General Information of the Protein
Protein ID
PT03705
Protein Name
Sodium- and chloride-dependent GABA transporter 2
Secondarily
Protein Name
Sodium- and chloride-dependent GABA transporter 3
Solute carrier family 6 member 13
Gene Name
SLC6A13
Secondarily
Gene Name
Gabt2
Gabt3
Gat-3
Gat2
Gat3
Sequence
MENRASGTTSNGETKPVCPAMEKVEEDGTLEREHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTNQGGITAWRRICPIFEGIGYASQMIVSLLNVYYIVVLAWALFYLFSSFTTDLPWGSCSHEWNTENCVEFQKANDSMNVTSENATSPVIEFWERRVLKLSDGIQHLGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNITRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCILNSSTSFMAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPRVFRKKNRREVLILIVSVISFFIGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAGRFYDNIEDMIGYKPWPLIKYCWLFFTPAVCLATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMICIPAWSIYKLRTLKGPLRERLRQLVCPAEDLPQKNQPEPTAPATPMTSLLRLTELESNC
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Organism
Mus musculus, Mouse
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC06 neurotransmitter transporter family
Function
Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:8420981, PubMed:22896705, PubMed:30270321). Can also mediate transport of beta-alanine, taurine and hypotaurine and is the major taurine transporter in hepatocytes (PubMed:8420981, PubMed:22896705, PubMed:30270321).
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Uniprot ID
P31649
Subcellular Location
Cell membrane
Basolateral cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000051 , BHK-21
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0390468
 Compound Info 
1-(3-carbazol-9-ylpropyl)-4-(2-methoxyphenyl)piperidin-4-ol
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C27H30N2O2
  2
1
IC50 = 1412.54 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
Ki = 41000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000335 , D8
 Cell Line Info 
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0419707
 Compound Info 
4-amino-N-[(2-chlorophenyl)methyl]-2-[4,4-diphenylbut-3-enyl(methyl)amino]butanamide
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C28H32ClN3O
  2
1 IC50 = 5128.61 nM
2 IC50 = 6456.54 nM
CP0000066
 Compound Info 
4-amino-n-[2,3-3H]butyric acid
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C4H9NO2
  1
1 IC50 = 7079.46 nM
CP0041604
 Compound Info 
3-aminopropanoic acidbeta-alanine
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C3H7NO2
  1
1 IC50 = 66069.34 nM
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT02525 Sodium- and chloride-dependent GABA transporter 2 Rattus norvegicus, Rat
 Protein Info 
PT05696 Sodium- and chloride-dependent GABA transporter 2 Homo sapiens, Human
 Protein Info