General Information of the Compound
Compound ID
CP0390316
Compound Name
(3S)-1-[2-[(4-methoxy-2-methylphenyl)-bis(4-methoxyphenyl)methoxy]ethyl]piperidine-3-carboxylic acid
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Structure
Formula
C31H37NO6
Molecular Weight
519.638
Canonical SMILES
COc1ccc(cc1)C(OCCN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1C
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InChI
InChI=1S/C31H37NO6/c1-22-20-28(37-4)15-16-29(22)31(24-7-11-26(35-2)12-8-24,25-9-13-27(36-3)14-10-25)38-19-18-32-17-5-6-23(21-32)30(33)34/h7-16,20,23H,5-6,17-19,21H2,1-4H3,(H,33,34)/t23-/m0/s1
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InChIKey
GPMXCWRTQWGABQ-QHCPKHFHSA-N
Physicochemical Property
logP
5.12592
Rotatable Bonds
11
Heavy Atom Count
38
Polar Areas
77.46
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145961028
ChEMBL ID
CHEMBL4126078
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03285, Sodium- and chloride-dependent GABA transporter 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 64565.42 nM
   TI
   LI
   LO
   TS
2
IC50 = 64570 nM
   TI
   LI
   LO
   TS
Protein ID: PT03705, Sodium- and chloride-dependent GABA transporter 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 75857.76 nM
   TI
   LI
   LO
   TS
2
IC50 = 75860 nM
   TI
   LI
   LO
   TS
Protein ID: PT03076, Sodium- and chloride-dependent GABA transporter 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 1659.59 nM
   TI
   LI
   LO
   TS
2
IC50 = 1660 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 5780 nM
Protein ID: PT02526, Sodium- and chloride-dependent GABA transporter 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000053 COS-7 Chlorocebus aethiops (Green monkey)  1
1
IC50 = 3160 nM
   TI
   LI
   LO
   TS