General Information of the Compound
Compound ID
CP0161144
Compound Name
tetraethylazanium
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Synonyms
[14C]-TEA
4-04-00-00331 (Beilstein Handbook Reference)
56-34-8 (chloride)
5AV7G7EIEE
66-40-0
68-05-3 (iodide)
71-91-0 (bromide)
77-98-5 (hydroxide)
AC1L1KAW
AMMONIUM, TETRAETHYL-
BRN 1738225
C8H20N
CHEBI:44296
CHEMBL9324
Ethanaminium,
GTPL2343
GTPL4575
Lopac-T-2265
N,N,N-Triethylethanaminium
NEt4(+)
SCHEMBL16267
TETRAETHYLAMMONIUM ION
Tetraethylammonium
Tetraetilammonio
Tetraetilammonio [Italian]
Tetramon
Tetrylammonium
UNII-5AV7G7EIEE
[14C]-TEA
[14C]TEA
tetraethyl ammonium
tetraethylamine
tetraethylammonium
tetraethylazanium
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Structure
Formula
C8H20N+
Molecular Weight
130.255
Canonical SMILES
CC[N+](CC)(CC)CC
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InChI
InChI=1S/C8H20N/c1-5-9(6-2,7-3)8-4/h5-8H2,1-4H3/q+1
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InChIKey
CBXCPBUEXACCNR-UHFFFAOYSA-N
Physicochemical Property
logP
1.8828
Rotatable Bonds
4
Heavy Atom Count
9
Polar Areas
0
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
0
Complexity
9

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 5413
SID: 15297244
ChEMBL ID
CHEMBL9324
DrugBank ID
DB08837
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06157, Solute carrier family 22 member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000031 MDCK Canis lupus familiaris (Dog)  2
1
Ki = 46600 nM
   TI
   LI
   LO
   TS
2
Km = 38000 nM
   TI
   LI
   LO
   TS
Protein ID: PT03795, Solute carrier family 22 member 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Km = 2320 nM
   TI
   LI
   LO
   TS
CL000017 HeLa Homo sapiens (Human)  1
1
Km = 229000 nM
   TI
   LI
   LO
   TS
Protein ID: PT04368, Solute carrier family 22 member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000031 MDCK Canis lupus familiaris (Dog)  2
1
Ki = 52200 nM
   TI
   LI
   LO
   TS
2
Km = 45000 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( [14C]TEA )
Drug Name [14C]TEA
Target(s)
Voltage-gated potassium channel Kv7.3 (KCNQ3)
Blocker (channel blocker)
Voltage-gated potassium channel Kv7.5 (KCNQ5)
Blocker (channel blocker)
Voltage-gated potassium channel Kv1.8 (KCNA10)
Blocker (channel blocker)
Voltage-gated potassium channel Kv7.2 (KCNQ2)
Blocker (channel blocker)
Voltage-gated potassium channel Kv3.2 (KCNC2)
Blocker (channel blocker)
Voltage-gated potassium channel Kv1.7 (KCNA7)
Blocker (channel blocker)
Calcium-activated potassium channel KCa4.1 (KCNT1)
Blocker (channel blocker)
Voltage-gated potassium channel Kv2.1 (KCNB1)
Blocker (channel blocker)
Calcium-activated potassium channel KCa4.2 (KCNT2)
Blocker (channel blocker)
Solute carrier family 47 member 1 (SLC47A1)
Modulator
Multidrug and toxin extrusion protein 2 (MATE2)
Modulator
Transient receptor potential cation channel V2 (TRPV2)
Blocker (channel blocker)
Voltage-gated potassium channel Kv7.4 (KCNQ4)
Blocker (channel blocker)
Calcium-activated potassium channel KCa2.2 (KCNN2)
Blocker (channel blocker)
Calcium-activated potassium channel KCa2.3 (KCNN3)
Blocker (channel blocker)
Calcium-activated potassium channel KCa2.1 (KCNN1)
Blocker (channel blocker)
Voltage-gated potassium channel Kv1.6 (KCNA6)
Blocker (channel blocker)
Voltage-gated potassium channel Kv1.2 (KCNA2)
Blocker (channel blocker)
Voltage-gated potassium channel Kv1.1 (KCNA1)
Blocker (channel blocker)
Voltage-gated potassium channel Kv1.3 (KCNA3)
Blocker (channel blocker)
Voltage-gated potassium channel Kv3.1 (KCNC1)
Blocker (channel blocker)
Voltage-gated potassium channel Kv1.5 (KCNA5)
Blocker (channel blocker)
Inward rectifier potassium channel Kir2.3 (KCNJ4)
Blocker (channel blocker)
Voltage-gated potassium channel Kv2.2 (KCNB2)
Blocker (channel blocker)
Charybdotoxin receptor beta-4 (BKbeta4)
Inhibitor
Aquaporin-1 (AQP1)
Inhibitor