General Information of the Protein
Protein ID
PT05696
Protein Name
Sodium- and chloride-dependent GABA transporter 2
Secondarily
Protein Name
Solute carrier family 6 member 13
Gene Name
SLC6A13
Secondarily
Gene Name
GAT2
Sequence
MDSRVSGTTSNGETKPVYPVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRERIRQLMCPAEDLPQRNPAGPSAPATPRTSLLRLTELESHC
    Show/Hide
Organism
Homo sapiens, Human
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC06 neurotransmitter transporter family
Function
Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:17502375, PubMed:22932902). Mediates transport of beta-alanine (PubMed:17502375). Can also mediate transport of taurine and hypotaurine (By similarity).
    Show/Hide
Uniprot ID
Primary ID:
Q9NSD5

Secondarily ID:
B4DJL1
Q8TCC2
Q8WW56
    Show/Hide
HGNC ID
HGNC:11046
Subcellular Location
Cell membrane
Basolateral cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0390468
 Compound Info 
1-(3-carbazol-9-ylpropyl)-4-(2-methoxyphenyl)piperidin-4-ol
   Show/Hide
C27H30N2O2
  1
1
IC50 = 6200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0081174
 Compound Info 
(S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piperidine-3-carboxylic acid
   Show/Hide
C30H35NO6
  1
1
IC50 = 11900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0860280
 Compound Info 
trans-(1S,2R)-2-amino-1-(carboxymethyl)cyclopropane hydrochloride
   Show/Hide
C5H10ClNO2
  1
1
IC50 = 36900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0386952
 Compound Info 
2-[(1S,2S)-2-aminocyclopropyl]acetic acid
   Show/Hide
C5H9NO2
  1
1
IC50 = 36900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0041604
 Compound Info 
3-aminopropanoic acidbeta-alanine
   Show/Hide
C3H7NO2
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0413260
 Compound Info 
(1S,2S,5R)-5-aminobicyclo[3.1.0]hexane-2-carboxylic acid
   Show/Hide
C7H11NO2
  1
1
IC50 > 100000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000386 , Flp-In-CHO
 Cell Line Info 
Cell Line ID: CL000027 , tsA201
 Cell Line Info 
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT02525 Sodium- and chloride-dependent GABA transporter 2 Rattus norvegicus, Rat
 Protein Info 
50% Identity
Protein ID Protein Name Protein Organism
PT03705 Sodium- and chloride-dependent GABA transporter 2 Mus musculus, Mouse
 Protein Info