Brief Information of the Compound and Protein
Compound Name
1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one
    Show/Hide
PubChem ID
CID: 71479709
SID: 163451440
Canonical SMILES
Nc1ncnc(NCC2CCN(CC2)C(=O)C=C)c1-c1ccc(Oc2ccccc2)cc1
    Show/Hide
Compound Formula C25H27N5O2
Compound Structure
Protein Name
Tyrosine-protein kinase BTK
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Tec family
Uniprot ID
Q06187
Gene Name
BTK
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000752 PBMC iPSC #1 Homo sapiens (Human)  1
1
IC50 = 61 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1.83 nM
2 IC50 = 5 nM
3 IC50 = 62 nM
4 IC50 = 8600 nM
5 Kd = 16 nM