| Compound ID |
Compound Name |
Compound Formula |
|
CP0694113
|
BRANEBRUTINIB
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|
C20H23FN4O2
|
1
|
| 1 |
IC50 = 0.3 nM
|
|
|
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CP0479182
|
2-[(6-methylpyridin-3-yl)amino]-6-[(1R,4R)-5-prop-2-enoyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]pyridine-3-carboxamide
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|
C20H22N6O2
|
1
|
| 1 |
IC50 = 1.4 nM
|
|
|
|
CP0143201
|
US10106559, Example 33
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|
C31H24Cl2N4O4
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0053964
|
(7S)-3-fluoro-4-[3-(8-fluoro-1-methyl-2,4-dioxoquinazolin-3-yl)-2-methylphenyl]-7-(2-hydroxypropan-2-yl)-6,7,8,9-tetrahydro-5H-carbazole-1-carboxamide
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|
C32H30F2N4O4
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0572688
|
6-(4-prop-2-enoylpiperazin-1-yl)-2-[4-(2-pyrrolidin-1-ylethyl)anilino]pyridine-3-carboxamide
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|
C25H32N6O2
|
1
|
| 1 |
IC50 = 4.3 nM
|
|
|
|
CP0007430
|
IBRUTINIB
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|
C25H24N6O2
|
1
|
| 1 |
IC50 = 4.6 nM
|
|
|
|
CP0477095
|
6-[(7S)-7-(prop-2-enoylamino)-5-azaspiro[2.4]heptan-5-yl]-2-[4-(2-pyrrolidin-1-ylethyl)anilino]pyridine-3-carboxamide
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|
C27H34N6O2
|
1
|
| 1 |
IC50 = 4.9 nM
|
|
|
|
CP0079085
|
2-[4-[(2S,6R)-2,6-dimethylmorpholin-4-yl]anilino]-6-[(3S)-3-(prop-2-enoylamino)pyrrolidin-1-yl]pyridine-3-carboxamide
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|
C25H32N6O3
|
1
|
| 1 |
IC50 = 6.1 nM
|
|
|
|
CP0567559
|
6-[(3S)-3-(prop-2-enoylamino)pyrrolidin-1-yl]-2-[4-(2-pyrrolidin-1-ylethyl)anilino]pyridine-3-carboxamide
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|
C25H32N6O2
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0476313
|
N-(3-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)oxy)phenyl)acrylamide
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|
C25H20N4O3
|
1
|
| 1 |
IC50 = 9.9 nM
|
|
|
|
CP0239951
|
US10106559, Comparative Example 75
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|
C31H26N4O3
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0552254
|
2-[4-[(2S,6R)-2,6-dimethylmorpholin-4-yl]anilino]-5-fluoro-6-[(3S)-3-(prop-2-enoylamino)pyrrolidin-1-yl]pyridine-3-carboxamide
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|
C25H31FN6O3
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0508340
|
N-(3-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)phenyl)acrylamide
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|
C25H21N5O2
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0508339
|
1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)-4-hydroxypiperidin-1-yl)prop-2-en-1-one
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|
C25H27N5O3
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
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CP0552255
|
6-[(3S)-3-[methyl(prop-2-enoyl)amino]pyrrolidin-1-yl]-2-[4-(2-pyrrolidin-1-ylethyl)anilino]pyridine-3-carboxamide
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|
C26H34N6O2
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0392591
|
4-[4-(2,6-dimethylmorpholine-4-carbonyl)anilino]-2-[(3S)-3-(prop-2-enoylamino)pyrrolidin-1-yl]pyrimidine-5-carboxamide
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|
C25H31N7O4
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0564407
|
5-(4-phenoxyphenyl)-N4-((1-(vinylsulfonyl)piperidin-4-yl)methyl)pyrimidine-4,6-diamine
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|
C24H27N5O3S
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0234676
|
1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one
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|
C25H27N5O2
|
1
|
| 1 |
IC50 = 61 nM
|
|
|
|
CP0446756
|
1-(6-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)-2-azaspiro[3.3]heptan-2-yl)prop-2-en-1-one
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|
C25H25N5O2
|
1
|
| 1 |
IC50 = 66 nM
|
|
|
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CP0508338
|
N-(4-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)bicyclo[2.1.1]hexan-1-yl)acrylamide
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|
C25H25N5O2
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
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CP0508337
|
(S)-1-(3-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)piperidin-1-yl)prop-2-en-1-one
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|
C24H25N5O2
|
1
|
| 1 |
IC50 = 143 nM
|
|
|
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CP0508341
|
1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)-2-chloroethanone
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|
C24H26ClN5O2
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
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CP0446755
|
(S)-1-(3-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)pyrrolidin-1-yl)prop-2-en-1-one
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|
C23H23N5O2
|
1
|
| 1 |
IC50 = 217 nM
|
|
|
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CP0550870
|
(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)(cyclobut-1-en-1-yl)methanone
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|
C27H29N5O2
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
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CP0438677
|
N-((1s,4s)-4-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)cyclohexyl)acrylamide
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|
C25H27N5O2
|
1
|
| 1 |
IC50 = 660 nM
|
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|
