Brief Information of the Compound and Protein
Compound Name
1-(2,6-Difluoro-benzyl)-3-{(S)-2-[(5-ethyl-furan-2-ylmethyl)-amino]-propyl}-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
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PubChem ID
CID: 11214860
SID: 16297388
Canonical SMILES
CCc1ccc(CN[C@@H](C)Cn2c(=O)c(c(C)n(Cc3c(F)cccc3F)c2=O)-c2cccc(OC)c2F)o1
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Compound Formula C29H30F3N3O4
Compound Structure
Protein Name
Gonadotropin-releasing hormone receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
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Peptide receptor (family A GPCR)
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Short peptide receptor (family A GPCR)
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GnRH receptor
Uniprot ID
P30968
Gene Name
GNRHR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 15 nM
   TI
   LI
   LO
   TS
CL000194 RBL-1 Rattus norvegicus (Rat)  1
1
IC50 = 27 nM
   TI
   LI
   LO
   TS