General Information of the Protein
Protein ID
PT02468
Protein Name
Small conductance calcium-activated potassium channel protein 3
Secondarily
Protein Name
KCa2.3
Gene Name
KCNN3
Sequence
MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQPPPPSAPPAVPQQPPGPLLQPQPPQLQQQQQQQQQQQQQQQQQQQAPLHPLPQLAQLQSQLVHPGLLHSSPTAFRAPNSANSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAEPEGQPLQLFSPSNPPEIIISSREDNHAHQTLLHHPNATHNHQHAGTTAGSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRGVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLTAFVEARGISVAVGTSHAPPSDSPIGISSTSFPTPYTSSSSC
    Show/Hide
Organism
Rattus norvegicus, Rat
Protein Classification
Ion channel
>
Voltage-gated ion channel
>
Potassium channels
>
Calcium-activated potassium channel
Function
Forms a voltage-independent potassium channel activated by intracellular calcium (PubMed:11533126, PubMed:11245600). Activation is followed by membrane hyperpolarization (PubMed:11533126). Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (PubMed:11533126).
    Show/Hide
Uniprot ID
Primary ID:
P70605

Secondarily ID:
Q9EQ81
Q9ERQ4
    Show/Hide
Ensembl ID
ENSG00000143603
Subcellular Location
Membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0897153
 Compound Info 
N-Me-bicuculline
   Show/Hide
C21H20ClNO6
  2
1
IC50 = 7000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
Ki = 4400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0876101
 Compound Info 
1,7-diazonia-15,21-diazapentacyclo[20.6.2.27,14.08,13.023,28]dotriaconta-1(28),7(32),8,10,12,14(31),22,24,26,29-decaene
   Show/Hide
C28H34I2N4
  2
1
Kd = 0.43 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
Ki = 1.4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0897154
 Compound Info 
6,10-diaza-3(1,3),8(1,4)-dibenzena-1,5(1,4)-diquinolinacyclodecaphane
   Show/Hide
C34H30N4+2
  2
1
Kd = 2.7 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
Ki = 1.8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0519185
 Compound Info 
(1H-Benzoimidazol-2-yl)-(6,7-dichloro-1,2,3,4-tetrahydronaphthalen-1-yl)amine
   Show/Hide
C17H15Cl2N3
  1
1
Kd = 9.1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0463863
 Compound Info 
(1H-Benzoimidazol-2-yl)-(7-bromo-1,2,3,4-tetrahydronaphthalen-1-yl)amine
   Show/Hide
C17H16BrN3
  1
1
Kd = 11 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0463862
 Compound Info 
(1H-Benzoimidazol-2-yl)-(7-chloro-1,2,3,4-tetrahydronaphthalen-1-yl)amine
   Show/Hide
C17H16ClN3
  1
1
Kd = 17 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0503278
 Compound Info 
(1H-Benzoimidazol-2-yl)-(7-methyl-1,2,3,4-tetrahydronaphthalen-1-yl)amine
   Show/Hide
C18H19N3
  1
1
Kd = 20 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0453682
 Compound Info 
(1H-Benzoimidazol-2-yl)-(8-chloro-1,2,3,4-tetrahydronaphthalen-1-yl)amine
   Show/Hide
C17H16ClN3
  1
1
Kd = 27 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0519183
 Compound Info 
(1H-Benzoimidazol-2-yl)-(1,2,3,4-tetrahydrophenanthren-4-yl)amine
   Show/Hide
C21H19N3
  1
1
Kd = 31 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0377441
 Compound Info 
(1H-Benzoimidazol-2-yl)-(4-methyl-1,2,3,4-tetrahydronaphthalen-1-yl)amine
   Show/Hide
C18H19N3
  1
1
Kd = 32 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0519181
 Compound Info 
(1H-Benzoimidazol-2-yl)-(5,7-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)amine
   Show/Hide
C19H21N3
  1
1
Kd = 33 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0434696
 Compound Info 
(1H-Benzoimidazol-2-yl)-(7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)amine
   Show/Hide
C17H16FN3
  1
1
Kd = 34 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0434695
 Compound Info 
(1H-Benzoimidazol-2-yl)-(5-chloro-1,2,3,4-tetrahydronaphthalen-1-yl)amine
   Show/Hide
C17H16ClN3
  1
1
Kd = 44 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0492089
 Compound Info 
(1H-Benzoimidazol-2-yl)-(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)amine
   Show/Hide
C18H19N3O
  1
1
Kd = 61 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0390687
 Compound Info 
(1H-Benzoimidazol-2-yl)-(R)-1,2,3,4-tetrahydronaphthalen-1-ylamine
   Show/Hide
C17H17N3
  2
1
Kd = 77 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
Ki > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0489774
 Compound Info 
(1H-Benzoimidazol-2-yl)-(6-chloro-1,2,3,4-tetrahydronaphthalen-1-yl)amine
   Show/Hide
C17H16ClN3
  1
1
Kd = 120 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0517433
 Compound Info 
(1H-Benzoimidazol-2-yl)-1,2,3,4-tetrahydronaphthalen-1-yl-amine
   Show/Hide
C17H17N3
  1
1
Kd = 130 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0553776
 Compound Info 
(1H-Benzoimidazol-2-yl)thiochroman-4-yl-amine
   Show/Hide
C16H15N3S
  1
1
Kd = 130 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0503277
 Compound Info 
(1H-Benzoimidazol-2-yl)-(2-methyl-1,2,3,4-tetrahydronaphthalen-1-yl)amine
   Show/Hide
C18H19N3
  1
1
Kd = 170 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0683533
 Compound Info 
SID50106101
   Show/Hide
C30H40Cl2N4
  2
1
Kd = 180 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
Ki = 140 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0462368
 Compound Info 
(1H-Benzoimidazol-2-yl)-(3,4-dichlorobenzyl)amine
   Show/Hide
C14H11Cl2N3
  1
1
Kd = 200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0463865
 Compound Info 
(S)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1H-benzo[d]imidazol-2-amine
   Show/Hide
C17H17N3
  1
1
Kd = 450 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0463864
 Compound Info 
(1H-Benzoimidazol-2-yl)-(4,5,6,7-tetrahydrobenzo[b]thiophen-4-yl)amine
   Show/Hide
C15H15N3S
  1
1
Kd = 540 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0502990
 Compound Info 
(1H-Benzoimidazol-2-yl)-(6,7,8,9-tetrahydro-5H-benzocyclohepten-5-yl)amine
   Show/Hide
C18H19N3
  1
1
Kd = 590 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0519184
 Compound Info 
(1H-Benzoimidazol-2-yl)(7-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)amine
   Show/Hide
C23H21N3
  1
1
Kd = 600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0502283
 Compound Info 
(1H-Benzoimidazol-2-yl)-(4-chlorobenzyl)amine
   Show/Hide
C14H12ClN3
  1
1
Kd = 640 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0453681
 Compound Info 
2-(2-Phenylpiperidin-1-yl)-1H-benzoimidazole
   Show/Hide
C18H19N3
  1
1
Kd = 750 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0553775
 Compound Info 
(1H-Benzoimidazol-2-yl)indan-1-ylamine
   Show/Hide
C16H15N3
  1
1
Kd = 790 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0463861
 Compound Info 
2-(2-Phenylpyrrolidin-1-yl)-1H-benzoimidazole
   Show/Hide
C17H17N3
  1
1
Kd = 1600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0434693
 Compound Info 
(1H-Benzoimidazol-2-yl)indan-2-ylamine
   Show/Hide
C16H15N3
  1
1
Kd = 1700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0434694
 Compound Info 
(1H-Benzoimidazol-2-yl)-(1,2,3,4-tetrahydronaphthalen-2-yl)amine
   Show/Hide
C17H17N3
  1
1
Kd = 2000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0816904
 Compound Info 
Laudanosine methiodide
   Show/Hide
C22H30INO4
  2
1
Kd = 2600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
Ki = 1500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0517432
 Compound Info 
(1H-benzoimidazol-2-yl)benzylamine
   Show/Hide
C14H13N3
  1
1
Kd = 2700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0423506
 Compound Info 
Atracurium besylate
   Show/Hide
C53H72N2O12+2
  2
1
Kd = 6400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
Ki = 5900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0519182
 Compound Info 
(1H-Benzoimidazol-2-yl)-(5,6,7,8-tetrahydroisoquinolin-8-yl)amine
   Show/Hide
C16H16N4
  1
1
Kd = 6500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0114181
 Compound Info 
2-Phenethyl-1H-benzoimidazole
   Show/Hide
C15H14N2
  1
1
Kd > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0434697
 Compound Info 
(1H-Benzoimidazol-2-yl)chroman-4-ylamine
   Show/Hide
C16H15N3O
  1
1
Kd > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0453683
 Compound Info 
N-(1H-benzimidazol-2-yl)-4-chlorobenzamide
   Show/Hide
C14H10ClN3O
  1
1
Kd > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0377440
 Compound Info 
2-(1H-Benzoimidazol-2-yl)-1,2,3,4-tetrahydroisoquinoline
   Show/Hide
C16H15N3
  1
1
Kd = 14000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0635512
 Compound Info 
10,25-dimethoxy-15,15,30-trimethyl-(1S,16R)-7,23-dioxa-15,30-diazoniaheptacyclo[22.6.2.23,6.112,16.118,22.08,36.027,31]hexatriaconta-3,5,8,10,12(36),18,20,22(35),24(32),25,27(31),33-dodecaene-9,21-diol, dichloride (tubocurarine)
   Show/Hide
C37H41ClN2O6
  2
1
Kd = 16000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
Ki = 9200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0914397
 Compound Info 
penucuronium
   Show/Hide
C36H62Br2N2O4
  2
1
Kd = 21000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
Ki = 16000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0423346
 Compound Info 
N-cyclohexyl-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
   Show/Hide
C16H23N5
  1
1
Ki > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0489773
 Compound Info 
1-ethyl-1H-benzo[d]imidazol-2(3H)-one
   Show/Hide
C9H10N2O
  1
1
Ki > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0679196
 Compound Info 
NS-309
   Show/Hide
C8H4Cl2N2O2
  1
1
Ki > 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0897154
 Compound Info 
6,10-diaza-3(1,3),8(1,4)-dibenzena-1,5(1,4)-diquinolinacyclodecaphane
   Show/Hide
C34H30N4+2
  1
1 IC50 = 4.1 nM
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT04088 Small conductance calcium-activated potassium channel protein 3 Homo sapiens, Human
 Protein Info