| Compound ID |
Compound Name |
Compound Formula |
|
CP0432068
|
(8S,9S,11S,13S,14S,17S)-17-hydroxy-11-methoxy-13-methyl-N-(2-methylpyridin-3-yl)-17-prop-1-ynyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3-carboxamide
Show/Hide
|
C29H34N2O3
|
1
|
| 1 |
EC50 = 0.04 nM
|
|
|
|
CP0307244
|
(8S,9S,11S,13S,14S,17S)-11-ethoxy-17-hydroxy-13-methyl-N-(2-methylpyridin-3-yl)-17-prop-1-ynyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3-carboxamide
Show/Hide
|
C30H36N2O3
|
1
|
| 1 |
EC50 = 0.05 nM
|
|
|
|
CP0294180
|
(8S,9S,11S,13S,14S,17S)-17-hydroxy-13-methyl-N-(2-methylpyridin-3-yl)-11-prop-2-enoxy-17-prop-1-ynyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3-carboxamide
Show/Hide
|
C31H36N2O3
|
2
|
| 1 |
EC50 = 0.11 nM
|
|
|
| 2 |
IC50 = 0.03 nM
|
|
|
|
CP0052526
|
(+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-ol
Show/Hide
|
C20H20F2N2O
|
3
|
| 1 |
EC50 = 0.6 nM
|
|
|
| 2 |
EC50 = 53 nM
|
|
|
| 3 |
IC50 = 1.5 nM
|
|
|
|
CP0242004
|
5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-2,3-dihydroquinolin-4(1H)-one O-isopropyl oxime
Show/Hide
|
C23H25F2N3O
|
3
|
| 1 |
EC50 = 0.6 nM
|
|
|
| 2 |
EC50 = 250 nM
|
|
|
| 3 |
IC50 = 4.9 nM
|
|
|
|
CP0070809
|
CCI-18781
Show/Hide
|
C25H31F3O5S
|
1
|
| 1 |
EC50 = 0.7 nM
|
|
|
|
CP0206803
|
(4Z)-4-ethoxyimino-5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-1,3-dihydroquinolin-3-ol
Show/Hide
|
C22H23F2N3O2
|
3
|
| 1 |
EC50 = 1.5 nM
|
|
|
| 2 |
EC50 = 115 nM
|
|
|
| 3 |
IC50 = 2.6 nM
|
|
|
|
CP0047174
|
(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
Show/Hide
|
C21H28O5
|
10
|
| 1 |
EC50 = 2.1 nM
|
|
|
| 2 |
EC50 = 2.6 nM
|
|
|
| 3 |
EC50 = 5.3 nM
|
|
|
| 4 |
EC50 = 24 nM
|
|
|
| 5 |
EC50 = 26 nM
|
|
|
| 6 |
EC50 = 211 nM
|
|
|
| 7 |
IC50 = 2.1 nM
|
|
|
| 8 |
IC50 = 4.1 nM
|
|
|
| 9 |
IC50 = 23 nM
|
|
|
| 10 |
IC50 = 340 nM
|
|
|
|
CP0206805
|
6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2-dimethyl-2,3-dihydroquinolin-4(1H)-one O-tert-butyl oxime
Show/Hide
|
C23H24ClF2N3O
|
3
|
| 1 |
EC50 = 3.4 nM
|
|
|
| 2 |
EC50 = 67 nM
|
|
|
| 3 |
IC50 = 4 nM
|
|
|
|
CP0281237
|
(4Z)-5,7-difluoro-4-methoxyimino-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-1,3-dihydroquinolin-3-ol
Show/Hide
|
C21H21F2N3O2
|
3
|
| 1 |
EC50 = 3.9 nM
|
|
|
| 2 |
EC50 = 560 nM
|
|
|
| 3 |
IC50 = 3.4 nM
|
|
|
|
CP0105112
|
10-Methoxy-2,2,4-trimethyl-5-(3-methylsulfanylmethoxy-phenyl)-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C28H29NO3S
|
2
|
| 1 |
EC50 = 4 nM
|
|
|
| 2 |
IC50 = 4 nM
|
|
|
|
CP0049051
|
5-Allyl-7-bromo-10-chloro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-9-ol
Show/Hide
|
C22H21BrClNO2
|
1
|
| 1 |
EC50 = 5 nM
|
|
|
|
CP0207400
|
5-Allyl-10-chloro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-9-ol
Show/Hide
|
C22H22ClNO2
|
1
|
| 1 |
EC50 = 5 nM
|
|
|
|
CP0160743
|
5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-2,3-dihydroquinolin-4(1H)-one O-tert-butyl oxime
Show/Hide
|
C24H27F2N3O
|
3
|
| 1 |
EC50 = 5 nM
|
|
|
| 2 |
EC50 = 70 nM
|
|
|
| 3 |
IC50 = 5.6 nM
|
|
|
|
CP0181072
|
(+/-)-(3R,4S)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinolin-3-ol
Show/Hide
|
C21H23ClN2O
|
3
|
| 1 |
EC50 = 7.1 nM
|
|
|
| 2 |
IC50 = 1.1 nM
|
|
|
| 3 |
IC50 = 16 nM
|
|
|
|
CP0342236
|
4-allyl-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2-dihydroquinolin-3(4H)-one
Show/Hide
|
C24H25ClN2O
|
3
|
| 1 |
EC50 = 7.4 nM
|
|
|
| 2 |
IC50 = 2.1 nM
|
|
|
| 3 |
IC50 = 36 nM
|
|
|
|
CP0249570
|
5-Allyl-2,2,4-trimethyl-10-vinyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C24H25NO
|
1
|
| 1 |
EC50 = 12 nM
|
|
|
|
CP0049090
|
(+)5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C23H25NO2
|
1
|
| 1 |
EC50 = 13 nM
|
|
|
|
CP0390323
|
[(8S,9S,10R,11S,13S,14S,17R)-11-hydroxy-10,13-dimethyl-17-[2-(4-methylpyrimidin-2-yl)sulfanylacetyl]-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl] furan-2-carboxylate
Show/Hide
|
C31H34N2O6S
|
1
|
| 1 |
EC50 = 13.3 nM
|
|
|
|
CP0301537
|
5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-9-ol
Show/Hide
|
C23H25NO3
|
1
|
| 1 |
EC50 = 14 nM
|
|
|
|
CP0393622
|
[(8S,9S,10R,11S,13S,14S,17R)-17-[2-(1,3-benzothiazol-2-ylsulfanyl)acetyl]-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl] furan-2-carboxylate
Show/Hide
|
C33H33NO6S2
|
2
|
| 1 |
EC50 = 14.1 nM
|
|
|
| 2 |
EC50 = 50.8 nM
|
|
|
|
CP0165335
|
10-Methoxy-2,2,4,5-tetramethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C21H23NO2
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0238565
|
(6S,8S,9R,10S,11S,13S,14S,16R,17R)-17-[2-(1,3-benzothiazol-2-ylsulfanyl)acetyl]-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Show/Hide
|
C29H31F2NO4S2
|
1
|
| 1 |
EC50 = 17 nM
|
|
|
|
CP0496091
|
[(8S,9S,10R,11S,13S,14S,17R)-11-hydroxy-17-(2-isoquinolin-1-ylsulfanylacetyl)-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl] furan-2-carboxylate
Show/Hide
|
C35H35NO6S
|
1
|
| 1 |
EC50 = 17.3 nM
|
|
|
|
CP0043449
|
5-Benzyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C25H29NO2
|
1
|
| 1 |
EC50 = 18 nM
|
|
|
|
CP0203617
|
5-Allyl-2,2,4-trimethyl-10-methylsulfanyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C23H25NOS
|
1
|
| 1 |
EC50 = 18 nM
|
|
|
|
CP0279616
|
5-Allyl-10-difluoromethoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C23H23F2NO2
|
1
|
| 1 |
EC50 = 18 nM
|
|
|
|
CP0049044
|
(5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-10-yl)-methyl-amine
Show/Hide
|
C23H26N2O
|
1
|
| 1 |
EC50 = 19 nM
|
|
|
|
CP0192512
|
(5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-10-yl)-methanol
Show/Hide
|
C23H25NO2
|
1
|
| 1 |
EC50 = 19 nM
|
|
|
|
CP0206806
|
5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-2,3-dihydroquinolin-4(1H)-one O-1-hydroxy-2-methylpropan-2-yl oxime
Show/Hide
|
C24H27F2N3O2
|
3
|
| 1 |
EC50 = 19 nM
|
|
|
| 2 |
EC50 = 350 nM
|
|
|
| 3 |
IC50 = 12 nM
|
|
|
|
CP0055671
|
(-)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinoline
Show/Hide
|
C21H23ClN2
|
3
|
| 1 |
EC50 = 20 nM
|
|
|
| 2 |
IC50 = 9.4 nM
|
|
|
| 3 |
IC50 = 59 nM
|
|
|
|
CP0094373
|
5-But-3-enyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C24H27NO2
|
1
|
| 1 |
EC50 = 22 nM
|
|
|
|
CP0388379
|
[(8S,9S,10R,11S,13S,14S,17R)-17-[2-[(4,5-dimethyl-1,3-thiazol-2-yl)sulfanyl]acetyl]-11-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] furan-2-carboxylate
Show/Hide
|
C31H37NO6S2
|
1
|
| 1 |
EC50 = 22.4 nM
|
|
|
|
CP0200231
|
10-Methoxy-2,2,4-trimethyl-5-prop-2-ynyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C23H23NO2
|
1
|
| 1 |
EC50 = 27 nM
|
|
|
|
CP0039833
|
(1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl]-1-(thiophen-3-yl)ethan-1-ol
Show/Hide
|
C24H25FN2OS
|
2
|
| 1 |
EC50 = 35.6 nM
|
|
|
| 2 |
EC50 = 36 nM
|
|
|
|
CP0213855
|
5-Isopropyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C23H27NO2
|
1
|
| 1 |
EC50 = 39 nM
|
|
|
|
CP0184196
|
5-Allyl-10-chloro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C22H22ClNO
|
1
|
| 1 |
EC50 = 45 nM
|
|
|
|
CP0283298
|
(8S,9R,10S,11S,13S,14S,16R,17R)-17-[2-(1,3-benzothiazol-2-ylsulfanyl)acetyl]-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Show/Hide
|
C29H32FNO4S2
|
1
|
| 1 |
EC50 = 45.5 nM
|
|
|
|
CP0508460
|
(8S,9S,11S,13S,14S,17S)-11,17-dihydroxy-13-methyl-N-(2-methylpyridin-3-yl)-17-(2-trimethylsilylethynyl)-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3-carboxamide
Show/Hide
|
C30H38N2O3Si
|
1
|
| 1 |
EC50 = 47 nM
|
|
|
|
CP0336358
|
(8S,9R,10S,11S,13S,14S,16R,17R)-17-[2-(1,3-benzothiazol-2-ylsulfanyl)acetyl]-9-chloro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Show/Hide
|
C29H32ClNO4S2
|
1
|
| 1 |
EC50 = 50 nM
|
|
|
|
CP0227926
|
(5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-9-yl)-methanol
Show/Hide
|
C24H27NO3
|
1
|
| 1 |
EC50 = 53 nM
|
|
|
|
CP0390324
|
[(8S,9S,10R,11S,13S,14S,17R)-17-[2-(1,3-benzoxazol-2-ylsulfanyl)acetyl]-11-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] furan-2-carboxylate
Show/Hide
|
C33H35NO7S
|
1
|
| 1 |
EC50 = 55.6 nM
|
|
|
|
CP0039831
|
(1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl]-1-(4-fluorophenyl)ethan-1-ol
Show/Hide
|
C26H26F2N2O
|
1
|
| 1 |
EC50 = 57.2 nM
|
|
|
|
CP0279829
|
5-Allyl-10-ethynyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C24H23NO
|
1
|
| 1 |
EC50 = 59 nM
|
|
|
|
CP0351377
|
5-Allyl-7-bromo-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C23H24BrNO2
|
1
|
| 1 |
EC50 = 59 nM
|
|
|
|
CP0078451
|
5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene-10-carbonitrile
Show/Hide
|
C23H22N2O
|
1
|
| 1 |
EC50 = 60 nM
|
|
|
|
CP0280014
|
5-Isobutyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C24H29NO2
|
1
|
| 1 |
EC50 = 69 nM
|
|
|
|
CP0290379
|
10-Methoxy-2,2,4-trimethyl-5-propyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C23H27NO2
|
1
|
| 1 |
EC50 = 70 nM
|
|
|
|
CP0178108
|
5-Allyl-9-fluoro-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C23H24FNO2
|
1
|
| 1 |
EC50 = 81 nM
|
|
|
|
CP0185418
|
5-Allyl-10-methoxy-2,2,4,7-tetramethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C24H27NO2
|
1
|
| 1 |
EC50 = 81 nM
|
|
|
|
CP0261174
|
5-Allyl-9-bromo-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C23H24BrNO2
|
1
|
| 1 |
EC50 = 82 nM
|
|
|
|
CP0273275
|
2-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl]propan-2-ol
Show/Hide
|
C21H25FN2O
|
1
|
| 1 |
EC50 = 83.5 nM
|
|
|
|
CP0046812
|
5-Ethyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C22H25NO2
|
1
|
| 1 |
EC50 = 90 nM
|
|
|
|
CP0257438
|
5-Allyl-9-chloro-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C23H24ClNO2
|
1
|
| 1 |
EC50 = 94 nM
|
|
|
|
CP0220479
|
5-chloro-6-(1H-indol-7-yl)-2,2,4,4,8-pentamethyl-1,2-dihydroquinolin-3(4H)-one
Show/Hide
|
C22H23ClN2O
|
2
|
| 1 |
EC50 = 95 nM
|
|
|
| 2 |
IC50 = 4.7 nM
|
|
|
|
CP0181615
|
5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene-9-carboxylic acid methyl ester
Show/Hide
|
C25H27NO4
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0179307
|
(8S,9S,11S,13S,14S,17S)-17-hex-1-ynyl-11,17-dihydroxy-13-methyl-N-(2-methylpyridin-3-yl)-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3-carboxamide
Show/Hide
|
C31H38N2O3
|
2
|
| 1 |
EC50 = 100 nM
|
|
|
| 2 |
IC50 = 2349 nM
|
|
|
|
CP0210811
|
5-chloro-6-(1H-indol-7-yl)-2,2,4,4,8-pentamethyl-1,2,3,4-tetrahydroquinolin-3-ol
Show/Hide
|
C22H25ClN2O
|
3
|
| 1 |
EC50 = 105 nM
|
|
|
| 2 |
IC50 = 14 nM
|
|
|
| 3 |
IC50 = 37 nM
|
|
|
|
CP0178212
|
5-Allyl-9,10-dimethoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C24H27NO3
|
1
|
| 1 |
EC50 = 120 nM
|
|
|
|
CP0219356
|
5-Butyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C24H29NO2
|
1
|
| 1 |
EC50 = 122 nM
|
|
|
|
CP0273903
|
10-Methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene-5-carboxylic acid ethyl ester
Show/Hide
|
C23H25NO4
|
1
|
| 1 |
EC50 = 126 nM
|
|
|
|
CP0082160
|
(5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-9-yloxy)-acetonitrile
Show/Hide
|
C25H26N2O3
|
1
|
| 1 |
EC50 = 130 nM
|
|
|
|
CP0185715
|
5-Allyl-9-allyloxy-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C26H29NO3
|
1
|
| 1 |
EC50 = 140 nM
|
|
|
|
CP0161236
|
10-Methoxy-2,2,4-trimethyl-5-propenyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C23H25NO2
|
1
|
| 1 |
EC50 = 144 nM
|
|
|
|
CP0060076
|
(8S,9S,11S,13S,14S,17S)-11,17-dihydroxy-13-methyl-N-(3-methylpyridin-4-yl)-17-prop-1-ynyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3-carboxamide
Show/Hide
|
C28H32N2O3
|
2
|
| 1 |
EC50 = 149 nM
|
|
|
| 2 |
IC50 = 1357 nM
|
|
|
|
CP0193537
|
5-Allyl-10-methoxy-2,2,4-trimethyl-7-vinyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C25H27NO2
|
1
|
| 1 |
EC50 = 156 nM
|
|
|
|
CP0048865
|
5-Allyl-10-methoxy-2,2,4-trimethyl-9-prop-2-ynyloxy-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C26H27NO3
|
1
|
| 1 |
EC50 = 160 nM
|
|
|
|
CP0164473
|
10-Methoxy-2,2,4-trimethyl-5-propenyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C23H25NO2
|
1
|
| 1 |
EC50 = 168 nM
|
|
|
|
CP0327972
|
5-Cyclohexyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C26H31NO2
|
1
|
| 1 |
EC50 = 204 nM
|
|
|
|
CP0343517
|
5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-4-(3-methylbut-2-enyl)-1,2-dihydroquinolin-3(4H)-one
Show/Hide
|
C26H29ClN2O
|
3
|
| 1 |
EC50 = 215 nM
|
|
|
| 2 |
IC50 = 18 nM
|
|
|
| 3 |
IC50 = 64 nM
|
|
|
|
CP0280333
|
5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2-dihydroquinolin-3(4H)-one
Show/Hide
|
C21H21ClN2O
|
2
|
| 1 |
EC50 = 235 nM
|
|
|
| 2 |
IC50 = 13 nM
|
|
|
|
CP0303623
|
(8S,9S,11S,13S,14S,17S)-11,17-dihydroxy-13-methyl-N-(4-methylpyridin-3-yl)-17-prop-1-ynyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3-carboxamide
Show/Hide
|
C28H32N2O3
|
1
|
| 1 |
EC50 = 240 nM
|
|
|
|
CP0184779
|
5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-10-ol
Show/Hide
|
C22H23NO2
|
1
|
| 1 |
EC50 = 250 nM
|
|
|
|
CP0183403
|
5-Benzyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C27H27NO2
|
1
|
| 1 |
EC50 = 255 nM
|
|
|
|
CP0094961
|
(1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl]pent-4-en-1-ol
Show/Hide
|
C23H27FN2O
|
1
|
| 1 |
EC50 = 255.7 nM
|
|
|
|
CP0296056
|
(8S,9S,11S,13S,14S,17S)-11,17-dihydroxy-13-methyl-N-(2-methylpyridin-3-yl)-17-prop-1-ynyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3-carboxamide
Show/Hide
|
C28H32N2O3
|
2
|
| 1 |
EC50 = 265 nM
|
|
|
| 2 |
IC50 = 626 nM
|
|
|
|
CP0410498
|
5-Allyl-2,2,4-trimethyl-10-prop-2-ynyloxy-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C25H25NO2
|
1
|
| 1 |
EC50 = 270 nM
|
|
|
|
CP0350715
|
(8S,9S,11S,13S,14S,17S)-11,17-dihydroxy-13-methyl-N-(3-methylpyridin-2-yl)-17-prop-1-ynyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3-carboxamide
Show/Hide
|
C28H32N2O3
|
1
|
| 1 |
EC50 = 280 nM
|
|
|
|
CP0283480
|
(6S,8S,9S,10R,11S,13S,14S,17R)-17-[2-(1,3-benzothiazol-2-ylsulfanyl)acetyl]-11,17-dihydroxy-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
Show/Hide
|
C29H33NO4S2
|
1
|
| 1 |
EC50 = 295 nM
|
|
|
|
CP0374171
|
5-Allyl-10-methoxymethyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C24H27NO2
|
1
|
| 1 |
EC50 = 305 nM
|
|
|
|
CP0291527
|
2-(10-methoxy-2,2,4-trimethyl-1,5-dihydrochromeno[3,4-f]quinolin-5-yl)-N,N-dimethylethanamine
Show/Hide
|
C24H30N2O2
|
1
|
| 1 |
EC50 = 306 nM
|
|
|
|
CP0332035
|
(1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl]-3-cyclopropylpropan-1-ol
Show/Hide
|
C24H29FN2O
|
1
|
| 1 |
EC50 = 332 nM
|
|
|
|
CP0197841
|
5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C22H23NO
|
1
|
| 1 |
EC50 = 350 nM
|
|
|
|
CP0151699
|
(S)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl](1-benzothiophen-3-yl)methanol
Show/Hide
|
C27H25FN2OS
|
1
|
| 1 |
EC50 = 356 nM
|
|
|
|
CP0280336
|
(3S,4S)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinolin-3-ol
Show/Hide
|
C21H23ClN2O
|
2
|
| 1 |
EC50 = 370 nM
|
|
|
| 2 |
IC50 = 24 nM
|
|
|
|
CP0401725
|
C-(5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-10-yl)-methylamine
Show/Hide
|
C23H26N2O
|
1
|
| 1 |
EC50 = 467 nM
|
|
|
|
CP0043410
|
(R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl](3,4-difluoro-5-methoxyphenyl)methanol
Show/Hide
|
C26H25F3N2O2
|
2
|
| 1 |
EC50 = 520.8 nM
|
|
|
| 2 |
EC50 = 521 nM
|
|
|
|
CP0203894
|
(8S,9R,10S,11S,13S,14S,17R)-17-[2-(1,3-benzothiazol-2-ylsulfanyl)acetyl]-9-fluoro-11,17-dihydroxy-10,13-dimethyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
Show/Hide
|
C28H32FNO4S2
|
1
|
| 1 |
EC50 = 535 nM
|
|
|
|
CP0207747
|
(1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl]but-3-en-1-ol
Show/Hide
|
C22H25FN2O
|
1
|
| 1 |
EC50 = 660.9 nM
|
|
|
|
CP0424208
|
(S)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H-cyclopenta[f]indazol-5-yl](1-benzothiophen-3-yl)methanol
Show/Hide
|
C26H23FN2OS
|
1
|
| 1 |
EC50 = 675 nM
|
|
|
|
CP0464253
|
(S)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H-cyclopenta[f]indazol-5-yl](naphthalen-1-yl)methanol
Show/Hide
|
C28H25FN2O
|
1
|
| 1 |
EC50 = 703 nM
|
|
|
|
CP0135024
|
(1S)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl]-2-(4-fluorophenyl)ethan-1-ol
Show/Hide
|
C26H26F2N2O
|
1
|
| 1 |
EC50 = 1004 nM
|
|
|
|
CP0289638
|
(R)-(5-Chloro-thiophen-2-yl)-[(4aR,5S)-1-(4-fluoro-phenyl)-4a-methyl-4,4a,5,6,7,8-hexahydro-1H-benzo[f]indazol-5-yl]-methanol
Show/Hide
|
C23H22ClFN2OS
|
1
|
| 1 |
EC50 = 1068 nM
|
|
|
|
CP0461955
|
(S)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H-cyclopenta[f]indazol-5-yl](1-benzofuran-3-yl)methanol
Show/Hide
|
C26H23FN2O2
|
1
|
| 1 |
EC50 = 1315 nM
|
|
|
|
CP0424336
|
(R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H-cyclopenta[f]indazol-5-yl](1-benzofuran-3-yl)methanol
Show/Hide
|
C26H23FN2O2
|
1
|
| 1 |
EC50 = 1624 nM
|
|
|
|
CP0507805
|
(8S,13S,14S,17S)-17-hydroxy-13-methyl-N-(2-methylpyridin-3-yl)-17-prop-1-ynyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthrene-3-carboxamide
Show/Hide
|
C28H30N2O2
|
1
|
| 1 |
EC50 = 1861 nM
|
|
|
|
CP0493195
|
(S)-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5,6,7,8-hexahydro-1H-benzo[f]indazol-5-yl]-(6-fluoro-pyridin-3-yl)-methanol
Show/Hide
|
C24H23F2N3O
|
1
|
| 1 |
EC50 = 4443 nM
|
|
|
|
CP0076637
|
10-Methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C20H21NO2
|
1
|
| 1 |
EC50 > 5000 nM
|
|
|
|
CP0205736
|
2-(10-Methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-5-yl)-N,N-dimethyl-acetamide
Show/Hide
|
C24H28N2O3
|
1
|
| 1 |
EC50 > 5000 nM
|
|
|
|
CP0213223
|
2-(10-Methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-5-yl)-ethanol
Show/Hide
|
C22H25NO3
|
1
|
| 1 |
EC50 > 5000 nM
|
|
|
|
CP0268651
|
2-(10-Methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-5-yl)-N-methyl-acetamide
Show/Hide
|
C23H26N2O3
|
1
|
| 1 |
EC50 > 5000 nM
|
|
|
|
CP0290389
|
(10-Methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-5-yl)-acetic acid
Show/Hide
|
C22H23NO4
|
1
|
| 1 |
EC50 > 5000 nM
|
|
|
|
CP0310330
|
10-Methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene-5-carboxylic acid amide
Show/Hide
|
C21H22N2O3
|
1
|
| 1 |
EC50 > 5000 nM
|
|
|
|
CP0153780
|
(8S,9S,11S,13S,14S,17S)-11,17-dihydroxy-13-methyl-17-(3-methylbut-1-ynyl)-N-(2-methylpyridin-3-yl)-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3-carboxamide
Show/Hide
|
C30H36N2O3
|
2
|
| 1 |
EC50 > 5000 nM
|
|
|
| 2 |
IC50 = 37 nM
|
|
|
|
CP0382536
|
(8S,9S,11S,13S,14S,17S)-11-[(4-chlorophenyl)methoxy]-17-hydroxy-13-methyl-N-(2-methylpyridin-3-yl)-17-prop-1-ynyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3-carboxamide
Show/Hide
|
C35H37ClN2O3
|
1
|
| 1 |
IC50 = 0.07 nM
|
|
|
|
CP0780512
|
5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetra hydroquinolin-3-ol
Show/Hide
|
C21H23ClN2O
|
1
|
| 1 |
IC50 = 0.2 nM
|
|
|
|
CP0362448
|
(8S,9S,11S,13S,14S,17S)-17-hydroxy-13-methyl-N-(2-methylpyridin-3-yl)-11-phenylmethoxy-17-prop-1-ynyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3-carboxamide
Show/Hide
|
C35H38N2O3
|
1
|
| 1 |
IC50 = 0.4 nM
|
|
|
|
CP0353545
|
(+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinoline-5-carbaldehyde O-ethyl oxime
Show/Hide
|
C24H29N3O2
|
1
|
| 1 |
IC50 = 0.9 nM
|
|
|
|
CP0060074
|
(8S,9S,11S,13S,14S,17S)-11-[(3-chlorophenyl)methoxy]-17-hydroxy-13-methyl-N-(2-methylpyridin-3-yl)-17-prop-1-ynyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3-carboxamide
Show/Hide
|
C35H37ClN2O3
|
1
|
| 1 |
IC50 = 0.9 nM
|
|
|
|
CP0153777
|
(8S,9S,11S,13S,14S,17S)-11-[(2-chlorophenyl)methoxy]-17-hydroxy-13-methyl-N-(2-methylpyridin-3-yl)-17-prop-1-ynyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3-carboxamide
Show/Hide
|
C35H37ClN2O3
|
1
|
| 1 |
IC50 = 1.4 nM
|
|
|
|
CP0049750
|
(+/-)-(3R,4S)-7-fluoro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinolin-3-ol
Show/Hide
|
C21H23FN2O
|
1
|
| 1 |
IC50 = 1.7 nM
|
|
|
|
CP0056753
|
(+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinoline-5-carbaldehyde O-methyl oxime
Show/Hide
|
C23H27N3O2
|
1
|
| 1 |
IC50 = 1.7 nM
|
|
|
|
CP0353544
|
(+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinoline-5-carbaldehyde O-phenyl oxime
Show/Hide
|
C29H31N3O2
|
1
|
| 1 |
IC50 = 3.1 nM
|
|
|
|
CP0460331
|
5,7-difluoro-6-(1H-indol-7-yl)-2,2-dimethyl-2,3-dihydroquinolin-4(1H)-one O-tert-butyl oxime
Show/Hide
|
C23H25F2N3O
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0287158
|
(+/-)-(3R,4S)-5,7,8-trifluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-ol
Show/Hide
|
C20H19F3N2O
|
1
|
| 1 |
IC50 = 3.8 nM
|
|
|
|
CP0113425
|
(+/-)-(3R,4S)-8-chloro-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-ol
Show/Hide
|
C20H19ClF2N2O
|
1
|
| 1 |
IC50 = 3.9 nM
|
|
|
|
CP0353546
|
(+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,5,8-pentamethyl-1,2,3,4-tetrahydroquinolin-3-ol
Show/Hide
|
C22H26N2O
|
1
|
| 1 |
IC50 = 4.7 nM
|
|
|
|
CP0380981
|
1-[(1S,2R,13S,14S,17R,18S,20S)-7-(4-fluorophenyl)-17,20-dihydroxy-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-pyridin-2-ylsulfanylethanone
Show/Hide
|
C33H36FN3O3S
|
1
|
| 1 |
IC50 = 4.7 nM
|
|
|
|
CP0288207
|
(+/-)-(3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinoline-5-carbonitrile
Show/Hide
|
C22H23N3O
|
1
|
| 1 |
IC50 = 5.3 nM
|
|
|
|
CP0056751
|
(+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinoline-5-carbaldehyde O-tert-butyl oxime
Show/Hide
|
C26H33N3O2
|
1
|
| 1 |
IC50 = 5.5 nM
|
|
|
|
CP0298248
|
(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 3-chloro-4-methoxyphenylcarbamate
Show/Hide
|
C28H25Cl2F2N3O3
|
1
|
| 1 |
IC50 = 5.7 nM
|
|
|
|
CP0049753
|
(+/-)-(3R,4S)-5-fluoro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinolin-3-ol
Show/Hide
|
C21H23FN2O
|
1
|
| 1 |
IC50 = 5.9 nM
|
|
|
|
CP0151198
|
[3-(10-methoxy-2,2,4-trimethyl-1,5-dihydrochromeno[3,4-f]quinolin-5-yl)phenyl] N,N-dimethylcarbamate
Show/Hide
|
C29H30N2O4
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0113426
|
(+/-)-3-((3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinolin-5-yl)acrylonitrile
Show/Hide
|
C24H25N3O
|
1
|
| 1 |
IC50 = 6.5 nM
|
|
|
|
CP0521552
|
5,7-difluoro-6-(1H-indol-7-yl)-2,2-dimethyl-2,3-dihydroquinolin-4(1H)-one O-ethyl oxime
Show/Hide
|
C21H21F2N3O
|
1
|
| 1 |
IC50 = 6.9 nM
|
|
|
|
CP0329293
|
(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 3-chloro-4-methoxyphenylcarbamate
Show/Hide
|
C28H26ClF2N3O3
|
1
|
| 1 |
IC50 = 7.5 nM
|
|
|
|
CP0353542
|
(+/-)-(3R,4S)-7,8-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-ol
Show/Hide
|
C20H20F2N2O
|
1
|
| 1 |
IC50 = 7.7 nM
|
|
|
|
CP0783981
|
(+/-)-4-((3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinolin-5-yl)but-3-en-2-one
Show/Hide
|
C25H28N2O2
|
1
|
| 1 |
IC50 = 7.8 nM
|
|
|
|
CP0371255
|
(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 4-cyanophenylcarbamate
Show/Hide
|
C28H23ClF2N4O2
|
1
|
| 1 |
IC50 = 8.1 nM
|
|
|
|
CP0225061
|
(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 4-(dimethylamino)phenylcarbamate
Show/Hide
|
C29H30F2N4O2
|
1
|
| 1 |
IC50 = 8.4 nM
|
|
|
|
CP0333655
|
(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl benzo[d][1,3]dioxol-5-ylcarbamate
Show/Hide
|
C28H25F2N3O4
|
1
|
| 1 |
IC50 = 8.5 nM
|
|
|
|
CP0466121
|
5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-2,3-dihydroquinolin-4(1H)-one O-benzyl oxime
Show/Hide
|
C27H25F2N3O
|
1
|
| 1 |
IC50 = 8.8 nM
|
|
|
|
CP0398943
|
5-(3,5-Difluoro-phenyl)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C26H23F2NO2
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0321171
|
(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl phenylcarbamate
Show/Hide
|
C27H24ClF2N3O2
|
1
|
| 1 |
IC50 = 9.1 nM
|
|
|
|
CP0272638
|
(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 4-cyanophenylcarbamate
Show/Hide
|
C28H24F2N4O2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0333652
|
(+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl methylcarbamate
Show/Hide
|
C22H23F2N3O2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0776055
|
(+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinoline-5-carbaldehyde oxime
Show/Hide
|
C22H25N3O2
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0298247
|
(+/-)-(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl methylcarbamate
Show/Hide
|
C22H22ClF2N3O2
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0181071
|
(+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-7-vinyl-1,2,3,4-tetrahydroquinolin-3-ol
Show/Hide
|
C23H26N2O
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0294135
|
(+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 3-cyanophenylcarbamate
Show/Hide
|
C28H24F2N4O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0422817
|
6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-3-hydroxy-2,2-dimethyl-2,3-dihydroquinolin-4(1H)-one O-methyl oxime
Show/Hide
|
C20H18ClF2N3O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0261459
|
(+/-)-(3R,4S)-5-ethyl-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinolin-3-ol
Show/Hide
|
C23H28N2O
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0297515
|
(+/-)-(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl cyclohexylcarbamate
Show/Hide
|
C27H30ClF2N3O2
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0088196
|
(8S,9S,10R,11S,13S,14S,16R,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
Show/Hide
|
C22H30O5
|
1
|
| 1 |
IC50 = 15.7 nM
|
|
|
|
CP0353543
|
(+/-)-(3R,4S)-5-chloro-8-fluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-ol
Show/Hide
|
C20H20ClFN2O
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0480575
|
5-(3,5-Dimethyl-phenyl)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C28H29NO2
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0492840
|
5-(3-Bromo-5-methyl-phenyl)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C27H26BrNO2
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0400173
|
1-[(1S,2R,13S,14S,17R,18S,20S)-7-(4-fluorophenyl)-17,20-dihydroxy-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-quinolin-2-ylsulfanylethanone
Show/Hide
|
C37H38FN3O3S
|
1
|
| 1 |
IC50 = 18.3 nM
|
|
|
|
CP0052482
|
(+/-)-(3R,4S)-7-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinolin-3-ol
Show/Hide
|
C21H23ClN2O
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0295461
|
(+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinolin-3-ol
Show/Hide
|
C21H24N2O
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0378164
|
methyl 2-[(E)-[5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-1,3-dihydroquinolin-4-ylidene]amino]oxy-2-methylpropanoate
Show/Hide
|
C25H27F2N3O3
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0415367
|
10-Methoxy-5-(3-methoxymethoxy-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C28H29NO4
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0225062
|
(+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 4-acetylphenylcarbamate
Show/Hide
|
C29H27F2N3O3
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0333656
|
methyl 4-[[(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-3,4-dihydro-1H-quinolin-3-yl]oxycarbonylamino]benzoate
Show/Hide
|
C29H27F2N3O4
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0416608
|
1-[(1S,2R,13S,14S,17R,18S,20S)-7-(4-fluorophenyl)-17,20-dihydroxy-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-naphthalen-2-yloxyethanone
Show/Hide
|
C38H39FN2O4
|
1
|
| 1 |
IC50 = 29.2 nM
|
|
|
|
CP0400160
|
1-[(1S,2R,13S,14S,17R,18S,20S)-7-(4-fluorophenyl)-17,20-dihydroxy-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-naphthalen-2-ylsulfanylethanone
Show/Hide
|
C38H39FN2O3S
|
1
|
| 1 |
IC50 = 30.5 nM
|
|
|
|
CP0380980
|
1-[(1S,2R,13S,14S,17R,18S,20S)-7-(4-fluorophenyl)-17,20-dihydroxy-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-isoquinolin-1-ylsulfanylethanone
Show/Hide
|
C37H38FN3O3S
|
1
|
| 1 |
IC50 = 37.3 nM
|
|
|
|
CP0400175
|
1-[(1S,2R,13S,14S,17R,18S,20S)-17,20-dihydroxy-2,18-dimethyl-7-phenyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-([1,3]oxazolo[4,5-b]pyridin-2-ylsulfanyl)ethanone
Show/Hide
|
C34H36N4O4S
|
1
|
| 1 |
IC50 = 37.7 nM
|
|
|
|
CP0416609
|
1-[(1S,2R,13S,14S,17R,18S,20S)-7-(4-fluorophenyl)-17,20-dihydroxy-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-pyrimidin-2-ylsulfanylethanone
Show/Hide
|
C32H35FN4O3S
|
1
|
| 1 |
IC50 = 37.7 nM
|
|
|
|
CP0400170
|
1-[(1S,2R,13S,14S,17R,18S,20S)-7-(4-fluorophenyl)-17,20-dihydroxy-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-([1,3]oxazolo[4,5-b]pyridin-2-ylsulfanyl)ethanone
Show/Hide
|
C34H35FN4O4S
|
1
|
| 1 |
IC50 = 38.6 nM
|
|
|
|
CP0281951
|
(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl phenylcarbamate
Show/Hide
|
C27H25F2N3O2
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0416607
|
1-[(1S,2R,13S,14S,17R,18S,20S)-7-(4-fluorophenyl)-17,20-dihydroxy-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-hydroxyethanone
Show/Hide
|
C28H33FN2O4
|
1
|
| 1 |
IC50 = 40.9 nM
|
|
|
|
CP0287369
|
(+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,7,8-pentamethyl-1,2,3,4-tetrahydroquinolin-3-ol
Show/Hide
|
C22H26N2O
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0504798
|
5,7-difluoro-6-(1H-indol-7-yl)-2,2-dimethyl-2,3-dihydroquinolin-4(1H)-one O-methyl oxime
Show/Hide
|
C20H19F2N3O
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0091080
|
(+/-)-(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl benzylcarbamate
Show/Hide
|
C28H26ClF2N3O2
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0321172
|
(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 4-chlorophenylcarbamate
Show/Hide
|
C27H24ClF2N3O2
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0218142
|
(+/-)-(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl isopropylcarbamate
Show/Hide
|
C24H26ClF2N3O2
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0257888
|
(+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl 3-acetylphenylcarbamate
Show/Hide
|
C29H27F2N3O3
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0460330
|
5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-2,3-dihydroquinolin-4(1H)-one O-phenyl oxime
Show/Hide
|
C26H23F2N3O
|
1
|
| 1 |
IC50 = 51 nM
|
|
|
|
CP0101878
|
10-Methoxy-2,2,4-trimethyl-5-(3-trifluoromethyl-phenyl)-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C27H24F3NO2
|
1
|
| 1 |
IC50 = 57 nM
|
|
|
|
CP0400177
|
1-[(1S,2R,13S,14S,17R,18S,20S)-17,20-dihydroxy-2,18-dimethyl-7-phenyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-quinolin-2-ylsulfanylethanone
Show/Hide
|
C37H39N3O3S
|
1
|
| 1 |
IC50 = 60.1 nM
|
|
|
|
CP0410217
|
1-[(1S,2R,13S,14S,17R,18S,20S)-17,20-dihydroxy-2,18-dimethyl-7-phenyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-(1-methylbenzimidazol-2-yl)sulfanylethanone
Show/Hide
|
C36H40N4O3S
|
1
|
| 1 |
IC50 = 66.7 nM
|
|
|
|
CP0090362
|
5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C26H23Cl2NO2
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
|
CP0427353
|
(8S,9S,10R,11S,13S,14S,16R,17R)-11,17-dihydroxy-10,13,16-trimethyl-17-[2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetyl]-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
Show/Hide
|
C30H34N2O5S
|
1
|
| 1 |
IC50 = 80.3 nM
|
|
|
|
CP0428604
|
2-(1,3-benzoxazol-2-ylsulfanyl)-1-[(1S,2R,13S,14S,17R,18S,20S)-7-cyclohexyl-17,20-dihydroxy-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]ethanone
Show/Hide
|
C35H43N3O4S
|
1
|
| 1 |
IC50 = 82.1 nM
|
|
|
|
CP0350712
|
[(8S,9S,11S,13S,14S,17S)-17-hydroxy-13-methyl-3-[(2-methylpyridin-3-yl)carbamoyl]-17-prop-1-ynyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-11-yl] prop-2-enyl carbonate
Show/Hide
|
C32H36N2O5
|
1
|
| 1 |
IC50 = 84 nM
|
|
|
|
CP0410216
|
1-[(1S,2R,13S,14S,17R,18S,20S)-7-(4-fluorophenyl)-17,20-dihydroxy-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-(1-methylbenzimidazol-2-yl)sulfanylethanone
Show/Hide
|
C36H39FN4O3S
|
1
|
| 1 |
IC50 = 88.7 nM
|
|
|
|
CP0060078
|
(8S,9S,11S,13S,14S,17S)-11,17-dihydroxy-13-methyl-N-(6-methylpyridin-3-yl)-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3-carboxamide
Show/Hide
|
C25H30N2O3
|
1
|
| 1 |
IC50 = 91 nM
|
|
|
|
CP0385328
|
2-[2-[(1S,2R,13S,14S,17R,18S,20S)-7-(4-fluorophenyl)-17,20-dihydroxy-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-oxoethyl]sulfanyl-3H-quinazolin-4-one
Show/Hide
|
C36H37FN4O4S
|
1
|
| 1 |
IC50 = 93.5 nM
|
|
|
|
CP0432422
|
1-[(1S,2R,13S,14S,17R,18S,20S)-7-(4-fluorophenyl)-17,20-dihydroxy-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-quinoxalin-2-yloxyethanone
Show/Hide
|
C36H37FN4O4
|
1
|
| 1 |
IC50 = 98.7 nM
|
|
|
|
CP0400172
|
2-(1,3-benzothiazol-2-ylsulfanyl)-1-[(1S,2R,13S,14S,17R,18S,20S)-7-(4-fluorophenyl)-17,20-dihydroxy-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]ethanone
Show/Hide
|
C35H36FN3O3S2
|
1
|
| 1 |
IC50 = 101 nM
|
|
|
|
CP0064021
|
10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
Show/Hide
|
C26H25NO2
|
1
|
| 1 |
IC50 = 123 nM
|
|
|
|
CP0416614
|
1-[(1S,2R,13S,14S,17R,18S,20S)-17,20-dihydroxy-2,18-dimethyl-7-phenyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-hydroxyethanone
Show/Hide
|
C28H34N2O4
|
1
|
| 1 |
IC50 = 143 nM
|
|
|
|
CP0380940
|
2-(1,3-benzothiazol-2-ylsulfanyl)-1-[(1S,2R,13S,14S,17R,18S,20S)-17,20-dihydroxy-2,18-dimethyl-7-phenyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]ethanone
Show/Hide
|
C35H37N3O3S2
|
1
|
| 1 |
IC50 = 165 nM
|
|
|
|
CP0446952
|
1-[(1S,2R,13S,14S,17R,18S,20S)-7-cyclohexyl-17,20-dihydroxy-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-[(4,5-dimethyl-1,3-thiazol-2-yl)sulfanyl]ethanone
Show/Hide
|
C33H45N3O3S2
|
1
|
| 1 |
IC50 = 168 nM
|
|
|
|
CP0416610
|
1-[(1S,2R,13S,14S,17R,18S,20S)-17,20-dihydroxy-2,18-dimethyl-7-phenyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-quinoxalin-2-ylsulfanylethanone
Show/Hide
|
C36H38N4O3S
|
1
|
| 1 |
IC50 = 226 nM
|
|
|
|
CP0385431
|
(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-17-(2-pyridin-2-ylsulfanylacetyl)-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
Show/Hide
|
C26H31NO4S
|
1
|
| 1 |
IC50 = 238 nM
|
|
|
|
CP0385432
|
(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-17-(2-quinolin-2-ylsulfanylacetyl)-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
Show/Hide
|
C30H33NO4S
|
1
|
| 1 |
IC50 = 262 nM
|
|
|
|
CP0434913
|
1-[(1S,2R,13S,14S,17R,18S,20S)-17,20-dihydroxy-2,18-dimethyl-7-phenyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-(1-prop-2-enylbenzimidazol-2-yl)sulfanylethanone
Show/Hide
|
C38H42N4O3S
|
1
|
| 1 |
IC50 = 278 nM
|
|
|
|
CP0218632
|
(+/-)-(3R,4S)-5,7-dichloro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-ol
Show/Hide
|
C20H20Cl2N2O
|
1
|
| 1 |
IC50 = 301 nM
|
|
|
|
CP0400171
|
2-(1,3-benzothiazol-2-ylsulfanyl)-1-[(1S,2R,13S,14S,17R,18S,20S)-7-cyclohexyl-17,20-dihydroxy-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]ethanone
Show/Hide
|
C35H43N3O3S2
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0060079
|
(8S,9S,11S,13S,14S,17S)-11,17-dihydroxy-13-methyl-17-prop-1-ynyl-N-pyridin-3-yl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3-carboxamide
Show/Hide
|
C27H30N2O3
|
1
|
| 1 |
IC50 = 455 nM
|
|
|
|
CP0294181
|
(8S,9S,11S,13S,14S,17S)-11,17-dihydroxy-13-methyl-N-(2-methylpyridin-3-yl)-17-(2-phenylethynyl)-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3-carboxamide
Show/Hide
|
C33H34N2O3
|
1
|
| 1 |
IC50 = 558 nM
|
|
|
|
CP0400174
|
1-[(1S,2R,13S,14S,17R,18S,20S)-17,20-dihydroxy-2,18-dimethyl-7-phenyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-pyridin-2-ylsulfanylethanone
Show/Hide
|
C33H37N3O3S
|
1
|
| 1 |
IC50 = 596 nM
|
|
|
|
CP0432716
|
(8S,9S,10R,11S,13S,14S,16R,17R)-11,17-dihydroxy-10,13,16-trimethyl-17-[2-([1,3]thiazolo[5,4-b]pyridin-2-ylsulfanyl)acetyl]-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
Show/Hide
|
C28H32N2O4S2
|
1
|
| 1 |
IC50 = 722 nM
|
|
|
|
CP0387984
|
(8S,9S,10R,11S,13S,14S,16R,17R)-17-[2-(1,3-benzothiazol-2-ylsulfanyl)acetyl]-11,17-dihydroxy-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
Show/Hide
|
C29H33NO4S2
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0400176
|
1-[(1S,2R,13S,14S,17R,18S,20S)-7-cyclohexyl-17,20-dihydroxy-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-pyrimidin-2-ylsulfanylethanone
Show/Hide
|
C32H42N4O3S
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0288262
|
(+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinolin-3-ol
Show/Hide
|
C22H23F3N2O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0292204
|
(+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-5-vinyl-1,2,3,4-tetrahydroquinolin-3-ol
Show/Hide
|
C23H26N2O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0297100
|
(+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl piperidine-1-carboxylate
Show/Hide
|
C26H29F2N3O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0329292
|
(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl methyl(phenyl)carbamate
Show/Hide
|
C28H27F2N3O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0311294
|
3-[[(4aR)-4a-(4-ethylpyridine-2-carbonyl)-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-6-yl]sulfonyl]benzonitrile
Show/Hide
|
C31H26FN5O3S
|
1
|
| 1 |
Ki = 1.7 nM
|
|
|
|
CP0035186
|
(10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]-14-hydroxy-15-methyl-14-(prop-1-yn-1-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1,6-dien-5-one
Show/Hide
|
C29H35NO2
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0396337
|
[(4aR)-1-(4-fluorophenyl)-6-(2-methyltriazol-4-yl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone
Show/Hide
|
C26H21F4N7O3S
|
1
|
| 1 |
Ki = 3.1 nM
|
|
|
|
CP0511727
|
[(4aR)-1-(4-fluorophenyl)-6-(3-methylphenyl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-(4-methylpyridin-2-yl)methanone
Show/Hide
|
C30H27FN4O3S
|
1
|
| 1 |
Ki = 3.3 nM
|
|
|
|
CP0567271
|
[(4aR)-6-(3,5-difluorophenyl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-(4-methylpyridin-2-yl)methanone
Show/Hide
|
C29H23F3N4O3S
|
1
|
| 1 |
Ki = 4.3 nM
|
|
|
|
CP0404426
|
[(4aR)-1-(4-fluorophenyl)-6-(4-methylphenyl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-pyridin-2-ylmethanone
Show/Hide
|
C29H25FN4O3S
|
1
|
| 1 |
Ki = 4.5 nM
|
|
|
|
CP0311284
|
3-[[(4aR)-1-(4-fluorophenyl)-4a-(4-methylpyridine-2-carbonyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-6-yl]sulfonyl]benzonitrile
Show/Hide
|
C30H24FN5O3S
|
1
|
| 1 |
Ki = 4.5 nM
|
|
|
|
CP0456433
|
[(4aR)-6-(1-ethylpyrazol-4-yl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone
Show/Hide
|
C28H24F4N6O3S
|
1
|
| 1 |
Ki = 4.6 nM
|
|
|
|
CP0311296
|
3-[[(4aR)-1-(4-fluorophenyl)-4a-[4-(trifluoromethyl)pyridine-2-carbonyl]-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-6-yl]sulfonyl]benzonitrile
Show/Hide
|
C30H21F4N5O3S
|
1
|
| 1 |
Ki = 4.8 nM
|
|
|
|
CP0311282
|
[(4aR)-1-(4-fluorophenyl)-6-[3-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-(4-methylpyridin-2-yl)methanone
Show/Hide
|
C30H24F4N4O3S
|
1
|
| 1 |
Ki = 5.1 nM
|
|
|
|
CP0110163
|
[(4aR)-6-(3,4-difluorophenyl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-(4-methylpyridin-2-yl)methanone
Show/Hide
|
C29H23F3N4O3S
|
1
|
| 1 |
Ki = 5.7 nM
|
|
|
|
CP0540830
|
[(4aR)-1-(4-fluorophenyl)-6-(1-methylpyrazol-3-yl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone
Show/Hide
|
C27H22F4N6O3S
|
1
|
| 1 |
Ki = 6.6 nM
|
|
|
|
CP0056834
|
[(4aR)-1-(4-fluorophenyl)-6-(3-methylphenyl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-pyridin-2-ylmethanone
Show/Hide
|
C29H25FN4O3S
|
1
|
| 1 |
Ki = 6.8 nM
|
|
|
|
CP0085839
|
[(4aR)-1-(4-fluorophenyl)-6-(1-methylpyrazol-4-yl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone
Show/Hide
|
C27H22F4N6O3S
|
1
|
| 1 |
Ki = 7.2 nM
|
|
|
|
CP0396336
|
[(4aR)-6-(3,4-dichlorophenyl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-(5-methyl-1,3-thiazol-2-yl)methanone
Show/Hide
|
C27H21Cl2FN4O3S2
|
1
|
| 1 |
Ki = 7.4 nM
|
|
|
|
CP0437264
|
[(4aR)-6-(3,4-difluorophenyl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-(5-methyl-1,3-thiazol-2-yl)methanone
Show/Hide
|
C27H21F3N4O3S2
|
1
|
| 1 |
Ki = 7.4 nM
|
|
|
|
CP0362198
|
[(4aR)-6-(3,4-difluorophenyl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-pyridin-2-ylmethanone
Show/Hide
|
C28H21F3N4O3S
|
1
|
| 1 |
Ki = 7.5 nM
|
|
|
|
CP0540828
|
[(4aR)-1-(4-fluorophenyl)-6-(3-methylphenyl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-(5-methylpyridin-2-yl)methanone
Show/Hide
|
C30H27FN4O3S
|
1
|
| 1 |
Ki = 7.5 nM
|
|
|
|
CP0540829
|
[(4aR)-1-(4-fluorophenyl)-6-[3-fluoro-4-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-(4-methylpyridin-2-yl)methanone
Show/Hide
|
C30H23F5N4O3S
|
1
|
| 1 |
Ki = 7.5 nM
|
|
|
|
CP0476129
|
[(4aR)-1-(4-fluorophenyl)-6-(1H-pyrazol-4-ylsulfonyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone
Show/Hide
|
C26H20F4N6O3S
|
1
|
| 1 |
Ki = 7.6 nM
|
|
|
|
CP0437262
|
[(4aR)-6-(3,5-difluorophenyl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-pyridin-2-ylmethanone
Show/Hide
|
C28H21F3N4O3S
|
1
|
| 1 |
Ki = 9.2 nM
|
|
|
|
CP0224497
|
[(4aR)-1-(4-fluorophenyl)-6-[4-fluoro-3-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-pyridin-2-ylmethanone
Show/Hide
|
C29H21F5N4O3S
|
1
|
| 1 |
Ki = 9.7 nM
|
|
|
|
CP0566644
|
[(4aR)-1-(4-fluorophenyl)-6-(1-methyltriazol-4-yl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone
Show/Hide
|
C26H21F4N7O3S
|
1
|
| 1 |
Ki = 9.7 nM
|
|
|
|
CP0110164
|
[(4aR)-1-(4-fluorophenyl)-6-[3-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-(5-methyl-1,3-thiazol-2-yl)methanone
Show/Hide
|
C28H22F4N4O3S2
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0540831
|
[(4aR)-6-(2-ethylpyrazol-3-yl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone
Show/Hide
|
C28H24F4N6O3S
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0149205
|
[(4aR)-6-(3-chlorophenyl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-pyridin-2-ylmethanone
Show/Hide
|
C28H22ClFN4O3S
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0368768
|
[(4aR)-1-(4-fluorophenyl)-6-[3-fluoro-4-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-pyridin-2-ylmethanone
Show/Hide
|
C29H21F5N4O3S
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0511728
|
[(4aR)-1-(4-fluorophenyl)-6-(2-methylpyrazol-3-yl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone
Show/Hide
|
C27H22F4N6O3S
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0397269
|
[(4aR)-1-(4-fluorophenyl)-6-(3-methoxyphenyl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-pyridin-2-ylmethanone
Show/Hide
|
C29H25FN4O4S
|
1
|
| 1 |
Ki = 11.4 nM
|
|
|
|
CP0257906
|
[(4aR)-1-(4-fluorophenyl)-6-[4-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-pyridin-2-ylmethanone
Show/Hide
|
C29H22F4N4O3S
|
2
|
| 1 |
Ki = 12 nM
|
|
|
| 2 |
Ki = 14 nM
|
|
|
|
CP0477391
|
[(4aR)-6-(1,5-dimethylpyrazol-4-yl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone
Show/Hide
|
C28H24F4N6O3S
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0566645
|
[(4aR,8aS)-1-(4-fluorophenyl)-6-(2-methyltriazol-4-yl)sulfonyl-4,5,7,8,8a,9-hexahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone
Show/Hide
|
C26H23F4N7O3S
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0056833
|
[(4aR)-6-(3,4-dichlorophenyl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-pyridin-2-ylmethanone
Show/Hide
|
C28H21Cl2FN4O3S
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0087285
|
[(4aR)-1-(4-fluorophenyl)-6-[3-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-pyridin-2-ylmethanone
Show/Hide
|
C29H22F4N4O3S
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0368767
|
[(4aR)-1-(4-fluorophenyl)-6-(3-methylphenyl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-(6-methylpyridin-2-yl)methanone
Show/Hide
|
C30H27FN4O3S
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0257905
|
3-[[(4aR)-1-(4-fluorophenyl)-4a-(pyridine-2-carbonyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-6-yl]sulfonyl]benzonitrile
Show/Hide
|
C29H22FN5O3S
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0470450
|
[(4aR)-1-(4-fluorophenyl)-6-(4-fluorophenyl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-pyridin-2-ylmethanone
Show/Hide
|
C28H22F2N4O3S
|
1
|
| 1 |
Ki = 16 nM
|
|
|
|
CP0567272
|
[(4aR)-6-(3,4-dichlorophenyl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-(1,3-thiazol-2-yl)methanone
Show/Hide
|
C26H19Cl2FN4O3S2
|
1
|
| 1 |
Ki = 16 nM
|
|
|
|
CP0162458
|
[(4aR)-1-(4-fluorophenyl)-6-[3-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-(1,3-thiazol-2-yl)methanone
Show/Hide
|
C27H20F4N4O3S2
|
1
|
| 1 |
Ki = 17 nM
|
|
|
|
CP0133935
|
[(4aR)-1-(4-fluorophenyl)-6-[4-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-(1,3-thiazol-2-yl)methanone
Show/Hide
|
C27H20F4N4O3S2
|
1
|
| 1 |
Ki = 18 nM
|
|
|
|
CP0149068
|
[(4aR)-1-(4-fluorophenyl)-6-(2-methylphenyl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-pyridin-2-ylmethanone
Show/Hide
|
C29H25FN4O3S
|
1
|
| 1 |
Ki = 18.5 nM
|
|
|
|
CP0224498
|
[(4aR)-1-(4-fluorophenyl)-6-[4-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-(1,3-thiazol-4-yl)methanone
Show/Hide
|
C27H20F4N4O3S2
|
1
|
| 1 |
Ki = 22 nM
|
|
|
|
CP0396339
|
[(4aR,8aS)-1-(4-fluorophenyl)-6-(1-methylpyrazol-3-yl)sulfonyl-4,5,7,8,8a,9-hexahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone
Show/Hide
|
C27H24F4N6O3S
|
1
|
| 1 |
Ki = 24 nM
|
|
|
|
CP0087287
|
[(4aR)-1-(4-fluorophenyl)-6-[4-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-thiophen-2-ylmethanone
Show/Hide
|
C28H21F4N3O3S2
|
1
|
| 1 |
Ki = 27 nM
|
|
|
|
CP0437265
|
[(4aR)-1-(4-fluorophenyl)-6-(1-methylpyrazol-4-yl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-pyridin-2-ylmethanone
Show/Hide
|
C26H23FN6O3S
|
1
|
| 1 |
Ki = 28 nM
|
|
|
|
CP0133934
|
[(4aR)-1-(4-fluorophenyl)-6-[4-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-(furan-2-yl)methanone
Show/Hide
|
C28H21F4N3O4S
|
1
|
| 1 |
Ki = 31 nM
|
|
|
|
CP0408531
|
[(4aR)-1-(4-fluorophenyl)-6-(3-methyltriazol-4-yl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone
Show/Hide
|
C26H21F4N7O3S
|
1
|
| 1 |
Ki = 31 nM
|
|
|
|
CP0437266
|
[(4aR,8aS)-1-(4-fluorophenyl)-6-(1-methylpyrazol-4-yl)sulfonyl-4,5,7,8,8a,9-hexahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone
Show/Hide
|
C27H24F4N6O3S
|
1
|
| 1 |
Ki = 34 nM
|
|
|
|
CP0368769
|
[(4aR)-6-(3,4-difluorophenyl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-(1,3-thiazol-2-yl)methanone
Show/Hide
|
C26H19F3N4O3S2
|
1
|
| 1 |
Ki = 37 nM
|
|
|
|
CP0396338
|
[(4aR,8aS)-1-(4-fluorophenyl)-6-[3-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8,8a,9-hexahydropyrazolo[3,4-g]isoquinolin-4a-yl]-pyridin-2-ylmethanone
Show/Hide
|
C29H24F4N4O3S
|
1
|
| 1 |
Ki = 44 nM
|
|
|
|
CP0566913
|
[(4aR)-1-(4-fluorophenyl)-6-[4-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-(1H-imidazol-2-yl)methanone
Show/Hide
|
C27H21F4N5O3S
|
1
|
| 1 |
Ki = 52 nM
|
|
|
|
CP0540832
|
[(4aR,8aS)-1-(4-fluorophenyl)-6-(1-methyltriazol-4-yl)sulfonyl-4,5,7,8,8a,9-hexahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone
Show/Hide
|
C26H23F4N7O3S
|
1
|
| 1 |
Ki = 60 nM
|
|
|
|
CP0056837
|
[(4aR)-1-(4-fluorophenyl)-6-[4-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-(1,3-oxazol-4-yl)methanone
Show/Hide
|
C27H20F4N4O4S
|
1
|
| 1 |
Ki = 63 nM
|
|
|
|
CP0110379
|
[(4aR)-1-(4-fluorophenyl)-6-[3-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-(4-methyl-1,3-thiazol-2-yl)methanone
Show/Hide
|
C28H22F4N4O3S2
|
1
|
| 1 |
Ki = 63 nM
|
|
|
|
CP0567273
|
[(4aR,8aS)-6-(2-ethylpyrazol-3-yl)sulfonyl-1-(4-fluorophenyl)-4,5,7,8,8a,9-hexahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone
Show/Hide
|
C28H26F4N6O3S
|
1
|
| 1 |
Ki = 68 nM
|
|
|
|
CP0544081
|
[(4aR)-6-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl]-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone
Show/Hide
|
C28H24F4N6O3S
|
1
|
| 1 |
Ki = 69 nM
|
|
|
|
CP0460359
|
[(4aR)-1-(4-fluorophenyl)-6-[4-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-pyrazin-2-ylmethanone
Show/Hide
|
C28H21F4N5O3S
|
1
|
| 1 |
Ki = 98 nM
|
|
|
|
CP0567374
|
[(4aR,8aS)-1-(4-fluorophenyl)-6-(3-methyltriazol-4-yl)sulfonyl-4,5,7,8,8a,9-hexahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone
Show/Hide
|
C26H23F4N7O3S
|
1
|
| 1 |
Ki = 120 nM
|
|
|
|
CP0224499
|
[(4aR)-1-(4-fluorophenyl)-6-[4-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-pyridin-3-ylmethanone
Show/Hide
|
C29H22F4N4O3S
|
1
|
| 1 |
Ki = 151 nM
|
|
|
|
CP0087286
|
[(4aR)-1-(4-fluorophenyl)-6-[4-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-(1,3-thiazol-5-yl)methanone
Show/Hide
|
C27H20F4N4O3S2
|
1
|
| 1 |
Ki = 260 nM
|
|
|
