General Information of the Compound
Compound ID
CP0464411
Compound Name
3-[8-[4-[2-[4-[3-(azepan-1-yl)propoxy]phenyl]ethyl]piperazin-1-yl]-6-ethylquinolin-2-yl]propanoic acid
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Structure
Formula
C35H48N4O3
Molecular Weight
572.794
Canonical SMILES
CCc1cc(N2CCN(CCc3ccc(OCCCN4CCCCCC4)cc3)CC2)c2nc(CCC(O)=O)ccc2c1
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InChI
InChI=1S/C35H48N4O3/c1-2-28-26-30-10-11-31(12-15-34(40)41)36-35(30)33(27-28)39-23-21-38(22-24-39)20-16-29-8-13-32(14-9-29)42-25-7-19-37-17-5-3-4-6-18-37/h8-11,13-14,26-27H,2-7,12,15-25H2,1H3,(H,40,41)
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InChIKey
WRWUGHDNJYUGGD-UHFFFAOYSA-N
Physicochemical Property
logP
5.824
Rotatable Bonds
13
Heavy Atom Count
42
Polar Areas
69.14
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
42

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 57780007
ChEMBL ID
CHEMBL3926412
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01089, Alpha-1A adrenergic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000019 Rat1 Rattus norvegicus (Rat)  1
1
Ki = 251.19 nM
   TI
   LI
   LO
   TS
Protein ID: PT01007, Alpha-1B adrenergic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000019 Rat1 Rattus norvegicus (Rat)  1
1
Ki > 1995.26 nM
   TI
   LI
   LO
   TS
Protein ID: PT01206, Histamine H1 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
Kd = 2.512 nM
   TI
   LI
   LO
   TS
2
Ki = 15.85 nM
   TI
   LI
   LO
   TS
Protein ID: PT01194, Histamine H3 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1.995 nM
   TI
   LI
   LO
   TS
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
IC50 = 50118.72 nM
   TI
   LI
   LO
   TS