General Information of the Compound
Compound ID
CP0392591
Compound Name
4-[4-(2,6-dimethylmorpholine-4-carbonyl)anilino]-2-[(3S)-3-(prop-2-enoylamino)pyrrolidin-1-yl]pyrimidine-5-carboxamide
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Structure
Formula
C25H31N7O4
Molecular Weight
493.568
Canonical SMILES
CC1CN(CC(C)O1)C(=O)c1ccc(Nc2nc(ncc2C(N)=O)N2CC[C@@H](C2)NC(=O)C=C)cc1
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InChI
InChI=1S/C25H31N7O4/c1-4-21(33)28-19-9-10-31(14-19)25-27-11-20(22(26)34)23(30-25)29-18-7-5-17(6-8-18)24(35)32-12-15(2)36-16(3)13-32/h4-8,11,15-16,19H,1,9-10,12-14H2,2-3H3,(H2,26,34)(H,28,33)(H,27,29,30)/t15?,16?,19-/m0/s1
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InChIKey
LEVFSNASLBAQKJ-RJYAGPCLSA-N
Physicochemical Property
logP
1.4494
Rotatable Bonds
7
Heavy Atom Count
36
Polar Areas
142.78
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
8
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145984386
ChEMBL ID
CHEMBL4277754
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01308, Tyrosine-protein kinase BTK
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000752 PBMC iPSC #1 Homo sapiens (Human)  1
1
IC50 = 44 nM
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