Compound ID |
Compound Name |
Compound Formula |
CP0471713
|
[(3S,4E)-4-[2-[(1R,4aS,5R,8aS)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-5,8a-dimethyl-2-methylidene-6-oxo-1,3,4,4a,7,8-hexahydronaphthalen-1-yl]ethylidene]-5-oxooxolan-3-yl] acetate
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|
C28H44O6Si
|
3
|
1 |
EC50 = 990 nM
|
|
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2 |
EC50 = 1970 nM
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3 |
EC50 = 7520 nM
|
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CP0408663
|
[(3S,4E)-4-[2-[(1R,4aS,5R,6R,8aS)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-6-hydroxy-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-5-oxooxolan-3-yl] acetate
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|
C28H46O6Si
|
3
|
1 |
EC50 = 1180 nM
|
|
|
2 |
EC50 = 2210 nM
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3 |
EC50 = 6920 nM
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CP0471712
|
[(1R,4aR,5S,6S,8aS)-5-[(2E)-2-[(4R)-4-[tert-butyl(dimethyl)silyl]oxy-2-oxooxolan-3-ylidene]ethyl]-1,4a-dimethyl-2-oxospiro[3,4,5,7,8,8a-hexahydronaphthalene-6,2'-oxirane]-1-yl]methyl acetate
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|
C28H44O7Si
|
3
|
1 |
EC50 = 2230 nM
|
|
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2 |
EC50 = 2560 nM
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3 |
EC50 > 10000 nM
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CP0408666
|
[(1R,4aR,5S,6R,8aS)-5-[(2E)-2-[(4R)-4-[tert-butyl(dimethyl)silyl]oxy-2-oxooxolan-3-ylidene]ethyl]-1,4a-dimethyl-2-oxospiro[3,4,5,7,8,8a-hexahydronaphthalene-6,2'-oxirane]-1-yl]methyl acetate
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|
C28H44O7Si
|
3
|
1 |
EC50 = 2550 nM
|
|
|
2 |
EC50 = 2650 nM
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|
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3 |
EC50 > 10000 nM
|
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CP0404201
|
[(3S,4E)-4-[2-[(1S,2S,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethylspiro[3,4,4a,6,7,8-hexahydro-1H-naphthalene-2,2'-oxirane]-1-yl]ethylidene]-5-oxooxolan-3-yl] acetate
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|
C22H32O7
|
3
|
1 |
EC50 = 2600 nM
|
|
|
2 |
EC50 = 3040 nM
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|
|
3 |
EC50 = 8510 nM
|
|
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CP0404202
|
(3E,4S)-3-[2-[(1S,2R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethylspiro[3,4,4a,6,7,8-hexahydro-1H-naphthalene-2,2'-oxirane]-1-yl]ethylidene]-4-[tert-butyl(dimethyl)silyl]oxyoxolan-2-one
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|
C26H44O6Si
|
3
|
1 |
EC50 = 3050 nM
|
|
|
2 |
EC50 = 3450 nM
|
|
|
3 |
EC50 > 10000 nM
|
|
|
CP0404198
|
[(3S,4E)-4-[2-[(1S,2R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethylspiro[3,4,4a,6,7,8-hexahydro-1H-naphthalene-2,2'-oxirane]-1-yl]ethylidene]-5-oxooxolan-3-yl] acetate
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|
C22H32O7
|
3
|
1 |
EC50 = 3110 nM
|
|
|
2 |
EC50 = 5110 nM
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|
|
3 |
EC50 = 9490 nM
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|
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CP0429965
|
[(3R,4E)-4-[2-[(1R,4aS,5R,6R,8aS)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-6-hydroxy-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-5-oxooxolan-3-yl] acetate
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|
C28H46O6Si
|
3
|
1 |
EC50 = 3220 nM
|
|
|
2 |
EC50 = 7280 nM
|
|
|
3 |
EC50 = 8150 nM
|
|
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CP0404205
|
(3E,4S)-3-[2-[(1R,4aS,5R,8aS)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-5,8a-dimethyl-2-methylidene-6-oxo-1,3,4,4a,7,8-hexahydronaphthalen-1-yl]ethylidene]-4-hydroxyoxolan-2-one
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|
C26H42O5Si
|
3
|
1 |
EC50 = 3450 nM
|
|
|
2 |
EC50 = 6450 nM
|
|
|
3 |
EC50 = 7750 nM
|
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CP0110604
|
(1R,4aR,5S,6R,8aS)-5-[(2E)-2-[(4S)-4-[tert-butyl(dimethyl)silyl]oxy-2-oxooxolan-3-ylidene]ethyl]-1-(hydroxymethyl)-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydronaphthalene-6,2'-oxirane]-2-one
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|
C26H42O6Si
|
3
|
1 |
EC50 = 3950 nM
|
|
|
2 |
EC50 = 5990 nM
|
|
|
3 |
EC50 > 10000 nM
|
|
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CP0230172
|
(3E,4S)-3-[2-[(1S,2S,4aS,5R,6R,8aR)-6-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)-5,8a-dimethylspiro[3,4,4a,6,7,8-hexahydro-1H-naphthalene-2,2'-oxirane]-1-yl]ethylidene]-4-hydroxyoxolan-2-one
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|
C26H44O6Si
|
3
|
1 |
EC50 = 4160 nM
|
|
|
2 |
EC50 = 5390 nM
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|
|
3 |
EC50 > 10000 nM
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CP0471717
|
(3E,4R)-3-[2-[(1R,4aS,5R,8aS)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-5,8a-dimethyl-2-methylidene-6-oxo-1,3,4,4a,7,8-hexahydronaphthalen-1-yl]ethylidene]-4-hydroxyoxolan-2-one
Show/Hide
|
C26H42O5Si
|
3
|
1 |
EC50 = 4340 nM
|
|
|
2 |
EC50 = 4720 nM
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|
|
3 |
EC50 > 10000 nM
|
|
|
CP0471718
|
(1R,4aR,5S,6R,8aS)-1-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-[(2E)-2-[(4S)-4-[tert-butyl(dimethyl)silyl]oxy-2-oxooxolan-3-ylidene]ethyl]-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydronaphthalene-6,2'-oxirane]-2-one
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|
C32H56O6Si2
|
2
|
1 |
EC50 = 4400 nM
|
|
|
2 |
EC50 > 10000 nM
|
|
|
CP0404200
|
[(3R,4E)-4-[2-[(1R,4aS,5R,8aS)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-5,8a-dimethyl-2-methylidene-6-oxo-1,3,4,4a,7,8-hexahydronaphthalen-1-yl]ethylidene]-5-oxooxolan-3-yl] acetate
Show/Hide
|
C28H44O6Si
|
3
|
1 |
EC50 = 4750 nM
|
|
|
2 |
EC50 = 4780 nM
|
|
|
3 |
EC50 = 7980 nM
|
|
|
CP0110602
|
[(1R,2R,4aS,5R,8aS)-5-[(2E)-2-[(4S)-4-acetyloxy-2-oxooxolan-3-ylidene]ethyl]-1-[[tert-butyl(dimethyl)silyl]oxymethyl]-1,4a-dimethyl-6-methylidene-3,4,5,7,8,8a-hexahydro-2H-naphthalen-2-yl] acetate
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|
C30H48O7Si
|
2
|
1 |
EC50 = 5050 nM
|
|
|
2 |
EC50 > 10000 nM
|
|
|
CP0101485
|
[(1R,4aR,5S,6R,8aS)-5-[(2E)-2-[(4S)-4-[tert-butyl(dimethyl)silyl]oxy-2-oxooxolan-3-ylidene]ethyl]-1,4a-dimethyl-2-oxospiro[3,4,5,7,8,8a-hexahydronaphthalene-6,2'-oxirane]-1-yl]methyl acetate
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|
C28H44O7Si
|
2
|
1 |
EC50 = 5380 nM
|
|
|
2 |
EC50 > 10000 nM
|
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|
CP0352431
|
(3E,4S)-3-[2-[(1S,2R,4aS,5R,6R,8aR)-6-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)-5,8a-dimethylspiro[3,4,4a,6,7,8-hexahydro-1H-naphthalene-2,2'-oxirane]-1-yl]ethylidene]-4-hydroxyoxolan-2-one
Show/Hide
|
C26H44O6Si
|
2
|
1 |
EC50 = 5380 nM
|
|
|
2 |
EC50 > 10000 nM
|
|
|
CP0349882
|
(3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-4-[tert-butyl(dimethyl)silyl]oxyoxolan-2-one
Show/Hide
|
C26H44O5Si
|
3
|
1 |
EC50 = 5680 nM
|
|
|
2 |
EC50 > 10000 nM
|
|
|
3 |
EC50 = 10570 nM
|
|
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CP0429963
|
[(1R,4aR,5S,6S,8aS)-5-[(2E)-2-[(4S)-4-[tert-butyl(dimethyl)silyl]oxy-2-oxooxolan-3-ylidene]ethyl]-1,4a-dimethyl-2-oxospiro[3,4,5,7,8,8a-hexahydronaphthalene-6,2'-oxirane]-1-yl]methyl acetate
Show/Hide
|
C28H44O7Si
|
3
|
1 |
EC50 = 5810 nM
|
|
|
2 |
EC50 = 7980 nM
|
|
|
3 |
EC50 > 10000 nM
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CP0471716
|
[(3S,4E)-4-[2-[(1R,4aS,5R,8aS)-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-6-oxo-1,3,4,4a,7,8-hexahydronaphthalen-1-yl]ethylidene]-5-oxooxolan-3-yl] acetate
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|
C22H30O6
|
3
|
1 |
EC50 = 6100 nM
|
|
|
2 |
EC50 = 7930 nM
|
|
|
3 |
EC50 > 10000 nM
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CP0408664
|
[(1R,2R,4aS,5R,8aS)-2-acetyloxy-5-[(2E)-2-[(4S)-4-[tert-butyl(dimethyl)silyl]oxy-2-oxooxolan-3-ylidene]ethyl]-1,4a-dimethyl-6-methylidene-3,4,5,7,8,8a-hexahydro-2H-naphthalen-1-yl]methyl acetate
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|
C30H48O7Si
|
2
|
1 |
EC50 = 8180 nM
|
|
|
2 |
EC50 > 10000 nM
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|
|
CP0077619
|
Andrographolide
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|
C20H30O5
|
1
|
1 |
EC50 > 10000 nM
|
|
|
CP0404199
|
(3E,4R)-3-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-4-[tert-butyl(dimethyl)silyl]oxyoxolan-2-one
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|
C26H44O5Si
|
1
|
1 |
EC50 > 10000 nM
|
|
|
CP0404203
|
[(1R,2R,4aS,5R,8aS)-2-acetyloxy-5-[(2E)-2-[(4R)-4-[tert-butyl(dimethyl)silyl]oxy-2-oxooxolan-3-ylidene]ethyl]-1,4a-dimethyl-6-methylidene-3,4,5,7,8,8a-hexahydro-2H-naphthalen-1-yl]methyl acetate
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|
C30H48O7Si
|
1
|
1 |
EC50 > 10000 nM
|
|
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CP0404204
|
(3E,4S)-3-[2-[(1R,4aS,5R,8aS)-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-6-oxo-1,3,4,4a,7,8-hexahydronaphthalen-1-yl]ethylidene]-4-[tert-butyl(dimethyl)silyl]oxyoxolan-2-one
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|
C26H42O5Si
|
1
|
1 |
EC50 > 10000 nM
|
|
|
CP0408665
|
(3E,4R)-3-[2-[(1R,4aS,5R,8aS)-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-6-oxo-1,3,4,4a,7,8-hexahydronaphthalen-1-yl]ethylidene]-4-[tert-butyl(dimethyl)silyl]oxyoxolan-2-one
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|
C26H42O5Si
|
1
|
1 |
EC50 > 10000 nM
|
|
|
CP0408667
|
[(3R,4E)-4-[2-[(1R,4aS,5R,8aS)-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-6-oxo-1,3,4,4a,7,8-hexahydronaphthalen-1-yl]ethylidene]-5-oxooxolan-3-yl] acetate
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|
C22H30O6
|
1
|
1 |
EC50 > 10000 nM
|
|
|
CP0408668
|
[(1R,4aS,5R,8aS)-5-[(2E)-2-[(4S)-4-[tert-butyl(dimethyl)silyl]oxy-2-oxooxolan-3-ylidene]ethyl]-1,4a-dimethyl-6-methylidene-2-oxo-3,4,5,7,8,8a-hexahydronaphthalen-1-yl]methyl acetate
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|
C28H44O6Si
|
1
|
1 |
EC50 > 10000 nM
|
|
|
CP0408670
|
(1R,4aR,5S,6R,8aS)-1-(hydroxymethyl)-5-[(2E)-2-[(4S)-4-hydroxy-2-oxooxolan-3-ylidene]ethyl]-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydronaphthalene-6,2'-oxirane]-2-one
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|
C20H28O6
|
1
|
1 |
EC50 > 10000 nM
|
|
|
CP0429962
|
(1R,4aR,5S,6R,8aS)-1-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-[(2E)-2-[(4S)-4-hydroxy-2-oxooxolan-3-ylidene]ethyl]-1,4a-dimethylspiro[3,4,5,7,8,8a-hexahydronaphthalene-6,2'-oxirane]-2-one
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|
C26H42O6Si
|
1
|
1 |
EC50 > 10000 nM
|
|
|
CP0471711
|
[(1R,4aS,5R,8aS)-5-[(2E)-2-[(4R)-4-[tert-butyl(dimethyl)silyl]oxy-2-oxooxolan-3-ylidene]ethyl]-1,4a-dimethyl-6-methylidene-2-oxo-3,4,5,7,8,8a-hexahydronaphthalen-1-yl]methyl acetate
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|
C28H44O6Si
|
1
|
1 |
EC50 > 10000 nM
|
|
|
CP0176150
|
6-nitro-1-benzothiophene 1,1-dioxide
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|
C8H5NO4S
|
1
|
1 |
IC50 = 5100 nM
|
|
|
CP0532130
|
4-[[2-(4-methylphenyl)sulfonyloxyacetyl]amino]benzoic acid
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|
C16H15NO6S
|
1
|
1 |
IC50 = 86000 nM
|
|
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