Brief Information of the Cell Line and Protein
Cell Line ID: CL000118 , U-251MG
 Cell Line Info 
Synonyms
U-251 MG
U-251-MG
U-251_MG
U251-MG
U251MG
U-251
U251
U251n
U251N
251 MG
251MG
251 MG(6)
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0021
Protein ID: PT04559 , Splicing factor 3B subunit 3
 Protein Info 
Gene Name SF3B3
Organism Homo sapiens, Human
Protein Classification Other nuclear protein
Uniprot ID Q15393
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000118
 Cell Line Info 
 Protein ID: PT04559
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0846153
 Compound Info 
pladienolide B
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C30H50O8
  1
1
IC50 = 1.3 nM
 Bioactivity Info 
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CP0845437
 Compound Info 
pladienolides D
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C30H50O9
  1
1
IC50 = 3.3 nM
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CP0850965
 Compound Info 
(3R,6R,7S,8E,10S,11S,12E,14E,16R,18R,19R,20R,21S)-7-[(4-cycloheptylpiperazin-1-yl)carbonyl]oxy-3,6,16,21-tetrahydroxy-6,10,12,16,20-pentamethyl-18,19-epoyxtrichosa-8,12,14-trien-11-olide
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C40H68N2O9
  1
1
IC50 = 3.6 nM
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CP0852133
 Compound Info 
pladienolide C
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C30H48O8
  1
1
IC50 = 5 nM
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CP0852132
 Compound Info 
(3R,6R,7S,8E,10S,11S,12E,14E,16S,18R,19R,20R,21S)-7-(N-[G-3H]-ethylcarbamoyloxy)-3,6,21-trihydroxy-6,10,12,16,20-pentamethyl-18,19-epoxytricosa-8,12,14-triene-11-olide
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C31H53NO8
  1
1
IC50 = 6.6 nM
 Bioactivity Info 
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CP0666814
 Compound Info 
FK-506
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C44H69NO12
  1
1
IC50 = 13.8 nM
 Bioactivity Info 
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CP0849646
 Compound Info 
pladienolide E
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C30H50O9
  1
1
IC50 = 58.9 nM
 Bioactivity Info 
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CP0863725
 Compound Info 
(3R,6R,7S,8E,10S,11S,12E,14E,16S,18R,19R,20R,21S)-7-(N-{2-[2-(2-{N-[5-(5,5-difluoro-7,9-dimethyl-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uido-3-yl)pentanoyl]amino}ethoxy)ethoxy]ethyl}carbamoyloxy)-3,6,21-trihydroxy-6,10,12,16,20-pentamethyl-18,19-epoyxtrichosa-8,12,14-trien-11-olide
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C51H79BF2N4O11
  1
1
IC50 = 78.4 nM
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CP0849645
 Compound Info 
pladienolide A
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C28H48O7
  1
1
IC50 = 307.7 nM
 Bioactivity Info 
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CP0005479
 Compound Info 
CHEBI:46024
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C17H22N2O3
  1
1
IC50 = 611.2 nM
 Bioactivity Info 
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CP0849647
 Compound Info 
(3R,6R,7S,8E,10S,11S,12E,14E,16S,18R,19R,20R,21S)-3,6,21-trihydroxy-6,10,12,16,20-pentamethyl-7-{N-[(5S)-6-{N-methyl-N-[2-(N-methyl-N-{5-[(3aR,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)ethyl]amino}-6-oxo-5-(N-{4-[3-(trifluoromethyl)-3H-diaziren-3-yl]benzoyl}amino)hexyl]carbamoyloxy}-18,19-epoxytricosa-8,12,14-triene-11-olide
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C58H87F3N8O12S
  1
1
IC50 = 644.8 nM
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CP0877427
 Compound Info 
pladienolide F
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C28H48O8
  1
1
IC50 = 2153.9 nM
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CP0009077
 Compound Info 
LACTACYSTIN
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C15H24N2O7S
  1
1
IC50 = 3481 nM
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