BrN3O2
|
1
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| 1 |
EC50 = 4100 nM
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CP0867724
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-ethylsulfanyl-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C21H25BrN2O2S
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1
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| 1 |
EC50 = 4120 nM
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CP0867732
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-methyl-N6-(2-dimethylamino-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C22H28BrN3O2
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1
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| 1 |
EC50 = 4160 nM
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CP0880631
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-[(butanoylamino)-methyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
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C21H25BrN2O2
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1
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| 1 |
EC50 = 4270 nM
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CP0894082
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-pyridin-2-yl-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C24H24BrN3O2
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1
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| 1 |
EC50 = 4378 nM
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CP0867725
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(cyclopentyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C22H25BrN2O2
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1
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| 1 |
EC50 = 4400 nM
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CP0861395
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(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(piperidin-4-yl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C19H25BrN4O2S
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1
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| 1 |
EC50 = 4420 nM
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CP0954129
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(5R*)-N5-(4-Bromophenyl-methyl)-(6R*)-N6-(3-ethoxy-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C23H29BrN2O3
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1
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| 1 |
EC50 = 4460 nM
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CP0961794
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-[(isobutyrylamino)-methyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
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C21H25BrN2O2
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1
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| 1 |
EC50 = 4610 nM
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CP0859410
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(cyclopropyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C20H21BrN2O2
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1
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| 1 |
EC50 = 4615 nM
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CP0949167
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(5R)-N5-(4-Bromophenyl)-(6R)-N6-(2-carbamoyl-ethyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C20H22BrN3O3
|
1
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| 1 |
EC50 = 4620 nM
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CP0904417
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-tetrahydrofuranyl-methyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C22H25BrN2O3
|
1
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| 1 |
EC50 = 4640 nM
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CP0873895
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(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(piperidin-4-yl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C19H23BrN4O2S
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1
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| 1 |
EC50 = 4690 nM
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CP0877225
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-{[(4-methoxycarbonyl-butanoyl)-amino]-methyl}-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
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C23H27BrN2O4
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1
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| 1 |
EC50 = 4710 nM
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CP0967633
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(5R)-N5-(4-Bromophenyl)-(6R)-N6-(3-fluoro-4-(pyrrolidin-1-yl)butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt
Show/Hide
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C26H33BrFN3O4
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1
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| 1 |
EC50 = 4770 nM
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CP0946602
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(4-amino-4-oxobutyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt
Show/Hide
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C22H26BrN3O5
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1
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| 1 |
EC50 = 4780 nM
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CP0946872
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-[(3-pyridin-3-yl-propionylamino)-methyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
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C25H26BrN3O2
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1
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| 1 |
EC50 = 4810 nM
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CP0894677
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-amino-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C19H22BrN3O2
|
1
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| 1 |
EC50 = 4910 nM
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CP0891847
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-methoxy-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C21H25BrN2O3
|
1
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| 1 |
EC50 = 5030 nM
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CP0954128
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(tetrahydrofuran-2-yl-methyl)-(4S*,7R*)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C22H27BrN2O3
|
1
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| 1 |
EC50 = 5250 nM
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CP0949171
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-isobutyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C21H25BrN2O2
|
1
|
| 1 |
EC50 = 5310 nM
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|
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CP0951059
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(5R*)-N5-(4-Bromo-phenyl-methyl)-(6R*)-N6-(isobutyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C22H27BrN2O2
|
1
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| 1 |
EC50 = 5330 nM
|
|
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CP0902294
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-diethyl-amino-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C24H32BrN3O2
|
1
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| 1 |
EC50 = 5480 nM
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CP0867755
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-(N-tert-butoxycarbonyl-piperidin-3-yl)-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C29H38BrN3O4
|
1
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| 1 |
EC50 = 5488 nM
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CP0867720
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-methyl-N6-hexyl-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C24H31BrN2O2
|
1
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| 1 |
EC50 = 5500 nM
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CP0867195
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2,2-dimethyl-3-N-tert-butoxycarbonyl-amino-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C27H36BrN3O4
|
1
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| 1 |
EC50 = 5550 nM
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CP0951773
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-imidazolidin-2-on-1-yl-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C22H25BrN4O3
|
1
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| 1 |
EC50 = 5584 nM
|
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CP0863201
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-[(3-methoxy-propionylamino)-methyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
|
C21H25BrN2O3
|
1
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| 1 |
EC50 = 5680 nM
|
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CP0877370
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-[(1S)-2-methoxy-1-benzyl-ethyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C27H29BrN2O3
|
1
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| 1 |
EC50 = 6114 nM
|
|
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CP0895806
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(5R)-N5-(2-Bromo-pyrid-5-yl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C19H21BrN4O3
|
1
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| 1 |
EC50 = 6140 nM
|
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CP0866464
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-methyl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C22H27BrN2O2
|
1
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| 1 |
EC50 = 6190 nM
|
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CP0903264
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-dimethyl-amino-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C22H28BrN3O2
|
1
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| 1 |
EC50 = 6357 nM
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CP0900485
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(5R*)-N5-(5-Cyano-thiazol-2-yl)-(6R*)-N6-(4-pyrrolidin-1-yl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C23H29N5O2S
|
1
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| 1 |
EC50 = 6370 nM
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|
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CP0964069
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(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(cis-4-(hydroxymethyl)-cyclohexyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C21H28BrN3O3S
|
1
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| 1 |
EC50 = 6520 nM
|
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CP0900482
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(1-piperidin-1-yl-propan-1-on-2-yl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C25H30BrN3O3
|
1
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| 1 |
EC50 = 6587 nM
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CP0903263
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-1H-[1,2,4]-triazol-1-yl-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C22H24BrN5O2
|
1
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| 1 |
EC50 = 6680 nM
|
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CP0859189
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-[(3-(N,N-dimethyl-aminocarbonyl)-propionyl-amino)-methyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
|
C23H28BrN3O3
|
1
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| 1 |
EC50 = 6820 nM
|
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CP0903261
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-methoxy-propyl)-(4S*,7R*)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C21H27BrN2O3
|
1
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| 1 |
EC50 = 6920 nM
|
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CP0850493
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(N-methyl-piperidin-4-yl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C23H28BrN3O2
|
1
|
| 1 |
EC50 = 6942 nM
|
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CP0882511
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(5R*)-N5-(4-Bromophenyl-methyl)-(6R*)-N6-((2-imidazolidin-2-on)-1-yl-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C23H27BrN4O3
|
1
|
| 1 |
EC50 = 7040 nM
|
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CP0951787
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-{[N-(3-methoxy-propionyl)-N-methyl-amino]-methyl}-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
|
C22H27BrN2O3
|
1
|
| 1 |
EC50 = 7210 nM
|
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CP0891843
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-amino-2-oxoethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C19H20BrN3O3
|
1
|
| 1 |
EC50 = 7430 nM
|
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CP0951280
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(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-(pyrrolidin-1-yl)pentyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt
Show/Hide
|
C27H36BrN3O4
|
1
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| 1 |
EC50 = 7510 nM
|
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CP0935545
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(5R)-N5-(4-Bromophenyl)-(6R)-N6-(4-(2-(methoxymethyl)pyrrolidin-1-yl)butyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide, formate salt
Show/Hide
|
C28H38BrN3O5
|
1
|
| 1 |
EC50 = 7650 nM
|
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CP0867761
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(4-hydroxy-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C21H25BrN2O3
|
1
|
| 1 |
EC50 = 7840 nM
|
|
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CP0880921
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(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(4-hydroxybutyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C18H24BrN3O3S
|
1
|
| 1 |
EC50 = 7840 nM
|
|
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CP0904451
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-morpholino-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C23H28BrN3O3
|
1
|
| 1 |
EC50 = 7875 nM
|
|
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CP0859933
|
(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-[(4-(2-oxo-pyrrolidin-1-yl)-butyryl amino)-methyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
|
C25H30BrN3O3
|
1
|
| 1 |
EC50 = 7920 nM
|
|
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CP0864635
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(hexyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C23H29BrN2O2
|
1
|
| 1 |
EC50 = 7976 nM
|
|
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CP0867718
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C24H30BrN3O3
|
1
|
| 1 |
EC50 = 8045 nM
|
|
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CP0951792
|
(5R*)-N5-(5-Bromo-thiazol-2-yl)-(6R*)-N6-(isobutyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C19H24BrN3O2S
|
1
|
| 1 |
EC50 = 8240 nM
|
|
|
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CP0900488
|
(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(isobutyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C18H24BrN3O2S
|
1
|
| 1 |
EC50 = 8250 nM
|
|
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CP0866463
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-[(2S)-1-hydroxy-4-methyl-pent-2-yl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C23H29BrN2O3
|
1
|
| 1 |
EC50 = 8280 nM
|
|
|
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CP0877232
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3,3-dimethyl-butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C23H29BrN2O2
|
1
|
| 1 |
EC50 = 8300 nM
|
|
|
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CP0867731
|
(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-([1,4]-dioxan-2-yl-methyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
|
C22H25BrN2O4
|
1
|
| 1 |
EC50 = 8510 nM
|
|
|
|
CP0877374
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(5R*)-N5-(5-Bromo-thiazol-2-yl)-(6R*)-N6-((2-imidazolidin-2-on)-1-yl-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C19H22BrN5O3S
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1
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| 1 |
EC50 = 8730 nM
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CP0860086
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-carbamoyl-cyclohexyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C24H28BrN3O3
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1
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| 1 |
EC50 = 8734 nM
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CP0861847
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-{[N-(1,5-dimethyl-1H-pyrazole-3-carbonyl)-N-methyl-amino]-methyl}-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
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C24H27BrN4O2
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1
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| 1 |
EC50 = 8900 nM
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CP0894111
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-[(3-1H-indol-3-yl-propionylamino)-methyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
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C28H28BrN3O2
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1
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| 1 |
EC50 = 8960 nM
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CP0946860
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(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-[(1-hydroxy-cyclohexyl)methyl]-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C21H28BrN3O3S
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1
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| 1 |
EC50 = 9190 nM
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CP0900477
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(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(2-(2-hydroxyethoxy)ethyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C18H24BrN3O4S
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1
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| 1 |
EC50 = 9230 nM
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CP0850866
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(3-(5-methyl-1H-pyrazol-4-yl)-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C24H27BrN4O2
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1
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| 1 |
EC50 = 9420 nM
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CP0940779
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(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(3-hydroxypropyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C17H22BrN3O3S
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1
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| 1 |
EC50 = 10000 nM
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CP0866447
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(cyano-methyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C19H18BrN3O2
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1
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| 1 |
EC50 = 11500 nM
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CP0861397
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(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6,N6-(3-(aminomethyl)pentane-1,5-diyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C20H25BrN4O2S
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1
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| 1 |
EC50 > 14120 nM
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CP0903051
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-[(2-cyclopropyl-acetylamino)-methyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
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C22H25BrN2O2
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1
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| 1 |
EC50 > 14505 nM
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CP0951279
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(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(2-methyl-3-hydroxyprop-2-yl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C18H24BrN3O3S
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1
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| 1 |
EC50 = 15200 nM
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CP0877375
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(5R*)-N5-(4-Acetyl-thiazol-2-yl-methyl)-(6R*)-N6-(3-dimethylamino-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C22H30N4O3S
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1
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| 1 |
EC50 = 15300 nM
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CP0902278
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-hydroxy-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C19H21BrN2O3
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1
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| 1 |
EC50 = 16100 nM
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CP0952458
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(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(4-hydroxy-cyclohexyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C20H26BrN3O3S
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1
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| 1 |
EC50 = 16300 nM
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CP0850492
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(butyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C21H25BrN2O2
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1
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| 1 |
EC50 = 18200 nM
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CP0861447
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(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(trans-4-(hydroxymethyl)-cyclohexyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C21H28BrN3O3S
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1
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| 1 |
EC50 = 18200 nM
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CP0937309
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(5R)-N5-(5-Bromothiazol-2-yl)-(6R)-N6-(2-hydroxyethyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C16H20BrN3O3S
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1
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| 1 |
EC50 = 21400 nM
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CP0861401
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(5R*)-N5-(4-Acetyl-thiazol-2-yl-methyl)-(6R*)-N6-(3-(4-methylpiperazin-1-yl)-propyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C25H35N5O3S
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1
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| 1 |
EC50 = 22900 nM
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CP0846041
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(5R)-N5-(2-Bromothiazol-5-yl-methyl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C18H21BrN4O3S
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1
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| 1 |
EC50 > 25000 nM
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CP0846043
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(5R*)-N5-(5-Bromo-thiazol-2-yl)-(6R*)-N6-(2-fluoro-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C16H17BrFN3O2S
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1
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| 1 |
EC50 > 25000 nM
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CP0849526
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(5R)-N5-(5-Methyl-pyridin-2-yl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C20H24N4O3
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1
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| 1 |
EC50 > 25000 nM
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CP0849529
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(5R)-N5-(5-Bromopyrid-2-yl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C20H23BrN4O3
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1
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| 1 |
EC50 > 25000 nM
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CP0850392
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(5R)-N5-(4-Bromo-phenyl-methyl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C21H24BrN3O3
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1
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| 1 |
EC50 > 25000 nM
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CP0850494
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-{[(3-aminocarbonyl-propionyl)-amino]-methyl}-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
Show/Hide
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C21H24BrN3O3
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1
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| 1 |
EC50 > 25000 nM
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CP0867112
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(5R*)-N5-(4-Bromo-phenyl)-(6R*)-6-{[(5-phenyl-isoxazole-4-carbonyl)-amino]-methyl}-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5-carboxamide
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C27H24BrN3O3
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1
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| 1 |
EC50 > 25000 nM
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CP0867729
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(1-hydroxy-prop-2-yl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C22H28BrN3O3
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1
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| 1 |
EC50 > 25000 nM
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CP0870029
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-[(1S)-1-carbamoyl-ethyl]-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C20H22BrN3O3
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1
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| 1 |
EC50 > 25000 nM
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CP0873846
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(5R*)-N5-(4-Bromophenyl-methyl)-(6R*)-N6-(2-fluoroethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C20H22BrFN2O2
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1
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| 1 |
EC50 > 25000 nM
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CP0877233
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(pentyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C22H27BrN2O2
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1
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| 1 |
EC50 > 25000 nM
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CP0877373
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(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C17H19BrN4O3S
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1
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| 1 |
EC50 > 25000 nM
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CP0877376
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(5R)-N5-(4-Bromophenyl-methyl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C21H26BrN3O3
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1
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| 1 |
EC50 > 25000 nM
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CP0900487
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(5R)-N5-(4-Methoxyphenyl)-(6R)-N6-(3-hydroxyl-3-oxopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C21H24N2O5
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1
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| 1 |
EC50 > 25000 nM
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CP0904332
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(5R)-N5-(2-Bromopyrid-5-yl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
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C20H25BrN4O3
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1
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| 1 |
EC50 > 25000 nM
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CP0904333
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(5R)-N5-(2-Chloropyrid-5-yl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C20H23ClN4O3
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1
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| 1 |
EC50 > 25000 nM
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CP0940772
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(5R*)-N5-(4-Acetyl-thiazol-2-yl-methyl)-(6R*)-N6-(3-amino-3-oxopropyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C20H24N4O4S
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1
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| 1 |
EC50 > 25000 nM
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CP0949166
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(4-hydroxy-cyclohexyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C24H29BrN2O3
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1
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| 1 |
EC50 > 25000 nM
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CP0949189
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(5R*)-N5-(4-Acetyl-thiazol-2-yl-methyl)-(6R*)-N6-(isobutyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C21H27N3O4
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1
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| 1 |
EC50 > 25000 nM
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CP0951745
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(5R)-N5-(4-Bromo-2-fluorophenyl-methyl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C21H23BrFN3O3
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1
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| 1 |
EC50 > 25000 nM
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CP0951791
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(cyclohexyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C23H27BrN2O2
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1
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| 1 |
EC50 > 25000 nM
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CP0952118
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(5R*)-N5-(5-Bromothiazol-2-yl)-(6R*)-N6-(2-methoxy-ethyl)-(4S*,7R*)-[4,7-ethenylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C17H20BrN3O3S
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1
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| 1 |
EC50 > 25000 nM
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CP0952724
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(5R)-N5-(5-Bromo-thiazol-2-yl)-(6R)-N6-(3-amino-3-oxopropyl)-(4S,7R)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C17H21BrN4O3S
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1
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| 1 |
EC50 > 25000 nM
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CP0952725
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(5R*)-N5-(4-Bromophenyl)-(6R*)-N6-(2-carbamoyl-ethyl)-(4S*,7R*)-[4,7-ethylene-spiro[2.4]heptane]-5,6-dicarboxamide
Show/Hide
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C20H24BrN3O3
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1
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| 1 |
EC50 > 25000 nM
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