General Information of the Protein
Protein ID
PT05865
Protein Name
Small conductance calcium-activated potassium channel protein 2
Secondarily
Protein Name
KCa2.2
Gene Name
KCNN2
Sequence
MSSCRYNGGVMRPLSNLSASRRNLHEMDSEAQPLQPPASVGGGGGASSPSAAAAAAAAVSSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
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Organism
Homo sapiens, Human
Protein Classification
Ion channel
>
Voltage-gated ion channel
>
Potassium channels
>
Calcium-activated potassium channel
Function
Forms a voltage-independent potassium channel activated by intracellular calcium (PubMed:10991935, PubMed:9287325, PubMed:33242881). Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization.
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Uniprot ID
Primary ID:
Q9H2S1

Secondarily ID:
A6NF94
Q0VFZ4
Q6PJI0
Q6X2Y2
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Ensembl ID
ENSG00000080709
HGNC ID
HGNC:6291
Subcellular Location
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0375052
 Compound Info 
N-(4-methylpyridin-2-yl)-4-pyridin-2-yl-1,3-thiazol-2-amine
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C14H12N4S
  2
1
IC50 = 11 nM
 Bioactivity Info 
   TI
   LI
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   TS
2
IC50 = 59 nM
 Bioactivity Info 
   TI
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CP0383396
 Compound Info 
N,4-dipyridin-2-yl-1,3-thiazol-2-amine
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C13H10N4S
  2
1
IC50 = 123 nM
 Bioactivity Info 
   TI
   LI
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   TS
2
IC50 = 543 nM
 Bioactivity Info 
   TI
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CP0401123
 Compound Info 
5-chloro-N-(thiophen-2-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine
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C11H9ClN4S
  1
1
IC50 = 530 nM
 Bioactivity Info 
   TI
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CP0388337
 Compound Info 
N-benzyl-5-chloropyrazolo[1,5-a]pyrimidin-7-amine
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C13H11ClN4
  1
1
IC50 = 1100 nM
 Bioactivity Info 
   TI
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CP0867692
 Compound Info 
1,1'-(1,3-phenylenebis(methylene))bis(8-isopropyl-2-methylisoquinolinium)iodide
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C34H38I2N2
  1
1
Ki = 90 nM
 Bioactivity Info 
   TI
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CP0858748
 Compound Info 
1,1'-(butane-1,4-diyl)bis(8-isopropyl-2-methylisoquinolinium)iodide
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C30H38I2N2
  1
1
Ki = 194 nM
 Bioactivity Info 
   TI
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CP0851749
 Compound Info 
1,1'-(1,4-phenylenebis(methylene))bis(8-isopropyl-2-methylisoquinolinium)iodide
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C34H38I2N2
  1
1
Ki = 397 nM
 Bioactivity Info 
   TI
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CP0916019
 Compound Info 
1,1'-(propane-1,3-diyl)bis(8-isopropyl-2-methylisoquinolinium)iodide
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C29H36I2N2
  1
1
Ki = 593 nM
 Bioactivity Info 
   TI
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CP0894247
 Compound Info 
1,1'-(pentane-1,5-diyl)bis(8-isopropyl-2-methylisoquinolinium)iodide
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C31H40I2N2
  1
1
Ki = 878 nM
 Bioactivity Info 
   TI
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Clinical Information about the Protein
Target 1 ( Calcium-activated potassium channel KCa2.2 (KCNN2) )
Target Type Clinical trial Target
Disease 2 Target-related Diseases  2
1 Myelopathy [ICD-11: 8B42]
2 Multiple myeloma [ICD-11: 2A83]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 dequalinium
 Drug Info 
Clinical trial
Myelopathy
Discontinued Drug(s) 1 Discontinued Drug  1
1 zoxazolamine
 Drug Info 
Terminated
Multiple myeloma