Compound ID |
Compound Name |
Compound Formula |
CP0158198
|
(R)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4(1H,3H)-dione
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|
C28H24F5N3O3
|
1
|
1 |
IC50 = 0.5 nM
|
|
|
CP0288327
|
(R)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyl-3-(2-(pyridin-2-ylmethylamino)propyl)pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C28H27F3N4O3
|
1
|
1 |
IC50 = 0.5 nM
|
|
|
CP0268718
|
(R)-6-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)hexanoic acid
Show/Hide
|
C33H32F5N3O5
|
2
|
1 |
IC50 = 0.6 nM
|
|
|
2 |
Ki = 1.2 nM
|
|
|
CP0740587
|
ELAGOLIX SODIUM
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|
C32H29F5N3NaO5
|
1
|
1 |
IC50 = 1.5 nM
|
|
|
CP0070855
|
(S)-1-(3-(1-(4-(1H-tetrazol-5-yl)phenethylamino)propan-2-yl)-2-(3,5-dimethylphenyl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone
Show/Hide
|
C36H37F4N7O
|
1
|
1 |
IC50 = 1.5 nM
|
|
|
CP0197703
|
(R)-5-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)pentanoic acid
Show/Hide
|
C32H30F5N3O5
|
2
|
1 |
IC50 = 2.6 nM
|
|
|
2 |
Ki = 1 nM
|
|
|
CP0046868
|
(R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethyl)-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C27H24F3N3O3
|
1
|
1 |
IC50 = 2.8 nM
|
|
|
CP0169141
|
(R)-6-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phenoxy)hexanoic acid
Show/Hide
|
C33H33F4N3O5
|
2
|
1 |
IC50 = 2.8 nM
|
|
|
2 |
Ki = 1.1 nM
|
|
|
CP0247647
|
(R)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-chloro-6-fluorobenzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyric Acid
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|
C31H30ClF2N3O5
|
1
|
1 |
IC50 = 3.2 nM
|
|
|
CP0395046
|
1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-3-{(S)-2-[(3-methyl-thiophen-2-ylmethyl)-amino]-propyl}-1H-pyrimidine-2,4-dione
Show/Hide
|
C28H28F3N3O3S
|
1
|
1 |
IC50 = 4 nM
|
|
|
CP0156900
|
(S)-1-(2,6-difluorobenzyl)-3-(2-(cyclopentylamino)propyl)-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4(1H,3H)-dione
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|
C27H30F3N3O3
|
1
|
1 |
IC50 = 5.5 nM
|
|
|
CP0176635
|
(R)-1-(2,6-difluorobenzyl)-3-(1-(2-methoxybenzylamino)propan-2-yl)-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C30H30F3N3O4
|
1
|
1 |
IC50 = 5.7 nM
|
|
|
CP0488102
|
1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-3-{(R)-2-[(thiazol-2-ylmethyl)-amino]-propyl}-1H-pyrimidine-2,4-dione
Show/Hide
|
C26H25F3N4O3S
|
1
|
1 |
IC50 = 6.1 nM
|
|
|
CP0252450
|
1-(3-((S)-1-(2-(6-(1H-tetrazol-5-yl)pyridin-3-yl)ethylamino)propan-2-yl)-2-(3,5-dimethylphenyl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone
Show/Hide
|
C35H36F4N8O
|
1
|
1 |
IC50 = 7 nM
|
|
|
CP0252451
|
(S)-1-(3-(1-(2-(3H-[1,2,3]triazolo[4,5-b]pyridin-6-yl)ethylamino)propan-2-yl)-2-(3,5-dimethylphenyl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone
Show/Hide
|
C34H35F4N7O
|
1
|
1 |
IC50 = 9 nM
|
|
|
CP0845482
|
3-[2-((S)-Cyclobutylamino)-propyl]-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione hydrochloride
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|
C26H29ClF3N3O3
|
1
|
1 |
IC50 = 10 nM
|
|
|
CP0418511
|
1-(2,6-Difluoro-benzyl)-3-[(S)-2-(1-ethyl-propylamino)-propyl]-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
|
C27H32F3N3O3
|
1
|
1 |
IC50 = 14 nM
|
|
|
CP0371780
|
1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione
Show/Hide
|
C29H30F2N4O3
|
1
|
1 |
IC50 = 16 nM
|
|
|
CP0155998
|
(S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(6-fluoro-1H-benzo[d][1,2,3]triazol-5-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone
Show/Hide
|
C35H35F5N6O
|
1
|
1 |
IC50 = 16 nM
|
|
|
CP0155995
|
(S)-4-(2-(2-(2-(3,5-dimethylphenyl)-5-(2-(2-fluoro-6-(trifluoromethyl)phenyl)acetyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)propylamino)ethyl)benzoic acid
Show/Hide
|
C36H37F4N3O3
|
1
|
1 |
IC50 = 22 nM
|
|
|
CP0137680
|
(R)-4-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phenoxy)butanoic acid
Show/Hide
|
C31H29F4N3O5
|
2
|
1 |
IC50 = 23 nM
|
|
|
2 |
Ki = 7.5 nM
|
|
|
CP0104205
|
(S)-1-(3-(1-(2-(1H-benzo[d][1,2,3]triazol-5-yl)ethylamino)propan-2-yl)-2-(3,5-dimethylphenyl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone
Show/Hide
|
C35H36F4N6O
|
1
|
1 |
IC50 = 26 nM
|
|
|
CP0201536
|
(R)-5-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phenoxy)pentanoic acid
Show/Hide
|
C32H31F4N3O5
|
1
|
1 |
IC50 = 26 nM
|
|
|
CP0371030
|
(R)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2,6-difluorobenzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyric Acid
Show/Hide
|
C31H30F3N3O5
|
1
|
1 |
IC50 = 27 nM
|
|
|
CP0511198
|
1-(2,6-Difluoro-benzyl)-3-{(S)-2-[(5-ethyl-furan-2-ylmethyl)-amino]-propyl}-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
|
C29H30F3N3O4
|
1
|
1 |
IC50 = 27 nM
|
|
|
CP0365408
|
(S)-5-(2-(2-(2-(3,5-dimethylphenyl)-5-(2-(2-fluoro-6-(trifluoromethyl)phenyl)acetyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)propylamino)ethyl)-1-methylpyridin-2(1H)-one
Show/Hide
|
C35H38F4N4O2
|
1
|
1 |
IC50 = 32 nM
|
|
|
CP0167737
|
1-((R)-2-Amino-2-phenyl-ethyl)-3-(2-bromo-6-fluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
|
C25H21BrF2N4O4
|
1
|
1 |
IC50 = 33 nM
|
|
|
CP0460869
|
3-((S)-2-Benzylamino-propyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
|
C29H28F3N3O3
|
1
|
1 |
IC50 = 38 nM
|
|
|
CP0039736
|
(R)-4-(2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-5-(2-fluoro-3-methoxyphenyl)-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethylamino)butanoic acid
Show/Hide
|
C31H28F5N3O5
|
1
|
1 |
IC50 = 47 nM
|
|
|
CP0104206
|
(S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(quinoxalin-6-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone
Show/Hide
|
C37H37F4N5O
|
1
|
1 |
IC50 = 60 nM
|
|
|
CP0292634
|
(S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone
Show/Hide
|
C34H36F4N4O
|
1
|
1 |
IC50 = 62 nM
|
|
|
CP0155997
|
(S)-1-(3-(1-(2-(4-(1H-tetrazol-5-yl)phenoxy)ethylamino)propan-2-yl)-2-(3,5-dimethylphenyl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone
Show/Hide
|
C36H37F4N7O2
|
1
|
1 |
IC50 = 63 nM
|
|
|
CP0104209
|
(S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-(trifluoromethyl)phenyl)ethanone
Show/Hide
|
C34H37F3N4O
|
1
|
1 |
IC50 = 86 nM
|
|
|
CP0155999
|
(S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(2-methyl-1H-benzo[d]imidazol-5-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone
Show/Hide
|
C37H39F4N5O
|
1
|
1 |
IC50 = 87 nM
|
|
|
CP0252452
|
(S)-7-(2-(2-(2-(3,5-dimethylphenyl)-5-(2-(2-fluoro-6-(trifluoromethyl)phenyl)acetyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)propylamino)ethyl)-3-ethylquinazoline-2,4(1H,3H)-dione
Show/Hide
|
C39H41F4N5O3
|
1
|
1 |
IC50 = 91 nM
|
|
|
CP0263178
|
2-[3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-3-methoxy-phenyl)-2,4,6-trioxo-[1,3,5]triazinan-1-ylmethyl]-benzonitrile
Show/Hide
|
C26H22FN5O4
|
1
|
1 |
IC50 = 190 nM
|
|
|
CP0104207
|
(S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(tetrahydro-2H-pyran-4-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-(trifluoromethyl)phenyl)ethanone
Show/Hide
|
C34H42F3N3O2
|
1
|
1 |
IC50 = 205 nM
|
|
|
CP0206580
|
(S)-2-(2-chlorophenyl)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)ethanone
Show/Hide
|
C33H37ClN4O
|
1
|
1 |
IC50 = 267 nM
|
|
|
CP0156000
|
(S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluorophenyl)ethanone
Show/Hide
|
C33H37FN4O
|
1
|
1 |
IC50 = 271 nM
|
|
|
CP0145405
|
(S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-methoxyphenyl)ethanone
Show/Hide
|
C34H40N4O2
|
1
|
1 |
IC50 = 462 nM
|
|
|
CP0104210
|
(S)-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)(2,2,3,3-tetramethylcyclopropyl)methanone
Show/Hide
|
C33H44N4O
|
1
|
1 |
IC50 = 475 nM
|
|
|
CP0370351
|
1-((R)-2-Amino-2-phenyl-ethyl)-3-(2-fluoro-3-methoxy-phenyl)-5-(2-trifluoromethoxy-benzyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
|
C26H22F4N4O5
|
1
|
1 |
IC50 = 480 nM
|
|
|
CP0332788
|
1-adamantyl-[2-(3,5-dimethylphenyl)-3-[(2S)-1-(2-pyridin-4-ylethylamino)propan-2-yl]-1,4,6,7-tetrahydropyrrolo[3,2-c]pyridin-5-yl]methanone
Show/Hide
|
C36H46N4O
|
1
|
1 |
IC50 = 546 nM
|
|
|
CP0206581
|
(S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-phenylethanone
Show/Hide
|
C33H38N4O
|
1
|
1 |
IC50 = 1110 nM
|
|
|
CP0155996
|
(S)-1-(3-(1-(4-(1H-tetrazol-5-yl)benzylamino)propan-2-yl)-2-(3,5-dimethylphenyl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone
Show/Hide
|
C35H35F4N7O
|
1
|
1 |
IC50 = 1600 nM
|
|
|
CP0365410
|
(S)-cyclopentyl(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)methanone
Show/Hide
|
C31H40N4O
|
1
|
1 |
IC50 = 3480 nM
|
|
|
CP0167352
|
(S)-1-(3-(1-aminopropan-2-yl)-2-(3,5-dimethylphenyl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone
Show/Hide
|
C27H29F4N3O
|
1
|
1 |
IC50 = 4180 nM
|
|
|
CP0199924
|
(S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)ethanone
Show/Hide
|
C27H34N4O
|
1
|
1 |
IC50 = 8090 nM
|
|
|
CP0199923
|
(S)-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)(phenyl)methanone
Show/Hide
|
C32H36N4O
|
1
|
1 |
IC50 > 10000 nM
|
|
|
CP0501783
|
(S)-2-(2-(3,5-dimethylphenyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-N-(2-(pyridin-4-yl)ethyl)propan-1-amine
Show/Hide
|
C25H32N4
|
1
|
1 |
IC50 > 10000 nM
|
|
|
CP0124091
|
(R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethyl)-5-(5-chlorothiophen-2-yl)-6-methylpyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C24H20ClF2N3O2S
|
1
|
1 |
Ki = 2 nM
|
|
|
CP0379165
|
3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-(5-methyl-thiophen-2-yl)-1H-pyrimidine-2,4-dione
Show/Hide
|
C25H23F2N3O2S
|
1
|
1 |
Ki = 3 nM
|
|
|
CP0137679
|
(R)-4-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)butanoic acid
Show/Hide
|
C31H28F5N3O5
|
1
|
1 |
Ki = 4.7 nM
|
|
|
CP0088206
|
(R)-1-(2,6-difluorobenzyl)-5-(3-methoxyphenyl)-6-methyl-3-(2-(methyl(pyridin-2-ylmethyl)amino)propyl)pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C29H30F2N4O3
|
1
|
1 |
Ki = 5 nM
|
|
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CP0378032
|
(4-{4-[3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-thiazol-2-yl}-phenyl)-carbamic acid ethyl ester
Show/Hide
|
C32H29F2N5O4S
|
1
|
1 |
Ki = 7 nM
|
|
|
CP0484126
|
3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-benzyl-thiazol-4-yl)-1-(2,6-difluoro-benzyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
|
C30H26F2N4O2S
|
1
|
1 |
Ki = 9 nM
|
|
|
CP0086827
|
(R)-2-(2-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-3-(2-(methylamino)-2-phenylethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)ethoxy)acetic acid
Show/Hide
|
C32H30F5N3O6
|
1
|
1 |
Ki = 9.3 nM
|
|
|
CP0515457
|
3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-thiophen-2-yl-1H-pyrimidine-2,4-dione
Show/Hide
|
C24H21F2N3O2S
|
1
|
1 |
Ki = 10 nM
|
|
|
CP0213306
|
(R)-3-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)propanoic acid
Show/Hide
|
C30H26F5N3O5
|
1
|
1 |
Ki = 10.1 nM
|
|
|
CP0515460
|
3-((R)-2-Amino-2-phenyl-ethyl)-5-(4-chloro-phenyl)-1-(2,6-difluoro-benzyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
|
C26H22ClF2N3O2
|
1
|
1 |
Ki = 14 nM
|
|
|
CP0508109
|
3-((R)-2-Amino-2-phenyl-ethyl)-5-[2-(4-chloro-phenyl)-thiazol-4-yl]-1-(2,6-difluoro-benzyl)-6-methyl-1H-pyrimidine-2,4-dione
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C29H23ClF2N4O2S
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1
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1 |
Ki = 15 nM
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CP0379162
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-(2-p-tolyl-thiazol-4-yl)-1H-pyrimidine-2,4-dione
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C30H26F2N4O2S
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1
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1 |
Ki = 18 nM
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CP0480336
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-5-[2-(2,3-dihydro-benzofuran-5-yl)-thiazol-4-yl]-6-methyl-1H-pyrimidine-2,4-dione
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C31H26F2N4O3S
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1
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1 |
Ki = 20 nM
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CP0379161
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-(2-phenyl-thiazol-4-yl)-1H-pyrimidine-2,4-dione
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C29H24F2N4O2S
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1
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1 |
Ki = 26 nM
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CP0137684
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(R)-2-(2-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-3-(2-(methylamino)-2-phenylethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)ethylamino)acetic acid
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C32H31F5N4O5
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1
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1 |
Ki = 27 nM
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CP0206951
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(R)-5-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-3-(2-(methylamino)-2-phenylethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)-3,3-dimethylpentanoic acid
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C35H36F5N3O5
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1
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1 |
Ki = 29 nM
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CP0522551
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3-((R)-2-Amino-2-phenyl-ethyl)-5-[2-(2-chloro-phenyl)-thiazol-4-yl]-1-(2,6-difluoro-benzyl)-6-methyl-1H-pyrimidine-2,4-dione
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C29H23ClF2N4O2S
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1
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1 |
Ki = 30 nM
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CP0379160
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-5-[2-(3,4-dimethoxy-phenylamino)-thiazol-4-yl]-6-methyl-1H-pyrimidine-2,4-dione
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C31H29F2N5O4S
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1
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1 |
Ki = 33 nM
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CP0475874
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-[2-(methyl-phenyl-amino)-thiazol-4-yl]-1H-pyrimidine-2,4-dione
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C30H27F2N5O2S
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1
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1 |
Ki = 34 nM
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CP0541730
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3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-benzylamino-thiazol-4-yl)-1-(2,6-difluoro-benzyl)-6-methyl-1H-pyrimidine-2,4-dione
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C30H27F2N5O2S
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1
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1 |
Ki = 35 nM
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CP0268678
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(R)-2-((3-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-3-(2-(methylamino)-2-phenylethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)propyl)(methyl)amino)acetic acid
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C34H35F5N4O5
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1
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1 |
Ki = 35 nM
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CP0169143
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(R)-2-(3-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-3-(2-(methylamino)-2-phenylethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)propoxy)acetic acid
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C33H32F5N3O6
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1
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1 |
Ki = 38 nM
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CP0490723
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-5-[2-(4-fluoro-phenyl)-thiazol-4-yl]-6-methyl-1H-pyrimidine-2,4-dione
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C29H23F3N4O2S
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1
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1 |
Ki = 42 nM
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CP0498460
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-5-[2-(4-methoxy-phenylamino)-thiazol-4-yl]-6-methyl-1H-pyrimidine-2,4-dione
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C30H27F2N5O3S
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1
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1 |
Ki = 42 nM
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CP0490722
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-[2-(4-trifluoromethyl-phenyl)-thiazol-4-yl]-1H-pyrimidine-2,4-dione
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C30H23F5N4O2S
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1
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1 |
Ki = 47 nM
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CP0506263
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-5-[2-(3-fluoro-4-methyl-phenyl)-thiazol-4-yl]-6-methyl-1H-pyrimidine-2,4-dione
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C30H25F3N4O2S
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1
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1 |
Ki = 49 nM
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CP0522547
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-(2-p-tolylamino-thiazol-4-yl)-1H-pyrimidine-2,4-dione
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C30H27F2N5O2S
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1
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1 |
Ki = 49 nM
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CP0352229
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(R)-2-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)acetic acid
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C29H24F5N3O5
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1
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1 |
Ki = 52 nM
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CP0476033
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-(2-phenylamino-thiazol-4-yl)-1H-pyrimidine-2,4-dione
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C29H25F2N5O2S
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1
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1 |
Ki = 70 nM
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CP0086828
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(R)-2-((2-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-3-(2-(methylamino)-2-phenylethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)ethyl)(methyl)amino)acetic acid
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C33H33F5N4O5
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1
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1 |
Ki = 98 nM
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CP0445584
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-(2-methyl-thiazol-4-yl)-1H-pyrimidine-2,4-dione
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C24H22F2N4O2S
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1
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1 |
Ki = 120 nM
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CP0485935
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-5-[2-(2,4-dimethyl-phenylamino)-thiazol-4-yl]-6-methyl-1H-pyrimidine-2,4-dione
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C31H29F2N5O2S
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1
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1 |
Ki = 130 nM
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CP0501351
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-5-[2-(2-methoxy-phenylamino)-thiazol-4-yl]-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C30H27F2N5O3S
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1
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1 |
Ki = 130 nM
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CP0467148
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-[2-(3-trifluoromethyl-phenyl)-thiazol-4-yl]-1H-pyrimidine-2,4-dione
Show/Hide
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C30H23F5N4O2S
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1
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1 |
Ki = 150 nM
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CP0268679
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(R)-2-(3-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-3-(2-(methylamino)-2-phenylethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)propylamino)acetic acid
Show/Hide
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C33H33F5N4O5
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1
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1 |
Ki = 155 nM
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CP0515453
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-[2-(4-nitro-phenylamino)-thiazol-4-yl]-1H-pyrimidine-2,4-dione
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C29H24F2N6O4S
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1
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1 |
Ki = 160 nM
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CP0464601
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-(2-o-tolylamino-thiazol-4-yl)-1H-pyrimidine-2,4-dione
Show/Hide
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C30H27F2N5O2S
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1
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1 |
Ki = 210 nM
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CP0541729
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(2-ethylamino-thiazol-4-yl)-6-methyl-1H-pyrimidine-2,4-dione
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C25H25F2N5O2S
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1
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1 |
Ki = 270 nM
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CP0480337
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3-((R)-2-Amino-2-phenyl-ethyl)-5-[2-(4-tert-butyl-phenyl)-thiazol-4-yl]-1-(2,6-difluoro-benzyl)-6-methyl-1H-pyrimidine-2,4-dione
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C33H32F2N4O2S
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1
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1 |
Ki = 500 nM
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CP0547179
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-(2-morpholin-4-yl-thiazol-4-yl)-1H-pyrimidine-2,4-dione
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C27H27F2N5O3S
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1
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1 |
Ki = 1500 nM
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CP0432545
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3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-amino-thiazol-4-yl)-1-(2,6-difluoro-benzyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C23H21F2N5O2S
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1
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1 |
Ki = 3000 nM
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