| Compound ID |
Compound Name |
Compound Formula |
|
CP0911962
|
(S)-3-(4-(2,4-difluorobenzyl)piperazin-1-yl)-7-methyl-N-(tetrahydrofuran-3-yl)pyrido[3,4-b]pyrazin-2-amine
Show/Hide
|
C23H26F2N6O
|
1
|
| 1 |
EC50 = 16.5 nM
|
|
|
|
CP0964623
|
N-cyclopropyl-3-(4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl)-7-methylpyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetate
Show/Hide
|
C25H27F4N5O4
|
1
|
| 1 |
EC50 = 18.5 nM
|
|
|
|
CP0958682
|
3-(4-(2,4-difluorobenzyl)piperazin-1-yl)-7-methyl-N-(oxetan-3-yl)pyrido[3,4-b]pyrazin-2-amine
Show/Hide
|
C22H24F2N6O
|
1
|
| 1 |
EC50 = 21.9 nM
|
|
|
|
CP0887612
|
(R)-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-7-methyl-N-(tetrahydrofuran-3-yl)pyrido[3,4-b]pyrazin-2-amine
Show/Hide
|
C23H25F2N5O2
|
1
|
| 1 |
EC50 = 30.1 nM
|
|
|
|
CP0931299
|
N-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(methylsulfonyl)phenyl)-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
|
C25H25F2N3O5S
|
1
|
| 1 |
EC50 = 31.62 nM
|
|
|
|
CP0956052
|
3-(4-(2-fluoro-4-methoxybenzyl)piperazin-1-yl)-N-isopropyl-7-methylpyrido[3,4-b]pyrazin-2-amine
Show/Hide
|
C23H29FN6O
|
1
|
| 1 |
EC50 = 37.3 nM
|
|
|
|
CP0902932
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyridin-3-yl)-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
|
C24H21F2N5O3
|
1
|
| 1 |
EC50 = 39.81 nM
|
|
|
|
CP0909961
|
N-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(methylsulfonyl)phenyl)-2-methoxynicotinamide
Show/Hide
|
C25H25F2N3O5S
|
1
|
| 1 |
EC50 = 39.81 nM
|
|
|
|
CP0931291
|
N-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-methylpyridin-3-yl)-4-methoxynicotinamide
Show/Hide
|
C24H24F2N4O3
|
1
|
| 1 |
EC50 = 39.81 nM
|
|
|
|
CP0931293
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2,3-dihydrobenzofuran-7-carboxamide
Show/Hide
|
C27H23F2N3O3
|
1
|
| 1 |
EC50 = 39.81 nM
|
|
|
|
CP0938776
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyridin-3-yl)-1-ethyl-5-methoxy-1H-pyrazole-4-carboxamide
Show/Hide
|
C24H24F2N6O3
|
1
|
| 1 |
EC50 = 39.81 nM
|
|
|
|
CP0953843
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyridin-3-yl)-6-methylpicolinamide
Show/Hide
|
C24H21F2N5O2
|
1
|
| 1 |
EC50 = 39.81 nM
|
|
|
|
CP0953848
|
N-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(methylsulfonyl)phenyl)-4-methoxynicotinamide
Show/Hide
|
C25H25F2N3O5S
|
1
|
| 1 |
EC50 = 39.81 nM
|
|
|
|
CP0960267
|
N-(4-(4-(2,4-difluorophenoxy)piperidin-1-yl)-6-methoxypyridin-3-yl)-4-methoxynicotinamide
Show/Hide
|
C24H24F2N4O4
|
1
|
| 1 |
EC50 = 39.81 nM
|
|
|
|
CP0965084
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-4-methoxy-2-methylpyrimidine-5-carboxamide
Show/Hide
|
C25H23F2N5O3
|
1
|
| 1 |
EC50 = 39.81 nM
|
|
|
|
CP0968966
|
N-(4-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(dimethylcarbamoyl)phenyl)-2-methoxynicotinamide
Show/Hide
|
C28H27F2N5O4
|
1
|
| 1 |
EC50 = 39.81 nM
|
|
|
|
CP0911963
|
3-(4-(4-(difluoromethoxy)-2-fluorophenoxy)piperidin-1-yl)-N-isopropyl-7-methylpyrido[3,4-b]pyrazin-2-amine
Show/Hide
|
C23H26F3N5O2
|
1
|
| 1 |
EC50 = 39.9 nM
|
|
|
|
CP0970134
|
(R)-3-(4-(2,4-difluorobenzyl)piperazin-1-yl)-7-methyl-N-(tetrahydrofuran-3-yl)pyrido[3,4-b]pyrazin-2-amine
Show/Hide
|
C23H26F2N6O
|
1
|
| 1 |
EC50 = 47.9 nM
|
|
|
|
CP0887613
|
trans-3-((3-(4-(2,4-difluorophenoxy)piperidin-l-yl)-7-methylpyrido[3,4-b]pyrazin-2-yl)amino)cyclobutanol
Show/Hide
|
C23H25F2N5O2
|
1
|
| 1 |
EC50 = 48.2 nM
|
|
|
|
CP0965006
|
trans-3-(4-(2,4-difluorobenzyl)piperazin-l-yl)-N-(3-fluorocyclobutyl)-7-methylpyrido[3,4-b]pyrazin-2-amine
Show/Hide
|
C23H25F3N6
|
1
|
| 1 |
EC50 = 49.4 nM
|
|
|
|
CP0965005
|
(S)-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-7-methyl-N-(tetrahydrofuran-3-yl)pyrido[3,4-b]pyrazin-2-amine
Show/Hide
|
C23H25F2N5O2
|
1
|
| 1 |
EC50 = 49.6 nM
|
|
|
|
CP0902931
|
N-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(methoxymethyl)pyridin-3-yl)-2-methoxynicotinamide
Show/Hide
|
C25H26F2N4O4
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
|
CP0902933
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-4-fluorophenyl)-2-methoxy-6-methylnicotinamide
Show/Hide
|
C26H23F3N4O3
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
|
CP0903874
|
N-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-6-methylpyridin-3-yl)-4-methoxynicotinamide
Show/Hide
|
C24H24F2N4O3
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
|
CP0930966
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-4-(dimethylcarbamoyl)phenyl)-2-methoxynicotinamide
Show/Hide
|
C28H27F2N5O4
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
|
CP0930968
|
5-(4-(2,4-difluorophenoxy)piperidin-1-yl)-4-(4-methoxynicotinamido)-N,N-dimethylpicolinamide
Show/Hide
|
C26H27F2N5O4
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
|
CP0931286
|
N-(5-cyano-2-(4-(4-fluorobenzyl)piperazin-1-yl)pyridin-3-yl)-2-methoxynicotinamide
Show/Hide
|
C24H23FN6O2
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
|
CP0938780
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C23H22F2N6O3
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
|
CP0938781
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyridin-3-yl)-3-fluoro-6-methylpicolinamide
Show/Hide
|
C24H20F3N5O2
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
|
CP0938784
|
N-(5-cyano-2-(4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl)phenyl)-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
|
C26H25FN4O4
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
|
CP0953807
|
N-(4-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-4-methoxynicotinamide
Show/Hide
|
C25H22F2N4O3
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
|
CP0953829
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-(difluoromethoxy)nicotinamide
Show/Hide
|
C25H20F4N4O3
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
|
CP0960254
|
N-(6-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyridin-3-yl)-5-fluoro-2-methoxynicotinamide
Show/Hide
|
C24H20F3N5O3
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
|
CP0960269
|
N-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(methylsulfonyl)phenyl)-2-methoxybenzamide
Show/Hide
|
C26H26F2N2O5S
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
|
CP0961731
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyridin-3-yl)-3-methylpicolinamide
Show/Hide
|
C24H21F2N5O2
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
|
CP0963450
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyridin-3-yl)picolinamide
Show/Hide
|
C23H19F2N5O2
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
|
CP0965086
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-5-fluoro-2-methoxynicotinamide
Show/Hide
|
C25H21F3N4O3
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
|
CP0965087
|
N-(5-cyano-2-(4-2,4-difluorophenoxy)piperidin-1-yl)phenyl)-5-fluoro-2-methoxybenzamide
Show/Hide
|
C26H22F3N3O3
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
|
CP0969414
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-4,5-difluoro-2-methoxybenzamide
Show/Hide
|
C26H21F4N3O3
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
|
CP0970086
|
4-chloro-N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyridin-3-yl)picolinamide
Show/Hide
|
C23H18ClF2N5O2
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
|
CP0943660
|
cis-3-((3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-7-methylpyrido[3,4-b]pyrazin-2-yl)amino)cyclobutanol
Show/Hide
|
C23H25F2N5O2
|
1
|
| 1 |
EC50 = 52.3 nM
|
|
|
|
CP0578202
|
N-cyclopropyl-3-[4-[(2,5-dichlorophenyl)methyl]piperazin-1-yl]pyrido[3,4-b]pyrazin-2-amine
Show/Hide
|
C21H22Cl2N6
|
1
|
| 1 |
EC50 = 53 nM
|
|
|
|
CP0551155
|
N-cyclopropyl-2-[4-[(2,5-dichlorophenyl)methyl]piperazin-1-yl]pyrido[3,4-b]pyrazin-3-amine
Show/Hide
|
C21H22Cl2N6
|
1
|
| 1 |
EC50 = 55 nM
|
|
|
|
CP0528130
|
3-[4-[(2,4-difluorophenyl)methyl]piperazin-1-yl]-7-methyl-N-propan-2-ylpyrido[3,4-b]pyrazin-2-amine
Show/Hide
|
C22H26F2N6
|
2
|
| 1 |
EC50 = 59.4 nM
|
|
|
| 2 |
EC50 = 51000 nM
|
|
|
|
CP0961054
|
trans-3-(4-(2,4-difluorophenoxy)piperidin-l-yl)-N-(3-fluorocyclobutyl)-7-methylpyrido[3,4-b]pyrazin-2-amine
Show/Hide
|
C23H24F3N5O
|
1
|
| 1 |
EC50 = 61.4 nM
|
|
|
|
CP0944919
|
N-cyclopropyl-3-(4-(4-(difluoromethoxy)-2-fluorophenoxy)piperidin-1-yl)-7-methylpyrido[3,4-b]pyrazin-2-amine
Show/Hide
|
C23H24F3N5O2
|
1
|
| 1 |
EC50 = 62.6 nM
|
|
|
|
CP0900038
|
4-chloro-N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxybenzamide
Show/Hide
|
C26H22ClF2N3O3
|
1
|
| 1 |
EC50 = 63.1 nM
|
|
|
|
CP0902925
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-6-methoxypyrazine-2-carboxamide
Show/Hide
|
C24H21F2N5O3
|
1
|
| 1 |
EC50 = 63.1 nM
|
|
|
|
CP0905677
|
N-(2-cyano-5-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyridin-4-yl)-2-methoxynicotinamide
Show/Hide
|
C24H21F2N5O3
|
1
|
| 1 |
EC50 = 63.1 nM
|
|
|
|
CP0909919
|
N-(5-cyano-2-(4-((2,5-difluorophenyl)fluoromethyl)piperidin-1-yl)phenyl)-1-methyl-2-oxo-1,2-dilhydropyridine-3-carboxamide
Show/Hide
|
C26H23F3N4O2
|
1
|
| 1 |
EC50 = 63.1 nM
|
|
|
|
CP0909960
|
N-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-4-(methylsulfonyl)phenyl)-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
|
C25H25F2N3O5S
|
1
|
| 1 |
EC50 = 63.1 nM
|
|
|
|
CP0931297
|
N-(6-chloro-4-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyridin-3-yl)-1-methyl-2-oxo-1,2-dihdropyridine-3-carboxamide
Show/Hide
|
C23H21ClF2N4O3
|
1
|
| 1 |
EC50 = 63.1 nM
|
|
|
|
CP0931300
|
N-(6-cyano-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyridazin-4-yl)-2-methoxynicotinamide
Show/Hide
|
C23H20F2N6O3
|
1
|
| 1 |
EC50 = 63.1 nM
|
|
|
|
CP0938782
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-4-methoxythiophene-3-carboxamide
Show/Hide
|
C24H21F2N3O3S
|
1
|
| 1 |
EC50 = 63.1 nM
|
|
|
|
CP0953842
|
(R)-N-(5-cyano-2-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)phenyl)-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
|
C26H23F3N4O2
|
1
|
| 1 |
EC50 = 63.1 nM
|
|
|
|
CP0960255
|
4-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(2-methoxynicotinamido)-N-propylpicolinamide
Show/Hide
|
C27H29F2N5O4
|
1
|
| 1 |
EC50 = 63.1 nM
|
|
|
|
CP0961162
|
N-(2-(4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl)-5-(methylsulfonyl)phenyl)-1-(2-fluoroethyl)-3-methoxy-1H-pyrazole-4-carboxamide
Show/Hide
|
C26H30F2N4O6S
|
1
|
| 1 |
EC50 = 63.1 nM
|
|
|
|
CP0961165
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methylpyrimidine-4-carboxamide
Show/Hide
|
C24H21F2N5O2
|
1
|
| 1 |
EC50 = 63.1 nM
|
|
|
|
CP0961732
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyridin-3-yl)-4-fIuoro-2-methoxybenzamide
Show/Hide
|
C25H21F3N4O3
|
1
|
| 1 |
EC50 = 63.1 nM
|
|
|
|
CP0963447
|
N-(5-cyano-2-(4-(2-fluoro-4-methoxybenzyl)piperidin-1-yl)phenyl)-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
|
C27H27FN4O3
|
1
|
| 1 |
EC50 = 63.1 nM
|
|
|
|
CP0968683
|
N-(2-(4-(2,4-difluorobenzyl)piperazin-1-yl)-5-(methoxymethyl)pyridin-3-yl)-2-methoxynicotinamide
Show/Hide
|
C25H27F2N5O3
|
1
|
| 1 |
EC50 = 63.1 nM
|
|
|
|
CP0969755
|
6-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(2-methoxynicotinamido)-N,N-dimethylnicotinamide
Show/Hide
|
C26H27F2N5O4
|
1
|
| 1 |
EC50 = 63.1 nM
|
|
|
|
CP0969759
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-3-methoxythiophene-2-carboxamide
Show/Hide
|
C24H21F2N3O3S
|
1
|
| 1 |
EC50 = 63.1 nM
|
|
|
|
CP0578199
|
2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-7-methyl-N-propan-2-ylpyrido[3,4-b]pyrazin-3-amine
Show/Hide
|
C22H25F2N5O
|
2
|
| 1 |
EC50 = 66.4 nM
|
|
|
| 2 |
EC50 = 61000 nM
|
|
|
|
CP0964624
|
cis-3-((3-(4-(2,4-difluorobenzyl)piperazin-1-yl)-7-methylpyrido[3,4-b]pyrazin-2-yl)amino)cyclobutanol
Show/Hide
|
C23H26F2N6O
|
1
|
| 1 |
EC50 = 69.3 nM
|
|
|
|
CP0969876
|
trans-3-((3-(4-(2,4-difluorobenzyl)piperazin-l-yl)-7-methylpyrido[3,4-b]pyrazin-2-yl)amino)cyclobutanol
Show/Hide
|
C23H26F2N6O
|
1
|
| 1 |
EC50 = 75.2 nM
|
|
|
|
CP0970135
|
(R)-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-7-methyl-N-(tetrahydrofuran-3-yl)pyrido[3,4-b]pyrazin-3-amine
Show/Hide
|
C23H25F2N5O2
|
1
|
| 1 |
EC50 = 76.3 nM
|
|
|
|
CP0866390
|
N-(5-cyano-2-(4-(3,4-difluorobenzyl)piperazin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
|
C25H23F2N5O2
|
1
|
| 1 |
EC50 = 79.43 nM
|
|
|
|
CP0866391
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2,3-dimethoxybenzamide
Show/Hide
|
C27H25F2N3O4
|
1
|
| 1 |
EC50 = 79.43 nM
|
|
|
|
CP0902921
|
N-(5-cyano-2-(4-(2-fIuoro-4-methoxybenzyl)piperazin-1-yl)pyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C24H26FN7O3
|
1
|
| 1 |
EC50 = 79.43 nM
|
|
|
|
CP0902924
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-6-methylpyrazine-2-carboxamide
Show/Hide
|
C24H21F2N5O2
|
1
|
| 1 |
EC50 = 79.43 nM
|
|
|
|
CP0903873
|
N-(4-(4-(2,4-difluorophenoxy)piperidin-1-yl)-2-methylpyrimidin-5-yl)-2-methoxy-6-methylnicotinamide
Show/Hide
|
C24H25F2N5O3
|
1
|
| 1 |
EC50 = 79.43 nM
|
|
|
|
CP0905678
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2,4-dimethoxybenzamide
Show/Hide
|
C27H25F2N3O4
|
1
|
| 1 |
EC50 = 79.43 nM
|
|
|
|
CP0909903
|
N-(4,5-dicyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
|
C26H21F2N5O3
|
1
|
| 1 |
EC50 = 79.43 nM
|
|
|
|
CP0909918
|
N-(5-cyano-2-(4-(4-fluorobenzyl)piperazin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
|
C25H24FN5O2
|
1
|
| 1 |
EC50 = 79.43 nM
|
|
|
|
CP0931271
|
N-(2-(4-(4-chloro-2,6-difluorobenzyl)piperazin-1-yl)-5-cyanopyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C23H22ClF2N7O2
|
1
|
| 1 |
EC50 = 79.43 nM
|
|
|
|
CP0931280
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-5-methoxypicolinamide
Show/Hide
|
C25H22F2N4O3
|
1
|
| 1 |
EC50 = 79.43 nM
|
|
|
|
CP0931288
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyridin-3-yl)-2-methoxynicotinamide
Show/Hide
|
C24H21F2N5O3
|
1
|
| 1 |
EC50 = 79.43 nM
|
|
|
|
CP0931292
|
4-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(2-methoxynicotinamido)-N,N-dimethylpicolinamide
Show/Hide
|
C26H27F2N5O4
|
1
|
| 1 |
EC50 = 79.43 nM
|
|
|
|
CP0931298
|
N-(5-cyano-2-(4-(2,5-difluorophenoxy)piperidin-1-yl)phenyl)-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
|
C25H22F2N4O3
|
1
|
| 1 |
EC50 = 79.43 nM
|
|
|
|
CP0938764
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxy-4-methylbenzamide
Show/Hide
|
C27H25F2N3O3
|
1
|
| 1 |
EC50 = 79.43 nM
|
|
|
|
CP0953838
|
N-(2-(4-(4-chloro-2-fluorobenzyl)piperazin-1-yl)-5-cyanopyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C23H23ClFN7O2
|
1
|
| 1 |
EC50 = 79.43 nM
|
|
|
|
CP0953840
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-5-fluoro-6-methylpicolinamide
Show/Hide
|
C25H21F3N4O2
|
1
|
| 1 |
EC50 = 79.43 nM
|
|
|
|
CP0960266
|
4-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(2-methoxynicotinamido)-N,N-bis(methyl-d3)picolinamide
Show/Hide
|
C26H27F2N5O4
|
1
|
| 1 |
EC50 = 79.43 nM
|
|
|
|
CP0960270
|
N-(2-cyano-4-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyrimidin-5-yl)-2-methoxy-6-methylnicotinamide
Show/Hide
|
C24H22F2N6O3
|
1
|
| 1 |
EC50 = 79.43 nM
|
|
|
|
CP0961160
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-4-methoxypyrimidine-5-carboxamide
Show/Hide
|
C24H21F2N5O3
|
1
|
| 1 |
EC50 = 79.43 nM
|
|
|
|
CP0969813
|
N-(4-(4-(2,4-difluorophenoxy)piperidin-1-yl)-6-methylpyridin-3-yl)-4-methoxynicotinamide
Show/Hide
|
C24H24F2N4O3
|
1
|
| 1 |
EC50 = 79.43 nM
|
|
|
|
CP0956053
|
2-(4-(2,4-difluorobenzyl)piperazin-1-yl)-N-isopropyl-7-methylpyrido[3,4-b]pyrazin-3-amine 2,2,2-trifluoroacetate
Show/Hide
|
C24H27F5N6O2
|
1
|
| 1 |
EC50 = 80.1 nM
|
|
|
|
CP0969085
|
(R)-3-(4-(4-(difluoromethoxy)-2-fluorophenoxy)piperidin-1-yl)-7-methyl-N-(tetrahydrofuran-3-yl)pyrido[3,4-b]pyrazin-2-amine
Show/Hide
|
C24H26F3N5O3
|
1
|
| 1 |
EC50 = 81.4 nM
|
|
|
|
CP0344349
|
3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-7-methyl-N-propan-2-ylpyrido[3,4-b]pyrazin-2-amine
Show/Hide
|
C22H25F2N5O
|
2
|
| 1 |
EC50 = 88.2 nM
|
|
|
| 2 |
EC50 = 16000 nM
|
|
|
|
CP0578201
|
2-(cyclopropylamino)-3-[4-[(2,5-dichlorophenyl)methyl]piperazin-1-yl]-N,N-dimethylquinoxaline-6-carboxamide
Show/Hide
|
C25H28Cl2N6O
|
1
|
| 1 |
EC50 = 90 nM
|
|
|
|
CP0344350
|
N-cyclopropyl-2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-7-methylpyrido[3,4-b]pyrazin-3-amine
Show/Hide
|
C22H23F2N5O
|
2
|
| 1 |
EC50 = 94.9 nM
|
|
|
| 2 |
EC50 = 95000 nM
|
|
|
|
CP0900037
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
|
C24H20F2N4O3
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0900039
|
4-bromo-N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxybenzamide
Show/Hide
|
C26H22BrF2N3O3
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0909921
|
4-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(5-fluoro-2-methoxynicotinamido)-N,N-dimethylpicolinamide
Show/Hide
|
C26H26F3N5O4
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0931282
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methylthiazole-4-carboxamide
Show/Hide
|
C23H20F2N4O2S
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0931290
|
N-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-methylpyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C23H25F2N5O3
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0938762
|
N-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
|
C24H23F2N3O3
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0938775
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-4,5-dimethylisoxazole-3-carboxamide
Show/Hide
|
C24H22F2N4O3
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0946427
|
N-(5-cyano-2-(4-(2,5-difluorobenzoyl)piperidin-1-yl)phenyl)-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
|
C26H22F2N4O3
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0953837
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-6-methoxypicolinamide
Show/Hide
|
C25H22F2N4O3
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0960258
|
N-(5-cyano-2-(4-(2-cyanobenzyl)piperazin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
|
C26H24N6O2
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0962502
|
4-(4-(2,4-difluorophenoxy)piperidn-1-yl)-N-ethyl-5-(2-methoxynicotinamido)piclinamide
Show/Hide
|
C26H27F2N5O4
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0962510
|
N-(2-(4-benzylpiperidin-1-yl)-5-cyanopyridin-3-yl)picolinamide
Show/Hide
|
C23H21N5O2
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0962512
|
N-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(hydroxymethyl)pyridin-3-yl)-2-methoxynicotinamide
Show/Hide
|
C24H24F2N4O4
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0962513
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-3-methoxyisonicotinamide
Show/Hide
|
C25H22F2N4O3
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0963451
|
N-(5-(acetamidomethyl)-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyridin-3-yl)-2-methoxynicotinamide
Show/Hide
|
C26H27F2N5O4
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0968968
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-3-fluoropicolinamide
Show/Hide
|
C24H19F3N4O2
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0969573
|
N-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(morpholinosulfonyl)pyridin-3-yl)-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
|
C27H29F2N5O6S
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0969761
|
N-(2-(4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl)-5-(methylsulfonyl)phenyl)-1-(fluoromethyl)-3-methoxy-1H-pyrazole-4-carboxamide
Show/Hide
|
C25H28F2N4O6S
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0887615
|
(R)-2-(4-(2,4-difluorobenzyl)piperazin-1-yl)-7-methyl-N-(tetrahydrofuran-3-yl)pyrido[3,4-b]pyrazin-3-amine
Show/Hide
|
C23H26F2N6O
|
1
|
| 1 |
EC50 = 101.7 nM
|
|
|
|
CP0901650
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-1-methyl-1H-pyrazole-3-carboxamide
Show/Hide
|
C23H21F2N5O2
|
1
|
| 1 |
EC50 = 125.89 nM
|
|
|
|
CP0902926
|
N-(4-(4-(2,4-difluorophenoxy)piperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)-2-methoxynicotinamide
Show/Hide
|
C24H21F5N4O3
|
1
|
| 1 |
EC50 = 125.89 nM
|
|
|
|
CP0902930
|
N-(5-cyano-2-(4-(2-fluoro-4-methoxybenzoyl)piperidin-1-yl)phenyl)-1-methyl-2-oxo-1,2-dihydropyridin-3-carboxamide
Show/Hide
|
C27H25FN4O4
|
1
|
| 1 |
EC50 = 125.89 nM
|
|
|
|
CP0905676
|
N-(6-cyano-4-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyridin-3-yl)-2-methoxynicotinamide
Show/Hide
|
C24H21F2N5O3
|
1
|
| 1 |
EC50 = 125.89 nM
|
|
|
|
CP0905696
|
N-(2-(4-(4-chlorobenzoyl)piperazin-1-yl)-5-cyanophenyl)-2-methoxynicotinamide
Show/Hide
|
C25H22ClN5O3
|
1
|
| 1 |
EC50 = 125.89 nM
|
|
|
|
CP0909904
|
N-(5-cyano-2-(4-(3-cyanobenzyl)piperidin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
|
C26H24N6O2
|
1
|
| 1 |
EC50 = 125.89 nM
|
|
|
|
CP0931277
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxypyrimidine-4-carboxamide
Show/Hide
|
C24H21F2N5O3
|
1
|
| 1 |
EC50 = 125.89 nM
|
|
|
|
CP0931281
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-5-methylpicolinamide
Show/Hide
|
C25H22F2N4O2
|
1
|
| 1 |
EC50 = 125.89 nM
|
|
|
|
CP0938767
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-5-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxamide
Show/Hide
|
C25H19F2N5O3S
|
1
|
| 1 |
EC50 = 125.89 nM
|
|
|
|
CP0946422
|
N-(5-cyano-2-(4-(2-fluorobenzyl)piperazin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
|
C25H24FN5O2
|
1
|
| 1 |
EC50 = 125.89 nM
|
|
|
|
CP0953808
|
N-(2-(4-(5-chloro-2-fluorobenzoyl)piperidin-1-yl)-5-cyanophenyl)-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
|
C26H22ClFN4O3
|
1
|
| 1 |
EC50 = 125.89 nM
|
|
|
|
CP0953810
|
N-(5-cyano-2-(4-(2-cyano-4-fluorobenzyl)piperazin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
|
C26H23FN6O2
|
1
|
| 1 |
EC50 = 125.89 nM
|
|
|
|
CP0953846
|
N-4-(4-(2,4-difluorophenoxy)piperidin-1-yl)-6-methoxypyridin-3-yl)-2-methoxynicotinamide
Show/Hide
|
C24H24F2N4O4
|
1
|
| 1 |
EC50 = 125.89 nM
|
|
|
|
CP0956611
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2,6-dimethoxynicotinamide
Show/Hide
|
C26H24F2N4O4
|
1
|
| 1 |
EC50 = 125.89 nM
|
|
|
|
CP0956614
|
N-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(methylsulfonyl)phenyl)-3-fluoro-2-methoxybenzamide
Show/Hide
|
C26H25F3N2O5S
|
1
|
| 1 |
EC50 = 125.89 nM
|
|
|
|
CP0960251
|
4-(4-(2,4-difluorophenoxy)piperidin-1-yl-5-(2-methoxynicotinamido)picolinamide
Show/Hide
|
C24H23F2N5O4
|
1
|
| 1 |
EC50 = 125.89 nM
|
|
|
|
CP0960252
|
N-(4-(4-(2,4-diflurophenoxy)piperidin-1-yl)-6-(methoxymethyl)pyridin-3-yl)-2-methoxynicotinamide
Show/Hide
|
C25H26F2N4O4
|
1
|
| 1 |
EC50 = 125.89 nM
|
|
|
|
CP0960261
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-1,5-dimethyl-1H-pyrazole-3-carboxamide
Show/Hide
|
C24H23F2N5O2
|
1
|
| 1 |
EC50 = 125.89 nM
|
|
|
|
CP0961163
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxy-5-(trifluoromethyl)benzamide
Show/Hide
|
C27H22F5N3O3
|
1
|
| 1 |
EC50 = 125.89 nM
|
|
|
|
CP0968416
|
N-(5-cyano-2-(4-(2-fluorophenoxy)piperidin-1-yl)phenyl)-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
|
C25H23FN4O3
|
1
|
| 1 |
EC50 = 125.89 nM
|
|
|
|
CP0969570
|
6-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(2-methoxy-5-methylnicotinamido)-N,N-dimethylnicotinamide
Show/Hide
|
C27H29F2N5O4
|
1
|
| 1 |
EC50 = 125.89 nM
|
|
|
|
CP0887616
|
(S)-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-7-methyl-N-(tetrahydrofuran-3-yl)pyrido[3,4-b]pyrazin-3-amine
Show/Hide
|
C23H25F2N5O2
|
1
|
| 1 |
EC50 = 128 nM
|
|
|
|
CP0958683
|
N-cyclopropyl-3-(4-(2-fluoro-4-methoxybenzyl)piperazin-1-yl)-7-methylpyrido[3,4-b]pyrazin-2-amine
Show/Hide
|
C23H27FN6O
|
1
|
| 1 |
EC50 = 158.1 nM
|
|
|
|
CP0900040
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxy-6-(trifluoromethyl)nicotinamide
Show/Hide
|
C26H21F5N4O3
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0902915
|
N-(5-cyano-2-(4-(2,4-(difluoromethoxy)piperidin-1-yl)phenyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxamide
Show/Hide
|
C27H21F2N5O3
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0903876
|
N-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(methylsulfonyl)phenyl)-5,6,7,8-tetrahydropyrazolo[5,1-b][1,3]oxazepine-3-carboxamide
Show/Hide
|
C26H28F2N4O5S
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0905679
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-7-methyl-4-oxo-4H-pyrido[1,2-a]primidine-3-carboxamide
Show/Hide
|
C28H23F2N5O3
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0909911
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-1-ethyl-5-methyl-1H-pyrazole-3-carboxamide
Show/Hide
|
C25H25F2N5O2
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0909913
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2,6-dimethylpyrimidine-4-carboxamide
Show/Hide
|
C25H23F2N5O2
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0931279
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-6-methoxypyridazine-3-carboxamide
Show/Hide
|
C24H21F2N5O3
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0931289
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)pyrrolo[1,2-c]pyrimidine-3-carboxamide
Show/Hide
|
C26H21F2N5O2
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0931295
|
N-(4-(4-(2,4-difluorophenoxy)piperidin-1-yl)-2-methylpyrimidin-5-yl)-2-methoxynicotinamide
Show/Hide
|
C23H23F2N5O3
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0938760
|
N-(4-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyridin-3-yl)-2-methoxynicotinamide
Show/Hide
|
C23H22F2N4O3
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0938763
|
N-(5-cyano-2-(4-(2-fluoro-5-methoxybenzyl)piperazin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
|
C26H26FN5O3
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0938769
|
6-chloro-N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
|
C25H21ClF2N4O3
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0953809
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-carboxamide
Show/Hide
|
C26H24F2N4O3
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0959715
|
N-(5-cyano-2-(4-(3-fluorobenzyl)piperidin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
|
C25H24FN5O2
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0960256
|
4-(2,4-difluorophenoxy)piperidin-1-yl)-N-isopropyl-5-(2-methoxynicotinamido)picolinamide
Show/Hide
|
C27H29F2N5O4
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0961720
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-3-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxamide
Show/Hide
|
C26H21F2N5O3S
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0961736
|
4-(4-(2,4-difluorophenoxy)piperidin-1-yl-5-(2-methoxy-6-methylnicotinamido)-N,N-dimethylpicolinamide
Show/Hide
|
C27H29F2N5O4
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0962503
|
(R)-4-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(2-methoxynicotinamido)-N-(tetrahydrofuran-3-yl)picolinamide
Show/Hide
|
C28H29F2N5O5
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0963448
|
N-(5-cyano-2-(4-((2,4-difluorophenyl)difluoromethyl)piperidin-1-yl)phenyl)-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
|
C26H22F4N4O2
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0963452
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-4-methylthiazole-2-carboxamide
Show/Hide
|
C23H20F2N4O2S
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0965085
|
N-(2-cyano-5-(4-(2,3,4-trifluorobenzyl)piperazin-1-yl)pyridin-4-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C23H22F3N7O2
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0969415
|
N-(5-cyano-2-(4-(2,4,6-trifluorobenzyl)piperazin-1-yl)pyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C23H22F3N7O2
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0969565
|
5-fluoro-N-(2-(4-(4-fluorobenzyl)piperazin-1-yl)-6-methylpyridin-3-yl)-2-methoxynicotinamide
Show/Hide
|
C24H25F2N5O2
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0969574
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-1,5,6-trimethyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
|
C27H26F2N4O3
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0969754
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-3,5-difluoro-2-methoxybenzamide
Show/Hide
|
C26H21F4N3O3
|
1
|
| 1 |
EC50 = 158.49 nM
|
|
|
|
CP0970385
|
(S)-3-(4-(4-(difluoromethoxy)-2-fluorophenoxy)piperidin-1-yl)-7-methyl-N-(tetrahydrofuran-3-yl)pyrido[3,4-b]pyrazin-2-amine
Show/Hide
|
C24H26F3N5O3
|
1
|
| 1 |
EC50 = 162.2 nM
|
|
|
|
CP0911967
|
2-(4-(2,4-difluorobenzyl)piperazin-1-yl)-7-methyl-N-(oxetan-3-yl)pyrido[3,4-b]pyrazin-3-amine
Show/Hide
|
C22H24F2N6O
|
1
|
| 1 |
EC50 = 163.7 nM
|
|
|
|
CP0570672
|
3-(cyclopropylamino)-2-[4-[(2,5-dichlorophenyl)methyl]piperazin-1-yl]quinoxaline-6-carbonitrile
Show/Hide
|
C23H22Cl2N6
|
1
|
| 1 |
EC50 = 174 nM
|
|
|
|
CP0911965
|
N-cyclopropyl-2-(4-(2,4-difluorobenzyl)piperazin-1-yl)-7-methylpyrido[3,4-b]pyrazin-3-amine 2,2,2-trifluoroacetate
Show/Hide
|
C24H25F5N6O2
|
1
|
| 1 |
EC50 = 188 nM
|
|
|
|
CP0902917
|
N-(5-cyano-2-(4-(3-(trifluoromethoxy)benzyl)piperazin-1-yl)pyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C24H24F3N7O3
|
1
|
| 1 |
EC50 = 199.53 nM
|
|
|
|
CP0902918
|
N-(5-cyano-2-(4-(2-(difluoromethoxy)benzyl)piperazin-1-yl)pyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C24H25F2N7O3
|
1
|
| 1 |
EC50 = 199.53 nM
|
|
|
|
CP0902928
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-4-methoxypicolinamide
Show/Hide
|
C25H22F2N4O3
|
1
|
| 1 |
EC50 = 199.53 nM
|
|
|
|
CP0903868
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyridin-3-yl)-5-ethoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C24H24F2N6O3
|
1
|
| 1 |
EC50 = 199.53 nM
|
|
|
|
CP0930967
|
N-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(dimethylcarbamoyl)phenyl)-2-methoxynicotinamide
Show/Hide
|
C27H28F2N4O4
|
1
|
| 1 |
EC50 = 199.53 nM
|
|
|
|
CP0931266
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxamide
Show/Hide
|
C28H23F2N5O3
|
1
|
| 1 |
EC50 = 199.53 nM
|
|
|
|
CP0931267
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxy-6,7-dihydro-5H-cyclopenta[blpyridine-3-carboxamide
Show/Hide
|
C28H26F2N4O3
|
1
|
| 1 |
EC50 = 199.53 nM
|
|
|
|
CP0931294
|
4-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(2-methoxynicotinamido)-N-methylpicolinamide
Show/Hide
|
C25H25F2N5O4
|
1
|
| 1 |
EC50 = 199.53 nM
|
|
|
|
CP0938765
|
3-chloro-N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxybenzamide
Show/Hide
|
C26H22ClF2N3O3
|
1
|
| 1 |
EC50 = 199.53 nM
|
|
|
|
CP0938773
|
N-(5-cyano-2-(4-(4-methoxybenzyl)piperazin-1-yl)pyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C24H27N7O3
|
1
|
| 1 |
EC50 = 199.53 nM
|
|
|
|
CP0953831
|
N-(6-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyridin-3-yl)-5-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C23H22F2N6O3
|
1
|
| 1 |
EC50 = 199.53 nM
|
|
|
|
CP0953834
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxamide
Show/Hide
|
C26H21F2N5O3S
|
1
|
| 1 |
EC50 = 199.53 nM
|
|
|
|
CP0956608
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxy-5-methylbenzamide
Show/Hide
|
C27H25F2N3O3
|
1
|
| 1 |
EC50 = 199.53 nM
|
|
|
|
CP0959716
|
5-chloro-N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxybenzamide
Show/Hide
|
C26H22ClF2N3O3
|
1
|
| 1 |
EC50 = 199.53 nM
|
|
|
|
CP0960268
|
N-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(methylsulfonyl)phenyl)-2-fluoro-6-methoxybenzamide
Show/Hide
|
C26H25F3N2O5S
|
1
|
| 1 |
EC50 = 199.53 nM
|
|
|
|
CP0962509
|
N-(5-cyano-2-(4-(p-tolylthio)piperidin-1-yl)pyridin-3-yl)picolinamide
Show/Hide
|
C24H23N5OS
|
1
|
| 1 |
EC50 = 199.53 nM
|
|
|
|
CP0968413
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-5-cyclopropylisoxazole-3-carboxamide
Show/Hide
|
C25H22F2N4O3
|
1
|
| 1 |
EC50 = 199.53 nM
|
|
|
|
CP0969818
|
N-(5-cyano-2-(4-(4-fluorophenoxy)piperidin-1-yl)phenyl)-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
|
C25H23FN4O3
|
1
|
| 1 |
EC50 = 199.53 nM
|
|
|
|
CP0969819
|
N-(5-cyano-2-(4-(4-fluorobenzoyl)piperazin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
|
C25H22FN5O3
|
1
|
| 1 |
EC50 = 199.53 nM
|
|
|
|
CP0902922
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-6-methylpyridazine-3-carboxamide
Show/Hide
|
C24H21F2N5O2
|
1
|
| 1 |
EC50 = 251.19 nM
|
|
|
|
CP0903869
|
N-(5-cyano-2-(4-((2,5-difluoropyridin-3-yl)oxy)piperidin-1-yl)phenyl)-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
|
C24H21F2N5O3
|
1
|
| 1 |
EC50 = 251.19 nM
|
|
|
|
CP0903871
|
(S)-N-(5-cyano-2-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)phenyl)-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
|
C26H23F3N4O2
|
1
|
| 1 |
EC50 = 251.19 nM
|
|
|
|
CP0909907
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-6-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxamide
Show/Hide
|
C28H23F2N5O3
|
1
|
| 1 |
EC50 = 251.19 nM
|
|
|
|
CP0931276
|
N-5-cyano-2-(4-(2,4-difluorophenoxy)piperiddin-1-yl)phenyl)-1-methyl-1H-1,2,3-triazole-4-carboxamide
Show/Hide
|
C22H20F2N6O2
|
1
|
| 1 |
EC50 = 251.19 nM
|
|
|
|
CP0931301
|
N-(5-cyano-2-(4-(2-fluoro-4-methoxybenzoyl)piperazin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
|
C26H24FN5O4
|
1
|
| 1 |
EC50 = 251.19 nM
|
|
|
|
CP0931303
|
N-(5-cyano-2-(4-((3,5-difluoropyridin-2-yl)oxy)piperidin-1-yl)phenyl)-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
|
C24H21F2N5O3
|
1
|
| 1 |
EC50 = 251.19 nM
|
|
|
|
CP0938779
|
N-(2-(4-(2-chloro-5-methylphenoxy)piperidin-1-yl)-5-cyanopyridin-3-yl)picolinamide
Show/Hide
|
C24H22ClN5O2
|
1
|
| 1 |
EC50 = 251.19 nM
|
|
|
|
CP0946425
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxamide
Show/Hide
|
C25H23F2N5O2
|
1
|
| 1 |
EC50 = 251.19 nM
|
|
|
|
CP0953805
|
N-(5-cyano-2-(4-(2,4-difIuorophenoxy)piperidin-1-yl)phenyl)isothiazole-3-carboxamide
Show/Hide
|
C22H18F2N4O2S
|
1
|
| 1 |
EC50 = 251.19 nM
|
|
|
|
CP0953847
|
N-(5-cyano-2-(4-(3,4-difluorophenoxy)piperidin-1-yl)phenyl)-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
|
C25H22F2N4O3
|
1
|
| 1 |
EC50 = 251.19 nM
|
|
|
|
CP0959718
|
N-(5-cyano-2-(4-(2,4,6-trifluoro-3-methoxybenzyl)piperazin-1-yl)pyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C24H24F3N7O3
|
1
|
| 1 |
EC50 = 251.19 nM
|
|
|
|
CP0961734
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-1-methyl-1H-imidazole-4-carboxamide
Show/Hide
|
C23H21F2N5O2
|
1
|
| 1 |
EC50 = 251.19 nM
|
|
|
|
CP0968415
|
N-(5-cyano-2-(4-(thiophen-2-ylmethyl)piperazin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
|
C23H23N5O2S
|
1
|
| 1 |
EC50 = 251.19 nM
|
|
|
|
CP0968974
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-ethoxynicotinamide
Show/Hide
|
C26H24F2N4O3
|
1
|
| 1 |
EC50 = 251.19 nM
|
|
|
|
CP0969571
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-3-methylpyrazine-2-carboxamide
Show/Hide
|
C24H21F2N5O2
|
1
|
| 1 |
EC50 = 251.19 nM
|
|
|
|
CP0970085
|
N-(5-cyano-2-(4-(4-(difluoromethoxy)benzyl)piperazin-1-yl)pyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C24H25F2N7O3
|
1
|
| 1 |
EC50 = 251.19 nM
|
|
|
|
CP0970136
|
2-(4-(2-fluoro-4-methoxybenzyl)piperazin-1-yl)-N-isopropyl-7-methylpyrido[3,4-b]pyrazin-3-amine
Show/Hide
|
C23H29FN6O
|
1
|
| 1 |
EC50 = 275.6 nM
|
|
|
|
CP0967490
|
(S)-3-(4-(2-fluoro-4-methoxybenzyl)piperazin-1-yl)-7-methyl-N-(tetrahydrofuran-3-yl)pyrido[3,4-b]pyrazin-2-amine
Show/Hide
|
C24H29FN6O2
|
1
|
| 1 |
EC50 = 277.8 nM
|
|
|
|
CP0969089
|
2-(4-(4-(difluoromethoxy)-2-fluorophenoxy)piperidin-1-yl)-N-isopropyl-7-methylpyrido[3,4-b]pyrazin-3-amine
Show/Hide
|
C23H26F3N5O2
|
1
|
| 1 |
EC50 = 309 nM
|
|
|
|
CP0965007
|
(R)-3-(4-(2-fluoro-4-methoxybenzyl)piperazin-1-yl)-7-methyl-N-(tetrahydrofuran-3-yl)pyrido[3,4-b]pyrazin-2-amine
Show/Hide
|
C24H29FN6O2
|
1
|
| 1 |
EC50 = 311.2 nM
|
|
|
|
CP0902914
|
4,5-dichloro-N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl-2-methoxybenzamide
Show/Hide
|
C26H21Cl2F2N3O3
|
1
|
| 1 |
EC50 = 316.23 nM
|
|
|
|
CP0902916
|
N-(5-cyano-2-(4-(2-(trifluoromethoxy)benzyl)piperazin-1-yl)pyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C24H24F3N7O3
|
1
|
| 1 |
EC50 = 316.23 nM
|
|
|
|
CP0905675
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-1-(difluoromethyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
|
C25H20F4N4O3
|
1
|
| 1 |
EC50 = 316.23 nM
|
|
|
|
CP0909909
|
N-(5-cyano-2-(4-(3-fluoro-2-methoxybeozyl)piperazin-1-yl)pyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C24H26FN7O3
|
1
|
| 1 |
EC50 = 316.23 nM
|
|
|
|
CP0931272
|
N-(5-cyano-2-(4-(3-(difluoromethoxy)benzyl)piperazin-1-yl)pyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C24H25F2N7O3
|
1
|
| 1 |
EC50 = 316.23 nM
|
|
|
|
CP0931273
|
N-(5-cyano-2-(4-(5-fluoro-2-methoxybenzyl)piperazin-1-yl)pyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C24H26FN7O3
|
1
|
| 1 |
EC50 = 316.23 nM
|
|
|
|
CP0931274
|
N-(5-cyano-2-(4-(3-cyano-4-fluorobenzyl)piperazin-1-yl)pyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
|
C24H23FN8O2
|
1
|
| 1 |
EC50 = 316.23 nM
|
|
|
|
CP0931284
|
N-(5-cyano-2-(4-((4-fluorophenyl)(methoxy)methyl)piperidin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
|
C27H27FN4O3
|
1
|
| 1 |
EC50 = 316.23 nM
|
|
|
|
CP0931287
|
N-(2-(4-(2-chloro-6-fluorobenzyl)piperazin-1-yl)-5-cyanophenyl)-2-methoxynicotinamide
Show/Hide
|
C25H23ClFN5O2
|
1
|
| 1 |
EC50 = 316.23 nM
|
|
|
|
CP0946424
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-5-methylpyrazine-2-carboxamide
Show/Hide
|
C24H21F2N5O2
|
1
|
| 1 |
EC50 = 316.23 nM
|
|
|
|
CP0953806
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-5-fluoropicolinamide
Show/Hide
|
C24H19F3N4O2
|
1
|
| 1 |
EC50 = 316.23 nM
|
|
|
|
CP0953830
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-hydroxybenzamide
Show/Hide
|
C25H21F2N3O3
|
1
|
| 1 |
EC50 = 316.23 nM
|
|
|
|
CP0953833
|
N-(5-cyano-2-(4-(2,3-difluorobenzyl)piperazin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
|
C25H23F2N5O2
|
1
|
| 1 |
EC50 = 316.23 nM
|
|
|
|
CP0961728
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-1,4,6-trimethyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
|
C27H26F2N4O3
|
1
|
| 1 |
EC50 = 316.23 nM
|
|
|
|
CP0961733
|
N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl-3,5-difluoropicolinamide
Show/Hide
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C24H18F4N4O2
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1
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| 1 |
EC50 = 316.23 nM
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CP0961737
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N-(5-cyano-2-(4-((3,5-difluoropyridin-2-yl)methyl)piperazin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
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C24H22F2N6O2
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1
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| 1 |
EC50 = 316.23 nM
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CP0962508
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N-(2-(4-(4-fluorobenzyl)piperazin-1-yl)-6-methylpyridin-3-yl)-5-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
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C23H27FN6O2
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1
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| 1 |
EC50 = 316.23 nM
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CP0963441
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N-(5-cyano-2-(4-(4,5-difluoro-2-methoxybenzyl)piperazin-1-yl)pyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
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C24H25F2N7O3
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1
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| 1 |
EC50 = 316.23 nM
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CP0963449
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N-(5-cyano-2-(4-(thiophen-3-ylmethyl)piperazin-1-yl)phenyl)-2-methoxynicotinamide
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C23H23N5O2S
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1
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| 1 |
EC50 = 316.23 nM
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CP0969088
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(S)-2-(4-(2,4-difluorobenzyl)piperazin-1-yl)-7-methyl-N-(tetrahydrofuran-3-yl)pyrido[3,4-b]pyrazin-3-amine
Show/Hide
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C23H26F2N6O
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1
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| 1 |
EC50 = 326 nM
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CP0866392
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5-bromo-N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxybenzamide
Show/Hide
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C26H22BrF2N3O3
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1
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| 1 |
EC50 = 398.11 nM
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CP0902913
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2,3-dimethyl-5-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxamide
Show/Hide
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C27H23F2N5O3S
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1
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| 1 |
EC50 = 398.11 nM
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CP0902919
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N-(5-cyano-2-(4-(3-methoxybenzyl)piperazin-1-yl)pyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
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C24H27N7O3
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1
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| 1 |
EC50 = 398.11 nM
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CP0902920
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N-(5-cyano-2-(4-(4-cyanobenzyl)piperazin-1-yl)pyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
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C24H24N8O2
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1
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| 1 |
EC50 = 398.11 nM
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CP0903867
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N-(5-cyano-2-(4-(3-fluorophenoxy)piperidin-1-yl)phenyl)-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
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C25H23FN4O3
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1
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| 1 |
EC50 = 398.11 nM
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CP0909908
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N-(5-cyano-2-(4-(3,5-difluorobenzyl)piperazin-1-yl)pyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
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C23H23F2N7O2
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1
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| 1 |
EC50 = 398.11 nM
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CP0909916
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N-(5-cyano-2-(4-(2,4-difIuorophenoxy)piperidin-1-yl)phenyl)-5-ethylisoxazole-3-carboxamide
Show/Hide
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C24H22F2N4O3
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1
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| 1 |
EC50 = 398.11 nM
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CP0909920
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyridin-3-yl)-4-hydroxynicotinamide
Show/Hide
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C23H19F2N5O3
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1
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| 1 |
EC50 = 398.11 nM
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CP0931268
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-methyl-2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide
Show/Hide
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C29H28F2N4O3
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1
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| 1 |
EC50 = 398.11 nM
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CP0938771
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-6-isopropyl-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
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C28H28F2N4O3
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1
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| 1 |
EC50 = 398.11 nM
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CP0938777
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)thiazole-4-carboxamide
Show/Hide
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C22H18F2N4O2S
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1
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| 1 |
EC50 = 398.11 nM
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CP0938778
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N-(5-cyano-2-(4-((2,5-difluorophenyl)difluoromethyl)piperidin-1-yl)phenyl)-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
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C26H22F4N4O2
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1
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| 1 |
EC50 = 398.11 nM
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CP0938783
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-5-methylisoxazole-3-carboxamide
Show/Hide
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C23H20F2N4O3
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1
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| 1 |
EC50 = 398.11 nM
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CP0959639
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N-(5-cyano-2-(4-((3-methoxyphenyl)sulfonyl)piperidin-1-yl)phenyl)-3-methoxy-1-methyl-1H-pyrazoIe-4-carboxamide
Show/Hide
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C25H27N5O5S
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1
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| 1 |
EC50 = 398.11 nM
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CP0960253
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N-(2-cyano-5-(4-(3,4,5-trifluorobenzyl)piperazin-1-yl)pyridin-4-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
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C23H22F3N7O2
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1
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| 1 |
EC50 = 398.11 nM
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CP0960260
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-3,4-difluoro-2-methoxybenzamide
Show/Hide
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C26H21F4N3O3
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1
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| 1 |
EC50 = 398.11 nM
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CP0960264
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N-(2-(4-benzoylpiperidin-1-yl)-5-cyanophenyl)-2-methoxynicotinamide
Show/Hide
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C26H24N4O3
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1
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| 1 |
EC50 = 398.11 nM
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CP0961721
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4-(tert-butyl)-N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxybenzamide
Show/Hide
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C30H31F2N3O3
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1
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| 1 |
EC50 = 398.11 nM
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CP0961725
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-4-(dimethylamino)-2-methoxybenzamide
Show/Hide
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C28H28F2N4O3
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1
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| 1 |
EC50 = 398.11 nM
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CP0961727
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-1-isopropyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
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C27H26F2N4O3
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1
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| 1 |
EC50 = 398.11 nM
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CP0961735
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4-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(2-methoxynicotinamido)-N,N-dimethylpyrimidine-2-carboxamide
Show/Hide
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C25H26F2N6O4
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1
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| 1 |
EC50 = 398.11 nM
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CP0962504
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N-(5-cyano-2-(4-(2,6-difluorobenzyl)piperazin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
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C25H23F2N5O2
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1
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| 1 |
EC50 = 398.11 nM
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CP0962505
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxy-3-methylbenzamide
Show/Hide
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C27H25F2N3O3
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1
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| 1 |
EC50 = 398.11 nM
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CP0962507
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N-(5-cyano-2-(4-(3-fIuoro-4-methoxybenzyl)piperazin-1-yl)pyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
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C24H26FN7O3
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1
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| 1 |
EC50 = 398.11 nM
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CP0963446
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N-(5-cyano-2-(4-((3-fIuorophenyl)sulfonyl)piperidin-1-yl)phenyl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
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C24H24FN5O4S
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1
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| 1 |
EC50 = 398.11 nM
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CP0969082
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-3-methoxypicolinamide
Show/Hide
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C25H22F2N4O3
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1
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| 1 |
EC50 = 398.11 nM
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CP0911964
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N-cyclopropyl-3-(4-(4-(difluoromethoxy)-2-fluorobenzyl)piperazin-1-yl)-7-methylpyrido[3,4-b]pyrazin-2-amine
Show/Hide
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C23H25F3N6O
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1
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| 1 |
EC50 = 446.3 nM
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CP0964625
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3-(4-(4-(difluoromethoxy)-2-fluorobenzyl)piperazin-1-yl)-N-isopropyl-7-methylpyrido[3,4-b]pyrazin-2-amine
Show/Hide
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C23H27F3N6O
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1
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| 1 |
EC50 = 466.2 nM
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CP0902934
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N-(4-(4-(2,4-difluorophenoxy)piperidin-1-yl)-2-methoxypyrimidin-5-yl)-2-methoxy-6-methylnicotinamide
Show/Hide
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C24H25F2N5O4
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1
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| 1 |
EC50 = 501.19 nM
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CP0909917
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)isoxazole-3-carboxamide
Show/Hide
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C22H18F2N4O3
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1
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| 1 |
EC50 = 501.19 nM
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CP0930969
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxy-5-(trifluoromethoxy)benzamide
Show/Hide
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C27H22F5N3O4
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1
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| 1 |
EC50 = 501.19 nM
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CP0930971
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-1-ethyl-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
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C28H28F2N4O3
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1
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| 1 |
EC50 = 501.19 nM
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CP0931285
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N-(2-(4-((5-chIoro-2-fluorophenyl)difluoromethyl)piperidin-1-yl)-5-cyanophenyl)-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
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C26H22ClF3N4O2
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1
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| 1 |
EC50 = 501.19 nM
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CP0946423
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N-(5-cyano-2-(4-(4-fluoro-2-methoxybenzyl)piperazin-1-yl)pyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
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C24H26FN7O3
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1
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| 1 |
EC50 = 501.19 nM
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CP0953839
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N-(5-cyano-2-(4-(5-cyano-2-fluorobenzyl)piperidin-1-yl)pyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
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C24H23FN8O2
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1
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| 1 |
EC50 = 501.19 nM
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CP0953844
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-6,7-dihvdro-5H-pyrazolo[5,1-b][1,3]oxazine-3-carboxamide
Show/Hide
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C25H23F2N5O3
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1
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| 1 |
EC50 = 501.19 nM
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CP0956613
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N-(5-cyano-2-(4-(2,6-difluorophenoxy)piperidin-1-yl)phenyl)-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
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C25H22F2N4O3
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1
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| 1 |
EC50 = 501.19 nM
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CP0960262
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N-(5-cyano-2-(4-(2,4-difluorobenzoyl)piperazin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
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C25H21F2N5O3
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1
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| 1 |
EC50 = 501.19 nM
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CP0960263
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxy-4,6-dimethylnicotinamide
Show/Hide
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C27H26F2N4O3
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1
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| 1 |
EC50 = 501.19 nM
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CP0961719
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-4-methoxy-1-phenyl-1H-pyrazole-3-carboxamide
Show/Hide
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C29H25F2N5O3
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1
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| 1 |
EC50 = 501.19 nM
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CP0961723
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxy-4-(trifluoromethyl)benzamide
Show/Hide
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C27H22F5N3O3
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1
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| 1 |
EC50 = 501.19 nM
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CP0961724
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2,3-difluoro-6-methoxybenzamide
Show/Hide
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C26H21F4N3O3
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1
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| 1 |
EC50 = 501.19 nM
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CP0961726
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5-bromo-N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-1-isopropyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
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C27H25BrF2N4O3
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1
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| 1 |
EC50 = 501.19 nM
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CP0961729
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N-(5-cyano-2-(4-(2,4-difIuorophenoxy)piperidin-1-yl)phenyl)pyridazine-3-carboxamide
Show/Hide
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C23H19F2N5O2
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1
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| 1 |
EC50 = 501.19 nM
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CP0963442
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N-(5-cyano-2-(4-(4-fIuoro-3-methoxybenzyl)piperazin-1-yl)pyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
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C24H26FN7O3
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1
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| 1 |
EC50 = 501.19 nM
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CP0969564
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2,5-dimethyloxazole-4-carboxamide
Show/Hide
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C24H22F2N4O3
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1
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| 1 |
EC50 = 501.19 nM
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CP0969568
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N-(5-cyano-2-(4-((5-fluoropyridin-2-yl)methyl)piperazin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
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C24H23FN6O2
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1
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| 1 |
EC50 = 501.19 nM
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CP0903875
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N-(4-(4-(4-cyano-2-fluorophenoxy)piperidin-1-yl)-6-methylpyridin-3-yl)-2-methoxynicotinamide
Show/Hide
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C25H24FN5O3
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1
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| 1 |
EC50 = 630.96 nM
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CP0953845
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)pyrazine-2-carboxamide
Show/Hide
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C23H19F2N5O2
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1
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| 1 |
EC50 = 630.96 nM
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CP0961159
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-1-methyl-1H-imidazole-2-carboxamide
Show/Hide
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C23H21F2N5O2
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1
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| 1 |
EC50 = 630.96 nM
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CP0961161
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-1,6-dimethyl-4-oxo-1,4-dihydropyridine-3-carboxamide
Show/Hide
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C26H24F2N4O3
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1
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| 1 |
EC50 = 630.96 nM
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CP0962506
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1-butyl-N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
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C28H28F2N4O3
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1
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| 1 |
EC50 = 630.96 nM
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CP0962511
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-6-hydroxypyridazine-3-carboxamide
Show/Hide
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C23H19F2N5O3
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1
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| 1 |
EC50 = 630.96 nM
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CP0969563
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N-(4-(4-(2,4-difluorophenoxy)piperidin-1-yl)-6-methylpyridin-3-yl)-5-methoxypyrazine-2-carboxamide
Show/Hide
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C23H23F2N5O3
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1
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| 1 |
EC50 = 630.96 nM
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CP0969757
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N-(2-(4-(4-fluoro-2-methylbenzoyl)piperazin-1-yl)-5-(methylsulfonyl)phenyl)-2-methoxynicotinamide
Show/Hide
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C26H27FN4O5S
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1
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| 1 |
EC50 = 630.96 nM
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CP0969820
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N-(5-cyano-2-(4-((4-fluorophenyl)sulfonyl)piperazin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
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C24H22FN5O4S
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1
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| 1 |
EC50 = 630.96 nM
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CP0902911
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5-(tert-butyl)-N-(5-cyano-2-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxybenzamide
Show/Hide
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C30H31F2N3O3
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1
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| 1 |
EC50 = 794.33 nM
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CP0902927
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-3,5-dimethylpyrazine-2-carboxamide
Show/Hide
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C25H23F2N5O2
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1
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| 1 |
EC50 = 794.33 nM
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CP0909915
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)oxazole-4-carboxamide
Show/Hide
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C22H18F2N4O3
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1
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| 1 |
EC50 = 794.33 nM
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CP0938772
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N-(5-cyano-2-(4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)pyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
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C24H24F3N7O3
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1
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| 1 |
EC50 = 794.33 nM
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CP0946426
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N-(2-(4-(4-cyano-3-fluorobenzyl)piperazin-1-yl)-5-methylpyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
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C24H26FN7O2
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1
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| 1 |
EC50 = 794.33 nM
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CP0963443
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N-(5-cyano-2-(4-(2,4-difIuorophenoxy)piperidin-1-yl)phenyl)-5-methyloxazole-4-carboxamide
Show/Hide
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C23H20F2N4O3
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1
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| 1 |
EC50 = 794.33 nM
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CP0968414
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N-(4-(4-((2,4-difluorophenyl)sulfonyl)piperidin-1-yl)-6-methylpyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
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C23H25F2N5O4S
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1
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| 1 |
EC50 = 794.33 nM
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CP0968685
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N-(5-cyano-2-(4-(2,3-difluorophenoxy)piperidin-1-yl)phenyl)-1-methyl-2-oxo-1,2-dihvdropyridine-3-carboxamide
Show/Hide
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C25H22F2N4O3
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1
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| 1 |
EC50 = 794.33 nM
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CP0969508
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methyloxazole-4-carboxamide
Show/Hide
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C23H20F2N4O3
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1
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| 1 |
EC50 = 794.33 nM
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CP0931302
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N-(5-cyano-2-(4-(1-(4-fluorophenyl)ethyl)piperazin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
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C26H26FN5O2
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1
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| 1 |
EC50 = 1000 nM
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CP0960257
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N-(5-cyano-2-(4-((5-methoxypyridin-2-yl)methyl)piperazin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
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C25H26N6O3
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1
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| 1 |
EC50 = 1000 nM
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CP0961722
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2,5-dimethoxybenzamide
Show/Hide
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C27H25F2N3O4
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1
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| 1 |
EC50 = 1000 nM
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CP0969562
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N-(5-cyano-2-(4-(3-fluoro-5-methoxybenzyl)piperazin-1-yl)pyridin-3-yl)-3-methoxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
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C24H26FN7O3
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1
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| 1 |
EC50 = 1000 nM
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CP0969753
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N-(5-cyano-2-(4-(thiazol-4-yl)methyl)piperazin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
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C22H22N6O2S
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1
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| 1 |
EC50 = 1000 nM
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CP0569266
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N-cyclopropyl-3-[4-[(2,5-dichlorophenyl)methyl]piperazin-1-yl]-7-fluoroquinoxalin-2-amine
Show/Hide
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C22H22Cl2FN5
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1
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| 1 |
EC50 = 1200 nM
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CP0909905
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N-(5-cyano-2-(4-(2-methoxybenzyl)piperazin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
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C26H27N5O3
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1
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| 1 |
EC50 = 1258.93 nM
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CP0909906
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5-chloro-N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-metlhoxy-3-methylbenzamide
Show/Hide
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C27H24ClF2N3O3
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1
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| 1 |
EC50 = 1258.93 nM
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CP0931265
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-1-(3-methoxypropyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
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C28H28F2N4O4
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1
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| 1 |
EC50 = 1258.93 nM
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CP0931269
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-1-methyl-6-oxo-2-phenyl-1,6-dihydropyrimidine-5-carboxamide
Show/Hide
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C30H25F2N5O3
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1
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| 1 |
EC50 = 1258.93 nM
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CP0938768
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5-chloro-N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
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C25H21ClF2N4O3
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1
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| 1 |
EC50 = 1258.93 nM
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CP0961730
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-1,2,3-thiadiazole-4-carboxamide
Show/Hide
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C21H17F2N5O2S
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1
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| 1 |
EC50 = 1258.93 nM
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CP0969756
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5-fluoro-N-(2-(4-(4-fluorobenzyl)piperazin-1-yl)-6-methylpyridin-3-yl)-2-hydroxynicotinamide
Show/Hide
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C23H23F2N5O2
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1
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| 1 |
EC50 = 1258.93 nM
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CP0909914
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-1,2,5-thiadiazole-3-carboxamide
Show/Hide
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C21H17F2N5O2S
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1
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| 1 |
EC50 = 1584.89 nM
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CP0930970
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1-benzyl-N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-5-methoxy-1H-1,2,3-triazole-4-carboxamide
Show/Hide
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C29H26F2N6O3
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1
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| 1 |
EC50 = 1584.89 nM
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CP0938770
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-3,6-difluoro-2-methoxybenzamide
Show/Hide
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C26H21F4N3O3
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1
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| 1 |
EC50 = 1584.89 nM
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CP0938774
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N-(7-(4-(2,4-difluorophenoxy)piperidin-1-yl)-2-methyl-2H-indazol-6-yl)picolinamide
Show/Hide
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C25H23F2N5O2
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1
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| 1 |
EC50 = 1584.89 nM
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CP0961718
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxy-6-methylbenzamide
Show/Hide
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C27H25F2N3O3
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1
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| 1 |
EC50 = 1584.89 nM
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CP0969575
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-1-cyclohexyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
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C30H30F2N4O3
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1
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| 1 |
EC50 = 1584.89 nM
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CP0902923
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-5-methyl-1,2,4-oxadiazole-3-carboxamide
Show/Hide
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C22H19F2N5O3
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1
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| 1 |
EC50 = 1995.26 nM
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CP0931270
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1-benzyl-N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
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C31H26F2N4O3
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1
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| 1 |
EC50 = 1995.26 nM
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CP0968684
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N-(5-cyano-2-(4-(3,5-difluorophenoxy)piperidin-1-yl)phenyl)-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
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C25H22F2N4O3
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1
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| 1 |
EC50 = 1995.26 nM
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CP0551154
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N-cyclopropyl-3-[4-[(2,5-dichlorophenyl)methyl]piperazin-1-yl]quinoxalin-2-amine
Show/Hide
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C22H23Cl2N5
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1
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| 1 |
EC50 = 2100 nM
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CP0953841
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-5-methyl-1,3,4-oxadiazole-2-carboxamide
Show/Hide
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C22H19F2N5O3
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1
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| 1 |
EC50 = 2511.89 nM
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CP0956609
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4-chloro-N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxynicotinamide
Show/Hide
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C25H21ClF2N4O3
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1
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| 1 |
EC50 = 2511.89 nM
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CP0970084
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-oxo-1-(pyridin-2-ylmethyl)-1,2-dihydropyridine-3-carboxamide
Show/Hide
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C30H25F2N5O3
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1
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| 1 |
EC50 = 2511.89 nM
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CP0903870
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-5-cyclopropyloxazole-4-carboxamide
Show/Hide
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C25H22F2N4O3
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1
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| 1 |
EC50 = 3162.28 nM
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CP0938766
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxy-5-morpholinobenzamide
Show/Hide
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C30H30F2N4O4
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1
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| 1 |
EC50 = 3162.28 nM
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CP0946544
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxy-3,6-dimethylbenzamide
Show/Hide
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C28H27F2N3O3
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1
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| 1 |
EC50 = 3162.28 nM
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CP0573288
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N-cyclopropyl-3-[4-[(2,5-dichlorophenyl)methyl]piperazin-1-yl]-7-methoxyquinoxalin-2-amine
Show/Hide
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C23H25Cl2N5O
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1
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| 1 |
EC50 = 4100 nM
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CP0903865
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N-(2-(4-(4-chlorobenzoyl)piperazin-1-yl)phenyl)pyrimidine-4-carboxamide
Show/Hide
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C22H20ClN5O2
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1
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| 1 |
EC50 = 5011.87 nM
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CP0556509
|
US10000468, Example 18
Show/Hide
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C26H34F3N7O
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1
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| 1 |
EC50 = 6800 nM
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CP0953836
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3,6-dichloro-N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxybenzamide
Show/Hide
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C26H21Cl2F2N3O3
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1
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| 1 |
EC50 = 7943.28 nM
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CP0961717
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2,6-dimethoxybenzamide
Show/Hide
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C27H25F2N3O4
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1
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| 1 |
EC50 = 10000 nM
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CP0902912
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-1-(2-(dimethylamino)-2-oxoethyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Show/Hide
|
C28H27F2N5O4
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1
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| 1 |
EC50 = 12589.25 nM
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CP0938761
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N-(2-(4-(4-chlorobenzoyl)piperazin-1-yl)phenyl)pyrimidine-2-carboxamide
Show/Hide
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C22H20ClN5O2
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1
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| 1 |
EC50 = 12589.25 nM
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CP0969752
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N-(2-(4-(4-chlorobenzoyl)piperazin-1-yl)phenyl)-2-hydroxy-N-methylbenzamide
Show/Hide
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C25H24ClN3O3
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1
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| 1 |
EC50 = 12589.25 nM
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CP0557572
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6-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(isopropylamino)-3-(methoxy methyl)pyrazine-2-carbonitrile
Show/Hide
|
C21H25F2N5O2
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1
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| 1 |
EC50 = 13700 nM
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CP0551153
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N-cyclopropyl-3-[4-[(3-methylphenyl)methyl]piperazin-1-yl]quinoxalin-2-amine
Show/Hide
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C23H27N5
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1
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| 1 |
EC50 = 14000 nM
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CP0569265
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N-cyclopropyl-3-[4-[(2,5-dichlorophenyl)methyl]piperazin-1-yl]-7-methylquinoxalin-2-amine
Show/Hide
|
C23H25Cl2N5
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1
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| 1 |
EC50 = 16000 nM
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CP0483157
|
US10000468, Example 31
Show/Hide
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C20H22F3N5
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1
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| 1 |
EC50 = 18000 nM
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CP0543676
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3-[4-[(2,4-difluorophenyl)methyl]piperazin-1-yl]-N-propan-2-ylpyrido[3,4-b]pyrazin-2-amine
Show/Hide
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C21H24F2N6
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1
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| 1 |
EC50 = 21000 nM
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CP0867799
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5-(4-(5-chloro-2-fluorobenzoyl)piperidin-1-yl)-3-cyano-6-(isopropylamino)-N,N-dimethylpyrazine-2-carboxamide
Show/Hide
|
C22H26ClFN6O2
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1
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| 1 |
EC50 = 23000 nM
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CP0557571
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6-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(isopropylamino)-3-morpholinopyrazine-2-carbonitrile
Show/Hide
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C23H28F2N6O2
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1
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| 1 |
EC50 = 23500 nM
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CP0571150
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1-[2-[4-[(2,4-difluorophenyl)methyl]piperazin-1-yl]-3-(propan-2-ylamino)-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone
Show/Hide
|
C23H28F2N6O
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1
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| 1 |
EC50 = 27000 nM
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CP0576319
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2-[4-[(2,4-difluorophenyl)methyl]piperazin-1-yl]-6-methylsulfonyl-N-propan-2-yl-5H-pyrido[3,4-b]pyrazin-3-amine
Show/Hide
|
C22H28F2N6O2S
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1
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| 1 |
EC50 = 27000 nM
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CP0542589
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3-[4-[(5-chloro-2-fluorophenyl)methyl]piperazin-1-yl]-N-cyclopropylpyrido[3,4-b]pyrazin-2-amine
Show/Hide
|
C21H22ClFN6
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1
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| 1 |
EC50 = 29000 nM
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CP0575890
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N-cyclopropyl-3-[4-[(2,4-difluorophenyl)methyl]piperazin-1-yl]-7-methylpyrido[3,4-b]pyrazin-2-amine
Show/Hide
|
C22H24F2N6
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1
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| 1 |
EC50 = 29000 nM
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CP0578198
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N-cyclopropyl-3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-7-methylpyrido[3,4-b]pyrazin-2-amine
Show/Hide
|
C22H23F2N5O
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1
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| 1 |
EC50 = 29000 nM
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CP0577989
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1-[2-[4-[(2,4-difluorophenyl)methyl]piperazin-1-yl]-3-(propan-2-ylamino)-5H-pyrido[3,4-b]pyrazin-6-yl]propan-1-one
Show/Hide
|
C24H30F2N6O
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1
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| 1 |
EC50 = 30000 nM
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CP0416925
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(S)-5-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-6-(isopropylamino)pyrazine-2-carbonitrile
Show/Hide
|
C20H22F3N5
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1
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| 1 |
EC50 = 30200 nM
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CP0556612
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(S)-6-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-5-(isopropylamino)-N-methylpyrazine-2-carboxamide
Show/Hide
|
C21H26F3N5O
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1
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| 1 |
EC50 = 30200 nM
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CP0909912
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-1,2,5-oxadiazole-3-carboxamide
Show/Hide
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C21H17F2N5O3
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1
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| 1 |
EC50 > 31622.78 nM
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CP0931278
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-4-methoxypyrimidine-2-carboxamide
Show/Hide
|
C24H21F2N5O3
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1
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| 1 |
EC50 > 31622.78 nM
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CP0953835
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3-chloro-N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2,6-dimethoxybenzamide
Show/Hide
|
C27H24ClF2N3O4
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1
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| 1 |
EC50 > 31622.78 nM
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CP0960259
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3,5-dichloro-N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-2-methoxybenzamide
Show/Hide
|
C26H21Cl2F2N3O3
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1
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| 1 |
EC50 > 31622.78 nM
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CP0970082
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1-(2-chlorobenzyl)-N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-5-methoxy-1H-1,2,3-triazole-4-carboxamide
Show/Hide
|
C29H25ClF2N6O3
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1
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| 1 |
EC50 > 31622.78 nM
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CP0416924
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5-(4-(4-chloro-2-fluorophenoxy)piperidin-1-yl)-6-(isopropylamino)pyrazine-2,3-dicarbonitrile
Show/Hide
|
C20H20ClFN6O
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1
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| 1 |
EC50 = 32700 nM
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|
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CP0542590
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1-[2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-3-(propan-2-ylamino)-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone
Show/Hide
|
C23H27F2N5O2
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1
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| 1 |
EC50 = 34000 nM
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CP0579676
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1-[2-(cyclopropylamino)-3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone
Show/Hide
|
C23H25F2N5O2
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1
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| 1 |
EC50 = 34000 nM
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CP0568433
|
US10000468, Example 15
Show/Hide
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C22H26F2N6O2
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1
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| 1 |
EC50 = 36900 nM
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CP0231638
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1-[2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-3-[[(3R)-oxolan-3-yl]amino]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone
Show/Hide
|
C24H29F2N5O3
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1
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| 1 |
EC50 = 38000 nM
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CP0909990
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3-cyano-6-(cyclopropylamino)-5-(4-(2,4-difluorobenzyl)piperazin-1-yl)-N,N-dimethylpyraZine-2-carboxamide
Show/Hide
|
C21H23F2N7O2
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1
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| 1 |
EC50 = 38700 nM
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CP0353832
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N-cyclopropyl-3-[4-[(2,4-difluorophenyl)methyl]piperazin-1-yl]pyrido[3,4-b]pyrazin-2-amine
Show/Hide
|
C21H22F2N6
|
1
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| 1 |
EC50 = 39000 nM
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CP0344351
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1-[3-(cyclopropylamino)-2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone
Show/Hide
|
C23H25F2N5O2
|
1
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| 1 |
EC50 = 43000 nM
|
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CP0528132
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N-cyclopropyl-5-[4-[(3-methylphenyl)methyl]piperazin-1-yl]-[1,2,5]oxadiazolo[3,4-b]pyrazin-6-amine
Show/Hide
|
C19H23N7O
|
1
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| 1 |
EC50 = 43000 nM
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CP0556614
|
US10000468, Example 24
Show/Hide
|
C22H26F3N5O2
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1
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| 1 |
EC50 = 48200 nM
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CP0544617
|
5-(4-(4-chloro-2-fluorophenoxy)piperidin-1-yl)-3-cyano-6-(isopropylamino)-N,N-dimethylpyrazine-2-carboxamide
Show/Hide
|
C22H26ClFN6O2
|
1
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| 1 |
EC50 = 49300 nM
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CP0564732
|
(R)-6-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-5-(isopropylamino)-N-methylpyrazine-2-carboxamide
Show/Hide
|
C21H26F3N5O
|
1
|
| 1 |
EC50 = 50300 nM
|
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CP0556611
|
US10000468, Example 19
Show/Hide
|
C21H27F2N5O2
|
1
|
| 1 |
EC50 = 50500 nM
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CP0488736
|
3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-2-(propan-2-ylamino)pyrido[3,4-b]pyrazine-7-carbonitrile
Show/Hide
|
C22H22F2N6O
|
1
|
| 1 |
EC50 = 55000 nM
|
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CP0958665
|
6-(4-(2,4-difluorobenzyl)piperazin-1-yl)-3-((2-(dimethylamino)ethoxy)methyl)-5-(isopropylamino)pyrazine-2-carbonitrile
Show/Hide
|
C24H32F2N6O2
|
1
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| 1 |
EC50 = 62500 nM
|
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CP0572074
|
2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-6-methylsulfonyl-N-propan-2-yl-5H-pyrido[3,4-b]pyrazin-3-amine
Show/Hide
|
C22H27F2N5O3S
|
1
|
| 1 |
EC50 = 65000 nM
|
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CP0420695
|
US10000468, Example 26
Show/Hide
|
C20H20F3N5
|
1
|
| 1 |
EC50 = 72300 nM
|
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CP0544618
|
5-(4-(2,4-difluorophenoxy)piperidin-1-yl)-6-(isopropylamino)pyrazine-2-carbonitrile
Show/Hide
|
C19H21F2N5O
|
1
|
| 1 |
EC50 = 77000 nM
|
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CP0577990
|
2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-6-methyl-N-propan-2-yl-5H-pyrido[3,4-b]pyrazin-3-amine
Show/Hide
|
C22H27F2N5O
|
1
|
| 1 |
EC50 = 89000 nM
|
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CP0578200
|
1-[3-[4-(2,4-difluorophenoxy)piperidin-1-yl]-2-(propan-2-ylamino)-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone
Show/Hide
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C23H27F2N5O2
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1
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| 1 |
EC50 = 96000 nM
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CP0579677
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2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-N-propan-2-yl-5,6-dihydropyrido[3,4-b]pyrazin-3-amine
Show/Hide
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C21H25F2N5O
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1
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| 1 |
EC50 = 100000 nM
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CP0887614
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(R)-3-(4-(4-(difluoromethoxy)-2-fluorobenzyl)piperazin-1-yl)-7-methyl-N-(tetrahydrofuran-3-yl)pyrido[3,4-b]pyrazin-2-amine
Show/Hide
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C24H27F3N6O2
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1
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| 1 |
EC50 > 1000 nM
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CP0887617
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(R)-2-(4-(2-fluoro-4-methoxybenzyl)piperazin-1-yl)-7-methyl-N-(tetrahydrofuran-3-yl)pyrido[3,4-b]pyrazin-3-amine
Show/Hide
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C24H29FN6O2
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1
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| 1 |
EC50 > 1000 nM
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CP0887618
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(S)-2-(4-(2-fluoro-4-methoxybenzyl)piperazin-1-yl)-7-methyl-N-(tetrahydrofuran-3-yl)pyrido[3,4-b]pyrazin-3-amine
Show/Hide
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C24H29FN6O2
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1
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| 1 |
EC50 > 1000 nM
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CP0911966
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N-cyclopropyl-2-(4-(4-(difluoromethoxy)-2-fluorophenoxy)piperidin-1-yl)-7-methylpyrido[3,4-b]pyrazin-3-amine
Show/Hide
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C23H24F3N5O2
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1
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| 1 |
EC50 > 1000 nM
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CP0943699
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2-(4-(4-(difluoromethoxy)-2-fluorobenzyl)piperazin-1-yl)-N-isopropyl-7-methylpyrido[3,4-b]pyrazin-3-amine
Show/Hide
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C23H27F3N6O
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1
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| 1 |
EC50 > 1000 nM
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CP0956054
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(R)-2-(4-(4-(difluoromethoxy)-2-fluorobenzyl)piperazin-1-yl)-7-methyl-N-(tetrahydrofuran-3-yl)pyrido[3,4-b]pyrazin-3-amine
Show/Hide
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C24H27F3N6O2
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1
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| 1 |
EC50 > 1000 nM
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CP0958684
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(S)-3-(4-(4-(difluoromethoxy)-2-fluorobenzyl)piperazin-1-yl)-7-methyl-N-(tetrahydrofuran-3-yl)pyrido[3,4-b]pyrazin-2-amine
Show/Hide
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C24H27F3N6O2
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1
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| 1 |
EC50 > 1000 nM
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CP0964626
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(R)-2-(4-(4-(difluoromethoxy)-2-fluorophenoxy)piperidin-1-yl)-7-methyl-N-(tetrahydrofuran-3-yl)pyrido[3,4-b]pyrazin-3-amine
Show/Hide
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C24H26F3N5O3
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1
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| 1 |
EC50 > 1000 nM
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CP0964627
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N-cyclopropyl-2-(4-(4-(difluoromethoxy)-2-fluorobenzyl)piperazin-1-yl)-7-methylpyrido[3,4-b]pyrazin-3-amine
Show/Hide
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C23H25F3N6O
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1
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| 1 |
EC50 > 1000 nM
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CP0967491
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(S)-2-(4-(4-(difluoromethoxy)-2-fluorobenzyl)piperazin-1-yl)-7-methyl-N-(tetrahydrofuran-3-yl)pyrido[3,4-b]pyrazin-3-amine
Show/Hide
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C24H27F3N6O2
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1
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| 1 |
EC50 > 1000 nM
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CP0970132
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N-cyclopropyl-2-(4-(2-fluoro-4-methoxybenzyl)piperazin-1-yl)-7-methylpyrido[3,4-b]pyrazin-3-amine
Show/Hide
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C23H27FN6O
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1
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| 1 |
EC50 > 1000 nM
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CP0970386
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(S)-2-(4-(4-(difluoromethoxy)-2-fluorophenoxy)piperidin-1-yl)-7-methyl-N-(tetrahydrofuran-3-yl)pyrido[3,4-b]pyrazin-3-amine
Show/Hide
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C24H26F3N5O3
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1
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| 1 |
EC50 > 1000 nM
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CP0902929
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-3-methoxypyrazine-2-carboxamide
Show/Hide
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C24H21F2N5O3
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1
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| 1 |
EC50 > 1995.26 nM
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CP0931275
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N-(5-(4-(2,4-difluorophenoxy)piperidin-1-yl)quinoxalin-6-yl)picolinamide
Show/Hide
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C25H21F2N5O2
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1
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| 1 |
EC50 > 1995.26 nM
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CP0931283
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N-(2-(4-(4-fluorobenzyl)piperazin-1-yl)-6-methylpyridin-3-yl)-5-hydroxy-1-methyl-1H-pyrazole-4-carboxamide
Show/Hide
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C22H25FN6O2
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1
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| 1 |
EC50 > 1995.26 nM
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CP0956612
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N-(7-(4-(2,4-difluorophenoxy)piperidin-1-yl)-1-methyl-1H-indazol-6-yl)picolinamide
Show/Hide
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C25H23F2N5O2
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1
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| 1 |
EC50 > 1995.26 nM
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CP0968967
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N-(5-cyano-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)phenyl)-4-methyl-1,2,5-oxadiazole-3-carboxamide
Show/Hide
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C22H19F2N5O3
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1
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| 1 |
EC50 > 1995.26 nM
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CP0969758
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N-(1-acetyl-7-(4-(2,4-difluorophenoxy)piperidin-1-yl)-1H-indazol-6-yl)picolinamide
Show/Hide
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C26H23F2N5O3
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1
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| 1 |
EC50 > 1995.26 nM
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CP0485489
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US9181249, 86
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C23H29ClFN5O
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1
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| 1 |
IC50 = 0.0137 nM
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CP0438901
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US9181249, 87
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C24H29ClFN5O2
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1
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| 1 |
IC50 = 0.0138 nM
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CP0530376
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US9181249, 83
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C25H34F2N6O2
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1
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| 1 |
IC50 = 0.0138 nM
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CP0559636
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US9181249, 63
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C23H28F3N5O2
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1
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| 1 |
IC50 = 0.0378 nM
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CP0564328
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US9181249, 14
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C26H36F2N6O2
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1
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| 1 |
IC50 = 0.0626 nM
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CP0559637
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US10077266, Example 126
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C24H31F2N5O3
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1
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| 1 |
IC50 = 0.1071 nM
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CP0862838
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N-cyclopropyl-3-(4-(2,4-difluorobenzyl)piperidin-1-yl)-5-methylpyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetate
Show/Hide
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C25H26F5N5O2
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1
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| 1 |
IC50 = 2 nM
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CP0952131
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3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-N-isopropylpyrazino[2,3-d]pyridazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C22H23F5N6O3
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1
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| 1 |
IC50 = 4 nM
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CP0850742
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2-(cyclopropylamino)-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-N,N-dimethylpyrido[3,4-b]pyrazine-7-carboxamide
Show/Hide
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C24H26F2N6O2
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1
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| 1 |
IC50 = 5 nM
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CP0867705
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3-(4-(2-fluoro-4-methoxyphenoxy)pipelidin-1-yl)-N-isopropylpyrazino[2,3-djpyridazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C23H26F4N6O4
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1
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| 1 |
IC50 = 6 nM
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CP0874147
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(S)-(2-(cyclopropylamino)-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)pyrido[4,3-b]pyrazin-5-yl)(morpholino)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C29H30F6N6O4
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1
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| 1 |
IC50 = 6 nM
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CP0918251
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3-(4-(4-chloro-2-fluorophenoxy)piperidin-1-yl)-2-(isopropylamino)-N,N-dimethylpyrido[3,4-b]pyrazine-7-carboxamide 2,2,2-trifluoroacetic acid
Show/Hide
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C26H29ClF4N6O4
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1
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| 1 |
IC50 = 6 nM
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CP0951963
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3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-N-isopropylpyrazino[2,3-d]pyridazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C23H24F6N6O2
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1
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| 1 |
IC50 = 6 nM
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CP0954246
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(R)-N-cyclopropyl-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-7-methylpyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C25H25F6N5O2
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1
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| 1 |
IC50 = 6 nM
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CP0901636
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(R)-(2-(cyclopropylamino)-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)pyrido[3,4-b]pyrazin-5-yl)(morpholino)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C29H30F6N6O4
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1
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| 1 |
IC50 = 7 nM
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CP0911528
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N-cyclopropyl-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-7-methylpyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C25H25F6N5O2
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1
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| 1 |
IC50 = 7 nM
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CP0951001
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3-(4-(4-chloro-2-fluorophenoxy)piperidin-1-yl)-N-isopropylpyrazino[2,3-d]pyridazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C22H23ClF4N6O3
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1
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| 1 |
IC50 = 7 nM
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CP0905655
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(R)-2-(cyclopropylamino)-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-N,N-dimethylpyrido[3,4-b]pyrazine-7-carboxamide 2,2,2-trifluoroacetic acid
Show/Hide
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C27H28F6N6O3
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1
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| 1 |
IC50 = 8 nM
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CP0938738
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3-(4-(2-fluoro-4-(fluoromethoxy)phenoxy)piperidin-1-yl)-N-isopropylpyrazino[2,3-d]pyridazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C23H25F5N6O4
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1
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| 1 |
IC50 = 8 nM
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CP0878894
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N-cyclopropyl-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-5-methylpyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C25H25F6N5O2
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1
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| 1 |
IC50 = 9 nM
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CP0903298
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(S)-2-(cyclopropylamino)-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-N,N-dimethylpyrido[3,4-b]pyrazine-7-carboxamide 2,2,2-trifluoroacetic acid
Show/Hide
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C27H28F6N6O3
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1
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| 1 |
IC50 = 10 nM
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CP0850741
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(S)-2-(cyclopropylamino)-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)pyrido[4,3-b]pyrazine-7-carbonitrile
Show/Hide
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C23H21F3N6
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1
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| 1 |
IC50 = 11 nM
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CP0862839
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(S)-N-cyclopropyl-3-(4-((2,5-difluorophenyl)fluoromethyl)piperidin-1-yl)-7-methylpyrido[3,4-b]pyrazin-2-amine
Show/Hide
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C23H24F3N5
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1
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| 1 |
IC50 = 11 nM
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CP0903300
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3-(4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl)-N-isopropylpyrido[3,4-b]pyrazin-3-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H27F4N5O4
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1
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| 1 |
IC50 = 12 nM
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CP0861430
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N-cyclopropyl-3-(4-(2-fluoro-4-(methylthio)phenoxy)piperidin-1-yl)pyrazino[2,3-d]pyridazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C23H24F4N6O3S
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1
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| 1 |
IC50 = 14 nM
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CP0874154
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(R)-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-N-isopropylpyrazino[2,3-d]pyridazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C23H24F6N6O2
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1
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| 1 |
IC50 = 14 nM
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CP0954418
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N-cyclobutyl-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyrido[3,4-b]pyrazin-3-amine
Show/Hide
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C22H23F2N5O
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1
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| 1 |
IC50 = 14 nM
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CP0848968
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2-(cyclopropylamino)-3-(4-(2,4-difluorobenzyl)piperidin-1-yl)pyrido[3,4-b]pyrazine-7-carbonitrile
Show/Hide
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C23H22F2N6
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1
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| 1 |
IC50 = 15 nM
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CP0949196
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(R)-7-chloro-N-cyclopropyl-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)pyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H22ClF6N5O2
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1
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| 1 |
IC50 = 15 nM
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CP0954795
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3-(4-(2-fluoro-4-methoxybenzyl)piperidin-1-yl)-N-isopropylpyrazino[2,3-d]pyridazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H28F4N6O3
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1
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| 1 |
IC50 = 15 nM
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CP0857809
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N-cyclopropyl-3-(4-((2,4-difluorophenyl)difluoromethyl)piperidin-1-yl)pyrido[3,4-b]pyrazin-2-amine
Show/Hide
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C22H21F4N5
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1
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| 1 |
IC50 = 16 nM
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CP0954211
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3-(4-(3,5-difluorobenzoyl)piperidin-1-yl)-2-(isopropylamino)-N,N-dimethylpyrido[3,4-b]pyrazine-7-carboxamide 2,2,2-trifluoroacetic acid
Show/Hide
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C27H29F5N6O4
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1
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| 1 |
IC50 = 16 nM
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CP0867703
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(R)-2-(cyclopropylamino)-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)pyrido[3,4-b]pyrazine-7-carbonitrile
Show/Hide
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C25H22F6N6O2
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1
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| 1 |
IC50 = 17 nM
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CP0970090
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(R)-2-(cyclopropylamino)-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)pyrido[3,4-b]pyrazine-7-carbonitrile
Show/Hide
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C23H21F3N6
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1
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| 1 |
IC50 = 17 nM
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CP0902217
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N-cyclopropyl-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-methylpyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H24F5N5O3
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1
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| 1 |
IC50 = 18 nM
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CP0961130
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N-cyclopropyl-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyrazino[2,3-d]pyridazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C22H21F5N6O3
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1
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| 1 |
IC50 = 18 nM
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CP0871089
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N-cyclopropyl-3-(4-(2,4-difluorobenzyl)piperidin-1-yl)pyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C25H25F5N4O2
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1
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| 1 |
IC50 = 19 nM
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CP0927580
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N-cyclopropyl-3-(4-(2,4-difluorobenzyl)piperidin-1-yl)pyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid salt
Show/Hide
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C24H24F5N5O2
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1
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| 1 |
IC50 = 19 nM
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CP0871090
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N-cyclopropyl-3-(4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl)pyrazino[2,3-d]pyridazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C23H24F4N6O4
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1
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| 1 |
IC50 = 20 nM
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CP0905662
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N-cyclopropyl-3-(4-(2,4-difluorobenzyl)piperidin-1-yl)-7-methylpyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C25H26F5N5O2
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1
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| 1 |
IC50 = 20 nM
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CP0918250
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N-cyclopropyl-3-(4-((2,5-difluorophenyl)fluoromethyl)piperidin-1-yl)pyrido[3,4-b]pyrazin-2-amine
Show/Hide
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C22H22F3N5
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1
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| 1 |
IC50 = 20 nM
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CP0959577
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2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-N-isopropylpyrido[3,4-b]pyrazin-3-amine
Show/Hide
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C21H23F2N5O
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1
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| 1 |
IC50 = 20 nM
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CP0878898
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3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-N-isopropylpyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C23H24F5N5O3
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1
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| 1 |
IC50 = 21 nM
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CP0909901
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(S)-N-sec-butyl-3-(4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl)pyrazino[2,3-d]pyridazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H28F4N6O4
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1
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| 1 |
IC50 = 21 nM
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CP0959223
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(1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)(2-fluoro-4-methoxyphenyl)methanone 2,2,2-trifluoroacetic acid salt
Show/Hide
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C25H25F4N5O4
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1
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| 1 |
IC50 = 21 nM
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CP0959232
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N-cyclopropyl-3-(4-(2,4-difluorobenzyl)piperazin-1-yl)pyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid salt
Show/Hide
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C23H23F5N6O2
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1
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| 1 |
IC50 = 21 nM
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CP0903274
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(R)-azetidin-1-yl(2-(cyclopropylamino)-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)pyrido[3,4-b]pyrazin-7-yl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C28H28F6N6O3
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1
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| 1 |
IC50 = 22 nM
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CP0931310
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(R)-N-cyclopropyl-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)pyrazino[2,3-d]pyridazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C23H22F6N6O2
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1
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| 1 |
IC50 = 22 nM
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CP0969418
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(R)-azetidin-1-yl(2-(cyclopropylamino)-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)pyrido[3,4-b]pyrazin-7-yl)methanone
Show/Hide
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C26H27F3N6O
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1
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| 1 |
IC50 = 22 nM
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CP0848976
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(S)-azetidin-1-yl(2-(cyclopropylamino)-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)pyrido[3,4-b]pyrazin-7-yl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C28H28F6N6O3
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1
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| 1 |
IC50 = 23 nM
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CP0965083
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(S)-azetidin-1-yl(2-(cyclopropylamino)-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)pyrido[3,4-b]pyrazin-7-yl)methanone
Show/Hide
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C26H27F3N6O
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1
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| 1 |
IC50 = 23 nM
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CP0874143
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(R)-3-(cyclopropylamino)-2-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)pyrido[3,4-b]pyrazine-7-carbonitrile
Show/Hide
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C23H21F3N6
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1
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| 1 |
IC50 = 24 nM
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CP0947499
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2-(cyclopropylamino)-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C26H23F6N5O2
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1
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| 1 |
IC50 = 24 nM
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CP0953975
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(S)-N-cyclopropyl-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)pyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H23F6N5O2
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1
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| 1 |
IC50 = 24 nM
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CP0902205
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3-(4-(2-fluoro-4-methoxybenzyl)piperidin-1-yl)-2-(isopropylamino)pyrido[3,4-b]pyrazine-7-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C26H28F4N6O3
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1
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| 1 |
IC50 = 26 nM
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CP0951962
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(R)-(2-(cyclopropylamino)-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)pyrido[3,4-b]pyrazin-7-yl)(2-fluoroazetidin-1-yl)methanone
Show/Hide
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C26H26F4N6O
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1
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| 1 |
IC50 = 26 nM
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CP0954421
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(S)-N-cyclopropyl-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)pyrazino[2,3-d]pyridazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C23H22F6N6O2
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1
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| 1 |
IC50 = 26 nM
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CP0927579
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N-cyclopropyl-2-(4-(2,4-difluorobenzyl)piperidin-1-yl)pyrido[3,4-b]pyrazin-3-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H24F5N5O2
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1
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| 1 |
IC50 = 27 nM
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CP0849532
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3-(4-(3,5-difluorobenzoyl)piperidin-1-yl)-2-(isopropylamino)pyrido[3,4-b]pyrazine-7-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C25H23F5N6O3
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1
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| 1 |
IC50 = 28 nM
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CP0848979
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3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-N-isopropylpyrido[3,4-b]pyrazin-3-amine 2,2,2-trifluoroacetate
Show/Hide
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C24H25F6N5O2
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1
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| 1 |
IC50 = 29 nM
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CP0878892
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7-bromo-N-cyclopropyl-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)pyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H22BrF6N5O2
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1
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| 1 |
IC50 = 29 nM
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CP0902228
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N-cyclopropyl-3-(4-(2,4-difluorobenzyl)piperidin-1-yl)-7-methoxypyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C25H26F5N5O3
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1
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| 1 |
IC50 = 29 nM
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CP0951286
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3-(4-(5-chloro-2-fluorobenzyl)piperazin-1-yl)-N-cyclopropylpyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetate
Show/Hide
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C23H23ClF4N6O2
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1
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| 1 |
IC50 = 29 nM
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CP0965096
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3-(cyclopropylamino)-2-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C26H23F6N5O2
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1
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| 1 |
IC50 = 29 nM
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CP0967880
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(S)-7-chloro-N-cyclopropyl-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)pyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H22ClF6N5O2
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1
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| 1 |
IC50 = 29 nM
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CP0867706
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3-(4-(4-chloro-2-fluorophenoxy)piperidin-1-yl)-N-cyclopropylpyrazino[2,3-d]pyridazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C22H21ClF4N6O3
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1
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| 1 |
IC50 = 30 nM
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CP0959234
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(R)-N-sec-butyl-3-(4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl)pyrazino[2,3-d]pyridazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H28F4N6O4
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1
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| 1 |
IC50 = 30 nM
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CP0967980
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3-(4-(2,4-difluorobenzyl)piperidin-1-yl)-N-(2-methoxyethyl)pyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H26F5N5O3
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1
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| 1 |
IC50 = 30 nM
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CP0858031
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7-chloro-N-cyclopropyl-3-(4-(2,4-difluorobenzyl)piperidin-1-yl)pyrido[3,4-b]pyrazin-2-amine
Show/Hide
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C22H22ClF2N5
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1
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| 1 |
IC50 = 31 nM
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CP0909900
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3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-N-isopropyl-8-methylpyrazino[2,3-d]pyridazin-2-amine 2,2,2-trifluoroacetic acid salt
Show/Hide
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C23H25F5N6O3
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1
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| 1 |
IC50 = 31 nM
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CP0957007
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N-cyclopropyl-3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)pyrido[3,4b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C23H23Cl2F3N6O2
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1
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| 1 |
IC50 = 32 nM
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CP0861674
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(5-chloro-2-fluorophenyl)(1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C24H22ClF4N5O3
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1
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| 1 |
IC50 = 35 nM
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CP0970092
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N-cyclopropyl-3-(4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl)pyridazino[4,5-b]pyrazin-2-amine
Show/Hide
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C21H23FN6O2
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1
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| 1 |
IC50 = 36 nM
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CP0903311
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N-ethyl-3-(4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl)pyrido[3,4-b]pyrazin-3-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C23H25F4N5O4
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1
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| 1 |
IC50 = 39 nM
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CP0931199
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3-(4-(2,4-difluorobenzyl)piperazin-1-yl)-2-(isopropylamino)-N,N-dimethylpyrido[3,4-b]pyrazine-7-carboxamide 2,2,2-trifluoroacetic acid
Show/Hide
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C26H30F5N7O3
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1
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| 1 |
IC50 = 40 nM
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CP0956605
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2-(cyclopropylamino)-3-(4-(2-fluoro-4-methoxybenzoyl)piperidin-1-yl)pyrido[3,4-b]pyrazine-5-carbonitrile 2,2,2-trifluoroacetic acid salt
Show/Hide
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C26H24F4N6O4
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1
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| 1 |
IC50 = 43 nM
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CP0850743
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N-cyclopropyl-2-(4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl)pyrido[3,4-b]pyrazin-3-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H25F4N5O4
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1
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| 1 |
IC50 = 44 nM
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CP0903312
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N-isopropyl-3-(4-(3-methoxybenzyl)piperazin-1-yl)pyrazino[2,3-d]pyridazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C23H28F3N7O3
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1
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| 1 |
IC50 = 44 nM
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CP0858029
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N-cyclopropyl-3-(4-((2,5-difluorophenyl)difluoromethyl)piperidin-1-yl)-5-methylpyrido[3,4-b]pyrazin-2-amine
Show/Hide
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C23H23F4N5
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1
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| 1 |
IC50 = 45 nM
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CP0874142
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(S)-3-(cyclopropylamino)-2-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)pyrido[3,4-b]pyrazine-7-carbonitrile
Show/Hide
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C23H21F3N6
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1
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| 1 |
IC50 = 45 nM
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CP0861428
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3-(4-((5-chloro-2-fluorophenyl)difluoromethyl)piperidin-1-yl)-N-cyclopropylpyrido[3,4-b]pyrazin-2-amine
Show/Hide
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C22H21ClF3N5
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1
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| 1 |
IC50 = 46 nM
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CP0931181
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(R)-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-2-(isopropylamino)quinoxaline-6-carbonitrile
Show/Hide
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C24H24F3N5
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1
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| 1 |
IC50 = 49 nM
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CP0865028
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N-cyclopropyl-3-(4-(2,4,5-trifluorobenzyl)piperazin-1-yl)pyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C23H22F6N6O2
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1
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| 1 |
IC50 = 50 nM
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CP0956833
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3-(4-(4-chloro-2-fluorophenoxy)piperidin-1-yl)-N-isopropylquinoxalin-2-amine hydrochloride
Show/Hide
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C22H25Cl2FN4O
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1
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| 1 |
IC50 = 51 nM
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CP0848970
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(2-fluoro-4-methoxyphenyl)(1-(3-(isopropylamino)pyrazino[2,3-d]pyridazin-2-yl)piperidin-4-yl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C24H26F4N6O4
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1
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| 1 |
IC50 = 54 nM
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CP0867674
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2-(cyclopropylamino)-3-(4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl)-N,N-dimethylpyrido[3,4-b]pyrazine-5-carboxamide
Show/Hide
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C25H29FN6O3
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1
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| 1 |
IC50 = 54 nM
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CP0931307
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4-((1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)oxy)-3-fluorophenol 2,2,2-trifluoroacetic acid
Show/Hide
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C23H23F4N5O4
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1
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| 1 |
IC50 = 54 nM
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CP0956834
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3-(1-(2-(cyclopropylamino)-7-(4-methylpiperazine-1-carbonyl)pyrido[3,4-b]pyrazin-3-yl)piperidine-4-carbonyl)-4-fluorobenzonitrile 2,2,2-trifluoroacetic acid salt
Show/Hide
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C31H32F4N8O4
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1
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| 1 |
IC50 = 54 nM
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CP0905669
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N-cyclopropyl-2-(4-(2,5-dichlorobenzyl)piperazin-1-yl)pyrido[3,4-b]pyrazin-3-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C23H23Cl2F3N6O2
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1
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| 1 |
IC50 = 56 nM
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CP0956602
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3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-N-isopropyl-5,8-dimethylpyrazino[2,3-d]pyridazin-2-amine 2,2,2-trifluoroacetic acid salt
Show/Hide
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C24H27F5N6O3
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1
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| 1 |
IC50 = 60 nM
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CP0874146
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(2-chloro-5-fluorophenyl)(1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)methanone 2,2,2-trifluoroacetate
Show/Hide
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C24H22ClF4N5O3
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1
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| 1 |
IC50 = 62 nM
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CP0896487
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8-chloro-N-cyclopropyl-3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)pyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C23H22Cl3F3N6O2
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1
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| 1 |
IC50 = 62 nM
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CP0953827
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8-chloro-N-cyclopropyl-3-(4-(2,5-difluorobenzyl)piperazin-1-yl)pyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid salt
Show/Hide
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C23H22ClF5N6O2
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1
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| 1 |
IC50 = 62 nM
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CP0962411
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2-(cyclopropylamino)-3-(4-(2,4-difluorobenzyl)piperidin-1-yl)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C26H24F5N5O2
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1
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| 1 |
IC50 = 64 nM
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CP0903302
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2-(2,2-difluoroethylamino)-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-N,N-dimethylpyrido[3,4-b]pyrazine-7-carboxamide 2,2,2-trifluoroacetic acid
Show/Hide
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C25H25F7N6O4
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1
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| 1 |
IC50 = 65 nM
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CP0938739
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2-(cyclopropylamino)-3-(4-(2,4-difluorobenzyl)piperazin-1-yl)pyrido[3,4-b]pyrazine-5-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C24H22F5N7O2
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1
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| 1 |
IC50 = 66 nM
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CP0874145
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(2-chlorophenyl)(1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C24H23ClF3N5O3
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1
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| 1 |
IC50 = 67 nM
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CP0931200
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3-(1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidine-4-carbonyl)-4-fluorobenzonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C25H22F4N6O3
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1
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| 1 |
IC50 = 69 nM
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CP0880923
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3-(4-(2,4-difluorobenzyl)piperidin-1-yl)-2-(2,2-difluoroethylamino)quinoxaline-6-carbonitrile
Show/Hide
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C23H21F4N5
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1
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| 1 |
IC50 = 71 nM
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CP0861431
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3-fluoro-4-(1-(3-(isopropylamino)pyrazino[2,3-d]pyridazin-2-yl)piperidin-4-yloxy)benzonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C23H23F4N7O3
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1
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| 1 |
IC50 = 72 nM
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CP0962410
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N-cyclopropyl-3-(4-(2,4-difluorobenzyl)piperidin-1-yl)-6-fluoroquinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C25H24F6N4O2
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1
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| 1 |
IC50 = 72 nM
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CP0949209
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2-(cyclopropylamino)-3-(4-((2,5-difluorophenyl)fluoromethyl)piperidin-1-yl)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C26H23F6N5O2
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1
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| 1 |
IC50 = 75 nM
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CP0880956
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2-(4-(2,4-difluorobenzyl)piperidin-1-yl)-N-(2,2-difluoroethyl)pyrido[3,4-b]pyrazin-3-amine
Show/Hide
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C21H21F4N5
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1
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| 1 |
IC50 = 78 nM
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CP0931311
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(2-bromophenyl)(1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C24H23BrF3N5O3
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1
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| 1 |
IC50 = 78 nM
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CP0947501
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(S)-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-2-(isopropylamino)quinoxaline-6-carbonitrile
Show/Hide
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C24H24F3N5
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1
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| 1 |
IC50 = 82 nM
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CP0878893
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(S)-3-(4-((2,5-difluorophenyl)fluoromethyl)piperidin-1-yl)-2-(isopropylamino)quinoxaline-6-carbonitrile
Show/Hide
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C24H24F3N5
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1
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| 1 |
IC50 = 82 nM
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CP0867673
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2-(cyclopropylamino)-3-(4-(2-fluoro-4-methoxybenzyl)piperazin-1-yl)pyrido[3,4-b]pyrazine-5-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C25H25F4N7O3
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1
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| 1 |
IC50 = 88 nM
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CP0953828
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4-chloro-3-(1-(7-chloro-2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidine-4-carbonyl)benzonitrile
Show/Hide
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C23H20Cl2N6O
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1
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| 1 |
IC50 = 89 nM
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CP0951871
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2-(cyclopropylamino)-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C25H22F5N5O3
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1
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| 1 |
IC50 = 90 nM
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CP0953507
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4-((1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)oxy)-3-fluorobenzonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C23H21F4N7O3
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1
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| 1 |
IC50 = 90 nM
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CP0967538
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N-cyclopropyl-3-(4-(2-fluoro-4-methoxybenzyl)piperazin-1-yl)-7-morpholinopyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C26H32FN7O2
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1
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| 1 |
IC50 = 92 nM
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CP0956604
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N-cyclopropyl-3-(4-(2-fluoro-4-methoxybenzyl)piperazin-1-yl)-7-morpholinopyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid salt
Show/Hide
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C28H33F4N7O4
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1
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| 1 |
IC50 = 92 nM
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CP0849533
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N-cyclopropyl-3-(4-(4-fluorophenylsulfonyl)piperidin-1-yl)-7-methylpyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H25F4N5O4S
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1
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| 1 |
IC50 = 93 nM
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CP0905664
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3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)-2-((3-oxocyclobutyl)amino)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C26H23Cl2F3N6O3
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1
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| 1 |
IC50 = 97 nM
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CP0909896
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3-(4-((2,5-difluorophenyl)fluoromethyl)piperidin-1-yl)-2-(isopropylamino)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C26H25F6N5O2
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1
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| 1 |
IC50 = 98 nM
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CP0931308
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N-cyclopropyl-3-(4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl)-5-morpholinopyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid salt
Show/Hide
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C28H32F4N6O5
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1
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| 1 |
IC50 = 114 nM
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CP0848981
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N-cyclopropyl-3-(4-(2,5-difluorobenzyl)piperazin-1-yl)pyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C23H23F5N6O2
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1
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| 1 |
IC50 = 120 nM
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CP0931197
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N-cyclopropyl-3-(4-(2,4-difluorobenzyl)piperidin-1-yl)-6,7-difluoroquinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C25H23F7N4O2
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1
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| 1 |
IC50 = 140 nM
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CP0953377
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N-cyclopropyl-2-(4-(2,5-difluorobenzyl)piperazin-1-yl)pyrido[3,4-b]pyrazin-3-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C23H23F5N6O2
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1
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| 1 |
IC50 = 140 nM
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CP0952985
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3-(4-((R)-(2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-N-((1R,2R)-2-methylcyclopropyl)pyrazino[2,3-d]pyridazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H24F6N6O2
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1
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| 1 |
IC50 = 145 nM
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CP0963445
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3-(4-((R)-(2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-N-(2-methylcyclopropyl)pyridazino[4,5-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid salt
Show/Hide
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C24H24F6N6O2
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1
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| 1 |
IC50 = 145 nM
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CP0848978
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N-cyclopropyl-3-(4-(4-(methylthio)phenoxy)piperidin-1-yl)pyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H26F3N5O3S
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1
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| 1 |
IC50 = 146 nM
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CP0909895
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3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-2-(3,3,3-trifluoropropylamino)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C25H21F8N5O3
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1
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| 1 |
IC50 = 160 nM
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CP0902214
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N-cyclopropyl-3-(4-(2,4,6-trifluorophenoxy)piperidin-1-yl)pyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C23H21F6N5O3
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1
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| 1 |
IC50 = 170 nM
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CP0954241
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N-cyclopropyl-3-(4-(4-methoxyphenoxy)piperidin-1-yl)pyrido[3,4-b]pyrazin-2-amine
Show/Hide
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C22H25N5O2
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1
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| 1 |
IC50 = 190 nM
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CP0848967
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(4-chloro-2,6-difluorophenyl)(1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C24H21ClF5N5O3
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1
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| 1 |
IC50 = 200 nM
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CP0860079
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2-(4-(2,4-difluorobenzyl)piperazin-1-yl)-N-(2,2-difluoroethyl)pyrido[3,4-b]pyrazin-3-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C22H21F7N6O2
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1
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| 1 |
IC50 = 230 nM
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CP0949208
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2-(cyclopropylamino)-3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)quinoxaline-6-carbonitrile
Show/Hide
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C23H22Cl2N6
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1
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| 1 |
IC50 = 250 nM
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CP0954819
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3-(4-(2,4-difluorobenzyl)piperidin-1-yl)-2-((2-methoxyethyl)amino)quinoxaline-6-carbonitrile
Show/Hide
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C24H25F2N5O
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1
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| 1 |
IC50 = 250 nM
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CP0967878
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N-cyclopropyl-3-(4-(2,4-difluorobenzyl)piperazin-1-y1)pyrazino[2,3-d]pyridazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C22H22F5N7O2
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1
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| 1 |
IC50 = 260 nM
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CP0848984
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3-(4-(5-chloro-2-(difluoromethoxy)benzyl)piperazin-1-yl)-N-cyclopropylpyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H24ClF5N6O3
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1
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| 1 |
IC50 = 270 nM
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CP0931136
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2-(4-(3-chloro-5-(isopropylamino)benzoyl)piperidin-1-yl)-3-(isopropylamino)quinoxaline-6-carbonitrile
Show/Hide
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C27H31ClN6O
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1
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| 1 |
IC50 = 276 nM
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CP0949195
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3-(4-(4-chlorobenzoyl)piperazin-1-yl)-2-(cyclobutylamino)quinoxaline-6-carbonitrile
Show/Hide
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C24H23ClN6O
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1
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| 1 |
IC50 = 300 nM
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CP0953238
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3-(4-(4-chlorophenoxy)piperidin-1-yl)-N-cyclopropylpyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C23H23ClF3N5O3
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1
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| 1 |
IC50 = 310 nM
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CP0962408
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3-(4-(2,5-difluorobenzyl)piperazin-1-yl)-2-(isopropylamino)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C25H25F5N6O2
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1
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| 1 |
IC50 = 310 nM
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CP0969577
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3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)-2-(isopropylamino)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid salt
Show/Hide
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C25H25Cl2F3N6O2
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1
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| 1 |
IC50 = 310 nM
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CP0935568
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3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-2-(2-methoxyethylamino)quinoxaline-6-carbonitrile
Show/Hide
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C24H24F3N5O
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1
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| 1 |
IC50 = 340 nM
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CP0946429
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2-(4-(4-chlorobenzoyl)piperazin-1-yl)-3-(cyclopropylamino)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C25H22ClF3N6O3
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1
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| 1 |
IC50 = 340 nM
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CP0880958
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2-(cyclopropylamino)-3-(4-(2,5-difluorobenzyl)piperazin-1-yl)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C25H23F5N6O2
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1
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| 1 |
IC50 = 380 nM
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CP0903275
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N-cyclopropyl-3-(4-(2,5-dimethylbenzyl)piperazin-1-yl)pyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C25H29F3N6O2
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1
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| 1 |
IC50 = 380 nM
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CP0954250
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1-((1-(2-(cyclopropylamino)-5-methylpyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)methyl)-4-fluoropyridin-2(1H)-one
Show/Hide
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C22H25FN6O
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1
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| 1 |
IC50 = 380 nM
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CP0938711
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1-((1-(2-(cyclopropylamino)-5-methylpyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)methyl)-4-fluoropyridin-2(1H)-one 2,2,2-trifluoroacetic acid salt
Show/Hide
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C24H26F4N6O3
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1
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| 1 |
IC50 = 380 nM
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CP0874139
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3-(4-(2,4-difluorobenzyl)piperazin-1-yl)-2-((3,3,3-trifluoropropyl)amino)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C25H22F8N6O2
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1
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| 1 |
IC50 = 390 nM
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CP0963761
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3-(4-(2,4-difluorobenzyl)piperidin-1-yl)-2-(pyridin-3-ylamino)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C28H23F5N6O2
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1
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| 1 |
IC50 = 390 nM
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CP0865005
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N-(pyridin-3-yl)-2-(4-(2,4,5-trifluorobenzyl)piperazin-1-yl)pyrido[3,4-b]pyrazin-3-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C25H21F6N7O2
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1
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| 1 |
IC50 = 400 nM
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CP0867669
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3-(4-(5-bromothiophen-2-ylsulfonyl)piperazin-1-yl)-2-(cyclopropylamino)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C22H20BrF3N6O4S2
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1
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| 1 |
IC50 = 420 nM
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CP0959578
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2-(4-(2,5-dichlorobenzyl)piperazin-1-yl)-3-(pyridin-3-ylamino)quinoxaline-6-carbonitrile
Show/Hide
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C25H21Cl2N7
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1
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| 1 |
IC50 = 440 nM
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CP0848982
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3-(4-((4-chloro-2,5-dimethylphenyl)sulfonyl)piperazin-1-yl)-2-(cyclopropylamino)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C26H26ClF3N6O4S
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1
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| 1 |
IC50 = 450 nM
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CP0909902
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(1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)(2-fluoro-5-(methylthio)phenyl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C25H25F4N5O3S
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1
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| 1 |
IC50 = 478 nM
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CP0861432
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(4-(3-(cyclopropylamino)quinoxalin-2-yl)piperazin-1-yl)(4-(methylsulfonyl)phenyl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C25H26F3N5O5S
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1
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| 1 |
IC50 = 530 nM
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CP0956603
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2-(tert-butylamino)-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyrido[3,4-b]pyrazine-7-carbonitrile
Show/Hide
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C23H24F2N6O
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1
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| 1 |
IC50 = 538 nM
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CP0905667
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3-(4-(4-chlorophenylsulfonyl)piperazin-1-yl)-2-(cyclopropylamino)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C24H22ClF3N6O4S
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1
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| 1 |
IC50 = 570 nM
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CP0956832
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2-(cyclopropylamino)-3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)quinoxaline-5-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C25H23Cl2F3N6O2
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1
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| 1 |
IC50 = 650 nM
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CP0878884
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3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-N-(2-methoxyethyl)pyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C23H24F5N5O4
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1
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| 1 |
IC50 = 670 nM
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CP0938740
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(1-(2-(cyclopropylamino)-5-morpholinopyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)(2-fluoro-4-methoxyphenyl)methanone 2,2,2-trifluoroacetic acid salt
Show/Hide
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C29H32F4N6O5
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1
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| 1 |
IC50 = 717 nM
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CP0952463
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(4-chloro-3-methylphenyl)(4-(3-(cyclopropylamino)quinoxalin-2-yl)piperazin-1-yl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C25H25ClF3N5O3
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1
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| 1 |
IC50 = 720 nM
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CP0850740
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5-chloro-1-((1-(2-(cyclopropylamino)-7-methylpyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)methyl)pyridin-2(1H)-one
Show/Hide
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C22H25ClN6O
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1
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| 1 |
IC50 = 770 nM
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CP0961169
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5-chloro-1-((1-(2-(cyclopropylamino)-7-methylpyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)methyl)pyridin-2(1H)-one 2,2,2-trifluoroacetic acid salt
Show/Hide
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C24H26ClF3N6O3
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1
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| 1 |
IC50 = 770 nM
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CP0931133
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N-cyclopropyl-3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)-6,7-difluoroquinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H22Cl2F5N5O2
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1
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| 1 |
IC50 = 800 nM
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CP0874152
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N-cyclopropyl-3-(4-(3-methylbenzyl)piperazin-1-yl)pyrido[2,3-b]pyrazin-2-amine
Show/Hide
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C22H26N6
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1
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| 1 |
IC50 = 840 nM
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CP0938734
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3-(4-((5-chloro-2-oxopyridin-1(2H)-yl)methyl)piperidin-1-yl)-2-(cyclopropylamino)quinoxaline-6-carbonitrile
Show/Hide
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C23H23ClN6O
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1
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| 1 |
IC50 = 930 nM
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CP0865026
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2-(cyclopropylamino)-3-(4-(2-fluoro-4-methoxybenzyl)piperazin-1-yl)-N,N-dimethylpyrido[3,4-b]pyrazine-7-carboxamide 2,2,2-trifluoroacetic acid
Show/Hide
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C27H31F4N7O4
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1
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| 1 |
IC50 = 939 nM
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CP0865027
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3-(4-(4-chlorobenzoyl)piperazin-1-yl)-2-((2-fluoroethyl)amino)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C24H21ClF4N6O3
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1
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| 1 |
IC50 = 960 nM
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CP0967539
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3-(4-((3-chloro-5-fluoro-2-methylphenyl)sulfonyl)piperazin-1-yl)-2-(cyclopropylamino)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C25H23ClF4N6O4S
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1
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| 1 |
IC50 = 960 nM
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CP0874155
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N-isopropyl-3-(4-(3-methoxyphenoxy)piperidin-1-yl)pyrazino[2,3-d]pyridazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C23H27F3N6O4
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1
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| 1 |
IC50 = 1000 nM
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CP0861429
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N-cyclopropyl-3-(4-(4-ethoxyphenoxy)piperidin-1-yl)pyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C25H28F3N5O4
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1
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| 1 |
IC50 = 1023 nM
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CP0905670
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(2-chloro-4-(methylsulfonyl)phenyl)(4-(3-(cyclopropylamino)quinoxalin-2-yl)piperazin-1-yl)methanone
Show/Hide
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C23H24ClN5O3S
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1
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| 1 |
IC50 = 1030 nM
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CP0957006
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N-cyclopropyl-3-(4-(2,5-difluorophenoxy)piperidin-1-yl)pyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C23H22F5N5O3
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1
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| 1 |
IC50 = 1100 nM
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CP0909897
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N-cyclopropyl-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)pyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid salt
Show/Hide
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C23H22F5N5O3
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1
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| 1 |
IC50 = 1100 nM
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CP0931135
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N-cyclopropyl-3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)pyrido[2,3-b]pyrazin-2-amine
Show/Hide
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C21H22Cl2N6
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1
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| 1 |
IC50 = 1130 nM
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CP0874156
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3-(4-(3-chlorobenzyl)piperazin-1-yl)-N-(pyridin-3-yl)quinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C26H24ClF3N6O2
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1
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| 1 |
IC50 = 1200 nM
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CP0866313
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3-(4-(2-chloro-4-(trifluoromethyl)phenylsulfonyl)piperazin-1-yl)-2-(cyclopropylamino)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C25H21ClF6N6O4S
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1
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| 1 |
IC50 = 1300 nM
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CP0935567
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3-(4-((2-chloro-5-(trifluoromethyl)phenyl)sulfonyl)piperazin-1-yl)-2-(cyclopropylamino)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C25H21ClF6N6O4S
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1
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| 1 |
IC50 = 1360 nM
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CP0951878
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6-bromo-N-cyclopropyl-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)quinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H22BrF5N4O3
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1
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| 1 |
IC50 = 1430 nM
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CP0954245
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N-cyclopropyl-3-(4-(2,5-difluorobenzyl)piperazin-1-yl)-6,7-difluoroquinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H22F7N5O2
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1
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| 1 |
IC50 = 1470 nM
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CP0954419
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3-(cyclopropylamino)-2-(4-(2,5-dichlorobenzyl)piperazin-1-yl)quinoxaline-5-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C25H23Cl2F3N6O2
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1
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| 1 |
IC50 = 1490 nM
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CP0880922
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3-(4-(2-chlorophenoxy)piperidin-1-yl)-N-cyclopropylpyrido[3,4-b]pyrazin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C23H23ClF3N5O3
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1
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| 1 |
IC50 = 1510 nM
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CP0954244
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(S)-2-(3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)quinoxalin-2-ylamino)propan-1-ol 2,2,2-trifluoroacetic acid
Show/Hide
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C24H26Cl2F3N5O3
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1
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| 1 |
IC50 = 1570 nM
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CP0909899
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(R)-2-(3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)quinoxalin-2-ylamino)propan-1-ol 2,2,2-trifluoroacetic acid salt
Show/Hide
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C24H26Cl2F3N5O3
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1
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| 1 |
IC50 = 1570 nM
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CP0931309
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3-(4-(2-chloro-5-fluorobenzoyl)piperazin-1-yl)-2-(cyclopropylamino)-N,N-dimethylpyrido[3,4-b]pyrazine-7-carboxamide
Show/Hide
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C24H25ClFN7O2
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1
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| 1 |
IC50 = 1572 nM
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CP0953974
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8-bromo-N-cyclopropyl-3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)quinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H23BrCl2F3N5O2
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1
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| 1 |
IC50 = 1640 nM
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CP0903289
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3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)-N-(pyridazin-3-yl)quinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C25H22Cl2F3N7O2
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1
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| 1 |
IC50 = 1670 nM
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CP0848975
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1-(4-((1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)oxy)phenyl)ethanone 2,2,2-trifluoroacetic acid
Show/Hide
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C25H26F3N5O4
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1
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| 1 |
IC50 = 1740 nM
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CP0967239
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3-(4-(2-bromophenylsulfonyl)piperazin-1-yl)-2-(cyclopropylamino)quinoxaline-6-carbonitrile
Show/Hide
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C22H21BrN6O2S
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1
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| 1 |
IC50 = 1850 nM
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CP0848973
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(1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)(2-methoxyphenyl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C25H26F3N5O4
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1
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| 1 |
IC50 = 1920 nM
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CP0862837
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4-(1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yloxy)benzonitrile
Show/Hide
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C22H22N6O
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1
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| 1 |
IC50 = 1940 nM
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CP0905671
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3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)-N-(3-methoxypropyl)quinoxalin-2-amine
Show/Hide
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C23H27Cl2N5O
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1
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| 1 |
IC50 = 1940 nM
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CP0850334
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N-cyclopropyl-3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)quinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H24Cl2F3N5O2
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1
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| 1 |
IC50 = 2160 nM
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CP0951874
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(1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)(2,6-difluorophenyl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C24H22F5N5O3
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1
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| 1 |
IC50 = 2180 nM
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CP0938709
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(1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)(thiophen-3-yl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C22H22F3N5O3S
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1
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| 1 |
IC50 = 2290 nM
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CP0896488
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7-bromo-N-cyclopropyl-3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)quinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H23BrCl2F3N5O2
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1
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| 1 |
IC50 = 2340 nM
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CP0954794
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3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)-N-(pyrazin-2-yl)quinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C25H22Cl2F3N7O2
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1
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| 1 |
IC50 = 2340 nM
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CP0878897
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3-(4-((3-cyanophenyl)sulfonyl)piperazin-1-yl)-2-(cyclopropylamino)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C25H22F3N7O4S
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1
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| 1 |
IC50 = 2540 nM
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CP0867668
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(4-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperazin-1-yl)(4-(difluoromethyl)phenyl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C24H23F5N6O3
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1
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| 1 |
IC50 = 2650 nM
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CP0946431
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(2-bromopyridin-3-yl)(1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C23H22BrF3N6O3
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1
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| 1 |
IC50 = 2740 nM
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CP0946861
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(2-chloro-3-fluorophenyl)(1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)methanone hydrogen chloride
Show/Hide
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C22H22Cl2FN5O
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1
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| 1 |
IC50 = 2800 nM
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CP0911514
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2-(1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yloxy)benzonitrile
Show/Hide
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C22H22N6O
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1
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| 1 |
IC50 = 2883 nM
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CP0959222
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2-(1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yloxy)benzonitrile 2,2,2-trifluoroacetic acid salt
Show/Hide
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C24H23F3N6O3
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1
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| 1 |
IC50 = 2883 nM
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CP0896491
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N-(4-bromophenyl)-3-(4-(3-chlorobenzyl)piperazin-1-yl)quinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C27H24BrClF3N5O2
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1
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| 1 |
IC50 = 3030 nM
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CP0874149
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N-(cyclopropylmethyl)-3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)quinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C25H26Cl2F3N5O2
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1
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| 1 |
IC50 = 3160 nM
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CP0902212
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(4-(3-(cyclopropylamino)quinoxalin-2-yl)piperazin-1-yl)(5-methylisoxazol-3-yl)methanone
Show/Hide
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C20H22N6O2
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1
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| 1 |
IC50 = 3210 nM
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CP0905665
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3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)-N-(pyridin-2-yl)quinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C26H23Cl2F3N6O2
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1
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| 1 |
IC50 = 3290 nM
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CP0931134
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3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)-N-isopropylquinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H26Cl2F3N5O2
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1
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| 1 |
IC50 = 3310 nM
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CP0957008
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3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)-N-(2-isopropoxyethyl)quinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C26H30Cl2F3N5O3
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1
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| 1 |
IC50 = 3330 nM
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CP0874148
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N-cyclopropyl-3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)-7-methoxyquinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C25H26Cl2F3N5O3
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1
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| 1 |
IC50 = 3360 nM
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CP0927582
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N-cyclopropyl-3-(4-(2,3-dimethylbenzyl)piperazin-1-yl)quinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C26H30F3N5O2
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1
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| 1 |
IC50 = 3640 nM
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CP0953976
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(6-chloro-2,3-difluorophenyl)(1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C24H21ClF5N5O3
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1
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| 1 |
IC50 = 3900 nM
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CP0878896
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3-(4-(benzofuran-3-ylmethyl)piperazin-1-yl)-N-cyclopropylquinoxalin-2-amine
Show/Hide
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C24H25N5O
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1
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| 1 |
IC50 = 3960 nM
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CP0931305
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3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)-N-isopentylquinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C26H30Cl2F3N5O2
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1
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| 1 |
IC50 = 3980 nM
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CP0878895
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3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)-N-(tetrahydro-2H-pyran-4-yl)quinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C26H28Cl2F3N5O3
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1
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| 1 |
IC50 = 4070 nM
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CP0862844
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2-(cyclopropylamino)-3-(4-((4-(trifluoromethoxy)phenyl)sulfonyl)piperazin-1-yl)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C25H22F6N6O5S
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1
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| 1 |
IC50 = 4290 nM
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CP0896501
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3-(4-((2-cyanophenyl)sulfonyl)piperazin-1-yl)-2-(cyclopropylamino)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C25H22F3N7O4S
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1
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| 1 |
IC50 = 4340 nM
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CP0954818
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N-cyclopropyl-3-(4-(2,5-difluorobenzyl)piperazin-1-yl)quinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H24F5N5O2
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1
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| 1 |
IC50 = 4580 nM
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CP0866315
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2-(cyclopropylamino)-3-(4-((2-fluorophenyl)sulfonyl)piperazin-1-yl)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C24H22F4N6O4S
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1
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| 1 |
IC50 = 4590 nM
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CP0954243
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3-(4-(phenylsulfonyl)piperazin-1-yl)-N-(pyridin-3-yl)quinoxalin-2-amine
Show/Hide
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C23H22N6O2S
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1
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| 1 |
IC50 = 4630 nM
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CP0951498
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2-(cyclopropylamino)-3-(4-tosylpiperazin-1-yl)quinoxaline-6-carbonitrile
Show/Hide
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C23H24N6O2S
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1
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| 1 |
IC50 = 4740 nM
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CP0867671
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(3-bromo-4-fluorophenyl)(4-(3-(cyclopropylamino)quinoxalin-2-yl)piperazin-1-yl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C24H22BrF4N5O3
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1
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| 1 |
IC50 = 4780 nM
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CP0954242
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(5-chlorothiophen-3-yl)(1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)methanone hydrogen chloride
Show/Hide
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C20H21Cl2N5OS
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1
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| 1 |
IC50 = 4810 nM
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CP0953802
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6-bromo-N-cyclopropyl-3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)quinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C24H23BrCl2F3N5O2
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1
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| 1 |
IC50 = 4820 nM
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CP0956831
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(2-chloro-6-fluorophenyl)(1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)methanone
Show/Hide
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C22H21ClFN5O
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1
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| 1 |
IC50 = 4900 nM
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CP0848965
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N-cyclopropyl-3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)-5,7-dimethylquinoxalin-2-amine
Show/Hide
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C24H27Cl2N5
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1
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| 1 |
IC50 = 5310 nM
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CP0965082
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4-((3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)quinoxalin-2-yl)amino)benzonitrile
Show/Hide
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C26H22Cl2N6
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1
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| 1 |
IC50 = 5530 nM
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CP0947500
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3-(4-(3-chlorophenylsulfonyl)piperazin-1-yl)-2-(cyclopropylamino)quinoxaline-6-carbonitrile
Show/Hide
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C22H21ClN6O2S
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1
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| 1 |
IC50 = 5620 nM
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CP0902213
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N-cyclopropyl-3-(4-(phenylsulfonyl)piperazin-1-yl)quinoxalin-2-amine
Show/Hide
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C21H23N5O2S
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1
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| 1 |
IC50 = 5660 nM
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CP0903276
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3-(4-(3-chlorobenzyl)piperazin-1-yl)-N-(4-fluorophenyl)quinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C27H24ClF4N5O2
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1
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| 1 |
IC50 = 5730 nM
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CP0909884
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(1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)(o-tolyl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C25H26F3N5O3
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1
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| 1 |
IC50 = 5780 nM
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CP0868773
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N-cyclopropyl-3-(4-((2,5-dichlorothiophen-3-yl)methyl)piperazin-1-yl)quinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C22H22Cl2F3N5O2S
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1
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| 1 |
IC50 = 6030 nM
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CP0938737
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3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)-N-isobutylquinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C25H28Cl2F3N5O2
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1
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| 1 |
IC50 = 6030 nM
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CP0866311
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1-(4-(1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yloxy)phenyl)ethanol 2,2,2-trifluoroacetic acid
Show/Hide
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C25H28F3N5O4
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1
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| 1 |
IC50 = 6040 nM
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CP0905672
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3(4-(3-chlorobenzyl)piperazin-1-yl)-N-(4-methoxyphenyl)quinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C28H27ClF3N5O3
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1
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| 1 |
IC50 = 6140 nM
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CP0874150
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(4-(3-(cyclopentylamino)quinoxalin-2-yl)piperazin-1-yl)(2,5-dichlorophenyl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C26H26Cl2F3N5O3
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1
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| 1 |
IC50 = 6150 nM
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CP0537883
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US10077266, Example 51
Show/Hide
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C24H29F4N5O3
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1
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| 1 |
IC50 = 6600 nM
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CP0968926
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(R)-1-(2-(2,2-difluoroethylamino)-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)-2-methoxypropan-1-one trifluoroacetic acid
Show/Hide
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C26H30F7N5O5
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1
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| 1 |
IC50 = 6600 nM
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CP0954251
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(4-(3-(cyclopropylamino)quinoxalin-2-yl)piperazin-1-yl)(2,5-dichlorophenyl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C24H22Cl2F3N5O3
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1
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| 1 |
IC50 = 6640 nM
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CP0902218
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(1-(2-(cyclopropylamino)pyrido[3.4-b]pyrazin-3-yl)piperidin-4-yl)(thiophen-2-yl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C22H22F3N5O3S
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1
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| 1 |
IC50 = 6750 nM
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CP0949210
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3-(1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidine-4-carbonyl)benzonitrile 2,2,2-trifluoroacetic acid
Show/Hide
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C25H23F3N6O3
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1
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| 1 |
IC50 = 7210 nM
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CP0866312
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3-(1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidine-4-carbonyl)benzonitrile
Show/Hide
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C23H22N6O
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1
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| 1 |
IC50 = 7210 nM
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CP0954240
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(2-bromo-5-methoxyphenyl)(4-(3-(cyclopropylamino)quinoxalin-2-yl)piperazin-1-yl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C25H25BrF3N5O4
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1
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| 1 |
IC50 = 7550 nM
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CP0931306
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2-(4-(3-chlorobenzyl)piperazin-1-yl)-N-phenylpyrido[2,3-b]pyrazin-3-amine 2,2,2-trifluoroacetic acid
Show/Hide
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C26H24ClF3N6O2
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1
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| 1 |
IC50 = 7670 nM
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CP0479872
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US10077266, Example 99
Show/Hide
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C24H29F4N5O3
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1
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| 1 |
IC50 = 8300 nM
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CP0954751
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(S)-1-(2-(2,2-difluoroethylamino)-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)-2-methoxypropan-1-one trifluoroacetic acid
Show/Hide
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C26H30F7N5O5
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1
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| 1 |
IC50 = 8300 nM
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CP0951876
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(1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)(3,4-difluorophenyl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
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C24H22F5N5O3
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1
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| 1 |
IC50 = 8390 nM
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CP0563391
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US10077266, Example 71
Show/Hide
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C24H30F3N5O
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1
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| 1 |
IC50 = 8500 nM
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CP0871850
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1-(3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-2-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)ethanone trifluoroacetic acid
Show/Hide
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C26H31F6N5O3
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1
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| 1 |
IC50 = 8500 nM
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CP0443079
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US10077266, Example 78
Show/Hide
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C23H29ClFN5O
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1
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| 1 |
IC50 = 8800 nM
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CP0968927
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(5-chloro-2-fluorophenyl)(1-(2-(isopropylamino)-6-methyl-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)methanone trifluoroacetic acid
Show/Hide
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C25H30ClF4N5O3
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1
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| 1 |
IC50 = 8800 nM
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CP0417126
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US10077266, Example 49
Show/Hide
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C23H28F4N6O2
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1
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| 1 |
IC50 = 9100 nM
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CP0961800
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2-(2,2-difluoroethylamino)-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-N,N-dimethyl-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxamide trifluoroacetic acid
Show/Hide
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C25H29F7N6O4
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1
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| 1 |
IC50 = 9100 nM
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CP0417125
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US10077266, Example 67
Show/Hide
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C23H28F3N5
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1
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| 1 |
IC50 = 9400 nM
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CP0904126
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N-cyclopropyl-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-6-methyl-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-amine trifluoroacetic acid
Show/Hide
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C25H29F6N5O2
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1
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| 1 |
IC50 = 9400 nM
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CP0938735
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N-cyclopropyl-6-fluoro-3-(4-(phenylsulfonyl)piperazin-1-yl)quinoxalin-2-amine
Show/Hide
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C21H22FN5O2S
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1
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| 1 |
IC50 = 9440 nM
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CP0413459
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US10077266, Example 156
Show/Hide
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C23H29F2N5O2
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2
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| 1 |
IC50 = 9500 nM
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| 2 |
IC50 = 73700 nM
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CP0853399
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1-(3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-2-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)ethanone hydrochloride
Show/Hide
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C23H30ClF2N5O2
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1
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| 1 |
IC50 = 9500 nM
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CP0477412
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US10077266, Example 79
Show/Hide
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C24H29ClFN5O2
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1
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| 1 |
IC50 = 9800 nM
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CP0853396
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1-(3-(4-(5-chloro-2-fluorobenzoyl)piperidin-1-yl)-2-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)ethanone trifluoroacetic acid
Show/Hide
|
C26H30ClF4N5O4
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1
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| 1 |
IC50 = 9800 nM
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CP0867704
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(3-chloro-4-methoxyphenyl)(4-(3-(cyclopropylamino)quinoxalin-2-yl)piperazin-1-yl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
|
C25H25ClF3N5O4
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1
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| 1 |
IC50 = 10070 nM
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CP0861673
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(4-bromo-2-methylphenyl)(4-(3-(cyclopropylamino)quinoxalin-2-yl)piperazin-1-yl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
|
C25H25BrF3N5O3
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1
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| 1 |
IC50 = 10300 nM
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CP0477411
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US10077266, Example 85
Show/Hide
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C24H32F2N6O2
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1
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| 1 |
IC50 = 10400 nM
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CP0504109
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US10077266, Example 112
Show/Hide
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C22H27F4N5O3S
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1
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| 1 |
IC50 = 10400 nM
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CP0871853
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N-(2,2-difluoroethyl)-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-7-methyl-6-(methylsulfonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-amine trifluoroacetic acid
Show/Hide
|
C24H28F7N5O5S
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1
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| 1 |
IC50 = 10400 nM
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CP0969377
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2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-3-(isopropylamino)-N,N-dimethyl-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxamide trifluoroacetic acid
Show/Hide
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C26H33F5N6O4
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1
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| 1 |
IC50 = 10400 nM
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CP0951872
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(3-chlorophenyl)(1-(2-(cyclopropylamino)pyrido[4,3-b]pyrazin-3-yl)piperidin-4-yl)methanone
Show/Hide
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C22H22ClN5O
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1
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| 1 |
IC50 = 11000 nM
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CP0530380
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US10077266, Example 118
Show/Hide
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C23H28F3N5O
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1
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| 1 |
IC50 = 11400 nM
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CP0871859
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(S)-2-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-3-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carbaldehyde trifluoroacetic acid
Show/Hide
|
C25H29F6N5O3
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1
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| 1 |
IC50 = 11400 nM
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CP0530377
|
US10077266, Example 91
Show/Hide
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C22H25F4N5O2
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1
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| 1 |
IC50 = 11500 nM
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CP0968382
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1-(2-(2,2-difluoroethylamino)-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)ethanone trifluoroacetic acid
Show/Hide
|
C24H26F7N5O4
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1
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| 1 |
IC50 = 11500 nM
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CP0443081
|
US10077266, Example 92
Show/Hide
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C25H32FN5O3
|
1
|
| 1 |
IC50 = 12000 nM
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CP0904129
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1-(2-(cyclobutylamino)-3-(4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)ethanone trifluoroacetic acid
Show/Hide
|
C27H33F4N5O5
|
1
|
| 1 |
IC50 = 12000 nM
|
|
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CP0504107
|
US10077266, Example 76
Show/Hide
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C24H30F3N5O
|
1
|
| 1 |
IC50 = 13400 nM
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CP0954747
|
1-(2-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-3-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)ethanone trifluoroacetic acid
Show/Hide
|
C26H31F6N5O3
|
1
|
| 1 |
IC50 = 13400 nM
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CP0477410
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(5-chloro-2-fluorophenyl)(1-(3-(isopropylamino)-6-methyl-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-yl)piperidin-4-yl)methanone
Show/Hide
|
C22H29ClFN5O
|
1
|
| 1 |
IC50 = 13700 nM
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CP0871851
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(5-chloro-2-fluorophenyl)(1-(3-(isopropylamino)-6-methyl-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-yl)piperidin-4-yl)methanone trifluoroacetic acid
Show/Hide
|
C25H30ClF4N5O3
|
1
|
| 1 |
IC50 = 13700 nM
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|
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CP0443082
|
US10077266, Example 93
Show/Hide
|
C26H35FN6O3
|
1
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| 1 |
IC50 = 13800 nM
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CP0576953
|
3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-2-(isopropylamino)-N,N-dimethyl-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxamide
Show/Hide
|
C24H32F2N6O2
|
1
|
| 1 |
IC50 = 13800 nM
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CP0577903
|
1-(2-(4-(5-chloro-2-fluorobenzoyl)piperidin-1-yl)-3-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)ethanone
Show/Hide
|
C23H29ClFN5O2
|
1
|
| 1 |
IC50 = 13800 nM
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CP0871852
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1-(2-(4-(5-chloro-2-fluorobenzoyl)piperidin-1-yl)-3-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)ethanone trifluoroacetic acid
Show/Hide
|
C26H30ClF4N5O4
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1
|
| 1 |
IC50 = 13800 nM
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CP0961801
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3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-2-(isopropylamino)-N,N-dimethyl-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxamide trifluoroacetic acid
Show/Hide
|
C26H33F5N6O4
|
1
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| 1 |
IC50 = 13800 nM
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CP0961802
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2-(cyclobutylamino)-3-(4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl)-N,N-dimethyl-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxamide trifluoroacetic acid
Show/Hide
|
C28H36F4N6O5
|
1
|
| 1 |
IC50 = 13800 nM
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CP0556906
|
US10077266, Example 15
Show/Hide
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C25H34F2N6O3
|
1
|
| 1 |
IC50 = 14900 nM
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CP0961798
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3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-2-(isopropylamino)-N-(2-methoxyethyl)-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxamide trifluoroacetic acid
Show/Hide
|
C27H35F5N6O5
|
1
|
| 1 |
IC50 = 14900 nM
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|
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CP0515471
|
US10077266, Example 68
Show/Hide
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C23H28F3N5
|
1
|
| 1 |
IC50 = 15200 nM
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CP0962309
|
(S)-N-cyclopropyl-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-6-methyl-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-amine trifluoroacetic acid
Show/Hide
|
C25H29F6N5O2
|
1
|
| 1 |
IC50 = 15200 nM
|
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CP0959224
|
3-((1-(2-(cyclopropylamino)pyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)oxy)benzonitrile
Show/Hide
|
C22H22N6O
|
1
|
| 1 |
IC50 = 15370 nM
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CP0927581
|
3-(4-(4-chlorobenzoyl)piperazin-1-yl)-2-(isoxazol-3-ylamino)quinoxaline-6-carbonitrile 2,2,2-trifluoroacetic acid
Show/Hide
|
C25H19ClF3N7O4
|
1
|
| 1 |
IC50 = 15430 nM
|
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CP0531629
|
US10077266, Example 73
Show/Hide
|
C25H35FN6O3
|
1
|
| 1 |
IC50 = 16600 nM
|
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CP0951383
|
3-(4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl)-2-(isopropylamino)-N,N-dimethyl-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxamide trifluoroacetic acid
Show/Hide
|
C27H36F4N6O5
|
1
|
| 1 |
IC50 = 16600 nM
|
|
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CP0531627
|
US10077266, Example 8
Show/Hide
|
C25H33F2N5O3
|
1
|
| 1 |
IC50 = 16800 nM
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CP0957835
|
1-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-3-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)-2-methoxypropan-1-one trifluoroacetic acid
Show/Hide
|
C27H34F5N5O5
|
1
|
| 1 |
IC50 = 16800 nM
|
|
|
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CP0417134
|
US10077266, Example 70
Show/Hide
|
C23H30F3N5
|
1
|
| 1 |
IC50 = 17100 nM
|
|
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CP0961803
|
3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-N-isopropyl-6-methyl-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-amine trifluoroacetic acid
Show/Hide
|
C25H31F6N5O2
|
1
|
| 1 |
IC50 = 17100 nM
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CP0564327
|
US10077266, Example 10
Show/Hide
|
C24H31F2N5O3
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1
|
| 1 |
IC50 = 17300 nM
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CP0969376
|
1-(3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-2-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)-2-methoxyethan-1-one trifluoroacetic acid
Show/Hide
|
C26H32F5N5O5
|
1
|
| 1 |
IC50 = 17300 nM
|
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CP0903288
|
N-cyclopropyl-3-(4-(3-methylbenzyl)piperazin-1-yl)quinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
|
C25H28F3N5O2
|
1
|
| 1 |
IC50 = 17687 nM
|
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CP0949194
|
3-(4-(2,5-dichlorobenzyl)piperazin-1-yl)-N-(5,6-dimethyl-1,2,4-triazin-3-yl)quinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
|
C26H25Cl2F3N8O2
|
1
|
| 1 |
IC50 = 17820 nM
|
|
|
|
CP0413456
|
US10077266, Example 5
Show/Hide
|
C26H33F2N5O3
|
1
|
| 1 |
IC50 = 17900 nM
|
|
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CP0954743
|
(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-3-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)(tetrahydrofuran-2-yl)methanone trifluoroacetic acid
Show/Hide
|
C28H34F5N5O5
|
1
|
| 1 |
IC50 = 17900 nM
|
|
|
|
CP0564329
|
US10077266, Example 17
Show/Hide
|
C24H28F2N6O2
|
1
|
| 1 |
IC50 = 18000 nM
|
|
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CP0853394
|
3-(3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-2-(isopropylamino)-7,8-dihydropyrido [3,4-b]pyrazin-6(5H)-yl)-3-oxopropanenitrile trifluoroacetic acid
Show/Hide
|
C26H29F5N6O4
|
1
|
| 1 |
IC50 = 18000 nM
|
|
|
|
CP0515472
|
US10077266, Example 114
Show/Hide
|
C25H31F4N5O3
|
1
|
| 1 |
IC50 = 18500 nM
|
|
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CP0947241
|
(2R)-1-(2-(2,2-difluoroethylamino)-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-7-methyl-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)-2-methoxypropan-1-one trifluoroacetic acid
Show/Hide
|
C27H32F7N5O5
|
1
|
| 1 |
IC50 = 18500 nM
|
|
|
|
CP0473643
|
US10077266, Example 16
Show/Hide
|
C26H33F2N5O3
|
1
|
| 1 |
IC50 = 19500 nM
|
|
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CP0944235
|
(3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-2-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)(tetrahydrofuran-2-yl)methanone trifluoroacetic acid
Show/Hide
|
C28H34F5N5O5
|
1
|
| 1 |
IC50 = 19500 nM
|
|
|
|
CP0477413
|
US10077266, Example 77
Show/Hide
|
C25H33F3N6O
|
1
|
| 1 |
IC50 = 19700 nM
|
|
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CP0954748
|
2-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-3-(isopropylamino)-N,N-dimethyl-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxamide trifluoroacetic acid
Show/Hide
|
C27H34F6N6O3
|
1
|
| 1 |
IC50 = 19700 nM
|
|
|
|
CP0530378
|
US10077266, Example 94
Show/Hide
|
C25H32FN5O3
|
1
|
| 1 |
IC50 = 19900 nM
|
|
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CP0853397
|
1-(3-(cyclobutylamino)-2-(4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)ethanone trifluoroacetic acid
Show/Hide
|
C27H33F4N5O5
|
1
|
| 1 |
IC50 = 19900 nM
|
|
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CP0848971
|
3-(4-((2-chloro-5-fluoropyridin-3-yl)methyl)piperazin-1-yl)-N-cyclopropylquinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
|
C23H23ClF4N6O2
|
1
|
| 1 |
IC50 = 20420 nM
|
|
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CP0560645
|
US10077266, Example 113
Show/Hide
|
C25H31F4N5O3
|
1
|
| 1 |
IC50 = 20900 nM
|
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CP0951420
|
(2S)-1-(2-(2,2-difluoroethylamino)-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-7-methyl-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)-2-methoxypropan-1-one trifluoroacetic acid
Show/Hide
|
C27H32F7N5O5
|
1
|
| 1 |
IC50 = 20900 nM
|
|
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CP0954817
|
4-(4-(3-(cyclopropylamino)quinoxalin-2-yl)piperazine-1-carbonyl)benzonitrile 2,2,2-trifluoroacetic acid
Show/Hide
|
C25H23F3N6O3
|
1
|
| 1 |
IC50 = 21780 nM
|
|
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CP0438907
|
US10077266, Example 110
Show/Hide
|
C23H25F6N5O2
|
1
|
| 1 |
IC50 = 22100 nM
|
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CP0957840
|
1-(2-(2,2-difluoroethylamino)-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-7-methyl-7,8-dihydropyrido[4,3-b]pyrazin-6(5H)-yl)-2,2-difluoroethanone trifluoroacetic acid
Show/Hide
|
C25H26F9N5O4
|
1
|
| 1 |
IC50 = 22100 nM
|
|
|
|
CP0867670
|
3-((4-(3-(cyclopropylamino)quinoxalin-2-yl)piperazin-1-yl)methyl)benzonitrile 2,2,2-trifluoroacetic acid
Show/Hide
|
C25H25F3N6O2
|
1
|
| 1 |
IC50 = 22160 nM
|
|
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CP0469974
|
US10077266, Example 111
Show/Hide
|
C24H29F4N5O3
|
1
|
| 1 |
IC50 = 23000 nM
|
|
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CP0951418
|
1-(2-(2,2-difluoroethylamino)-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-7-methyl-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)-2-methoxyethanone trifluoroacetic acid
Show/Hide
|
C26H30F7N5O5
|
1
|
| 1 |
IC50 = 23000 nM
|
|
|
|
CP0417138
|
US10077266, Example 109
Show/Hide
|
C22H27F4N5O
|
1
|
| 1 |
IC50 = 23200 nM
|
|
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|
CP0953260
|
N-(2,2-difluoroethyl)-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-6,7-dimethyl-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-amine trifluoroacetic acid
Show/Hide
|
C24H28F7N5O3
|
1
|
| 1 |
IC50 = 23200 nM
|
|
|
|
CP0477418
|
US10077266, Example 119
Show/Hide
|
C23H28F3N5O
|
1
|
| 1 |
IC50 = 23600 nM
|
|
|
|
CP0957842
|
(R)-2-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-3-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carbaldehyde trifluoroacetic acid
Show/Hide
|
C25H29F6N5O3
|
1
|
| 1 |
IC50 = 23600 nM
|
|
|
|
CP0504106
|
US10077266, Example 72
Show/Hide
|
C25H33F3N6O
|
1
|
| 1 |
IC50 = 23700 nM
|
|
|
|
CP0904127
|
3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-2-(isopropylamino)-N,N-dimethyl-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxamide trifluoroacetic acid
Show/Hide
|
C27H34F6N6O3
|
1
|
| 1 |
IC50 = 23700 nM
|
|
|
|
CP0417137
|
US10077266, Example 115
Show/Hide
|
C25H29F4N5O2
|
1
|
| 1 |
IC50 = 23900 nM
|
|
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|
CP0962314
|
cyclopropyl(2-(2,2-difluoroethylamino)-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-7-methyl-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)methanone trifluoroacetic acid
Show/Hide
|
C27H30F7N5O4
|
1
|
| 1 |
IC50 = 23900 nM
|
|
|
|
CP0423748
|
US10077266, Example 141
Show/Hide
|
C23H29F2N5O2
|
1
|
| 1 |
IC50 = 24600 nM
|
|
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|
CP0417139
|
US10077266, Example 107
Show/Hide
|
C23H27F4N5O2
|
1
|
| 1 |
IC50 = 24900 nM
|
|
|
|
CP0436159
|
US10077266, Example 80
Show/Hide
|
C25H32ClFN6O2
|
1
|
| 1 |
IC50 = 24900 nM
|
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CP0904128
|
3-(4-(5-chloro-2-fluorobenzoyl)piperidin-1-yl)-2-(isopropylamino)-N,N-dimethyl-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxamide trifluoroacetic acid
Show/Hide
|
C27H33ClF4N6O4
|
1
|
| 1 |
IC50 = 24900 nM
|
|
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CP0957839
|
1-(2-(2,2-difluoroethylamino)-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-7-methyl-7,8-dihydropyrido[4,3-b]pyrazin-6(5H)-yl)ethanone trifluoroacetic acid
Show/Hide
|
C25H28F7N5O4
|
1
|
| 1 |
IC50 = 24900 nM
|
|
|
|
CP0896492
|
N-cyclopropyl-3-(4-(pyridin-4-ylmethyl)piperazin-1-yl)quinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
|
C23H25F3N6O2
|
1
|
| 1 |
IC50 = 25900 nM
|
|
|
|
CP0904293
|
3-(4-(3-chlorobenzyl)piperazin-1-y1)-N-(p-tolyl)quinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
|
C28H27ClF3N5O2
|
1
|
| 1 |
IC50 = 26240 nM
|
|
|
|
CP0566275
|
US10077266, Example 69
Show/Hide
|
C23H28F3N5
|
1
|
| 1 |
IC50 = 26500 nM
|
|
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CP0871849
|
(R)-N-cyclopropyl-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-6-methyl-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-amine trifluoroacetic acid
Show/Hide
|
C25H29F6N5O2
|
1
|
| 1 |
IC50 = 26500 nM
|
|
|
|
CP0531628
|
US10077266, Example 58
Show/Hide
|
C23H32FN5O2
|
1
|
| 1 |
IC50 = 26600 nM
|
|
|
|
CP0853395
|
3-(4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl)-N-isopropyl-6-methyl-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-amine trifluoroacetic acid
Show/Hide
|
C25H33F4N5O4
|
1
|
| 1 |
IC50 = 26600 nM
|
|
|
|
CP0485491
|
US10077266, Example 96
Show/Hide
|
C23H28F4N6O2
|
1
|
| 1 |
IC50 = 26900 nM
|
|
|
|
CP0853398
|
3-(2,2-difluoroethylamino)-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-N,N-dimethyl-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxamide trifluoroacetic acid
Show/Hide
|
C25H29F7N6O4
|
1
|
| 1 |
IC50 = 26900 nM
|
|
|
|
CP0533929
|
US10077266, Example 134
Show/Hide
|
C23H30F2N6O
|
1
|
| 1 |
IC50 = 27000 nM
|
|
|
|
CP0413460
|
US10077266, Example 117
Show/Hide
|
C24H30F3N5O
|
1
|
| 1 |
IC50 = 27400 nM
|
|
|
|
CP0871858
|
(S)-1-(2-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-3-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)ethanone trifluoroacetic acid
Show/Hide
|
C26H31F6N5O3
|
1
|
| 1 |
IC50 = 27400 nM
|
|
|
|
CP0441095
|
US10077266, Example 131
Show/Hide
|
C24H31F2N5O2
|
1
|
| 1 |
IC50 = 27600 nM
|
|
|
|
CP0473638
|
US10077266, Example 136
Show/Hide
|
C22H30F2N6O2S
|
1
|
| 1 |
IC50 = 27900 nM
|
|
|
|
CP0557643
|
US10077266, Example 143
Show/Hide
|
C25H34F2N6O
|
1
|
| 1 |
IC50 = 29000 nM
|
|
|
|
CP0438897
|
US10077266, Example 4
Show/Hide
|
C25H34F2N6O3
|
1
|
| 1 |
IC50 = 29800 nM
|
|
|
|
CP0954744
|
2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-3-(isopropylamino)-N-(2-methoxyethyl)-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxamide trifluoroacetic acid
Show/Hide
|
C27H35F5N6O5
|
1
|
| 1 |
IC50 = 29800 nM
|
|
|
|
CP0540991
|
US10077266, Example 75
Show/Hide
|
C23H30F3N5
|
1
|
| 1 |
IC50 = 30300 nM
|
|
|
|
CP0951402
|
2-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-N-isopropyl-6-methyl-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-3-amine trifluoroacetic acid
Show/Hide
|
C25H31F6N5O2
|
1
|
| 1 |
IC50 = 30300 nM
|
|
|
|
CP0537881
|
US10077266, Example 137
Show/Hide
|
C24H32F2N6O
|
1
|
| 1 |
IC50 = 30900 nM
|
|
|
|
CP0573286
|
US10077266, Example 108
Show/Hide
|
C24H30F4N6O2
|
1
|
| 1 |
IC50 = 31400 nM
|
|
|
|
CP0946375
|
2-(2,2-difluoroethylamino)-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-N,N,7-trimethyl-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxamide trifluoroacetic acid
Show/Hide
|
C26H31F7N6O4
|
1
|
| 1 |
IC50 = 31400 nM
|
|
|
|
CP0485490
|
US10077266, Example 95
Show/Hide
|
C26H35FN6O3
|
1
|
| 1 |
IC50 = 32500 nM
|
|
|
|
CP0954750
|
3-(cyclobutylamino)-2-(4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl)-N,N-dimethyl-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxamide trifluoroacetic acid
Show/Hide
|
C28H36F4N6O5
|
1
|
| 1 |
IC50 = 32500 nM
|
|
|
|
CP0438902
|
US9181249, 88
Show/Hide
|
C25H32ClFN6O2
|
1
|
| 1 |
IC50 = 32700 nM
|
|
|
|
CP0954749
|
2-(4-(5-chloro-2-fluorobenzoyl)piperidin-1-yl)-3-(isopropylamino)-N,N-dimethyl-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxamide trifluoroacetic acid
Show/Hide
|
C27H33ClF4N6O4
|
1
|
| 1 |
IC50 = 32700 nM
|
|
|
|
CP0959214
|
1-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-3-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)-2-d3-ethan-1-one
Show/Hide
|
C23H29F2N5O2
|
1
|
| 1 |
IC50 = 33700 nM
|
|
|
|
CP0436158
|
US10077266, Example 46
Show/Hide
|
C25H35FN6O3
|
1
|
| 1 |
IC50 = 35000 nM
|
|
|
|
CP0954746
|
2-(4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl)-3-(isopropylamino)-N,N-dimethyl-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxamide trifluoroacetic acid
Show/Hide
|
C27H36F4N6O5
|
1
|
| 1 |
IC50 = 35000 nM
|
|
|
|
CP0533930
|
US10077266, Example 151
Show/Hide
|
C24H27F4N5O2
|
1
|
| 1 |
IC50 = 35900 nM
|
|
|
|
CP0477419
|
(R)-1-(2-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-3-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)ethan-1-one
Show/Hide
|
C24H30F3N5O
|
1
|
| 1 |
IC50 = 37800 nM
|
|
|
|
CP0904131
|
(R)-1-(2-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-3-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)ethan-1-one trifluoroacetic acid
Show/Hide
|
C26H31F6N5O3
|
1
|
| 1 |
IC50 = 37800 nM
|
|
|
|
CP0436153
|
US10077266, Example 18
Show/Hide
|
C25H28F2N6O3
|
1
|
| 1 |
IC50 = 38700 nM
|
|
|
|
CP0961797
|
(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-3-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)(isoxazol-5-yl)methanone trifluoroacetic acid
Show/Hide
|
C27H29F5N6O5
|
1
|
| 1 |
IC50 = 38700 nM
|
|
|
|
CP0477408
|
US10077266, Example 150
Show/Hide
|
C25H31F2N5O3
|
1
|
| 1 |
IC50 = 39200 nM
|
|
|
|
CP0874151
|
3-(4-(3-chlorobenzyl)piperazin-1-yl)-N-cyclopropylquinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
|
C24H25ClF3N5O2
|
1
|
| 1 |
IC50 = 40644 nM
|
|
|
|
CP0438909
|
US10077266, Example 124
Show/Hide
|
C22H27F2N5O2
|
1
|
| 1 |
IC50 = 43200 nM
|
|
|
|
CP0947228
|
3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-2-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carbaldehyde trifluoroacetic acid
Show/Hide
|
C24H28F5N5O4
|
1
|
| 1 |
IC50 = 43200 nM
|
|
|
|
CP0413463
|
US10077266, Example 135
Show/Hide
|
C24H30F2N6O
|
1
|
| 1 |
IC50 = 43700 nM
|
|
|
|
CP0874153
|
N-cyclopropyl-2-(4-(3-methylbenzyl)piperazin-1-yl)pyrido[2,3-b]pyrazin-3-amine 2,2,2-trifluoroacetic acid
Show/Hide
|
C24H27F3N6O2
|
1
|
| 1 |
IC50 = 45394 nM
|
|
|
|
CP0880957
|
3-(4-(3-chlorobenzyl)piperazin-1-yl)-N-(pyrimidin-2-yl)quinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
|
C25H23ClF3N7O2
|
1
|
| 1 |
IC50 = 46990 nM
|
|
|
|
CP0539715
|
US10077266, Example 152
Show/Hide
|
C23H29F2N5O3S
|
1
|
| 1 |
IC50 = 49300 nM
|
|
|
|
CP0485494
|
US10077266, Example 59
Show/Hide
|
C22H25F4N5O2
|
1
|
| 1 |
IC50 = 49700 nM
|
|
|
|
CP0871857
|
1-(3-((2,2-difluoroethyl)amino)-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)ethan-1-one trifluoroacetic acid
Show/Hide
|
C24H26F7N5O4
|
1
|
| 1 |
IC50 = 49700 nM
|
|
|
|
CP0477415
|
US10077266, Example 33
Show/Hide
|
C22H27F4N5O3S
|
1
|
| 1 |
IC50 = 52000 nM
|
|
|
|
CP0519136
|
US10077266, Example 128
Show/Hide
|
C24H29F2N5O2
|
1
|
| 1 |
IC50 = 55000 nM
|
|
|
|
CP0871860
|
1-(3-(cyclobutylamino)-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)ethan-1-one trifluoroacetic acid
Show/Hide
|
C26H30F5N5O4
|
1
|
| 1 |
IC50 = 55000 nM
|
|
|
|
CP0477417
|
US10077266, Example 6
Show/Hide
|
C24H28F2N6O2
|
1
|
| 1 |
IC50 = 55200 nM
|
|
|
|
CP0961799
|
3-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-3-(isopropylamino)-7,8-dihydropyrido [3,4-b]pyrazin-6(5H)-yl)-3-oxopropanenitrile trifluoroacetic acid
Show/Hide
|
C26H29F5N6O4
|
1
|
| 1 |
IC50 = 55200 nM
|
|
|
|
CP0436162
|
US10077266, Example 100
Show/Hide
|
C21H25F4N5O3S
|
1
|
| 1 |
IC50 = 57200 nM
|
|
|
|
CP0954752
|
N-(2,2-difluoroethyl)-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-6-(methylsulfonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-3-amine trifluoroacetic acid
Show/Hide
|
C23H26F7N5O5S
|
1
|
| 1 |
IC50 = 57200 nM
|
|
|
|
CP0218591
|
US10077266, Example 149
Show/Hide
|
C24H29F2N5O3
|
1
|
| 1 |
IC50 = 58700 nM
|
|
|
|
CP0473412
|
US10077266, Example 155
Show/Hide
|
C25H32F2N6O2
|
1
|
| 1 |
IC50 = 59100 nM
|
|
|
|
CP0477421
|
US10077266, Example 54
Show/Hide
|
C23H31F2N5O3S
|
1
|
| 1 |
IC50 = 59300 nM
|
|
|
|
CP0417132
|
US10077266, Example 81
Show/Hide
|
C22H29F2N5O
|
1
|
| 1 |
IC50 = 59500 nM
|
|
|
|
CP0951403
|
3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-N-isopropyl-6-methyl-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-amine trifluoroacetic acid
Show/Hide
|
C24H30F5N5O3
|
1
|
| 1 |
IC50 = 59500 nM
|
|
|
|
CP0426391
|
US10077266, Example 144
Show/Hide
|
C24H29F2N5O3
|
1
|
| 1 |
IC50 = 61500 nM
|
|
|
|
CP0417135
|
US10077266, Example 3
Show/Hide
|
C22H29F2N5O3S
|
1
|
| 1 |
IC50 = 61800 nM
|
|
|
|
CP0904130
|
2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-N-isopropyl-6-(methylsulfonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-3-amine trifluoroacetic acid
Show/Hide
|
C24H30F5N5O5S
|
1
|
| 1 |
IC50 = 61800 nM
|
|
|
|
CP0417129
|
US10077266, Example 129
Show/Hide
|
C24H31F2N5O2
|
1
|
| 1 |
IC50 = 62000 nM
|
|
|
|
CP0961805
|
(S)-1-(3-(sec-butylamino)-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)ethan-1-one trifluoroacetic acid
Show/Hide
|
C26H32F5N5O4
|
1
|
| 1 |
IC50 = 62000 nM
|
|
|
|
CP0546009
|
US10077266, Example 44
Show/Hide
|
C24H32FN5O3
|
1
|
| 1 |
IC50 = 62500 nM
|
|
|
|
CP0954754
|
1-(3-(4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl)-2-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)ethanone trifluoroacetic acid
Show/Hide
|
C26H33F4N5O5
|
1
|
| 1 |
IC50 = 62500 nM
|
|
|
|
CP0477416
|
(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-3-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)(morpholino)methanone
Show/Hide
|
C26H34F2N6O3
|
1
|
| 1 |
IC50 = 62600 nM
|
|
|
|
CP0954742
|
(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-3-(isopropylamino)-7,8-dihydropyrido [3,4-b]pyrazin-6(5H)-yl)(morpholino)methanone trifluoroacetic acid
Show/Hide
|
C28H35F5N6O5
|
1
|
| 1 |
IC50 = 62600 nM
|
|
|
|
CP0473411
|
US10077266, Example 153
Show/Hide
|
C24H30F2N6O2
|
1
|
| 1 |
IC50 = 63200 nM
|
|
|
|
CP0443083
|
US10077266, Example 103
Show/Hide
|
C24H29F4N5O3
|
1
|
| 1 |
IC50 = 64000 nM
|
|
|
|
CP0957838
|
(R)-1-(3-(2,2-difluoroethylamino)-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)-2-methoxypropan-1-one trifluoroacetic acid
Show/Hide
|
C26H30F7N5O5
|
1
|
| 1 |
IC50 = 64000 nM
|
|
|
|
CP0550688
|
US10077266, Example 34
Show/Hide
|
C24H29F4N5O3
|
1
|
| 1 |
IC50 = 68000 nM
|
|
|
|
CP0961129
|
N-cyclopropyl-3-(4-(pyridin-2-ylmethyl)piperazin-1-yl)quinoxalin-2-amine 2,2,2-trifluoroacetic acid
Show/Hide
|
C23H25F3N6O2
|
1
|
| 1 |
IC50 = 69180 nM
|
|
|
|
CP0477420
|
US10077266, Example 62
Show/Hide
|
C23H30F3N5O
|
1
|
| 1 |
IC50 = 69200 nM
|
|
|
|
CP0968929
|
3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-6-(2-fluoroethyl)-N-isopropyl-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-amine trifluoroacetic acid
Show/Hide
|
C25H31F6N5O3
|
1
|
| 1 |
IC50 = 69200 nM
|
|
|
|
CP0515473
|
US10077266, Example 2
Show/Hide
|
C24H31F2N5O3
|
1
|
| 1 |
IC50 = 71500 nM
|
|
|
|
CP0951401
|
1-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-3-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)-2-methoxyethan-1-one trifluoroacetic acid
Show/Hide
|
C26H32F5N5O5
|
1
|
| 1 |
IC50 = 71500 nM
|
|
|
|
CP0504110
|
US10077266, Example 52
Show/Hide
|
C24H31F2N5O2
|
1
|
| 1 |
IC50 = 73200 nM
|
|
|
|
CP0944233
|
1-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-3-(isopropylamino)-5-methyl-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)ethanone trifluoroacetic acid
Show/Hide
|
C26H32F5N5O4
|
1
|
| 1 |
IC50 = 73200 nM
|
|
|
|
CP0961804
|
1-(3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-2-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)ethanone trifluoroacetic acid
Show/Hide
|
C25H30F5N5O4
|
1
|
| 1 |
IC50 = 73700 nM
|
|
|
|
CP0426387
|
US10077266, Example 45
Show/Hide
|
C24H32FN5O3
|
1
|
| 1 |
IC50 = 74100 nM
|
|
|
|
CP0473996
|
US10077266, Example 133
Show/Hide
|
C23H30F3N5O
|
1
|
| 1 |
IC50 = 74800 nM
|
|
|
|
CP0417128
|
US10077266, Example 32
Show/Hide
|
C23H27F4N5O2
|
1
|
| 1 |
IC50 = 76000 nM
|
|
|
|
CP0545705
|
US10077266, Example 148
Show/Hide
|
C24H29F2N5O3
|
1
|
| 1 |
IC50 = 78000 nM
|
|
|
|
CP0485493
|
US10077266, Example 22
Show/Hide
|
C27H36F2N6O2
|
1
|
| 1 |
IC50 = 78100 nM
|
|
|
|
CP0962315
|
2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-3-(isopropylamino)-6-(methyl-L-prolyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine trifluoroacetic acid
Show/Hide
|
C29H37F5N6O4
|
1
|
| 1 |
IC50 = 78100 nM
|
|
|
|
CP0436163
|
US10077266, Example 101
Show/Hide
|
C22H23F6N5O2
|
1
|
| 1 |
IC50 = 78800 nM
|
|
|
|
CP0968928
|
1-(3-(2,2-difluoroethylamino)-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)-2,2-difluoroethanone trifluoroacetic acid
Show/Hide
|
C24H24F9N5O4
|
1
|
| 1 |
IC50 = 78800 nM
|
|
|
|
CP0467637
|
US10077266, Example 50
Show/Hide
|
C23H27F4N5O3
|
1
|
| 1 |
IC50 = 79500 nM
|
|
|
|
CP0867279
|
1-(2-((2,2-difluoroethyl)amino)-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)-2-methoxyethanone trifluoroacetic acid
Show/Hide
|
C25H28F7N5O5
|
1
|
| 1 |
IC50 = 79500 nM
|
|
|
|
CP0849534
|
(4-(3-(cyclopropylamino)quinoxalin-2-yl)piperazin-1-yl)(3,4-dichlorophenyl)methanone 2,2,2-trifluoroacetic acid
Show/Hide
|
C24H22Cl2F3N5O3
|
1
|
| 1 |
IC50 = 79620 nM
|
|
|
|
CP0477414
|
US10077266, Example 38
Show/Hide
|
C25H29F4N5O2
|
1
|
| 1 |
IC50 = 85000 nM
|
|
|
|
CP0954745
|
cyclopropyl(3-(2,2-difluoroethylamino)-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-methyl-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)methanone trifluoroacetic acid
Show/Hide
|
C27H30F7N5O4
|
1
|
| 1 |
IC50 = 85000 nM
|
|
|
|
CP0438898
|
US10077266, Example 7
Show/Hide
|
C24H29FN6O2
|
1
|
| 1 |
IC50 = 86600 nM
|
|
|
|
CP0962307
|
4-((1-(6-acetyl-3-(isopropylamino)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-yl)piperidin-4-yl)oxy)-3-fluorobenzonitrile trifluoroacetic acid
Show/Hide
|
C26H30F4N6O4
|
1
|
| 1 |
IC50 = 86600 nM
|
|
|
|
CP0436157
|
US10077266, Example 30
Show/Hide
|
C22H27F4N5O3S
|
1
|
| 1 |
IC50 = 87000 nM
|
|
|
|
CP0957834
|
N-(2,2-difluoroethyl)-2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-methyl-6-(methylsulfonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-3-amine trifluoroacetic acid
Show/Hide
|
C24H28F7N5O5S
|
1
|
| 1 |
IC50 = 87000 nM
|
|
|
|
CP0467636
|
US10077266, Example 35
Show/Hide
|
C24H31F2N5O2
|
1
|
| 1 |
IC50 = 88000 nM
|
|
|
|
CP0954741
|
1-(3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-2-(isopropylamino)-5-methyl-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)ethanone trifluoroacetic acid
Show/Hide
|
C26H32F5N5O4
|
1
|
| 1 |
IC50 = 88000 nM
|
|
|
|
CP0519134
|
US10077266, Example 84
Show/Hide
|
C22H29F2N5O
|
1
|
| 1 |
IC50 = 90100 nM
|
|
|
|
CP0947227
|
2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-N-isopropyl-6-methyl-5,6,7,8-tetrahydropyrido[4,3-b]pyrazin-3-amine trifluoroacetic acid
Show/Hide
|
C24H30F5N5O3
|
1
|
| 1 |
IC50 = 90100 nM
|
|
|
|
CP0425485
|
US10077266, Example 37
Show/Hide
|
C25H33F2N5O3
|
1
|
| 1 |
IC50 = 91000 nM
|
|
|
|
CP0423744
|
US10077266, Example 57
Show/Hide
|
C24H30F4N6O2
|
1
|
| 1 |
IC50 = 93500 nM
|
|
|
|
CP0441088
|
US10077266, Example 53
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C24H29F4N5O2
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1
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| 1 |
IC50 = 95000 nM
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CP0957841
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1-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-3-(isopropylamino)-5-methyl-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)-2,2-difluoroethanone trifluoroacetic acid
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C26H30F7N5O4
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1
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| 1 |
IC50 = 95000 nM
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CP0536815
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US10077266, Example 11
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C22H29F2N5O3S
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1
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| 1 |
IC50 = 95600 nM
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CP0944232
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3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-N-isopropyl-6-(methylsulfonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-amine trifluoroacetic acid
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C24H30F5N5O5S
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1
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| 1 |
IC50 = 95600 nM
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CP0477407
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US10077266, Example 154
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C24H30F2N6O2
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1
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| 1 |
IC50 = 97800 nM
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CP0417127
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US10077266, Example 36
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C23H31F2N5O3S
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1
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| 1 |
IC50 = 98000 nM
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CP0413461
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US10077266, Example 127
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C24H31F2N5O3
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1
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| 1 |
IC50 > 1 nM
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