Brief Information of the Cell Line and Protein
Cell Line ID: CL000192 , AD-293
Synonyms
Ad-293
AD293
Adeno-293
Adeno 293
HEK-AD293
HEK (AD293)
HEK AD293
HEK-AD 293
AdHek
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_9804
Protein ID: PT01503 , Signal transducer and activator of transcription 3
Gene Name STAT3
Organism Homo sapiens, Human
Protein Classification Transcription factor
Uniprot ID P40763
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000192  Protein ID: PT01503
 
Compound ID Compound Name Compound Formula
CP0471713
[(3S,4E)-4-[2-[(1R,4aS,5R,8aS)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-5,8a-dimethyl-2-methylidene-6-oxo-1,3,4,4a,7,8-hexahydronaphthalen-1-yl]ethylidene]-5-oxooxolan-3-yl] acetate
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C28H44O6Si
 3
1
EC50 = 990 nM
   TI
   LI
   LO
   TS
2
EC50 = 1970 nM
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   LI
   LO
   TS
3
EC50 = 7520 nM
   TI
   LI
   LO
   TS
CP0408663
[(3S,4E)-4-[2-[(1R,4aS,5R,6R,8aS)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-6-hydroxy-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-5-oxooxolan-3-yl] acetate
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C28H46O6Si
 3
1
EC50 = 1180 nM
   TI
   LI
   LO
   TS
2
EC50 = 2210 nM
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   LI
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   TS
3
EC50 = 6920 nM
   TI
   LI
   LO
   TS
CP0471712
[(1R,4aR,5S,6S,8aS)-5-[(2E)-2-[(4R)-4-[tert-butyl(dimethyl)silyl]oxy-2-oxooxolan-3-ylidene]ethyl]-1,4a-dimethyl-2-oxospiro[3,4,5,7,8,8a-hexahydronaphthalene-6,2'-oxirane]-1-yl]methyl acetate
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C28H44O7Si
 3
1
EC50 = 2230 nM
   TI
   LI
   LO
   TS
2
EC50 = 2560 nM
   TI
   LI
   LO
   TS
3
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0408666
[(1R,4aR,5S,6R,8aS)-5-[(2E)-2-[(4R)-4-[tert-butyl(dimethyl)silyl]oxy-2-oxooxolan-3-ylidene]ethyl]-1,4a-dimethyl-2-oxospiro[3,4,5,7,8,8a-hexahydronaphthalene-6,2'-oxirane]-1-yl]methyl acetate
   Show/Hide
C28H44O7Si
 3
1
EC50 = 2550 nM
   TI
   LI
   LO
   TS
2
EC50 = 2650 nM
   TI
   LI
   LO
   TS
3
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0404201
[(3S,4E)-4-[2-[(1S,2S,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethylspiro[3,4,4a,6,7,8-hexahydro-1H-naphthalene-2,2'-oxirane]-1-yl]ethylidene]-5-oxooxolan-3-yl] acetate
   Show/Hide
C22H32O7
 3
1
EC50 = 2600 nM
   TI
   LI
   LO
   TS
2
EC50 = 3040 nM
   TI
   LI
   LO
   TS
3
EC50 = 8510 nM
   TI
   LI
   LO
   TS
CP0404202
(3E,4S)-3-[2-[(1S,2R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethylspiro[3,4,4a,6,7,8-hexahydro-1H-naphthalene-2,2'-oxirane]-1-yl]ethylidene]-4-[tert-butyl(dimethyl)silyl]oxyoxolan-2-one
   Show/Hide
C26H44O6Si
 3
1
EC50 = 3050 nM
   TI
   LI
   LO
   TS
2
EC50 = 3450 nM
   TI
   LI
   LO
   TS
3
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0404198
[(3S,4E)-4-[2-[(1S,2R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethylspiro[3,4,4a,6,7,8-hexahydro-1H-naphthalene-2,2'-oxirane]-1-yl]ethylidene]-5-oxooxolan-3-yl] acetate
   Show/Hide
C22H32O7
 3
1
EC50 = 3110 nM
   TI
   LI
   LO
   TS
2
EC50 = 5110 nM
   TI
   LI
   LO
   TS
3
EC50 = 9490 nM
   TI
   LI
   LO
   TS
CP0429965
[(3R,4E)-4-[2-[(1R,4aS,5R,6R,8aS)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-6-hydroxy-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-5-oxooxolan-3-yl] acetate
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C28H46O6Si
 3
1
EC50 = 3220 nM
   TI
   LI
   LO
   TS
2
EC50 = 7280 nM
   TI
   LI
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   TS
3
EC50 = 8150 nM
   TI
   LI
   LO
   TS
CP0404205
(3E,4S)-3-[2-[(1R,4aS,5R,8aS)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-5,8a-dimethyl-2-methylidene-6-oxo-1,3,4,4a,7,8-hexahydronaphthalen-1-yl]ethylidene]-4-hydroxyoxolan-2-one
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C26H42O5Si
 3
1
EC50 = 3450 nM
   TI
   LI
   LO
   TS
2
EC50 = 6450 nM
   TI
   LI
   LO
   TS
3
EC50 = 7750 nM
   TI
   LI
   LO
   TS
CP0110604
(1R,4aR,5S,6R,8aS)-5-[(2E)-2-[(4S)-4-[tert-butyl(dimethyl)silyl]oxy-2-oxooxolan-3-ylidene]ethyl]-1-(hydroxymethyl)-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydronaphthalene-6,2'-oxirane]-2-one
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C26H42O6Si
 3
1
EC50 = 3950 nM
   TI
   LI
   LO
   TS
2
EC50 = 5990 nM
   TI
   LI
   LO
   TS
3
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0230172
(3E,4S)-3-[2-[(1S,2S,4aS,5R,6R,8aR)-6-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)-5,8a-dimethylspiro[3,4,4a,6,7,8-hexahydro-1H-naphthalene-2,2'-oxirane]-1-yl]ethylidene]-4-hydroxyoxolan-2-one
   Show/Hide
C26H44O6Si
 3
1
EC50 = 4160 nM
   TI
   LI
   LO
   TS
2
EC50 = 5390 nM
   TI
   LI
   LO
   TS
3
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0471717
(3E,4R)-3-[2-[(1R,4aS,5R,8aS)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-5,8a-dimethyl-2-methylidene-6-oxo-1,3,4,4a,7,8-hexahydronaphthalen-1-yl]ethylidene]-4-hydroxyoxolan-2-one
   Show/Hide
C26H42O5Si
 3
1
EC50 = 4340 nM
   TI
   LI
   LO
   TS
2
EC50 = 4720 nM
   TI
   LI
   LO
   TS
3
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0471718
(1R,4aR,5S,6R,8aS)-1-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-[(2E)-2-[(4S)-4-[tert-butyl(dimethyl)silyl]oxy-2-oxooxolan-3-ylidene]ethyl]-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydronaphthalene-6,2'-oxirane]-2-one
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C32H56O6Si2
 2
1
EC50 = 4400 nM
   TI
   LI
   LO
   TS
2
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0404200
[(3R,4E)-4-[2-[(1R,4aS,5R,8aS)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-5,8a-dimethyl-2-methylidene-6-oxo-1,3,4,4a,7,8-hexahydronaphthalen-1-yl]ethylidene]-5-oxooxolan-3-yl] acetate
   Show/Hide
C28H44O6Si
 3
1
EC50 = 4750 nM
   TI
   LI
   LO
   TS
2
EC50 = 4780 nM
   TI
   LI
   LO
   TS
3
EC50 = 7980 nM
   TI
   LI
   LO
   TS
CP0110602
[(1R,2R,4aS,5R,8aS)-5-[(2E)-2-[(4S)-4-acetyloxy-2-oxooxolan-3-ylidene]ethyl]-1-[[tert-butyl(dimethyl)silyl]oxymethyl]-1,4a-dimethyl-6-methylidene-3,4,5,7,8,8a-hexahydro-2H-naphthalen-2-yl] acetate
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C30H48O7Si
 2
1
EC50 = 5050 nM
   TI
   LI
   LO
   TS
2
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0101485
[(1R,4aR,5S,6R,8aS)-5-[(2E)-2-[(4S)-4-[tert-butyl(dimethyl)silyl]oxy-2-oxooxolan-3-ylidene]ethyl]-1,4a-dimethyl-2-oxospiro[3,4,5,7,8,8a-hexahydronaphthalene-6,2'-oxirane]-1-yl]methyl acetate
   Show/Hide
C28H44O7Si
 2
1
EC50 = 5380 nM
   TI
   LI
   LO
   TS
2
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0352431
(3E,4S)-3-[2-[(1S,2R,4aS,5R,6R,8aR)-6-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)-5,8a-dimethylspiro[3,4,4a,6,7,8-hexahydro-1H-naphthalene-2,2'-oxirane]-1-yl]ethylidene]-4-hydroxyoxolan-2-one
   Show/Hide
C26H44O6Si
 2
1
EC50 = 5380 nM
   TI
   LI
   LO
   TS
2
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0349882
(3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-4-[tert-butyl(dimethyl)silyl]oxyoxolan-2-one
   Show/Hide
C26H44O5Si
 3
1
EC50 = 5680 nM
   TI
   LI
   LO
   TS
2
EC50 > 10000 nM
   TI
   LI
   LO
   TS
3
EC50 = 10570 nM
   TI
   LI
   LO
   TS
CP0429963
[(1R,4aR,5S,6S,8aS)-5-[(2E)-2-[(4S)-4-[tert-butyl(dimethyl)silyl]oxy-2-oxooxolan-3-ylidene]ethyl]-1,4a-dimethyl-2-oxospiro[3,4,5,7,8,8a-hexahydronaphthalene-6,2'-oxirane]-1-yl]methyl acetate
   Show/Hide
C28H44O7Si
 3
1
EC50 = 5810 nM
   TI
   LI
   LO
   TS
2
EC50 = 7980 nM
   TI
   LI
   LO
   TS
3
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0471716
[(3S,4E)-4-[2-[(1R,4aS,5R,8aS)-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-6-oxo-1,3,4,4a,7,8-hexahydronaphthalen-1-yl]ethylidene]-5-oxooxolan-3-yl] acetate
   Show/Hide
C22H30O6
 3
1
EC50 = 6100 nM
   TI
   LI
   LO
   TS
2
EC50 = 7930 nM
   TI
   LI
   LO
   TS
3
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0408664
[(1R,2R,4aS,5R,8aS)-2-acetyloxy-5-[(2E)-2-[(4S)-4-[tert-butyl(dimethyl)silyl]oxy-2-oxooxolan-3-ylidene]ethyl]-1,4a-dimethyl-6-methylidene-3,4,5,7,8,8a-hexahydro-2H-naphthalen-1-yl]methyl acetate
   Show/Hide
C30H48O7Si
 2
1
EC50 = 8180 nM
   TI
   LI
   LO
   TS
2
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0077619
Andrographolide
   Show/Hide
C20H30O5
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0404199
(3E,4R)-3-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-4-[tert-butyl(dimethyl)silyl]oxyoxolan-2-one
   Show/Hide
C26H44O5Si
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0404203
[(1R,2R,4aS,5R,8aS)-2-acetyloxy-5-[(2E)-2-[(4R)-4-[tert-butyl(dimethyl)silyl]oxy-2-oxooxolan-3-ylidene]ethyl]-1,4a-dimethyl-6-methylidene-3,4,5,7,8,8a-hexahydro-2H-naphthalen-1-yl]methyl acetate
   Show/Hide
C30H48O7Si
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0404204
(3E,4S)-3-[2-[(1R,4aS,5R,8aS)-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-6-oxo-1,3,4,4a,7,8-hexahydronaphthalen-1-yl]ethylidene]-4-[tert-butyl(dimethyl)silyl]oxyoxolan-2-one
   Show/Hide
C26H42O5Si
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0408665
(3E,4R)-3-[2-[(1R,4aS,5R,8aS)-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-6-oxo-1,3,4,4a,7,8-hexahydronaphthalen-1-yl]ethylidene]-4-[tert-butyl(dimethyl)silyl]oxyoxolan-2-one
   Show/Hide
C26H42O5Si
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0408667
[(3R,4E)-4-[2-[(1R,4aS,5R,8aS)-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-6-oxo-1,3,4,4a,7,8-hexahydronaphthalen-1-yl]ethylidene]-5-oxooxolan-3-yl] acetate
   Show/Hide
C22H30O6
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0408668
[(1R,4aS,5R,8aS)-5-[(2E)-2-[(4S)-4-[tert-butyl(dimethyl)silyl]oxy-2-oxooxolan-3-ylidene]ethyl]-1,4a-dimethyl-6-methylidene-2-oxo-3,4,5,7,8,8a-hexahydronaphthalen-1-yl]methyl acetate
   Show/Hide
C28H44O6Si
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0408670
(1R,4aR,5S,6R,8aS)-1-(hydroxymethyl)-5-[(2E)-2-[(4S)-4-hydroxy-2-oxooxolan-3-ylidene]ethyl]-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydronaphthalene-6,2'-oxirane]-2-one
   Show/Hide
C20H28O6
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0429962
(1R,4aR,5S,6R,8aS)-1-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-[(2E)-2-[(4S)-4-hydroxy-2-oxooxolan-3-ylidene]ethyl]-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydronaphthalene-6,2'-oxirane]-2-one
   Show/Hide
C26H42O6Si
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0471711
[(1R,4aS,5R,8aS)-5-[(2E)-2-[(4R)-4-[tert-butyl(dimethyl)silyl]oxy-2-oxooxolan-3-ylidene]ethyl]-1,4a-dimethyl-6-methylidene-2-oxo-3,4,5,7,8,8a-hexahydronaphthalen-1-yl]methyl acetate
   Show/Hide
C28H44O6Si
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0176150
6-nitro-1-benzothiophene 1,1-dioxide
   Show/Hide
C8H5NO4S
 1
1
IC50 = 5100 nM
   TI
   LI
   LO
   TS
CP0532130
4-[[2-(4-methylphenyl)sulfonyloxyacetyl]amino]benzoic acid
   Show/Hide
C16H15NO6S
 1
1
IC50 = 86000 nM
   TI
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   TS