Protein Information

General Information of the Protein

Protein ID	PT04088
Protein Name	Small conductance calcium-activated potassium channel protein 3
Secondarily Protein Name	KCa2.3
Gene Name	KCNN3
Secondarily Gene Name	K3
Sequence	MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQPPHPLSQLAQLQSQPVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIGVSSTSFPTPYTSSSSC Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Ion channel > Voltage-gated ion channel > Potassium channels > Calcium-activated potassium channel
Function	Forms a voltage-independent potassium channel activated by intracellular calcium (PubMed:31155282, PubMed:20562108). Activation is followed by membrane hyperpolarization (By similarity). Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (By similarity). Show/Hide
Uniprot ID	Primary ID: Q9UGI6 Secondarily ID: B1ANX0 O43517 Q86VF9 Q8WXG7 Show/Hide
Ensembl ID	ENSG00000143603
HGNC ID	HGNC:6292
Subcellular Location	Membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000006 , HEK293

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0488487 Compound Info	N-(3-chloro-4-fluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine Show/Hide	C16H15ClFN5	1
1	EC50 = 190 nM Bioactivity Info	TI LI LO TS
CP0390687 Compound Info	(1H-Benzoimidazol-2-yl)-(R)-1,2,3,4-tetrahydronaphthalen-1-ylamine Show/Hide	C17H17N3	3
1	EC50 = 400 nM Bioactivity Info	TI LI LO TS
2	EC50 = 2200 nM Bioactivity Info	TI LI LO TS
3	Kd = 100 nM Bioactivity Info	TI LI LO TS
CP0495333 Compound Info	N-(5-chloro-2-fluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine Show/Hide	C16H15ClFN5	1
1	EC50 = 600 nM Bioactivity Info	TI LI LO TS
CP0519185 Compound Info	(1H-Benzoimidazol-2-yl)-(6,7-dichloro-1,2,3,4-tetrahydronaphthalen-1-yl)amine Show/Hide	C17H15Cl2N3	2
1	EC50 = 1810 nM Bioactivity Info	TI LI LO TS
2	Kd = 7.8 nM Bioactivity Info	TI LI LO TS
CP0211850 Compound Info	Apamin Show/Hide	C79H131N31O24S4	2
1	IC50 = 0.064 nM Bioactivity Info	TI LI LO TS
2	IC50 = 0.168 nM Bioactivity Info	TI LI LO TS
CP0375052 Compound Info	N-(4-methylpyridin-2-yl)-4-pyridin-2-yl-1,3-thiazol-2-amine Show/Hide	C14H12N4S	3
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
2	IC50 = 56 nM Bioactivity Info	TI LI LO TS
3	IC50 = 59 nM Bioactivity Info	TI LI LO TS
CP0383396 Compound Info	N,4-dipyridin-2-yl-1,3-thiazol-2-amine Show/Hide	C13H10N4S	3
1	IC50 = 25 nM Bioactivity Info	TI LI LO TS
2	IC50 = 290 nM Bioactivity Info	TI LI LO TS
3	IC50 = 543 nM Bioactivity Info	TI LI LO TS
CP0401123 Compound Info	5-chloro-N-(thiophen-2-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine Show/Hide	C11H9ClN4S	2
1	IC50 = 350 nM Bioactivity Info	TI LI LO TS
2	IC50 = 580 nM Bioactivity Info	TI LI LO TS
CP0401122 Compound Info	(R)-5-chloro-N-(1-phenylethyl)pyrazolo[1,5-a]pyrimidin-7-amine Show/Hide	C14H13ClN4	1
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0388337 Compound Info	N-benzyl-5-chloropyrazolo[1,5-a]pyrimidin-7-amine Show/Hide	C13H11ClN4	2
1	IC50 = 1100 nM Bioactivity Info	TI LI LO TS
2	IC50 = 1600 nM Bioactivity Info	TI LI LO TS
CP0683533 Compound Info	SID50106101 Show/Hide	C30H40Cl2N4	2
1	IC50 = 1300 nM Bioactivity Info	TI LI LO TS
2	IC50 = 2000 nM Bioactivity Info	TI LI LO TS
CP0867692 Compound Info	1,1'-(1,3-phenylenebis(methylene))bis(8-isopropyl-2-methylisoquinolinium)iodide Show/Hide	C34H38I2N2	2
1	IC50 = 2970 nM Bioactivity Info	TI LI LO TS
2	Ki = 46 nM Bioactivity Info	TI LI LO TS
CP0383141 Compound Info	5-chloro-N-(3-chlorobenzyl)pyrazolo[1,5-a]pyrimidin-7-amine Show/Hide	C13H10Cl2N4	1
1	IC50 = 5200 nM Bioactivity Info	TI LI LO TS
CP0519732 Compound Info	5-chloro-N-(1,2-diphenylethyl)pyrazolo[1,5-a]pyrimidin-7-amine Show/Hide	C20H17ClN4	1
1	IC50 = 7500 nM Bioactivity Info	TI LI LO TS
CP0460362 Compound Info	5-chloro-N-(3-nitrobenzyl)pyrazolo[1,5-a]pyrimidin-7-amine Show/Hide	C13H10ClN5O2	1
1	IC50 = 7900 nM Bioactivity Info	TI LI LO TS
CP0383142 Compound Info	5-chloro-N-(2-(trifluoromethoxy)benzyl)pyrazolo[1,5-a]pyrimidin-7-amine Show/Hide	C14H10ClF3N4O	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0460361 Compound Info	5-chloro-N-(3-methylbenzyl)pyrazolo[1,5-a]pyrimidin-7-amine Show/Hide	C14H13ClN4	1
1	IC50 = 10700 nM Bioactivity Info	TI LI LO TS
CP0519731 Compound Info	5-chloro-N-(3-(trifluoromethoxy)benzyl)pyrazolo[1,5-a]pyrimidin-7-amine Show/Hide	C14H10ClF3N4O	1
1	IC50 = 11000 nM Bioactivity Info	TI LI LO TS
CP0422721 Compound Info	5-chloro-N-(3-(trifluoromethyl)benzyl)pyrazolo[1,5-a]pyrimidin-7-amine Show/Hide	C14H10ClF3N4	1
1	IC50 = 14600 nM Bioactivity Info	TI LI LO TS
CP0460360 Compound Info	5-chloro-N-(2-methylbenzyl)pyrazolo[1,5-a]pyrimidin-7-amine Show/Hide	C14H13ClN4	1
1	IC50 = 14600 nM Bioactivity Info	TI LI LO TS
CP0522893 Compound Info	5-chloro-N-(4-(trifluoromethoxy)benzyl)pyrazolo[1,5-a]pyrimidin-7-amine Show/Hide	C14H10ClF3N4O	1
1	IC50 = 15400 nM Bioactivity Info	TI LI LO TS
CP0473899 Compound Info	5-chloro-N-(2-methoxybenzyl)pyrazolo[1,5-a]pyrimidin-7-amine Show/Hide	C14H13ClN4O	1
1	IC50 = 15900 nM Bioactivity Info	TI LI LO TS
CP0397147 Compound Info	5-chloro-N-(2-chlorobenzyl)pyrazolo[1,5-a]pyrimidin-7-amine Show/Hide	C13H10Cl2N4	1
1	IC50 = 19100 nM Bioactivity Info	TI LI LO TS
CP0042911 Compound Info	N-phenyl-4-pyridin-2-yl-1,3-thiazol-2-amine Show/Hide	C14H11N3S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0128555 Compound Info	N-pyridin-2-yl-4-pyridin-3-yl-1,3-thiazol-2-amine Show/Hide	C13H10N4S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0417754 Compound Info	N,4-diphenyl-1,3-thiazol-2-amine Show/Hide	C15H12N2S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0428143 Compound Info	4-pyridin-2-yl-N-pyridin-4-yl-1,3-thiazol-2-amine Show/Hide	C13H10N4S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0474541 Compound Info	2-(4-(pyridin-2-yl)thiazol-2-yl)pyridine Show/Hide	C13H9N3S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0480506 Compound Info	2-(2-(pyridin-2-ylmethyl)thiazol-4-yl)pyridine Show/Hide	C14H11N3S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0486792 Compound Info	5-iodo-N-(4-(pyridin-2-yl)thiazol-2-yl)pyridin-2-amine Show/Hide	C13H9IN4S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0494652 Compound Info	4-pyridin-2-yl-N-pyrimidin-2-yl-1,3-thiazol-2-amine Show/Hide	C12H9N5S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0495902 Compound Info	3-chloro-N-(4-(pyridin-2-yl)thiazol-2-yl)-5-(trifluoromethyl)pyridin-2-amine Show/Hide	C14H8ClF3N4S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0498523 Compound Info	N-pyridin-2-yl-4-pyridin-4-yl-1,3-thiazol-2-amine Show/Hide	C13H10N4S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0383143 Compound Info	5-chloro-N-(4-phenoxybenzyl)pyrazolo[1,5-a]pyrimidin-7-amine Show/Hide	C19H15ClN4O	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0397148 Compound Info	5-chloro-N-(3,4-dichlorobenzyl)pyrazolo[1,5-a]pyrimidin-7-amine Show/Hide	C13H9Cl3N4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0401121 Compound Info	5-chloro-N-(4-(trifluoromethyl)benzyl)pyrazolo[1,5-a]pyrimidin-7-amine Show/Hide	C14H10ClF3N4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0422720 Compound Info	5-chloro-N-(2-(trifluoromethyl)benzyl)pyrazolo[1,5-a]pyrimidin-7-amine Show/Hide	C14H10ClF3N4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0422854 Compound Info	5-chloro-N-(4-chlorobenzyl)pyrazolo[1,5-a]pyrimidin-7-amine Show/Hide	C13H10Cl2N4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0422855 Compound Info	5-chloro-N-(4-methylbenzyl)pyrazolo[1,5-a]pyrimidin-7-amine Show/Hide	C14H13ClN4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0422857 Compound Info	5-chloro-N-(4-nitrobenzyl)pyrazolo[1,5-a]pyrimidin-7-amine Show/Hide	C13H10ClN5O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0519730 Compound Info	5-chloro-N-(3,5-dichlorobenzyl)pyrazolo[1,5-a]pyrimidin-7-amine Show/Hide	C13H9Cl3N4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0858748 Compound Info	1,1'-(butane-1,4-diyl)bis(8-isopropyl-2-methylisoquinolinium)iodide Show/Hide	C30H38I2N2	1
1	Ki = 214 nM Bioactivity Info	TI LI LO TS
CP0894247 Compound Info	1,1'-(pentane-1,5-diyl)bis(8-isopropyl-2-methylisoquinolinium)iodide Show/Hide	C31H40I2N2	1
1	Ki = 575 nM Bioactivity Info	TI LI LO TS
CP0916019 Compound Info	1,1'-(propane-1,3-diyl)bis(8-isopropyl-2-methylisoquinolinium)iodide Show/Hide	C29H36I2N2	1
1	Ki = 837 nM Bioactivity Info	TI LI LO TS
CP0851749 Compound Info	1,1'-(1,4-phenylenebis(methylene))bis(8-isopropyl-2-methylisoquinolinium)iodide Show/Hide	C34H38I2N2	1
1	Ki = 1268 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Clinical Information about the Protein

Target 1 ( Calcium-activated potassium channel KCa2.3 (KCNN3) )

Target Type	Clinical trial Target
Disease	1 Target-related Disease				1
1	Myelopathy [ICD-11: 8B42]
Clinical Trial Drug(s)	1 Clinical Trial Drug				1
1	dequalinium	Drug Info	Clinical trial	Myelopathy

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT02468	Small conductance calcium-activated potassium channel protein 3	Rattus norvegicus, Rat	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han