| Compound ID |
Compound Name |
Compound Formula |
|
CP0853713
|
Trans-6-chloro-7-methyl-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C12H14Cl2N2O
|
2
|
| 1 |
EC50 = 21 nM
|
|
|
| 2 |
Ki = 13 nM
|
|
|
|
CP0404524
|
(11aR)-7-ethyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C14H18N2O
|
2
|
| 1 |
EC50 = 22 nM
|
|
|
| 2 |
Ki = 24 nM
|
|
|
|
CP0387715
|
(11aR)-8-ethyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C14H18N2O
|
2
|
| 1 |
EC50 = 37 nM
|
|
|
| 2 |
Ki = 111 nM
|
|
|
|
CP0396112
|
(11aR)-8-methoxy-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O2
|
2
|
| 1 |
EC50 = 47 nM
|
|
|
| 2 |
Ki = 85 nM
|
|
|
|
CP0395807
|
(11aR)-8-methyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O
|
2
|
| 1 |
EC50 = 53 nM
|
|
|
| 2 |
Ki = 322 nM
|
|
|
|
CP0847928
|
(4S,10bR)-4-isopropyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C15H17F3N2O
|
2
|
| 1 |
EC50 = 56 nM
|
|
|
| 2 |
Ki = 38 nM
|
|
|
|
CP0375891
|
(11aR)-7-methyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O
|
2
|
| 1 |
EC50 = 64 nM
|
|
|
| 2 |
Ki = 110 nM
|
|
|
|
CP0372018
|
8-methyl-2,3,4,5,5a,6-hexahydro-[1,4]diazepino[1,7-a]quinazolin-7(1H)-one
Show/Hide
|
C13H17N3O
|
2
|
| 1 |
EC50 = 70 nM
|
|
|
| 2 |
Ki = 141 nM
|
|
|
|
CP0419740
|
(1S,10bR)-1-methyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C13H13F3N2O
|
2
|
| 1 |
EC50 = 78 nM
|
|
|
| 2 |
Ki = 122 nM
|
|
|
|
CP0437014
|
(+/-)-1,3,4,10b-tetrahydro-7-trifluoromethoxypyrazino[2,1-a]-isoindol-6(2H)-one
Show/Hide
|
C12H11F3N2O2
|
2
|
| 1 |
EC50 = 87 nM
|
|
|
| 2 |
Ki = 67 nM
|
|
|
|
CP0853707
|
(3aR,9bS)-4-methyl-6-(trifluoromethyl)-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C13H14ClF3N2O
|
2
|
| 1 |
EC50 = 89 nM
|
|
|
| 2 |
Ki = 79 nM
|
|
|
|
CP0379007
|
(4S,10bR)-4-methyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C13H13F3N2O
|
2
|
| 1 |
EC50 = 91 nM
|
|
|
| 2 |
Ki = 117 nM
|
|
|
|
CP0375902
|
(11aR)-8-chloro-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C12H13ClN2O
|
2
|
| 1 |
EC50 = 97 nM
|
|
|
| 2 |
Ki = 85 nM
|
|
|
|
CP0396115
|
(11aR)-8-(trifluoromethyl)-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H13F3N2O
|
2
|
| 1 |
EC50 = 106 nM
|
|
|
| 2 |
Ki = 108 nM
|
|
|
|
CP0433506
|
(11aR)-7-(trifluoromethyl)-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H13F3N2O
|
2
|
| 1 |
EC50 = 107 nM
|
|
|
| 2 |
Ki = 84 nM
|
|
|
|
CP0396116
|
(11aR)-7-cyclopropyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C15H18N2O
|
2
|
| 1 |
EC50 = 109 nM
|
|
|
| 2 |
Ki = 73 nM
|
|
|
|
CP0399469
|
(+/-)-7-methylthio-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C12H14N2OS
|
2
|
| 1 |
EC50 = 111 nM
|
|
|
| 2 |
Ki = 216 nM
|
|
|
|
CP0446160
|
(R)-8-ethyl-7-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a]-isoindol-6(2H)-one
Show/Hide
|
C14H18N2O2
|
2
|
| 1 |
EC50 = 123 nM
|
|
|
| 2 |
Ki = 43 nM
|
|
|
|
CP0395804
|
(4R,11aR)-4-methyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O
|
2
|
| 1 |
EC50 = 123 nM
|
|
|
| 2 |
Ki = 81 nM
|
|
|
|
CP0850853
|
(3aR,9bS)-6-chloro-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C11H12Cl2N2O
|
2
|
| 1 |
EC50 = 124 nM
|
|
|
| 2 |
Ki = 258 nM
|
|
|
|
CP0378993
|
(1S,10bR)-1-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C14H15F3N2O
|
2
|
| 1 |
EC50 = 126 nM
|
|
|
| 2 |
Ki = 91 nM
|
|
|
|
CP0853710
|
(3aR,9bS)-6-methyl-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C12H15ClN2O
|
2
|
| 1 |
EC50 = 127 nM
|
|
|
| 2 |
Ki = 56 nM
|
|
|
|
CP0864127
|
Trans-6,7-dichloro-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C11H11Cl3N2O
|
2
|
| 1 |
EC50 = 128 nM
|
|
|
| 2 |
Ki = 72 nM
|
|
|
|
CP0376735
|
8-chloro-2,3,4,5,5a,6-hexahydro-[1,4]diazepino[1,7-a]quinazolin-7(1H)-one
Show/Hide
|
C12H14ClN3O
|
2
|
| 1 |
EC50 = 130 nM
|
|
|
| 2 |
Ki = 168 nM
|
|
|
|
CP0378520
|
(+/-)-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C12H11F3N2O
|
2
|
| 1 |
EC50 = 131 nM
|
|
|
| 2 |
Ki = 110 nM
|
|
|
|
CP0395796
|
(11aR)-10-methoxy-7-methyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C14H18N2O2
|
2
|
| 1 |
EC50 = 148 nM
|
|
|
| 2 |
Ki = 146 nM
|
|
|
|
CP0405776
|
(R)-9-methyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C13H13F3N2O
|
2
|
| 1 |
EC50 = 167 nM
|
|
|
| 2 |
Ki = 560 nM
|
|
|
|
CP0437018
|
(R)-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C12H11F3N2O
|
2
|
| 1 |
EC50 = 176 nM
|
|
|
| 2 |
Ki = 59 nM
|
|
|
|
CP0396445
|
(11aR)-7-methoxy-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O2
|
2
|
| 1 |
EC50 = 193 nM
|
|
|
| 2 |
Ki = 1655 nM
|
|
|
|
CP0395799
|
(11aR)-10-methyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O
|
2
|
| 1 |
EC50 = 206 nM
|
|
|
| 2 |
Ki = 1010 nM
|
|
|
|
CP0405794
|
(R)-7-chloro-10-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C12H13ClN2O2
|
2
|
| 1 |
EC50 = 220 nM
|
|
|
| 2 |
Ki = 86 nM
|
|
|
|
CP0373544
|
2,3,4,5,5a,6-hexahydro-[1,4]diazepino[1,7-a]quinazolin-7(1H)-one
Show/Hide
|
C12H15N3O
|
2
|
| 1 |
EC50 = 248 nM
|
|
|
| 2 |
Ki = 269 nM
|
|
|
|
CP0442070
|
(R)-9-methoxy-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C13H13F3N2O2
|
2
|
| 1 |
EC50 = 289 nM
|
|
|
| 2 |
Ki = 1400 nM
|
|
|
|
CP0046618
|
1-(3-chlorophenyl)piperazine
Show/Hide
|
C10H13ClN2
|
2
|
| 1 |
EC50 = 290 nM
|
|
|
| 2 |
Ki = 48 nM
|
|
|
|
CP0886365
|
Trans-6,8-dimethyl-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C13H17ClN2O
|
2
|
| 1 |
EC50 = 303 nM
|
|
|
| 2 |
Ki = 540 nM
|
|
|
|
CP0442059
|
(4R,10bR)-4-methyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C13H13F3N2O
|
2
|
| 1 |
EC50 = 370 nM
|
|
|
| 2 |
Ki = 360 nM
|
|
|
|
CP0442062
|
(R)-9-ethyl-8-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a]-isoindol-6(2H)-one
Show/Hide
|
C14H18N2O2
|
2
|
| 1 |
EC50 = 374 nM
|
|
|
| 2 |
Ki = 589 nM
|
|
|
|
CP0407525
|
(11aR)-7-chloro-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C12H13ClN2O
|
2
|
| 1 |
EC50 = 381 nM
|
|
|
| 2 |
Ki = 120 nM
|
|
|
|
CP0373770
|
(+/-)-7-isopropoxy-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C14H18N2O2
|
2
|
| 1 |
EC50 = 449 nM
|
|
|
| 2 |
Ki = 250 nM
|
|
|
|
CP0442066
|
(R)-9-cyclopropyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C15H15F3N2O
|
2
|
| 1 |
EC50 = 513 nM
|
|
|
| 2 |
Ki = 579 nM
|
|
|
|
CP0850855
|
Trans-8-ethyl-6-(trifluoromethyl)-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C14H16ClF3N2O
|
2
|
| 1 |
EC50 = 605 nM
|
|
|
| 2 |
Ki = 157 nM
|
|
|
|
CP0853679
|
Trans-6-chloro-8-methyl-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C12H14Cl2N2O
|
2
|
| 1 |
EC50 = 605 nM
|
|
|
| 2 |
Ki = 217 nM
|
|
|
|
CP0395816
|
(11aR)-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C12H14N2O
|
2
|
| 1 |
EC50 = 707 nM
|
|
|
| 2 |
Ki = 326 nM
|
|
|
|
CP0850854
|
Trans-8-ethyl-6-methyl-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C14H19ClN2O
|
2
|
| 1 |
EC50 = 856 nM
|
|
|
| 2 |
Ki = 703 nM
|
|
|
|
CP0399465
|
(R)-8-chloro-7-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a]-isoindol-6(2H)-one
Show/Hide
|
C12H13ClN2O2
|
2
|
| 1 |
EC50 = 872 nM
|
|
|
| 2 |
Ki = 813 nM
|
|
|
|
CP0395795
|
(11aR)-10-methoxy-9-methyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C14H18N2O2
|
2
|
| 1 |
EC50 = 921 nM
|
|
|
| 2 |
Ki = 231 nM
|
|
|
|
CP0379006
|
(10bR)-2-methyl-7-(trifluoromethyl)-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C13H13F3N2O
|
2
|
| 1 |
EC50 = 994 nM
|
|
|
| 2 |
Ki = 4120 nM
|
|
|
|
CP0397747
|
(11aR)-10-methoxy-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O2
|
2
|
| 1 |
EC50 = 1030 nM
|
|
|
| 2 |
Ki = 511 nM
|
|
|
|
CP0380657
|
(11aR)-7,9-dimethyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C14H18N2O
|
2
|
| 1 |
EC50 = 1046 nM
|
|
|
| 2 |
Ki = 326 nM
|
|
|
|
CP0104596
|
(R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C14H15F3N2O
|
2
|
| 1 |
EC50 = 1170 nM
|
|
|
| 2 |
Ki = 431 nM
|
|
|
|
CP0407526
|
(17R)-3-oxa-12,15-diazatetracyclo[8.8.0.02,7.012,17]octadeca-1(10),2(7),8-trien-11-one
Show/Hide
|
C15H18N2O2
|
2
|
| 1 |
EC50 = 1379 nM
|
|
|
| 2 |
Ki = 337 nM
|
|
|
|
CP0405773
|
(R)-9-ethenyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindo l-6(2H)-one
Show/Hide
|
C14H13F3N2O
|
2
|
| 1 |
EC50 = 1620 nM
|
|
|
| 2 |
Ki = 829 nM
|
|
|
|
CP0867971
|
Trans-6-chloro-9-ethyl-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C13H16Cl2N2O
|
2
|
| 1 |
EC50 = 1674 nM
|
|
|
| 2 |
Ki = 359 nM
|
|
|
|
CP0378517
|
(+/-)-7-chloro-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C11H11ClN2O
|
2
|
| 1 |
EC50 = 1780 nM
|
|
|
| 2 |
Ki = 586 nM
|
|
|
|
CP0850856
|
Trans-6-chloro-8-ethyl-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C13H16Cl2N2O
|
2
|
| 1 |
EC50 = 1872 nM
|
|
|
| 2 |
Ki = 1488 nM
|
|
|
|
CP0903448
|
Trans-8-ethyl-4-methyl-6-(trifluoromethyl)-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C15H18ClF3N2O
|
2
|
| 1 |
EC50 = 2089 nM
|
|
|
| 2 |
Ki = 328 nM
|
|
|
|
CP0442060
|
(R)-7-chloro-10-ethyl-1,3,4,10b-tetrahydropyrazino[2,1-a]-isoindol-6(2H)-one
Show/Hide
|
C13H15ClN2O
|
2
|
| 1 |
EC50 = 3280 nM
|
|
|
| 2 |
Ki = 2420 nM
|
|
|
|
CP0373769
|
(3R,10bR)-3-methyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C13H13F3N2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki > 10000 nM
|
|
|
|
CP0378518
|
(+/-)-7-fluoro-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C11H11FN2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki > 10000 nM
|
|
|
|
CP0378519
|
(+/-)-7-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C12H14N2O2
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 3280 nM
|
|
|
|
CP0379002
|
(3S,10bR)-3-methyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C13H13F3N2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki > 10000 nM
|
|
|
|
CP0399467
|
(R)-7-chloro-9-ethyl-1,3,4,10b-tetrahydropyrazino[2,1-a]-isoindol-6(2H)-one
Show/Hide
|
C13H15ClN2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 4960 nM
|
|
|
|
CP0405771
|
(R)-9-isopropyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C15H17F3N2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 2620 nM
|
|
|
|
CP0405772
|
(R)-9-propyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C15H17F3N2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 1070 nM
|
|
|
|
CP0405774
|
(R)-9-butyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C16H19F3N2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 627 nM
|
|
|
|
CP0405785
|
(R)-9-ethoxy-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindol -6(2H)-one
Show/Hide
|
C14H15F3N2O2
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 3820 nM
|
|
|
|
CP0405793
|
(S)-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C12H11F3N2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki > 10000 nM
|
|
|
|
CP0405795
|
(R)-7-chloro-9-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a]-isoindol-6(2H)-one
Show/Hide
|
C12H13ClN2O2
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 4500 nM
|
|
|
|
CP0425115
|
(+/-)-7-nitrile-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C12H11N3O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki > 10000 nM
|
|
|
|
CP0435876
|
1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C11H12N2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 8540 nM
|
|
|
|
CP0437017
|
(10bR)-3,3-dimethyl-7-(trifluoromethyl)-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C14H15F3N2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki > 10000 nM
|
|
|
|
CP0437019
|
(+/-)-7-hydroxy-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C11H12N2O2
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 1670 nM
|
|
|
|
CP0442063
|
(R)-9-(1-methylcyclopropyl)-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C16H17F3N2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 2310 nM
|
|
|
|
CP0046371
|
(+)-7-methyl-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a]quinazolin-6(2H)-one
Show/Hide
|
C12H15N3O
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0376709
|
7-chloro-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a]quinazolin-6(2H)-one
Show/Hide
|
C11H12ClN3O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 334 nM
|
|
|
|
CP0458927
|
10-methyl-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a]quinazolin-6(2H)-one
Show/Hide
|
C12H15N3O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki > 10000 nM
|
|
|
|
CP0850852
|
(3aS,9bR)-6-(trifluoromethyl)-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C12H12ClF3N2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 1796 nM
|
|
|
|
CP0864126
|
(3aR,9bS)-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C11H13ClN2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 7957 nM
|
|
|
|
CP0864171
|
Trans-6-chloro-8-propyl-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C14H18Cl2N2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 4441 nM
|
|
|
|
CP0886026
|
Trans-6-chloro-8-ethyl-4-methyl-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C14H18Cl2N2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 6528 nM
|
|
|
|
CP0395800
|
(11aR)-6-oxo-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinoline-7-carbonitrile
Show/Hide
|
C13H13N3O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 2710 nM
|
|
|
|
CP0395801
|
(11aR)-10-propoxy-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C15H20N2O2
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 1448 nM
|
|
|
|
CP0395802
|
(11aR)-10-ethoxy-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C14H18N2O2
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 1034 nM
|
|
|
|
CP0395803
|
(11aR)-9-chloro-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C12H13ClN2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 396 nM
|
|
|
|
CP0395806
|
(11aR)-9-(trifluoromethyl)-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H13F3N2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 795 nM
|
|
|
|
CP0396117
|
(11R,11aR)-11-methyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 3020 nM
|
|
|
|
CP0396440
|
(11aR)-2-methyl-3,4,11,11a-tetrahydro-1H-pyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 1460 nM
|
|
|
|
CP0396446
|
(11aR)-9-ethyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C14H18N2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 231 nM
|
|
|
|
CP0396447
|
(3S,11aR)-3-methyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 1740 nM
|
|
|
|
CP0396450
|
(11aR)-9-propyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C15H20N2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 275 nM
|
|
|
|
CP0407522
|
(11aR)-9-methoxy-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O2
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 1716 nM
|
|
|
|
CP0407527
|
(11aR)-9-ethyl-7-methyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C15H20N2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 456 nM
|
|
|
|
CP0477791
|
(11aR)-9-methyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
Ki = 260 nM
|
|
|
|
CP0372021
|
8-methyl-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a]quinazolin-6(2H)-one
Show/Hide
|
C12H15N3O
|
2
|
| 1 |
EC50 > 705 nM
|
|
|
| 2 |
Ki = 1220 nM
|
|
|
|
CP0399468
|
(R)-9-chloro-8-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a]-isoindol-6(2H)-one
Show/Hide
|
C12H13ClN2O2
|
2
|
| 1 |
EC50 > 1000 nM
|
|
|
| 2 |
Ki = 1780 nM
|
|
|
|
CP0437020
|
(R)-7,8-dichloro-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C11H10Cl2N2O
|
2
|
| 1 |
EC50 > 1000 nM
|
|
|
| 2 |
Ki = 383 nM
|
|
|
|
CP0382676
|
9-methyl-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a]quinazolin-6(2H)-one
Show/Hide
|
C12H15N3O
|
2
|
| 1 |
EC50 > 1000 nM
|
|
|
| 2 |
Ki = 600 nM
|
|
|
|
CP0396118
|
(4S,11aR)-4-methyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O
|
2
|
| 1 |
EC50 > 2500 nM
|
|
|
| 2 |
Ki = 1081 nM
|
|
|
|
CP0396442
|
(11aR)-6-oxo-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinoline-9-carbonitrile
Show/Hide
|
C13H13N3O
|
2
|
| 1 |
EC50 > 2500 nM
|
|
|
| 2 |
Ki = 6027 nM
|
|
|
|
CP0396443
|
(11aR)-6-oxo-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinoline-8-carbonitrile
Show/Hide
|
C13H13N3O
|
2
|
| 1 |
EC50 > 2500 nM
|
|
|
| 2 |
Ki = 4000 nM
|
|
|
|
CP0396448
|
(3R,11aR)-3-methyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C13H16N2O
|
2
|
| 1 |
EC50 > 2500 nM
|
|
|
| 2 |
Ki = 2960 nM
|
|
|
|
CP0405768
|
(R)-7-chloro-10-methyl-1,3,4,10b-tetrahydropyrazino[2,1-a]-isoindol-6(2H)-one
Show/Hide
|
C12H13ClN2O
|
2
|
| 1 |
EC50 > 3000 nM
|
|
|
| 2 |
Ki = 4010 nM
|
|
|
|
CP0405769
|
(R)-10-chloro-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindol-6(2H)-one
Show/Hide
|
C12H10ClF3N2O
|
2
|
| 1 |
EC50 > 3000 nM
|
|
|
| 2 |
Ki = 1473 nM
|
|
|
|
CP0850465
|
Trans-8-cyclopropyl-6-methyl-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C15H19ClN2O
|
2
|
| 1 |
EC50 > 3000 nM
|
|
|
| 2 |
Ki = 3180 nM
|
|
|
|
CP0853705
|
Trans-8-isopropyl-6-methyl-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
Show/Hide
|
C15H21ClN2O
|
2
|
| 1 |
EC50 > 3000 nM
|
|
|
| 2 |
Ki = 3334 nM
|
|
|
|
CP0396441
|
(11aR)-10-ethyl-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
Show/Hide
|
C14H18N2O
|
2
|
| 1 |
EC50 > 3000 nM
|
|
|
| 2 |
Ki = 1424 nM
|
|
|
|
CP0115745
|
1-(4-fluorophenyl)-4-[(10R,15S)-4-methyl-1,4-diaza-12-azoniatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one;4-methylbenzenesulfonate
Show/Hide
|
C31H36FN3O4S
|
1
|
| 1 |
Ki = 0.54 nM
|
|
|
|
CP0132711
|
1-(4-fluorophenyl)-4-[(10R,15S)-4-oxa-1,12-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one
Show/Hide
|
C23H25FN2O2
|
1
|
| 1 |
Ki = 0.89 nM
|
|
|
|
CP0115747
|
1-(4-fluorophenyl)-4-[(10R,15S)-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one
Show/Hide
|
C23H26FN3O
|
1
|
| 1 |
Ki = 0.94 nM
|
|
|
|
CP0121646
|
4-[(10R,15S)-1,12-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-5(16),6,8-trien-12-yl]-1-(4-fluorophenyl)butan-1-one
Show/Hide
|
C24H27FN2O
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0398728
|
4-[(11S,16R)-10,14-diazatetracyclo[8.6.1.05,17.011,16]heptadeca-1,3,5(17)-trien-14-yl]-1-(4-fluorophenyl)butan-1-one
Show/Hide
|
C25H29FN2O
|
1
|
| 1 |
Ki = 1.1 nM
|
|
|
|
CP0416218
|
1-(4-fluorophenyl)-4-[(10R,15S)-4-thia-1,12-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one
Show/Hide
|
C23H25FN2OS
|
1
|
| 1 |
Ki = 1.3 nM
|
|
|
|
CP0427106
|
US8586579, 27
Show/Hide
|
C21H30N4O2S
|
1
|
| 1 |
Ki = 1.4 nM
|
|
|
|
CP0480058
|
1-(4-fluorophenyl)-4-[(2S,8S)-14-methyl-1,5,14-triazatetracyclo[7.7.1.02,8.013,17]heptadeca-9(17),10,12-trien-5-yl]butan-1-one
Show/Hide
|
C25H30FN3O
|
1
|
| 1 |
Ki = 1.7 nM
|
|
|
|
CP0462836
|
US8586579, 24
Show/Hide
|
C25H36N4O2S
|
1
|
| 1 |
Ki = 1.7 nM
|
|
|
|
CP0411744
|
4-[(10R,15S)-4-ethyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]-1-(4-fluorophenyl)butan-1-one
Show/Hide
|
C25H30FN3O
|
1
|
| 1 |
Ki = 2.1 nM
|
|
|
|
CP0481513
|
US8586579, 22
Show/Hide
|
C22H32N4O2S
|
1
|
| 1 |
Ki = 2.2 nM
|
|
|
|
CP0480064
|
(10R,15S)-12-[3-(4-fluorophenoxy)propyl]-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-triene
Show/Hide
|
C23H28FN3O
|
1
|
| 1 |
Ki = 2.4 nM
|
|
|
|
CP0045063
|
2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine
Show/Hide
|
C17H20N4S
|
1
|
| 1 |
Ki = 2.5 nM
|
|
|
|
CP0059921
|
6-fluoro-3-[3-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]propyl]-1,2-benzoxazole
Show/Hide
|
C24H27FN4O
|
1
|
| 1 |
Ki = 2.5 nM
|
|
|
|
CP0409912
|
US8586579, 20
Show/Hide
|
C28H42N4O2S
|
1
|
| 1 |
Ki = 2.5 nM
|
|
|
|
CP0401493
|
US8586579, 18
Show/Hide
|
C22H32N4OS
|
1
|
| 1 |
Ki = 2.6 nM
|
|
|
|
CP0483361
|
4-[(2R,7S)-4,8-diazatetracyclo[6.6.1.02,7.011,15]pentadeca-1(14),11(15),12-trien-4-yl]-1-(4-fluorophenyl)butan-1-one
Show/Hide
|
C23H25FN2O
|
1
|
| 1 |
Ki = 2.9 nM
|
|
|
|
CP0408302
|
US8586579, 30
Show/Hide
|
C20H30N4O2S2
|
1
|
| 1 |
Ki = 2.9 nM
|
|
|
|
CP0519383
|
US8586579, 11
Show/Hide
|
C25H36N4O3
|
1
|
| 1 |
Ki = 2.9 nM
|
|
|
|
CP0524601
|
US8586579, 31
Show/Hide
|
C21H32N4O2S2
|
1
|
| 1 |
Ki = 2.9 nM
|
|
|
|
CP0385772
|
US8586579, 23
Show/Hide
|
C26H38N4O2S
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0115744
|
3-[3-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]propyl]-1,2-benzoxazole
Show/Hide
|
C24H28N4O
|
1
|
| 1 |
Ki = 3.3 nM
|
|
|
|
CP0389364
|
US8586579, 15
Show/Hide
|
C21H30N4OS
|
1
|
| 1 |
Ki = 3.3 nM
|
|
|
|
CP0480445
|
1-(4-fluorophenyl)-4-[(10R,15S)-7-methoxy-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one
Show/Hide
|
C25H30FN3O2
|
1
|
| 1 |
Ki = 3.5 nM
|
|
|
|
CP0429658
|
US8586579, 19
Show/Hide
|
C23H34N4O2S
|
1
|
| 1 |
Ki = 3.5 nM
|
|
|
|
CP0470016
|
US8586579, 62
Show/Hide
|
C29H35N5O2
|
1
|
| 1 |
Ki = 3.62 nM
|
|
|
|
CP0546697
|
US8598357, 66
Show/Hide
|
C27H40N2O4
|
1
|
| 1 |
Ki = 3.93 nM
|
|
|
|
CP0411745
|
4-[(10R,15S)-7-bromo-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]-1-(4-fluorophenyl)butan-1-one
Show/Hide
|
C24H27BrFN3O
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0382532
|
US8586579, 28
Show/Hide
|
C27H40N4O2S
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0384855
|
US8586579, 26
Show/Hide
|
C27H40N4O2S
|
1
|
| 1 |
Ki = 4.3 nM
|
|
|
|
CP0441464
|
US8586579, 8
Show/Hide
|
C22H32N4O3
|
1
|
| 1 |
Ki = 4.4 nM
|
|
|
|
CP0539458
|
US8586579, 13
Show/Hide
|
C23H32N4O2
|
1
|
| 1 |
Ki = 4.4 nM
|
|
|
|
CP0414017
|
US8586579, 118
Show/Hide
|
C31H44N6O2
|
1
|
| 1 |
Ki = 4.51 nM
|
|
|
|
CP0402806
|
US8586579, 57
Show/Hide
|
C30H41N5O3
|
1
|
| 1 |
Ki = 4.52 nM
|
|
|
|
CP0420005
|
US8598357, 52
Show/Hide
|
C25H36N2O5S
|
1
|
| 1 |
Ki = 4.57 nM
|
|
|
|
CP0480065
|
1-(4-fluorophenyl)-4-[(10S,15R)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one
Show/Hide
|
C24H28FN3O
|
1
|
| 1 |
Ki = 4.6 nM
|
|
|
|
CP0398730
|
4-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]-1-pyridin-4-ylbutan-1-one
Show/Hide
|
C23H28N4O
|
1
|
| 1 |
Ki = 4.7 nM
|
|
|
|
CP0480056
|
4-[(10R,15S)-4-benzyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]-1-(4-fluorophenyl)butan-1-one
Show/Hide
|
C30H32FN3O
|
1
|
| 1 |
Ki = 4.7 nM
|
|
|
|
CP0470027
|
US8598357, 32
Show/Hide
|
C24H36N2O4
|
1
|
| 1 |
Ki = 4.77 nM
|
|
|
|
CP0402804
|
US8598357, 9
Show/Hide
|
C27H34N2O3
|
1
|
| 1 |
Ki = 5.14 nM
|
|
|
|
CP0416214
|
1-(4-fluorophenyl)-4-[(10R,15S)-2,2,4-trimethyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one
Show/Hide
|
C26H32FN3O
|
1
|
| 1 |
Ki = 5.2 nM
|
|
|
|
CP0396422
|
US8586579, 29
Show/Hide
|
C29H33N5O2
|
1
|
| 1 |
Ki = 5.3 nM
|
|
|
|
CP0544676
|
US8586579, 17
Show/Hide
|
C21H33N5O3S
|
1
|
| 1 |
Ki = 5.3 nM
|
|
|
|
CP0541477
|
1-(4-fluorophenyl)-4-[(10S,15R)-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one
Show/Hide
|
C23H26FN3O
|
1
|
| 1 |
Ki = 5.5 nM
|
|
|
|
CP0390450
|
US8586579, 7
Show/Hide
|
C21H30N4O3
|
1
|
| 1 |
Ki = 5.6 nM
|
|
|
|
CP0442921
|
US8586579, 9
Show/Hide
|
C28H42N4O3
|
1
|
| 1 |
Ki = 5.6 nM
|
|
|
|
CP0403462
|
US8586579, 105
Show/Hide
|
C26H38N4O3
|
1
|
| 1 |
Ki = 5.67 nM
|
|
|
|
CP0474721
|
4-[(10R,15S)-2,4-dimethyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]-1-(4-fluorophenyl)butan-1-one
Show/Hide
|
C25H30FN3O
|
1
|
| 1 |
Ki = 5.7 nM
|
|
|
|
CP0480060
|
4-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]-1-phenylbutan-1-one
Show/Hide
|
C24H29N3O
|
1
|
| 1 |
Ki = 5.8 nM
|
|
|
|
CP0409767
|
US8586579, 33
Show/Hide
|
C25H38N4O3
|
1
|
| 1 |
Ki = 5.9 nM
|
|
|
|
CP0550866
|
US8598357, 61
Show/Hide
|
C27H41N3O3
|
1
|
| 1 |
Ki = 5.91 nM
|
|
|
|
CP0468240
|
US8586579, 58
Show/Hide
|
C23H34N4O3
|
1
|
| 1 |
Ki = 5.92 nM
|
|
|
|
CP0456765
|
US8586579, 10
Show/Hide
|
C26H38N4O3
|
1
|
| 1 |
Ki = 6.1 nM
|
|
|
|
CP0515353
|
US8586579, 55
Show/Hide
|
C27H42N4O3
|
1
|
| 1 |
Ki = 6.14 nM
|
|
|
|
CP0413788
|
US8586579, 43
Show/Hide
|
C24H36N4O3
|
1
|
| 1 |
Ki = 6.3 nM
|
|
|
|
CP0525123
|
US8586579, 53
Show/Hide
|
C25H38N4O3
|
1
|
| 1 |
Ki = 6.37 nM
|
|
|
|
CP0414027
|
US8586579, 2
Show/Hide
|
C27H40N4O3
|
1
|
| 1 |
Ki = 6.4 nM
|
|
|
|
CP0401290
|
US8586579, 4
Show/Hide
|
C22H32N4O2
|
1
|
| 1 |
Ki = 6.5 nM
|
|
|
|
CP0409928
|
US8586579, 14
Show/Hide
|
C20H30N4O3S
|
1
|
| 1 |
Ki = 6.8 nM
|
|
|
|
CP0472304
|
US8586579, 135
Show/Hide
|
C23H36N4O3
|
1
|
| 1 |
Ki = 7 nM
|
|
|
|
CP0474764
|
US8586579, 12
Show/Hide
|
C23H34N4O3
|
1
|
| 1 |
Ki = 7.4 nM
|
|
|
|
CP0398729
|
1-(4-fluorophenyl)-4-[(10R,15S)-4-propan-2-yl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one
Show/Hide
|
C26H32FN3O
|
1
|
| 1 |
Ki = 7.5 nM
|
|
|
|
CP0532693
|
US8586579, 44
Show/Hide
|
C26H34N4O2
|
1
|
| 1 |
Ki = 7.63 nM
|
|
|
|
CP0411748
|
4-[(10S,15R)-1,12-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-5(16),6,8-trien-12-yl]-1-(4-fluorophenyl)butan-1-one
Show/Hide
|
C24H27FN2O
|
1
|
| 1 |
Ki = 7.7 nM
|
|
|
|
CP0384900
|
US8586579, 124
Show/Hide
|
C23H36N4O3
|
1
|
| 1 |
Ki = 7.82 nM
|
|
|
|
CP0444170
|
US8586579, 5
Show/Hide
|
C23H34N4O3
|
1
|
| 1 |
Ki = 8.1 nM
|
|
|
|
CP0425047
|
US8586579, 67
Show/Hide
|
C25H38N4O4
|
1
|
| 1 |
Ki = 8.15 nM
|
|
|
|
CP0435045
|
US8598357, 49
Show/Hide
|
C24H34N2O4
|
1
|
| 1 |
Ki = 8.17 nM
|
|
|
|
CP0382220
|
US8586579, 16
Show/Hide
|
C21H32N4O3S
|
1
|
| 1 |
Ki = 8.5 nM
|
|
|
|
CP0384851
|
US8586579, 3
Show/Hide
|
C27H40N4O3
|
1
|
| 1 |
Ki = 8.8 nM
|
|
|
|
CP0415561
|
US8598357, 14
Show/Hide
|
C28H33N3O3
|
1
|
| 1 |
Ki = 9.02 nM
|
|
|
|
CP0539641
|
US8586579, 1
Show/Hide
|
C21H30N4O2
|
1
|
| 1 |
Ki = 9.1 nM
|
|
|
|
CP0547490
|
US8586579, 70
Show/Hide
|
C24H38N4O2
|
1
|
| 1 |
Ki = 9.4 nM
|
|
|
|
CP0425087
|
US8586579, 115
Show/Hide
|
C25H34N4O4S2
|
1
|
| 1 |
Ki = 9.46 nM
|
|
|
|
CP0409921
|
US8598357, 48
Show/Hide
|
C26H38N2O4
|
1
|
| 1 |
Ki = 9.52 nM
|
|
|
|
CP0376222
|
US8598357, 34
Show/Hide
|
C24H36N2O4
|
1
|
| 1 |
Ki = 9.57 nM
|
|
|
|
CP0025667
|
2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone
Show/Hide
|
C18H19ClN4
|
1
|
| 1 |
Ki = 9.6 nM
|
|
|
|
CP0488991
|
US8586579, 37
Show/Hide
|
C25H38N4O4
|
1
|
| 1 |
Ki = 9.7 nM
|
|
|
|
CP0493439
|
US8586579, 123
Show/Hide
|
C24H36N4O3
|
1
|
| 1 |
Ki = 9.8 nM
|
|
|
|
CP0470043
|
US8586579, 42
Show/Hide
|
C24H36N4O3
|
1
|
| 1 |
Ki = 9.9 nM
|
|
|
|
CP0435140
|
US8586579, 52
Show/Hide
|
C24H36N4O2
|
1
|
| 1 |
Ki = 10.1 nM
|
|
|
|
CP0545227
|
US8586579, 75
Show/Hide
|
C23H36N4O2
|
1
|
| 1 |
Ki = 10.2 nM
|
|
|
|
CP0486570
|
US8586579, 6
Show/Hide
|
C22H32N4O3
|
1
|
| 1 |
Ki = 10.3 nM
|
|
|
|
CP0385685
|
US8598357, 64
Show/Hide
|
C23H34N2O4
|
1
|
| 1 |
Ki = 10.7 nM
|
|
|
|
CP0419742
|
US8586579, 38
Show/Hide
|
C22H34N4O3
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0431791
|
US8586579, 60
Show/Hide
|
C22H31F3N4O2
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0544789
|
US8586579, 77
Show/Hide
|
C24H36N4O3
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0402825
|
US8586579, 63
Show/Hide
|
C23H34N4O2
|
1
|
| 1 |
Ki = 11.1 nM
|
|
|
|
CP0435053
|
US8586579, 45
Show/Hide
|
C26H33FN4O2
|
1
|
| 1 |
Ki = 11.1 nM
|
|
|
|
CP0417806
|
US8586579, 112
Show/Hide
|
C22H31F3N4O3
|
1
|
| 1 |
Ki = 11.4 nM
|
|
|
|
CP0539446
|
US8598357, 15
Show/Hide
|
C27H35N3O3
|
1
|
| 1 |
Ki = 11.49 nM
|
|
|
|
CP0538921
|
US8586579, 66
Show/Hide
|
C21H35N5O3S
|
1
|
| 1 |
Ki = 11.5 nM
|
|
|
|
CP0460193
|
US8598357, 67
Show/Hide
|
C28H42N2O4
|
1
|
| 1 |
Ki = 11.58 nM
|
|
|
|
CP0434797
|
US8586579, 106
Show/Hide
|
C27H40N4O3
|
1
|
| 1 |
Ki = 11.7 nM
|
|
|
|
CP0420628
|
US8586579, 61
Show/Hide
|
C25H38N4O4
|
1
|
| 1 |
Ki = 11.8 nM
|
|
|
|
CP0409819
|
US8598357, 4
Show/Hide
|
C26H38N2O5
|
1
|
| 1 |
Ki = 11.85 nM
|
|
|
|
CP0417227
|
US8586579, 107
Show/Hide
|
C24H36N4O3
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0438226
|
US8586579, 40
Show/Hide
|
C21H32N4O3
|
1
|
| 1 |
Ki = 12.2 nM
|
|
|
|
CP0462704
|
US8586579, 82
Show/Hide
|
C23H32N4O2
|
1
|
| 1 |
Ki = 12.2 nM
|
|
|
|
CP0441515
|
US8586579, 120
Show/Hide
|
C31H37N5O2
|
1
|
| 1 |
Ki = 12.3 nM
|
|
|
|
CP0425085
|
US8586579, 81
Show/Hide
|
C27H42N4O3
|
1
|
| 1 |
Ki = 12.6 nM
|
|
|
|
CP0472017
|
US8598357, 41
Show/Hide
|
C27H40N2O4
|
1
|
| 1 |
Ki = 12.63 nM
|
|
|
|
CP0406110
|
US8586579, 144
Show/Hide
|
C27H33N5O2
|
1
|
| 1 |
Ki = 13 nM
|
|
|
|
CP0380503
|
US8598357, 37
Show/Hide
|
C27H33FN2O3
|
1
|
| 1 |
Ki = 13.05 nM
|
|
|
|
CP0456780
|
US8586579, 103
Show/Hide
|
C24H38N4O2
|
1
|
| 1 |
Ki = 13.2 nM
|
|
|
|
CP0415723
|
US8586579, 73
Show/Hide
|
C25H38N4O2
|
1
|
| 1 |
Ki = 13.3 nM
|
|
|
|
CP0497788
|
US8586579, 36
Show/Hide
|
C22H34N4O2
|
1
|
| 1 |
Ki = 13.3 nM
|
|
|
|
CP0389370
|
US8586579, 51
Show/Hide
|
C24H36N4O2
|
1
|
| 1 |
Ki = 13.7 nM
|
|
|
|
CP0395050
|
US8586579, 131
Show/Hide
|
C22H32N4O2
|
1
|
| 1 |
Ki = 13.7 nM
|
|
|
|
CP0488982
|
US8598357, 3
Show/Hide
|
C26H38N2O5
|
1
|
| 1 |
Ki = 13.94 nM
|
|
|
|
CP0389323
|
US8598357, 12
Show/Hide
|
C23H31F3N2O4
|
1
|
| 1 |
Ki = 13.99 nM
|
|
|
|
CP0414459
|
1-(4-fluorophenyl)-4-[(2S,8S)-14-oxa-1,5-diazatetracyclo[7.7.1.02,8.013,17]heptadeca-9(17),10,12-trien-5-yl]butan-1-one
Show/Hide
|
C24H27FN2O2
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0480444
|
4-[(10R,15S)-4-butyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]-1-(4-fluorophenyl)butan-1-one
Show/Hide
|
C27H34FN3O
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0411422
|
US8598357, 46
Show/Hide
|
C25H36N2O4
|
1
|
| 1 |
Ki = 14.39 nM
|
|
|
|
CP0524577
|
US8586579, 95
Show/Hide
|
C25H38N4O3
|
1
|
| 1 |
Ki = 14.6 nM
|
|
|
|
CP0441543
|
US8598357, 13
Show/Hide
|
C23H34N2O4
|
1
|
| 1 |
Ki = 14.62 nM
|
|
|
|
CP0418376
|
US8586579, 73
Show/Hide
|
C26H33ClN4O2
|
1
|
| 1 |
Ki = 14.8 nM
|
|
|
|
CP0413986
|
US8586579, 92
Show/Hide
|
C28H44N4O3
|
1
|
| 1 |
Ki = 14.9 nM
|
|
|
|
CP0414029
|
US8586579, 84
Show/Hide
|
C25H35N5O3
|
1
|
| 1 |
Ki = 15.2 nM
|
|
|
|
CP0403388
|
US8586579, 143
Show/Hide
|
C26H35N5O2
|
1
|
| 1 |
Ki = 15.5 nM
|
|
|
|
CP0470183
|
US8598357, 22
Show/Hide
|
C27H40N2O4
|
1
|
| 1 |
Ki = 15.58 nM
|
|
|
|
CP0382553
|
US8586579, 146
Show/Hide
|
C29H40N6O3
|
1
|
| 1 |
Ki = 15.6 nM
|
|
|
|
CP0380474
|
US8586579, 71
Show/Hide
|
C24H38N4O2
|
1
|
| 1 |
Ki = 15.7 nM
|
|
|
|
CP0407665
|
US8586579, 112
Show/Hide
|
C24H33N5O3
|
1
|
| 1 |
Ki = 15.7 nM
|
|
|
|
CP0411524
|
US8586579, 140
Show/Hide
|
C24H38N4O4
|
1
|
| 1 |
Ki = 15.7 nM
|
|
|
|
CP0417805
|
US8586579, 59
Show/Hide
|
C22H31N5O2
|
1
|
| 1 |
Ki = 15.7 nM
|
|
|
|
CP0382552
|
US8598357, 21
Show/Hide
|
C28H42N2O4
|
1
|
| 1 |
Ki = 15.72 nM
|
|
|
|
CP0400903
|
US8586579, 39
Show/Hide
|
C22H34N4O4S
|
1
|
| 1 |
Ki = 16.1 nM
|
|
|
|
CP0397820
|
US8586579, 107
Show/Hide
|
C24H36N4O2
|
1
|
| 1 |
Ki = 16.2 nM
|
|
|
|
CP0417814
|
US8586579, 99
Show/Hide
|
C25H40N4O2
|
1
|
| 1 |
Ki = 16.2 nM
|
|
|
|
CP0462849
|
US8586579, 152
Show/Hide
|
C30H41N5O4S
|
1
|
| 1 |
Ki = 16.6 nM
|
|
|
|
CP0544598
|
US8598357, 7
Show/Hide
|
C23H34N2O3
|
1
|
| 1 |
Ki = 16.61 nM
|
|
|
|
CP0388917
|
US8586579, 91
Show/Hide
|
C25H38N4O3
|
1
|
| 1 |
Ki = 16.7 nM
|
|
|
|
CP0403489
|
US8598357, 54
Show/Hide
|
C25H36N2O3
|
1
|
| 1 |
Ki = 16.92 nM
|
|
|
|
CP0538223
|
US8598357, 5
Show/Hide
|
C26H38N2O5
|
1
|
| 1 |
Ki = 16.97 nM
|
|
|
|
CP0441455
|
US8598357, 23
Show/Hide
|
C24H36N2O3
|
1
|
| 1 |
Ki = 16.98 nM
|
|
|
|
CP0398727
|
1-(4-fluorophenyl)-4-[(2R,8R)-14-methyl-1,5,14-triazatetracyclo[7.7.1.02,8.013,17]heptadeca-9(17),10,12-trien-5-yl]butan-1-one
Show/Hide
|
C25H30FN3O
|
1
|
| 1 |
Ki = 17 nM
|
|
|
|
CP0425063
|
US8586579, 101
Show/Hide
|
C23H32F2N4O2
|
1
|
| 1 |
Ki = 17.3 nM
|
|
|
|
CP0491212
|
US8586579, 76
Show/Hide
|
C21H34N4O3S
|
1
|
| 1 |
Ki = 17.6 nM
|
|
|
|
CP0539626
|
US8586579, 148
Show/Hide
|
C27H34N4O4
|
1
|
| 1 |
Ki = 17.6 nM
|
|
|
|
CP0458986
|
US8598357, 8
Show/Hide
|
C25H36N2O3
|
1
|
| 1 |
Ki = 17.65 nM
|
|
|
|
CP0411746
|
(10R,15S)-12-[3-(6-fluoro-2H-indazol-3-yl)propyl]-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-triene
Show/Hide
|
C24H28FN5
|
1
|
| 1 |
Ki = 18 nM
|
|
|
|
CP0522194
|
US8598357, 10
Show/Hide
|
C23H31F3N2O3
|
1
|
| 1 |
Ki = 18.09 nM
|
|
|
|
CP0414174
|
US8586579, 141
Show/Hide
|
C25H40N4O4
|
1
|
| 1 |
Ki = 18.1 nM
|
|
|
|
CP0460190
|
US8586579, 157
Show/Hide
|
C28H39N7O3
|
1
|
| 1 |
Ki = 18.4 nM
|
|
|
|
CP0415063
|
US8598357, 56
Show/Hide
|
C31H41N3O4
|
1
|
| 1 |
Ki = 18.51 nM
|
|
|
|
CP0375738
|
US8598357, 28
Show/Hide
|
C25H35ClN2O3
|
1
|
| 1 |
Ki = 18.63 nM
|
|
|
|
CP0415635
|
US8586579, 74
Show/Hide
|
C27H33F3N4O2
|
1
|
| 1 |
Ki = 18.8 nM
|
|
|
|
CP0413934
|
US8598357, 50
Show/Hide
|
C25H33F3N2O3
|
1
|
| 1 |
Ki = 19.04 nM
|
|
|
|
CP0472516
|
US8586579, 83
Show/Hide
|
C31H43N5O2
|
1
|
| 1 |
Ki = 19.2 nM
|
|
|
|
CP0524288
|
US8586579, 106
Show/Hide
|
C21H29F3N4O2
|
1
|
| 1 |
Ki = 19.2 nM
|
|
|
|
CP0390397
|
US8598357, 39
Show/Hide
|
C23H31F3N2O4
|
1
|
| 1 |
Ki = 19.42 nM
|
|
|
|
CP0434731
|
US8586579, 136
Show/Hide
|
C26H40N4O3
|
1
|
| 1 |
Ki = 19.7 nM
|
|
|
|
CP0409813
|
US8598357, 43
Show/Hide
|
C27H40N2O4
|
1
|
| 1 |
Ki = 19.76 nM
|
|
|
|
CP0375693
|
US8598357, 19
Show/Hide
|
C26H35N3O4
|
1
|
| 1 |
Ki = 19.78 nM
|
|
|
|
CP0525521
|
US8598357, 42
Show/Hide
|
C27H40N2O4
|
1
|
| 1 |
Ki = 20.1 nM
|
|
|
|
CP0408247
|
US8586579, 61
Show/Hide
|
C26H40N4O3
|
1
|
| 1 |
Ki = 20.1 nM
|
|
|
|
CP0541425
|
US8586579, 164
Show/Hide
|
C23H36N4O3
|
1
|
| 1 |
Ki = 20.1 nM
|
|
|
|
CP0456468
|
US8598357, 58
Show/Hide
|
C29H36N2O5
|
1
|
| 1 |
Ki = 20.15 nM
|
|
|
|
CP0397112
|
US8598357, 78
Show/Hide
|
C22H35N3O4S
|
1
|
| 1 |
Ki = 20.67 nM
|
|
|
|
CP0406112
|
US8598357, 38
Show/Hide
|
C23H31F3N2O4
|
1
|
| 1 |
Ki = 20.76 nM
|
|
|
|
CP0375372
|
US8598357, 6
Show/Hide
|
C26H38N2O4
|
1
|
| 1 |
Ki = 21.03 nM
|
|
|
|
CP0384871
|
US8598357, 65
Show/Hide
|
C22H32N2O4
|
1
|
| 1 |
Ki = 21.41 nM
|
|
|
|
CP0468186
|
US8586579, 75
Show/Hide
|
C20H32N4O3S
|
1
|
| 1 |
Ki = 21.7 nM
|
|
|
|
CP0544848
|
US8586579, 159
Show/Hide
|
C26H32Cl2N4O2
|
1
|
| 1 |
Ki = 21.7 nM
|
|
|
|
CP0459018
|
US8598357, 60
Show/Hide
|
C30H38N2O4
|
1
|
| 1 |
Ki = 21.75 nM
|
|
|
|
CP0416411
|
US8598357, 18
Show/Hide
|
C22H32N2O4
|
1
|
| 1 |
Ki = 21.79 nM
|
|
|
|
CP0382066
|
US8598357, 36
Show/Hide
|
C27H33ClN2O3
|
1
|
| 1 |
Ki = 21.8 nM
|
|
|
|
CP0418375
|
US8598357, 29
Show/Hide
|
C25H36N2O4
|
1
|
| 1 |
Ki = 21.92 nM
|
|
|
|
CP0420034
|
US8598357, 62
Show/Hide
|
C25H36N2O4
|
1
|
| 1 |
Ki = 22.06 nM
|
|
|
|
CP0429660
|
US8586579, 117
Show/Hide
|
C27H42N4O3
|
1
|
| 1 |
Ki = 22.4 nM
|
|
|
|
CP0409843
|
US8598357, 20
Show/Hide
|
C23H31N3O3
|
1
|
| 1 |
Ki = 22.45 nM
|
|
|
|
CP0408183
|
US8586579, 168
Show/Hide
|
C25H38N4O3
|
1
|
| 1 |
Ki = 22.5 nM
|
|
|
|
CP0425028
|
US8586579, 118
Show/Hide
|
C25H38N4O4
|
1
|
| 1 |
Ki = 22.5 nM
|
|
|
|
CP0381707
|
US8586579, 108
Show/Hide
|
C24H36N4O2
|
1
|
| 1 |
Ki = 22.8 nM
|
|
|
|
CP0429155
|
US8586579, 32
Show/Hide
|
C21H32N4O2
|
1
|
| 1 |
Ki = 22.9 nM
|
|
|
|
CP0407188
|
US8598357, 57
Show/Hide
|
C30H35N3O3
|
1
|
| 1 |
Ki = 23.07 nM
|
|
|
|
CP0434805
|
US8586579, 119
Show/Hide
|
C23H36N4O2
|
1
|
| 1 |
Ki = 23.1 nM
|
|
|
|
CP0409763
|
US8586579, 155
Show/Hide
|
C29H35N5O2
|
1
|
| 1 |
Ki = 23.2 nM
|
|
|
|
CP0389369
|
US8586579, 161
Show/Hide
|
C32H38N4O2
|
1
|
| 1 |
Ki = 23.4 nM
|
|
|
|
CP0420477
|
US8586579, 110
Show/Hide
|
C20H30N4O2
|
1
|
| 1 |
Ki = 23.5 nM
|
|
|
|
CP0418310
|
US8598357, 1
Show/Hide
|
C22H32N2O3
|
1
|
| 1 |
Ki = 23.85 nM
|
|
|
|
CP0459962
|
US8586579, 113
Show/Hide
|
C25H39N5O3
|
1
|
| 1 |
Ki = 23.9 nM
|
|
|
|
CP0441510
|
US8598357, 47
Show/Hide
|
C25H36N2O4
|
1
|
| 1 |
Ki = 24.05 nM
|
|
|
|
CP0407663
|
US8586579, 62
Show/Hide
|
C23H36N4O3
|
1
|
| 1 |
Ki = 24.1 nM
|
|
|
|
CP0411382
|
US8586579, 160
Show/Hide
|
C30H37N5O2
|
1
|
| 1 |
Ki = 24.2 nM
|
|
|
|
CP0382188
|
US8586579, 120
Show/Hide
|
C25H40N4O2
|
1
|
| 1 |
Ki = 24.6 nM
|
|
|
|
CP0435217
|
US8586579, 121
Show/Hide
|
C24H38N4O2
|
1
|
| 1 |
Ki = 24.7 nM
|
|
|
|
CP0415900
|
US8586579, 96
Show/Hide
|
C25H38N4O3
|
1
|
| 1 |
Ki = 24.9 nM
|
|
|
|
CP0396408
|
US8598357, 31
Show/Hide
|
C27H40N2O5
|
1
|
| 1 |
Ki = 24.92 nM
|
|
|
|
CP0409881
|
US8586579, 114
Show/Hide
|
C24H38N4O3
|
1
|
| 1 |
Ki = 25 nM
|
|
|
|
CP0391608
|
US8598357, 51
Show/Hide
|
C25H38N2O3
|
1
|
| 1 |
Ki = 25.01 nM
|
|
|
|
CP0411507
|
US8598357, 74
Show/Hide
|
C29H37N3O3
|
1
|
| 1 |
Ki = 25.37 nM
|
|
|
|
CP0385022
|
US8586579, 124
Show/Hide
|
C26H38N4O3
|
1
|
| 1 |
Ki = 25.5 nM
|
|
|
|
CP0425107
|
US8598357, 35
Show/Hide
|
C25H38N2O4
|
1
|
| 1 |
Ki = 26.11 nM
|
|
|
|
CP0484507
|
US8598357, 26
Show/Hide
|
C24H32F2N2O3
|
1
|
| 1 |
Ki = 26.67 nM
|
|
|
|
CP0403470
|
US8598357, 45
Show/Hide
|
C26H38N2O4
|
1
|
| 1 |
Ki = 26.76 nM
|
|
|
|
CP0385684
|
US8598357, 55
Show/Hide
|
C23H34N2O5S
|
1
|
| 1 |
Ki = 27 nM
|
|
|
|
CP0407212
|
US8598357, 30
Show/Hide
|
C28H42N2O4
|
1
|
| 1 |
Ki = 27.45 nM
|
|
|
|
CP0415564
|
US8586579, 156
Show/Hide
|
C28H35N5O3
|
1
|
| 1 |
Ki = 27.8 nM
|
|
|
|
CP0384854
|
US8598357, 40
Show/Hide
|
C27H40N2O4
|
1
|
| 1 |
Ki = 27.9 nM
|
|
|
|
CP0474451
|
US8598357, 16
Show/Hide
|
C26H38N2O4
|
1
|
| 1 |
Ki = 27.96 nM
|
|
|
|
CP0431794
|
US8598357, 24
Show/Hide
|
C25H38N2O3
|
1
|
| 1 |
Ki = 28.54 nM
|
|
|
|
CP0427152
|
US8586579, 105
Show/Hide
|
C22H35N5O2
|
1
|
| 1 |
Ki = 28.7 nM
|
|
|
|
CP0460009
|
US8598357, 33
Show/Hide
|
C24H36N2O4
|
1
|
| 1 |
Ki = 29.06 nM
|
|
|
|
CP0508731
|
US8586579, 122
Show/Hide
|
C23H33F3N4O2
|
1
|
| 1 |
Ki = 29.6 nM
|
|
|
|
CP0381771
|
US8598357, 53
Show/Hide
|
C27H40N2O4
|
1
|
| 1 |
Ki = 29.63 nM
|
|
|
|
CP0376190
|
US8586579, 116
Show/Hide
|
C24H38N4O3
|
1
|
| 1 |
Ki = 30 nM
|
|
|
|
CP0474428
|
US8586579, 166
Show/Hide
|
C24H38N4O3
|
1
|
| 1 |
Ki = 30.4 nM
|
|
|
|
CP0407727
|
US8598357, 68
Show/Hide
|
C27H42N4O3
|
1
|
| 1 |
Ki = 30.97 nM
|
|
|
|
CP0470051
|
US8598357, 69
Show/Hide
|
C21H32N2O4S
|
1
|
| 1 |
Ki = 31.32 nM
|
|
|
|
CP0385140
|
US8598357, 11
Show/Hide
|
C24H33F3N2O3
|
1
|
| 1 |
Ki = 31.96 nM
|
|
|
|
CP0425061
|
US8586579, 115
Show/Hide
|
C23H33F3N4O3
|
1
|
| 1 |
Ki = 33.1 nM
|
|
|
|
CP0403477
|
US8598357, 27
Show/Hide
|
C25H38N2O4
|
1
|
| 1 |
Ki = 33.63 nM
|
|
|
|
CP0441416
|
US8586579, 149
Show/Hide
|
C28H36N4O4
|
1
|
| 1 |
Ki = 33.7 nM
|
|
|
|
CP0414712
|
US8598357, 17
Show/Hide
|
C26H38N2O4
|
1
|
| 1 |
Ki = 33.78 nM
|
|
|
|
CP0523877
|
US8598357, 63
Show/Hide
|
C29H44N2O4
|
1
|
| 1 |
Ki = 34.3 nM
|
|
|
|
CP0409839
|
US8586579, 41
Show/Hide
|
C22H34N4O3
|
1
|
| 1 |
Ki = 35.7 nM
|
|
|
|
CP0411364
|
US8598357, 25
Show/Hide
|
C24H36N2O3
|
1
|
| 1 |
Ki = 35.84 nM
|
|
|
|
CP0413807
|
US8586579, 153
Show/Hide
|
C29H36N6O2
|
1
|
| 1 |
Ki = 35.9 nM
|
|
|
|
CP0385024
|
US8598357, 59
Show/Hide
|
C29H36N2O5
|
1
|
| 1 |
Ki = 36.74 nM
|
|
|
|
CP0515346
|
US8586579, 138
Show/Hide
|
C24H38N4O3
|
1
|
| 1 |
Ki = 37 nM
|
|
|
|
CP0425079
|
US8598357, 73
Show/Hide
|
C22H29F3N2O3
|
1
|
| 1 |
Ki = 37.38 nM
|
|
|
|
CP0389378
|
US8598357, 2
Show/Hide
|
C24H36N2O4
|
1
|
| 1 |
Ki = 38.2 nM
|
|
|
|
CP0524277
|
US8586579, 50
Show/Hide
|
C25H33FN4O3S
|
1
|
| 1 |
Ki = 39.4 nM
|
|
|
|
CP0472521
|
US8598357, 76
Show/Hide
|
C22H31FN2O3
|
1
|
| 1 |
Ki = 39.89 nM
|
|
|
|
CP0409863
|
US8586579, 163
Show/Hide
|
C30H42N4O3
|
1
|
| 1 |
Ki = 41.4 nM
|
|
|
|
CP0534576
|
US8586579, 167
Show/Hide
|
C24H38N4O3
|
1
|
| 1 |
Ki = 42 nM
|
|
|
|
CP0416410
|
US8586579, 137
Show/Hide
|
C27H42N4O3
|
1
|
| 1 |
Ki = 44 nM
|
|
|
|
CP0406432
|
US8598357, 75
Show/Hide
|
C23H35N3O3
|
1
|
| 1 |
Ki = 45.55 nM
|
|
|
|
CP0486508
|
US8586579, 154
Show/Hide
|
C29H36N6O3
|
1
|
| 1 |
Ki = 48.9 nM
|
|
|
|
CP0474718
|
3-(4-fluorophenyl)-5-[[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]methyl]-4,5-dihydro-1,2-oxazole
Show/Hide
|
C24H27FN4O
|
1
|
| 1 |
Ki = 50 nM
|
|
|
|
CP0409786
|
US8598357, 70
Show/Hide
|
C26H34N2O4S
|
1
|
| 1 |
Ki = 52.25 nM
|
|
|
|
CP0436280
|
US8598357, 44
Show/Hide
|
C25H38N2O4
|
1
|
| 1 |
Ki = 54.98 nM
|
|
|
|
CP0420459
|
US8598357, 79
Show/Hide
|
C24H37N3O5S
|
1
|
| 1 |
Ki = 56.15 nM
|
|
|
|
CP0376195
|
US8586579, 128
Show/Hide
|
C26H40N4O3
|
1
|
| 1 |
Ki = 58.5 nM
|
|
|
|
CP0409871
|
US8598357, 72
Show/Hide
|
C24H34N4O4S
|
1
|
| 1 |
Ki = 64.77 nM
|
|
|
|
CP0425406
|
US8598357, 71
Show/Hide
|
C26H33FN2O4S
|
1
|
| 1 |
Ki = 65.55 nM
|
|
|
|
CP0422467
|
US8586579, 158
Show/Hide
|
C30H42N4O2
|
1
|
| 1 |
Ki = 66.7 nM
|
|
|
|
CP0486581
|
US8586579, 135
Show/Hide
|
C22H34N4O2
|
1
|
| 1 |
Ki = 67.5 nM
|
|
|
|
CP0547146
|
US8586579, 165
Show/Hide
|
C25H34N4O3S
|
1
|
| 1 |
Ki = 70.5 nM
|
|
|
|
CP0411379
|
US8586579, 96
Show/Hide
|
C22H32N4O2
|
1
|
| 1 |
Ki = 75.2 nM
|
|
|
|
CP0428007
|
US8586579, 98
Show/Hide
|
C27H40N4O3
|
1
|
| 1 |
Ki = 75.9 nM
|
|
|
|
CP0469312
|
US8586579, 99
Show/Hide
|
C24H36N4O3
|
1
|
| 1 |
Ki = 86.9 nM
|
|
|
|
CP0376711
|
7-(trifluoromethyl)-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a]quinazolin-6(2H)-one
Show/Hide
|
C12H12F3N3O
|
1
|
| 1 |
Ki = 184 nM
|
|
|
|
CP0425064
|
US8586579, 129
Show/Hide
|
C27H42N4O3
|
1
|
| 1 |
Ki = 193.4 nM
|
|
|
|
CP0385783
|
US8586579, 100
Show/Hide
|
C22H34N4O2
|
1
|
| 1 |
Ki = 215 nM
|
|
|
|
CP0460093
|
US8598357, 77
Show/Hide
|
C27H34ClN3O3
|
1
|
| 1 |
Ki = 223.52 nM
|
|
|
|
CP0472595
|
US8586579, 103
Show/Hide
|
C24H38N4O3
|
1
|
| 1 |
Ki = 255 nM
|
|
|
|
CP0411747
|
1-(4-fluorophenyl)-4-[(10R,15R)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one
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C24H28FN3O
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1
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| 1 |
Ki = 324 nM
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CP0382675
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8-chloro-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a]quinazolin-6(2H)-one
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C11H12ClN3O
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1
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| 1 |
Ki = 397 nM
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CP0288744
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5,6-dichloro-1,4-dihydroquinazolin-2-amine
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C8H7Cl2N3
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1
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| 1 |
Ki = 434 nM
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CP0398731
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4-fluoro-N-[2-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]ethyl]benzamide
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C23H27FN4O
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1
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| 1 |
Ki = 671 nM
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CP0474719
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2,8-dimethyl-3-[2-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]ethyl]pyrido[1,2-a]pyrimidin-4-one
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C26H31N5O
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1
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| 1 |
Ki = 702 nM
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CP0379019
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(R)-9-chloro-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindol-6(2H)-one
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C12H10ClF3N2O
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1
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| 1 |
Ki = 1040 nM
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CP0371440
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5-chloro-1,4-dihydroquinazolin-2-amine
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C8H8ClN3
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1
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| 1 |
Ki = 1164 nM
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CP0850464
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Rac-cis-6-(trifluoromethyl)-2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-one hydrochloride
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C12H12ClF3N2O
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1
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| 1 |
Ki = 1882 nM
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CP0376740
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3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a]quinazolin-6(2H)-one
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C11H13N3O
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1
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| 1 |
Ki = 1980 nM
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CP0405786
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(R)-9-hydroxymethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one
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C13H13F3N2O2
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1
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| 1 |
Ki = 3050 nM
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CP0405770
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(R)-9-acetyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindol-6(2H)-one
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C14H13F3N2O2
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1
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| 1 |
Ki = 5200 nM
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CP0405775
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(R)-9-ethynyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindol-6(2H)-one
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C14H11F3N2O
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1
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| 1 |
Ki = 6560 nM
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CP0397206
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(11aR)-11a-methyl-2,3,4,11-tetrahydro-1H-pyrazino[1,2-b]isoquinolin-6-one
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C13H16N2O
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1
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| 1 |
Ki = 6933 nM
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CP0405767
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((R)-10-chloro-7-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2 H)-one
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C12H13ClN2O2
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1
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| 1 |
Ki > 10000 nM
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CP0387174
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10-chloro-3,4,4a,5-tetrahydro-1H-pyrazino[1,2-a]quinazolin-6(2H)-one
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C11H12ClN3O
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1
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| 1 |
Ki > 10000 nM
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CP0407521
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(11aR)-10-(trifluoromethyl)-1,2,3,4,11,11a-hexahydropyrazino[1,2-b]isoquinolin-6-one
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C13H13F3N2O
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1
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| 1 |
Ki > 10000 nM
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CP0382677
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8-chloro-2,3,4,5,5a,6-hexahydro-1H-[1,4]diazepino[1,2-a]quinazolin-7-one
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C12H14ClN3O
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1
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| 1 |
Ki = 13560 nM
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CP0398726
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1-(4-fluorophenyl)-4-[(10S,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one
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C24H28FN3O
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1
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| 1 |
Ki > 1000 nM
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CP0416215
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(3aS,7aR)-2-[3-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]propyl]-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione
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C25H34N4O2
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1
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| 1 |
Ki > 1000 nM
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CP0474717
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(3aR,7aS)-2-[4-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butyl]-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione
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C26H36N4O2
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1
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| 1 |
Ki > 1000 nM
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CP0480057
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6-chloro-5-[2-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]ethyl]-1,3-dihydroindol-2-one
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C24H27ClN4O
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1
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| 1 |
Ki > 1000 nM
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CP0480062
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1-(4,4-difluoropiperidin-1-yl)-4-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one
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C23H32F2N4O
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1
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| 1 |
Ki > 1000 nM
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