General Information of the Protein
Protein ID
PT02525
Protein Name
Sodium- and chloride-dependent GABA transporter 2
Secondarily
Protein Name
Solute carrier family 6 member 13
Gene Name
SLC6A13
Secondarily
Gene Name
Gabt2
Gat-2
Sequence
MDNRVSGTTSNGETKPVCPVMEKVEEDGTLEREQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTNQGGITAWRKICPIFEGIGYASQMIVSLLNVYYIVVLAWALFYLFSSFTTDLPWGSCSHEWNTENCVEFQKTNNSLNVTSENATSPVIEFWERRVLKISDGIQHLGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNITRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCVALCILNSSTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPRVFRKKNRREILILIVSVVSFFIGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGASRFYDNIEDMIGYKPWPLIKYCWLFFTPAVCLATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSIYKLRTLKGPLRERLRQLVCPAEDLPQKSQPELTSPATPMTSLLRLTELESNC
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Organism
Rattus norvegicus, Rat
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC06 neurotransmitter transporter family
Function
Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:1400419, PubMed:22896705). Mediates transport of taurine and is the major taurine transporter in hepatocytes (PubMed:22896705). Can also mediate transport of beta-alanine and hypotaurine (By similarity).
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Uniprot ID
P31646
Subcellular Location
Cell membrane
Basolateral cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000440 , LM
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0172082
 Compound Info 
1-{2-[9-(4-Methoxy-phenyl)-9H-fluoren-9-yloxy]-ethyl}-piperidine-3-carboxylic acid
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C28H29NO4
  1
1
IC50 = 51000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0292269
 Compound Info 
1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid
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C30H35NO6
  1
1 IC50 = 34000 nM
CP0172082
 Compound Info 
1-{2-[9-(4-Methoxy-phenyl)-9H-fluoren-9-yloxy]-ethyl}-piperidine-3-carboxylic acid
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C28H29NO4
  1
1 IC50 = 51000 nM
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT05696 Sodium- and chloride-dependent GABA transporter 2 Homo sapiens, Human
 Protein Info 
50% Identity
Protein ID Protein Name Protein Organism
PT03705 Sodium- and chloride-dependent GABA transporter 2 Mus musculus, Mouse
 Protein Info