General Information of the Protein
Protein ID
PT03285
Protein Name
Sodium- and chloride-dependent GABA transporter 1
Secondarily
Protein Name
Solute carrier family 6 member 1
Gene Name
SLC6A1
Secondarily
Gene Name
Gabt1
Gat-1
Gat1
Sequence
MATDNSKVADGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAYI
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Organism
Mus musculus, Mouse
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC06 neurotransmitter transporter family
Function
Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:15234345, PubMed:16150932, PubMed:8420981, PubMed:30270321). The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (By similarity). The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA (By similarity). Can also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA (PubMed:30270321).
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Uniprot ID
P31648
Ensembl ID
ENSG00000157103
Subcellular Location
Cell membrane
Presynapse
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000051 , BHK-21
Compound ID Compound Name Compound Formula
CP0390468
1-(3-carbazol-9-ylpropyl)-4-(2-methoxyphenyl)piperidin-4-ol
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C27H30N2O2
 2
1
IC50 = 19054.61 nM
   TI
   LI
   LO
   TS
2
Ki = 19000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0221365
(R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-enyl)piperidine-3-carboxylic acid hydrochloride
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C20H25NO2S2
 1
1 IC50 = 131.83 nM
CP0059522
(R)-Piperidine-3-carboxylic acid
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C6H11NO2
 1
1 IC50 = 6456.54 nM
CP0419707
4-amino-N-[(2-chlorophenyl)methyl]-2-[4,4-diphenylbut-3-enyl(methyl)amino]butanamide
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C28H32ClN3O
 1
1 IC50 = 12882.5 nM
CP0000066
4-amino-n-[2,3-3H]butyric acid
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C4H9NO2
 1
1 IC50 = 30199.52 nM