General Information of the Protein
Protein ID
PT06983
Protein Name
Potassium channel subfamily T member 1
Secondarily
Protein Name
KCa4.1
Gene Name
KCNT1
Secondarily
Gene Name
KIAA1422
Sequence
MARAKLPRSPSEGKAGPGGAPAGAAAPEEPHGLSPLLPARGGGSVGSDVGQRLPVEDFSLDSSLSQVQVEFYVNENTFKERLKLFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQVIVAIISFLETMLLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEVDRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEKRKKRAFSGQGLHEGPARLPVHSIIASMGTVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSSALLPCDLLSDQSEDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLRAYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLFPSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTPGSGYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHVFSTSESQISVNVEDCEDTREVKGPWGSRAGTGGSSQGRHTGGGDPAEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYEDVANLTASDVMNRVNLGYLQDEMNDHQNTLSYVLINPPPDTRLEPSDIVYLIRSDPLAHVASSSQSRKSSCSHKLSSCNPETRDETQL
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Organism
Homo sapiens, Human
Protein Classification
Unclassified protein
Function
Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity).
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Uniprot ID
Primary ID:
Q5JUK3

Secondarily ID:
B3KXF7
B7ZVY4
B9EGP2
G5E9V0
Q9P2C5
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Ensembl ID
ENSG00000107147
HGNC ID
HGNC:18865
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
Compound ID Compound Name Compound Formula
CP0579556
N-(5-chloro-2-fluorophenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
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C18H26ClFN4O3S
 1
1
EC50 = 3800 nM
   TI
   LI
   LO
   TS
CP0578378
N-(4-methylphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C19H30N4O3S
 1
1
EC50 = 4100 nM
   TI
   LI
   LO
   TS
CP0545575
N-(3-fluorophenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
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C18H27FN4O3S
 1
1
EC50 = 4600 nM
   TI
   LI
   LO
   TS
CP0579658
N-(3-chlorophenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
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C18H27ClN4O3S
 1
1
EC50 = 7600 nM
   TI
   LI
   LO
   TS
CP0577400
N-(5-chloro-2-methoxyphenyl)-2-[4-[4-(4,4-dimethylpiperidine-1-carbonyl)piperazin-1-yl]sulfonylpiperazin-1-yl]acetamide
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C25H39ClN6O5S
 1
1
EC50 = 9000 nM
   TI
   LI
   LO
   TS
CP0568175
N-(5-chloro-2-methoxyphenyl)-2-[1-(4-methylpiperidin-1-yl)sulfonylpiperidin-4-yl]acetamide
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C20H30ClN3O4S
 1
1
EC50 = 9300 nM
   TI
   LI
   LO
   TS
CP0545566
N-(2-fluorophenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
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C18H27FN4O3S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0547358
N-(5-chloro-2-methoxyphenyl)-2-(4-methylpiperidin-1-yl)sulfonyl-2,7-diazaspiro[3.5]nonane-7-carboxamide
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C21H31ClN4O4S
 1
1
EC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0568174
2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]-N-phenylacetamide
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C18H28N4O3S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0570167
N-(5-chloro-2-methoxyphenyl)-2-[4-[4-(piperidine-1-carbonyl)piperazin-1-yl]sulfonylpiperazin-1-yl]acetamide
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C23H35ClN6O5S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0577399
N-(4-fluorophenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
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C18H27FN4O3S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0578930
N-(5-chloro-2-methoxyphenyl)-2-[4-[4-(3,3-difluoropyrrolidin-1-yl)sulfonylpiperazin-1-yl]sulfonylpiperazin-1-yl]acetamide
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C21H31ClF2N6O6S2
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0579274
2-[4-[4-(azepane-1-carbonyl)piperazin-1-yl]sulfonylpiperazin-1-yl]-N-(5-chloro-2-methoxyphenyl)acetamide
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C24H37ClN6O5S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0579554
N-(5-chloro-2-methoxyphenyl)-7-(4-methylpiperidin-1-yl)sulfonyl-2,7-diazaspiro[3.5]nonane-2-carboxamide
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C21H31ClN4O4S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0579839
N-(4-chlorophenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C18H27ClN4O3S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0579979
N-(4-methoxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
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C19H30N4O4S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0537139
2-methyl-5-(trifluoromethyl)-N-[(1S)-1-[3-[2-(trifluoromethyl)pyridin-4-yl]-1,2,4-oxadiazol-5-yl]ethyl]pyrazole-3-carboxamide
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C16H12F6N6O2
 1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
CP0569741
2-[4-[4-(benzenesulfonyl)piperazin-1-yl]sulfonylpiperazin-1-yl]-N-(5-chloro-2-methoxyphenyl)acetamide
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C23H30ClN5O6S2
 1
1
IC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0570176
N-(5-bromo-2-methoxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
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C19H29BrN4O4S
 1
1
IC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0545569
N-(5-chloro-2-methoxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C19H29ClN4O4S
 2
1
IC50 = 1700 nM
   TI
   LI
   LO
   TS
2
IC50 = 2400 nM
   TI
   LI
   LO
   TS
CP0547360
N-(5-chloro-2-methoxyphenyl)-2-[(2R)-2-methyl-4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
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C20H31ClN4O4S
 2
1
IC50 = 1700 nM
   TI
   LI
   LO
   TS
2
IC50 = 2400 nM
   TI
   LI
   LO
   TS
CP0545567
(2S)-N-(5-chloro-2-methoxyphenyl)-2-[4-[4-(trifluoromethyl)piperidin-1-yl]sulfonylpiperazin-1-yl]propanamide
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C20H28ClF3N4O4S
 2
1
IC50 = 1900 nM
   TI
   LI
   LO
   TS
2
IC50 = 3400 nM
   TI
   LI
   LO
   TS
CP0568173
N-(5-chloro-2-methoxyphenyl)-2-[4-[4-(4-chlorophenyl)sulfonylpiperazin-1-yl]sulfonylpiperazin-1-yl]acetamide
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C23H29Cl2N5O6S2
 1
1
IC50 = 2300 nM
   TI
   LI
   LO
   TS
CP0569389
N-[2-methoxy-5-(trifluoromethyl)phenyl]-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
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C20H29F3N4O4S
 2
1
IC50 = 2300 nM
   TI
   LI
   LO
   TS
2
IC50 = 2400 nM
   TI
   LI
   LO
   TS
CP0579553
2-(1,3-dioxoisoindol-2-yl)-N-[3-(trifluoromethyl)phenyl]-1,3-benzothiazole-6-carboxamide
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C23H12F3N3O3S
 1
1
IC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0579985
3-[4-[[2-(3-methylphenyl)acetyl]amino]pyrazol-1-yl]-N-[[2-(1,2,4-triazol-1-yl)phenyl]methyl]benzamide
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C28H25N7O2
 1
1
IC50 = 3200 nM
   TI
   LI
   LO
   TS
CP0545571
(2R)-N-(5-chloro-2-methoxyphenyl)-2-[4-[4-(trifluoromethyl)piperidin-1-yl]sulfonylpiperazin-1-yl]propanamide
   Show/Hide
C20H28ClF3N4O4S
 1
1
IC50 = 3500 nM
   TI
   LI
   LO
   TS
CP0545572
N-(5-chloro-2-methoxyphenyl)-2-[(2S)-2-methyl-4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C20H31ClN4O4S
 1
1
IC50 = 3500 nM
   TI
   LI
   LO
   TS
CP0574583
N-(5-chloro-2-propoxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C21H33ClN4O4S
 1
1
IC50 = 4300 nM
   TI
   LI
   LO
   TS
CP0578929
(2S)-N-(5-chloro-2-methoxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]propanamide
   Show/Hide
C20H31ClN4O4S
 1
1
IC50 = 4400 nM
   TI
   LI
   LO
   TS
CP0577397
(2R)-N-(5-chloro-2-methoxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]propanamide
   Show/Hide
C20H31ClN4O4S
 1
1
IC50 = 4900 nM
   TI
   LI
   LO
   TS
CP0577398
N-(5-fluoro-2-methoxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C19H29FN4O4S
 1
1
IC50 = 4900 nM
   TI
   LI
   LO
   TS
CP0568853
N-(5-chloro-2-propan-2-yloxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C21H33ClN4O4S
 1
1
IC50 = 5100 nM
   TI
   LI
   LO
   TS
CP0579273
N-(5-chloro-2-methoxyphenyl)-4-(4-methylpiperidin-1-yl)sulfonyl-1,4-diazepane-1-carboxamide
   Show/Hide
C19H29ClN4O4S
 1
1
IC50 = 6200 nM
   TI
   LI
   LO
   TS
CP0569380
N-(5-chloro-2-ethoxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C20H31ClN4O4S
 1
1
IC50 = 7100 nM
   TI
   LI
   LO
   TS
CP0569371
N-[5-chloro-2-(cyclopropylmethoxy)phenyl]-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C22H33ClN4O4S
 1
1
IC50 = 7500 nM
   TI
   LI
   LO
   TS
CP0522084
N-(5-chloro-2-methylphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C19H29ClN4O3S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0545570
N-(2-methoxy-5-methylphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C20H32N4O4S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0545573
N-(5-chloro-2-methoxyphenyl)-2-(4-methylpiperidin-1-yl)sulfonyl-2,6-diazaspiro[3.3]heptane-6-carboxamide
   Show/Hide
C19H27ClN4O4S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0545574
N-(2-methoxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C19H30N4O4S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0568828
N-(5-chloro-2-methoxyphenyl)-2-[4-[4-(4-propylpiperidine-1-carbonyl)piperazin-1-yl]sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C26H41ClN6O5S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0570175
N-(5-chloro-2-methoxyphenyl)-2-[(3S)-3-methyl-4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C20H31ClN4O4S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0574585
N-(5-chloro-2-methoxyphenyl)-2-[methyl-[2-[methyl-(4-methylpiperidin-1-yl)sulfonylamino]ethyl]amino]acetamide
   Show/Hide
C19H31ClN4O4S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0568829
N-(5-chloro-2-methoxyphenyl)-2-[(3R)-3-methyl-4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C20H31ClN4O4S
 1
1
IC50 = 13000 nM
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( Calcium-activated potassium channel KCa4.1 (KCNT1) )
Target Type Clinical trial Target
Disease 1 Target-related Disease  1
1 Acute myeloid leukaemia [ICD-11: 2A60]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 phorbol 12-myristate 13-acetate Phase 2
Acute myeloid leukaemia