General Information of the Protein
Protein ID
PT06983
Protein Name
Potassium channel subfamily T member 1
Secondarily
Protein Name
KCa4.1
Gene Name
KCNT1
Secondarily
Gene Name
KIAA1422
Sequence
MARAKLPRSPSEGKAGPGGAPAGAAAPEEPHGLSPLLPARGGGSVGSDVGQRLPVEDFSLDSSLSQVQVEFYVNENTFKERLKLFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQVIVAIISFLETMLLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEVDRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEKRKKRAFSGQGLHEGPARLPVHSIIASMGTVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSSALLPCDLLSDQSEDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLRAYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLFPSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTPGSGYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHVFSTSESQISVNVEDCEDTREVKGPWGSRAGTGGSSQGRHTGGGDPAEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYEDVANLTASDVMNRVNLGYLQDEMNDHQNTLSYVLINPPPDTRLEPSDIVYLIRSDPLAHVASSSQSRKSSCSHKLSSCNPETRDETQL
    Show/Hide
Organism
Homo sapiens, Human
Protein Classification
Unclassified protein
Function
Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity).
    Show/Hide
Uniprot ID
Primary ID:
Q5JUK3

Secondarily ID:
B3KXF7
B7ZVY4
B9EGP2
G5E9V0
Q9P2C5
    Show/Hide
Ensembl ID
ENSG00000107147
HGNC ID
HGNC:18865
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0579556
 Compound Info 
N-(5-chloro-2-fluorophenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C18H26ClFN4O3S
  1
1
EC50 = 3800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0578378
 Compound Info 
N-(4-methylphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C19H30N4O3S
  1
1
EC50 = 4100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0545575
 Compound Info 
N-(3-fluorophenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C18H27FN4O3S
  1
1
EC50 = 4600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0579658
 Compound Info 
N-(3-chlorophenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C18H27ClN4O3S
  1
1
EC50 = 7600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0577400
 Compound Info 
N-(5-chloro-2-methoxyphenyl)-2-[4-[4-(4,4-dimethylpiperidine-1-carbonyl)piperazin-1-yl]sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C25H39ClN6O5S
  1
1
EC50 = 9000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0568175
 Compound Info 
N-(5-chloro-2-methoxyphenyl)-2-[1-(4-methylpiperidin-1-yl)sulfonylpiperidin-4-yl]acetamide
   Show/Hide
C20H30ClN3O4S
  1
1
EC50 = 9300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0545566
 Compound Info 
N-(2-fluorophenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C18H27FN4O3S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0547358
 Compound Info 
N-(5-chloro-2-methoxyphenyl)-2-(4-methylpiperidin-1-yl)sulfonyl-2,7-diazaspiro[3.5]nonane-7-carboxamide
   Show/Hide
C21H31ClN4O4S
  1
1
EC50 = 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0568174
 Compound Info 
2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]-N-phenylacetamide
   Show/Hide
C18H28N4O3S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0570167
 Compound Info 
N-(5-chloro-2-methoxyphenyl)-2-[4-[4-(piperidine-1-carbonyl)piperazin-1-yl]sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C23H35ClN6O5S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0577399
 Compound Info 
N-(4-fluorophenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C18H27FN4O3S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0578930
 Compound Info 
N-(5-chloro-2-methoxyphenyl)-2-[4-[4-(3,3-difluoropyrrolidin-1-yl)sulfonylpiperazin-1-yl]sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C21H31ClF2N6O6S2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0579274
 Compound Info 
2-[4-[4-(azepane-1-carbonyl)piperazin-1-yl]sulfonylpiperazin-1-yl]-N-(5-chloro-2-methoxyphenyl)acetamide
   Show/Hide
C24H37ClN6O5S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0579554
 Compound Info 
N-(5-chloro-2-methoxyphenyl)-7-(4-methylpiperidin-1-yl)sulfonyl-2,7-diazaspiro[3.5]nonane-2-carboxamide
   Show/Hide
C21H31ClN4O4S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0579839
 Compound Info 
N-(4-chlorophenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C18H27ClN4O3S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0579979
 Compound Info 
N-(4-methoxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C19H30N4O4S
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0537139
 Compound Info 
2-methyl-5-(trifluoromethyl)-N-[(1S)-1-[3-[2-(trifluoromethyl)pyridin-4-yl]-1,2,4-oxadiazol-5-yl]ethyl]pyrazole-3-carboxamide
   Show/Hide
C16H12F6N6O2
  1
1
IC50 = 40 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0569741
 Compound Info 
2-[4-[4-(benzenesulfonyl)piperazin-1-yl]sulfonylpiperazin-1-yl]-N-(5-chloro-2-methoxyphenyl)acetamide
   Show/Hide
C23H30ClN5O6S2
  1
1
IC50 = 1100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0570176
 Compound Info 
N-(5-bromo-2-methoxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C19H29BrN4O4S
  1
1
IC50 = 1400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0545569
 Compound Info 
N-(5-chloro-2-methoxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C19H29ClN4O4S
  2
1
IC50 = 1700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 2400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0547360
 Compound Info 
N-(5-chloro-2-methoxyphenyl)-2-[(2R)-2-methyl-4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C20H31ClN4O4S
  2
1
IC50 = 1700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 2400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0545567
 Compound Info 
(2S)-N-(5-chloro-2-methoxyphenyl)-2-[4-[4-(trifluoromethyl)piperidin-1-yl]sulfonylpiperazin-1-yl]propanamide
   Show/Hide
C20H28ClF3N4O4S
  2
1
IC50 = 1900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 3400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0568173
 Compound Info 
N-(5-chloro-2-methoxyphenyl)-2-[4-[4-(4-chlorophenyl)sulfonylpiperazin-1-yl]sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C23H29Cl2N5O6S2
  1
1
IC50 = 2300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0569389
 Compound Info 
N-[2-methoxy-5-(trifluoromethyl)phenyl]-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C20H29F3N4O4S
  2
1
IC50 = 2300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 2400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0579553
 Compound Info 
2-(1,3-dioxoisoindol-2-yl)-N-[3-(trifluoromethyl)phenyl]-1,3-benzothiazole-6-carboxamide
   Show/Hide
C23H12F3N3O3S
  1
1
IC50 = 3000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0579985
 Compound Info 
3-[4-[[2-(3-methylphenyl)acetyl]amino]pyrazol-1-yl]-N-[[2-(1,2,4-triazol-1-yl)phenyl]methyl]benzamide
   Show/Hide
C28H25N7O2
  1
1
IC50 = 3200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0545571
 Compound Info 
(2R)-N-(5-chloro-2-methoxyphenyl)-2-[4-[4-(trifluoromethyl)piperidin-1-yl]sulfonylpiperazin-1-yl]propanamide
   Show/Hide
C20H28ClF3N4O4S
  1
1
IC50 = 3500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0545572
 Compound Info 
N-(5-chloro-2-methoxyphenyl)-2-[(2S)-2-methyl-4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C20H31ClN4O4S
  1
1
IC50 = 3500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0574583
 Compound Info 
N-(5-chloro-2-propoxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C21H33ClN4O4S
  1
1
IC50 = 4300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0578929
 Compound Info 
(2S)-N-(5-chloro-2-methoxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]propanamide
   Show/Hide
C20H31ClN4O4S
  1
1
IC50 = 4400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0577397
 Compound Info 
(2R)-N-(5-chloro-2-methoxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]propanamide
   Show/Hide
C20H31ClN4O4S
  1
1
IC50 = 4900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0577398
 Compound Info 
N-(5-fluoro-2-methoxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C19H29FN4O4S
  1
1
IC50 = 4900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0568853
 Compound Info 
N-(5-chloro-2-propan-2-yloxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C21H33ClN4O4S
  1
1
IC50 = 5100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0579273
 Compound Info 
N-(5-chloro-2-methoxyphenyl)-4-(4-methylpiperidin-1-yl)sulfonyl-1,4-diazepane-1-carboxamide
   Show/Hide
C19H29ClN4O4S
  1
1
IC50 = 6200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0569380
 Compound Info 
N-(5-chloro-2-ethoxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C20H31ClN4O4S
  1
1
IC50 = 7100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0569371
 Compound Info 
N-[5-chloro-2-(cyclopropylmethoxy)phenyl]-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C22H33ClN4O4S
  1
1
IC50 = 7500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0522084
 Compound Info 
N-(5-chloro-2-methylphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C19H29ClN4O3S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0545570
 Compound Info 
N-(2-methoxy-5-methylphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C20H32N4O4S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0545573
 Compound Info 
N-(5-chloro-2-methoxyphenyl)-2-(4-methylpiperidin-1-yl)sulfonyl-2,6-diazaspiro[3.3]heptane-6-carboxamide
   Show/Hide
C19H27ClN4O4S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0545574
 Compound Info 
N-(2-methoxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C19H30N4O4S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0568828
 Compound Info 
N-(5-chloro-2-methoxyphenyl)-2-[4-[4-(4-propylpiperidine-1-carbonyl)piperazin-1-yl]sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C26H41ClN6O5S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0570175
 Compound Info 
N-(5-chloro-2-methoxyphenyl)-2-[(3S)-3-methyl-4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C20H31ClN4O4S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0574585
 Compound Info 
N-(5-chloro-2-methoxyphenyl)-2-[methyl-[2-[methyl-(4-methylpiperidin-1-yl)sulfonylamino]ethyl]amino]acetamide
   Show/Hide
C19H31ClN4O4S
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0568829
 Compound Info 
N-(5-chloro-2-methoxyphenyl)-2-[(3R)-3-methyl-4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
   Show/Hide
C20H31ClN4O4S
  1
1
IC50 = 13000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000058 , T-REx-293
 Cell Line Info 
Clinical Information about the Protein
Target 1 ( Calcium-activated potassium channel KCa4.1 (KCNT1) )
Target Type Clinical trial Target
Disease 1 Target-related Disease  1
1 Acute myeloid leukaemia [ICD-11: 2A60]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 phorbol 12-myristate 13-acetate
 Drug Info 
Phase 2
Acute myeloid leukaemia