Brief Information of the Cell Line and Protein
Cell Line ID: CL000194 , RBL-1
Synonyms
RBL 1
RBL-I
RBL
Rat Basophilic Leukemia-1
Category Cancer cell line
Organism
Rattus norvegicus (Rat)
Cellosaurus ID
CVCL_0496
Protein ID: PT01836 , Gonadotropin-releasing hormone receptor
Gene Name GNRHR
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P30968
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000194  Protein ID: PT01836
 
Compound ID Compound Name Compound Formula
CP0158198
(R)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4(1H,3H)-dione
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C28H24F5N3O3
 1
1
IC50 = 0.5 nM
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CP0288327
(R)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyl-3-(2-(pyridin-2-ylmethylamino)propyl)pyrimidine-2,4(1H,3H)-dione
   Show/Hide
C28H27F3N4O3
 1
1
IC50 = 0.5 nM
   TI
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CP0268718
(R)-6-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)hexanoic acid
   Show/Hide
C33H32F5N3O5
 2
1
IC50 = 0.6 nM
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2
Ki = 1.2 nM
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CP0740587
ELAGOLIX SODIUM
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C32H29F5N3NaO5
 1
1
IC50 = 1.5 nM
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CP0070855
(S)-1-(3-(1-(4-(1H-tetrazol-5-yl)phenethylamino)propan-2-yl)-2-(3,5-dimethylphenyl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone
   Show/Hide
C36H37F4N7O
 1
1
IC50 = 1.5 nM
   TI
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CP0197703
(R)-5-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)pentanoic acid
   Show/Hide
C32H30F5N3O5
 2
1
IC50 = 2.6 nM
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2
Ki = 1 nM
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CP0046868
(R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethyl)-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4(1H,3H)-dione
   Show/Hide
C27H24F3N3O3
 1
1
IC50 = 2.8 nM
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CP0169141
(R)-6-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phenoxy)hexanoic acid
   Show/Hide
C33H33F4N3O5
 2
1
IC50 = 2.8 nM
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2
Ki = 1.1 nM
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CP0247647
(R)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-chloro-6-fluorobenzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyric Acid
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C31H30ClF2N3O5
 1
1
IC50 = 3.2 nM
   TI
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CP0395046
1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-3-{(S)-2-[(3-methyl-thiophen-2-ylmethyl)-amino]-propyl}-1H-pyrimidine-2,4-dione
   Show/Hide
C28H28F3N3O3S
 1
1
IC50 = 4 nM
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CP0156900
(S)-1-(2,6-difluorobenzyl)-3-(2-(cyclopentylamino)propyl)-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4(1H,3H)-dione
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C27H30F3N3O3
 1
1
IC50 = 5.5 nM
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CP0176635
(R)-1-(2,6-difluorobenzyl)-3-(1-(2-methoxybenzylamino)propan-2-yl)-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4(1H,3H)-dione
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C30H30F3N3O4
 1
1
IC50 = 5.7 nM
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CP0488102
1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-3-{(R)-2-[(thiazol-2-ylmethyl)-amino]-propyl}-1H-pyrimidine-2,4-dione
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C26H25F3N4O3S
 1
1
IC50 = 6.1 nM
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CP0252450
1-(3-((S)-1-(2-(6-(1H-tetrazol-5-yl)pyridin-3-yl)ethylamino)propan-2-yl)-2-(3,5-dimethylphenyl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone
   Show/Hide
C35H36F4N8O
 1
1
IC50 = 7 nM
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CP0252451
(S)-1-(3-(1-(2-(3H-[1,2,3]triazolo[4,5-b]pyridin-6-yl)ethylamino)propan-2-yl)-2-(3,5-dimethylphenyl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone
   Show/Hide
C34H35F4N7O
 1
1
IC50 = 9 nM
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CP0845482
3-[2-((S)-Cyclobutylamino)-propyl]-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione hydrochloride
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C26H29ClF3N3O3
 1
1
IC50 = 10 nM
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CP0418511
1-(2,6-Difluoro-benzyl)-3-[(S)-2-(1-ethyl-propylamino)-propyl]-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
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C27H32F3N3O3
 1
1
IC50 = 14 nM
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CP0371780
1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione
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C29H30F2N4O3
 1
1
IC50 = 16 nM
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CP0155998
(S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(6-fluoro-1H-benzo[d][1,2,3]triazol-5-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone
   Show/Hide
C35H35F5N6O
 1
1
IC50 = 16 nM
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CP0155995
(S)-4-(2-(2-(2-(3,5-dimethylphenyl)-5-(2-(2-fluoro-6-(trifluoromethyl)phenyl)acetyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)propylamino)ethyl)benzoic acid
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C36H37F4N3O3
 1
1
IC50 = 22 nM
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CP0137680
(R)-4-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phenoxy)butanoic acid
   Show/Hide
C31H29F4N3O5
 2
1
IC50 = 23 nM
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2
Ki = 7.5 nM
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CP0104205
(S)-1-(3-(1-(2-(1H-benzo[d][1,2,3]triazol-5-yl)ethylamino)propan-2-yl)-2-(3,5-dimethylphenyl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone
   Show/Hide
C35H36F4N6O
 1
1
IC50 = 26 nM
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CP0201536
(R)-5-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phenoxy)pentanoic acid
   Show/Hide
C32H31F4N3O5
 1
1
IC50 = 26 nM
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CP0371030
(R)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2,6-difluorobenzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyric Acid
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C31H30F3N3O5
 1
1
IC50 = 27 nM
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CP0511198
1-(2,6-Difluoro-benzyl)-3-{(S)-2-[(5-ethyl-furan-2-ylmethyl)-amino]-propyl}-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
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C29H30F3N3O4
 1
1
IC50 = 27 nM
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CP0365408
(S)-5-(2-(2-(2-(3,5-dimethylphenyl)-5-(2-(2-fluoro-6-(trifluoromethyl)phenyl)acetyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)propylamino)ethyl)-1-methylpyridin-2(1H)-one
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C35H38F4N4O2
 1
1
IC50 = 32 nM
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CP0167737
1-((R)-2-Amino-2-phenyl-ethyl)-3-(2-bromo-6-fluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
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C25H21BrF2N4O4
 1
1
IC50 = 33 nM
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CP0460869
3-((S)-2-Benzylamino-propyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
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C29H28F3N3O3
 1
1
IC50 = 38 nM
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CP0039736
(R)-4-(2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-5-(2-fluoro-3-methoxyphenyl)-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethylamino)butanoic acid
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C31H28F5N3O5
 1
1
IC50 = 47 nM
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CP0104206
(S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(quinoxalin-6-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone
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C37H37F4N5O
 1
1
IC50 = 60 nM
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CP0292634
(S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone
   Show/Hide
C34H36F4N4O
 1
1
IC50 = 62 nM
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CP0155997
(S)-1-(3-(1-(2-(4-(1H-tetrazol-5-yl)phenoxy)ethylamino)propan-2-yl)-2-(3,5-dimethylphenyl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone
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C36H37F4N7O2
 1
1
IC50 = 63 nM
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CP0104209
(S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-(trifluoromethyl)phenyl)ethanone
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C34H37F3N4O
 1
1
IC50 = 86 nM
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CP0155999
(S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(2-methyl-1H-benzo[d]imidazol-5-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone
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C37H39F4N5O
 1
1
IC50 = 87 nM
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CP0252452
(S)-7-(2-(2-(2-(3,5-dimethylphenyl)-5-(2-(2-fluoro-6-(trifluoromethyl)phenyl)acetyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)propylamino)ethyl)-3-ethylquinazoline-2,4(1H,3H)-dione
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C39H41F4N5O3
 1
1
IC50 = 91 nM
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CP0263178
2-[3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-3-methoxy-phenyl)-2,4,6-trioxo-[1,3,5]triazinan-1-ylmethyl]-benzonitrile
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C26H22FN5O4
 1
1
IC50 = 190 nM
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CP0104207
(S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(tetrahydro-2H-pyran-4-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-(trifluoromethyl)phenyl)ethanone
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C34H42F3N3O2
 1
1
IC50 = 205 nM
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CP0206580
(S)-2-(2-chlorophenyl)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)ethanone
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C33H37ClN4O
 1
1
IC50 = 267 nM
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CP0156000
(S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluorophenyl)ethanone
   Show/Hide
C33H37FN4O
 1
1
IC50 = 271 nM
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CP0145405
(S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-methoxyphenyl)ethanone
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C34H40N4O2
 1
1
IC50 = 462 nM
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CP0104210
(S)-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)(2,2,3,3-tetramethylcyclopropyl)methanone
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C33H44N4O
 1
1
IC50 = 475 nM
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CP0370351
1-((R)-2-Amino-2-phenyl-ethyl)-3-(2-fluoro-3-methoxy-phenyl)-5-(2-trifluoromethoxy-benzyl)-[1,3,5]triazinane-2,4,6-trione
   Show/Hide
C26H22F4N4O5
 1
1
IC50 = 480 nM
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CP0332788
1-adamantyl-[2-(3,5-dimethylphenyl)-3-[(2S)-1-(2-pyridin-4-ylethylamino)propan-2-yl]-1,4,6,7-tetrahydropyrrolo[3,2-c]pyridin-5-yl]methanone
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C36H46N4O
 1
1
IC50 = 546 nM
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CP0206581
(S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-phenylethanone
   Show/Hide
C33H38N4O
 1
1
IC50 = 1110 nM
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CP0155996
(S)-1-(3-(1-(4-(1H-tetrazol-5-yl)benzylamino)propan-2-yl)-2-(3,5-dimethylphenyl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone
   Show/Hide
C35H35F4N7O
 1
1
IC50 = 1600 nM
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CP0365410
(S)-cyclopentyl(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)methanone
   Show/Hide
C31H40N4O
 1
1
IC50 = 3480 nM
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CP0167352
(S)-1-(3-(1-aminopropan-2-yl)-2-(3,5-dimethylphenyl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone
   Show/Hide
C27H29F4N3O
 1
1
IC50 = 4180 nM
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CP0199924
(S)-1-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)ethanone
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C27H34N4O
 1
1
IC50 = 8090 nM
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CP0199923
(S)-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)ethylamino)propan-2-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)(phenyl)methanone
   Show/Hide
C32H36N4O
 1
1
IC50 > 10000 nM
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CP0501783
(S)-2-(2-(3,5-dimethylphenyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-N-(2-(pyridin-4-yl)ethyl)propan-1-amine
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C25H32N4
 1
1
IC50 > 10000 nM
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CP0124091
(R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethyl)-5-(5-chlorothiophen-2-yl)-6-methylpyrimidine-2,4(1H,3H)-dione
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C24H20ClF2N3O2S
 1
1
Ki = 2 nM
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CP0379165
3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-(5-methyl-thiophen-2-yl)-1H-pyrimidine-2,4-dione
   Show/Hide
C25H23F2N3O2S
 1
1
Ki = 3 nM
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CP0137679
(R)-4-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)butanoic acid
   Show/Hide
C31H28F5N3O5
 1
1
Ki = 4.7 nM
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CP0088206
(R)-1-(2,6-difluorobenzyl)-5-(3-methoxyphenyl)-6-methyl-3-(2-(methyl(pyridin-2-ylmethyl)amino)propyl)pyrimidine-2,4(1H,3H)-dione
   Show/Hide
C29H30F2N4O3
 1
1
Ki = 5 nM
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CP0378032
(4-{4-[3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-thiazol-2-yl}-phenyl)-carbamic acid ethyl ester
   Show/Hide
C32H29F2N5O4S
 1
1
Ki = 7 nM
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CP0484126
3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-benzyl-thiazol-4-yl)-1-(2,6-difluoro-benzyl)-6-methyl-1H-pyrimidine-2,4-dione
   Show/Hide
C30H26F2N4O2S
 1
1
Ki = 9 nM
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CP0086827
(R)-2-(2-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-3-(2-(methylamino)-2-phenylethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)ethoxy)acetic acid
   Show/Hide
C32H30F5N3O6
 1
1
Ki = 9.3 nM
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   TS
CP0515457
3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-thiophen-2-yl-1H-pyrimidine-2,4-dione
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C24H21F2N3O2S
 1
1
Ki = 10 nM
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CP0213306
(R)-3-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)propanoic acid
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C30H26F5N3O5
 1
1
Ki = 10.1 nM
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CP0515460
3-((R)-2-Amino-2-phenyl-ethyl)-5-(4-chloro-phenyl)-1-(2,6-difluoro-benzyl)-6-methyl-1H-pyrimidine-2,4-dione
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C26H22ClF2N3O2
 1
1
Ki = 14 nM
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CP0508109
3-((R)-2-Amino-2-phenyl-ethyl)-5-[2-(4-chloro-phenyl)-thiazol-4-yl]-1-(2,6-difluoro-benzyl)-6-methyl-1H-pyrimidine-2,4-dione
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C29H23ClF2N4O2S
 1
1
Ki = 15 nM
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CP0379162
3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-(2-p-tolyl-thiazol-4-yl)-1H-pyrimidine-2,4-dione
   Show/Hide
C30H26F2N4O2S
 1
1
Ki = 18 nM
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CP0480336
3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-5-[2-(2,3-dihydro-benzofuran-5-yl)-thiazol-4-yl]-6-methyl-1H-pyrimidine-2,4-dione
   Show/Hide
C31H26F2N4O3S
 1
1
Ki = 20 nM
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CP0379161
3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-(2-phenyl-thiazol-4-yl)-1H-pyrimidine-2,4-dione
   Show/Hide
C29H24F2N4O2S
 1
1
Ki = 26 nM
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CP0137684
(R)-2-(2-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-3-(2-(methylamino)-2-phenylethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)ethylamino)acetic acid
   Show/Hide
C32H31F5N4O5
 1
1
Ki = 27 nM
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CP0206951
(R)-5-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-3-(2-(methylamino)-2-phenylethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)-3,3-dimethylpentanoic acid
   Show/Hide
C35H36F5N3O5
 1
1
Ki = 29 nM
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CP0522551
3-((R)-2-Amino-2-phenyl-ethyl)-5-[2-(2-chloro-phenyl)-thiazol-4-yl]-1-(2,6-difluoro-benzyl)-6-methyl-1H-pyrimidine-2,4-dione
   Show/Hide
C29H23ClF2N4O2S
 1
1
Ki = 30 nM
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CP0379160
3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-5-[2-(3,4-dimethoxy-phenylamino)-thiazol-4-yl]-6-methyl-1H-pyrimidine-2,4-dione
   Show/Hide
C31H29F2N5O4S
 1
1
Ki = 33 nM
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CP0475874
3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-[2-(methyl-phenyl-amino)-thiazol-4-yl]-1H-pyrimidine-2,4-dione
   Show/Hide
C30H27F2N5O2S
 1
1
Ki = 34 nM
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CP0541730
3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-benzylamino-thiazol-4-yl)-1-(2,6-difluoro-benzyl)-6-methyl-1H-pyrimidine-2,4-dione
   Show/Hide
C30H27F2N5O2S
 1
1
Ki = 35 nM
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CP0268678
(R)-2-((3-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-3-(2-(methylamino)-2-phenylethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)propyl)(methyl)amino)acetic acid
   Show/Hide
C34H35F5N4O5
 1
1
Ki = 35 nM
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CP0169143
(R)-2-(3-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-3-(2-(methylamino)-2-phenylethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)propoxy)acetic acid
   Show/Hide
C33H32F5N3O6
 1
1
Ki = 38 nM
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CP0490723
3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-5-[2-(4-fluoro-phenyl)-thiazol-4-yl]-6-methyl-1H-pyrimidine-2,4-dione
   Show/Hide
C29H23F3N4O2S
 1
1
Ki = 42 nM
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CP0498460
3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-5-[2-(4-methoxy-phenylamino)-thiazol-4-yl]-6-methyl-1H-pyrimidine-2,4-dione
   Show/Hide
C30H27F2N5O3S
 1
1
Ki = 42 nM
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CP0490722
3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-[2-(4-trifluoromethyl-phenyl)-thiazol-4-yl]-1H-pyrimidine-2,4-dione
   Show/Hide
C30H23F5N4O2S
 1
1
Ki = 47 nM
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CP0506263
3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-5-[2-(3-fluoro-4-methyl-phenyl)-thiazol-4-yl]-6-methyl-1H-pyrimidine-2,4-dione
   Show/Hide
C30H25F3N4O2S
 1
1
Ki = 49 nM
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CP0522547
3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-(2-p-tolylamino-thiazol-4-yl)-1H-pyrimidine-2,4-dione
   Show/Hide
C30H27F2N5O2S
 1
1
Ki = 49 nM
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CP0352229
(R)-2-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)acetic acid
   Show/Hide
C29H24F5N3O5
 1
1
Ki = 52 nM
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CP0476033
3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-(2-phenylamino-thiazol-4-yl)-1H-pyrimidine-2,4-dione
   Show/Hide
C29H25F2N5O2S
 1
1
Ki = 70 nM
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CP0086828
(R)-2-((2-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-3-(2-(methylamino)-2-phenylethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)ethyl)(methyl)amino)acetic acid
   Show/Hide
C33H33F5N4O5
 1
1
Ki = 98 nM
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CP0445584
3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-(2-methyl-thiazol-4-yl)-1H-pyrimidine-2,4-dione
   Show/Hide
C24H22F2N4O2S
 1
1
Ki = 120 nM
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CP0485935
3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-5-[2-(2,4-dimethyl-phenylamino)-thiazol-4-yl]-6-methyl-1H-pyrimidine-2,4-dione
   Show/Hide
C31H29F2N5O2S
 1
1
Ki = 130 nM
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CP0501351
3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-5-[2-(2-methoxy-phenylamino)-thiazol-4-yl]-6-methyl-1H-pyrimidine-2,4-dione
   Show/Hide
C30H27F2N5O3S
 1
1
Ki = 130 nM
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CP0467148
3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-[2-(3-trifluoromethyl-phenyl)-thiazol-4-yl]-1H-pyrimidine-2,4-dione
   Show/Hide
C30H23F5N4O2S
 1
1
Ki = 150 nM
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CP0268679
(R)-2-(3-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-3-(2-(methylamino)-2-phenylethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)propylamino)acetic acid
   Show/Hide
C33H33F5N4O5
 1
1
Ki = 155 nM
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CP0515453
3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-[2-(4-nitro-phenylamino)-thiazol-4-yl]-1H-pyrimidine-2,4-dione
   Show/Hide
C29H24F2N6O4S
 1
1
Ki = 160 nM
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CP0464601
3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-(2-o-tolylamino-thiazol-4-yl)-1H-pyrimidine-2,4-dione
   Show/Hide
C30H27F2N5O2S
 1
1
Ki = 210 nM
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CP0541729
3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(2-ethylamino-thiazol-4-yl)-6-methyl-1H-pyrimidine-2,4-dione
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C25H25F2N5O2S
 1
1
Ki = 270 nM
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CP0480337
3-((R)-2-Amino-2-phenyl-ethyl)-5-[2-(4-tert-butyl-phenyl)-thiazol-4-yl]-1-(2,6-difluoro-benzyl)-6-methyl-1H-pyrimidine-2,4-dione
   Show/Hide
C33H32F2N4O2S
 1
1
Ki = 500 nM
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CP0547179
3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-6-methyl-5-(2-morpholin-4-yl-thiazol-4-yl)-1H-pyrimidine-2,4-dione
   Show/Hide
C27H27F2N5O3S
 1
1
Ki = 1500 nM
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CP0432545
3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-amino-thiazol-4-yl)-1-(2,6-difluoro-benzyl)-6-methyl-1H-pyrimidine-2,4-dione
   Show/Hide
C23H21F2N5O2S
 1
1
Ki = 3000 nM
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