General Information of the Protein
| Protein ID |
PT03076
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| Protein Name |
Sodium- and chloride-dependent GABA transporter 3
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| Secondarily Protein Name |
Sodium- and chloride-dependent GABA transporter 4
Solute carrier family 6 member 11
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| Gene Name |
SLC6A11
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| Secondarily Gene Name |
Gabt3
Gabt4
Gat-4
Gat3
Gat4
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| Sequence |
MTAEQALPLGNGKAAEEARGSETLGGGGGGAAGTREARDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRRVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTEKCVEFQKLNFSNYSHVSLQNATSPVMEFWERRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSIISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECVCIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKYKPLKYNNVYTYPAWGYGIGWLMALSSMLCIPLWIFIKLWKTEGTLPEKLQKLTVPSADLKMRGKLGASPRTVTVNDCEAKVKGDGTISAITEKETHF
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| Organism |
Mus musculus, Mouse
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| Protein Classification |
Transporter
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Electrochemical transporter
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SLC superfamily of solute carriers
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SLC06 neurotransmitter transporter family
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| Function |
Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:8420981, PubMed:30270321). Can also mediate transport of beta-alanine and to a lower extent that of taurine and hypotaurine (PubMed:8420981, PubMed:30270321).
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| Uniprot ID |
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| Ensembl ID | |||||
| Subcellular Location |
Cell membrane
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Map of Molecular Bioactivity Related to the Protein
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Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000051 , BHK-21
| Compound ID | Compound Name | Compound Formula | |
| CP0390468 |
1-(3-carbazol-9-ylpropyl)-4-(2-methoxyphenyl)piperidin-4-ol
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C27H30N2O2
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2 |
| 1 |
IC50 = 15135.61 nM
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TI
LI
LO
TS
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| 2 |
Ki = 15000 nM
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TI
LI
LO
TS
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Biochemical Assays