Brief Information of the Cell Line and Protein
Cell Line ID: CL000324 , NCI-H3255
 Cell Line Info 
Synonyms
H3255
H-3255
H3255_DA
NCIH3255
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_6831
Protein ID: PT01068 , Receptor tyrosine-protein kinase erbB-3
 Protein Info 
Gene Name ERBB3
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P21860
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000324
 Cell Line Info 
 Protein ID: PT01068
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0393180
 Compound Info 
N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]prop-2-enamide
   Show/Hide
C18H14ClFN4O2
  1
1
IC50 = 1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0210831
 Compound Info 
N-[(3R,4R)-4-fluoro-1-[6-[(3-methoxy-1-methylpyrazol-4-yl)amino]-9-propan-2-ylpurin-2-yl]pyrrolidin-3-yl]prop-2-enamide
   Show/Hide
C20H26FN9O2
  1
1
IC50 = 2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0238701
 Compound Info 
N-[(3R,4R)-4-fluoro-1-[6-[(1-methylpyrazol-4-yl)amino]-9-propan-2-ylpurin-2-yl]pyrrolidin-3-yl]prop-2-enamide
   Show/Hide
C19H24FN9O
  1
1
IC50 = 2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0164799
 Compound Info 
Mavelertinib
   Show/Hide
C18H22FN9O2
  1
1
IC50 = 4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0164797
 Compound Info 
N-[(3R,4R)-1-[6-[(1,3-dimethylpyrazol-4-yl)amino]-9-propan-2-ylpurin-2-yl]-4-fluoropyrrolidin-3-yl]prop-2-enamide
   Show/Hide
C20H26FN9O
  1
1
IC50 = 9 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0037987
 Compound Info 
N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
   Show/Hide
C22H23N3O4
  1
1
IC50 = 10 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0393179
 Compound Info 
1-[(3R,4R)-3-[[5-chloro-2-[(1-methylpyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxymethyl]-4-methoxypyrrolidin-1-yl]prop-2-en-1-one
   Show/Hide
C19H22ClN7O3
  1
1
IC50 = 21 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0551865
 Compound Info 
N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[2-(1-methylindol-3-yl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide
   Show/Hide
C28H33N7O2
  1
1
IC50 = 36 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0065286
 Compound Info 
AVL-301
   Show/Hide
C27H28F3N7O3
  1
1
IC50 = 46 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS