Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethyl)-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4(1H,3H)-dione
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 PubChem ID
CID: 11167850
SID: 16247393
Canonical SMILES
COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](N)c2ccccc2)c1=O
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Compound Formula C27H24F3N3O3
Compound Structure
Protein Name
 Protein Info 
Gonadotropin-releasing hormone receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
GnRH receptor
Uniprot ID
P30968
Gene Name
GNRHR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 0.59 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 87 nM
   TI
   LI
   LO
   TS
2
Ki = 0.56 nM
   TI
   LI
   LO
   TS
CL000194 RBL-1
 Cell Line Info 
Rattus norvegicus (Rat)  1
1
IC50 = 2.8 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.5 nM
2 IC50 = 0.6 nM
3 IC50 = 0.7 nM
4 IC50 = 0.8 nM
5 IC50 = 0.9 nM
6 IC50 = 1 nM
7 IC50 = 1.1 nM
8 IC50 = 1.2 nM
9 IC50 = 1.3 nM
10 IC50 = 1.4 nM
11 IC50 = 1.5 nM
12 IC50 = 1.6 nM
13 IC50 = 1.7 nM
14 IC50 = 1.8 nM
15 IC50 = 2.3 nM
16 IC50 = 2.4 nM
17 IC50 = 2.5 nM
18 IC50 = 2.6 nM
19 IC50 = 2.7 nM
20 IC50 = 2.8 nM
21 IC50 = 3 nM
22 IC50 = 3.1 nM
23 IC50 = 3.2 nM
24 IC50 = 3.4 nM
25 IC50 = 3.7 nM
26 IC50 = 5.5 nM
27 IC50 = 5.7 nM
28 IC50 = 6.6 nM
29 IC50 = 7.5 nM
30 IC50 = 8 nM
31 IC50 = 8.9 nM
32 IC50 = 9.2 nM
33 IC50 = 11.4 nM
34 IC50 = 13.9 nM
35 IC50 = 15.2 nM
36 IC50 = 24.2 nM
37 IC50 = 42.7 nM
38 IC50 = 80 nM
39 IC50 = 123 nM
40 IC50 = 182 nM
41 IC50 = 262 nM
42 IC50 = 980 nM
43 IC50 = 4200 nM
44 IC50 = 5000 nM
45 IC50 = 5030 nM
46 IC50 = 5200 nM
47 Ki = 0.56 nM
48 Ki = 3.5 nM