| Compound ID |
Compound Name |
Compound Formula |
|
CP0256816
|
N-[(1R,3S)-3-hydroxycyclohexyl]-5-[4-(trifluoromethyl)phenyl]-4-[[[(2S)-1,1,1-trifluoropropan-2-yl]amino]methyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C21H23F6N3O3
|
1
|
| 1 |
IC50 = 0.1585 nM
|
|
|
|
CP0330503
|
(2S)-2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C23H28F4N4O3S
|
4
|
| 1 |
IC50 = 0.8 nM
|
|
|
| 2 |
IC50 = 6.3 nM
|
|
|
| 3 |
Ki = 0.01 nM
|
|
|
| 4 |
Ki = 0.2 nM
|
|
|
|
CP0170940
|
N-[(1R,3S)-3-hydroxycyclohexyl]-4-[(2-methylpropylamino)methyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
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|
C22H28F3N3O3
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0441588
|
4-[(cyclobutylmethylamino)methyl]-N-[(1R,3S)-3-hydroxycyclohexyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
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|
C23H28F3N3O3
|
1
|
| 1 |
IC50 = 1.259 nM
|
|
|
|
CP0271870
|
N-[(1R,3S)-3-hydroxycyclohexyl]-4-[[[(2R)-1-hydroxy-3-methylbutan-2-yl]amino]methyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C23H30F3N3O4
|
1
|
| 1 |
IC50 = 2.512 nM
|
|
|
|
CP0297675
|
4-[(cyclopropylamino)methyl]-N-[(1R,3S)-3-hydroxycyclohexyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
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|
C21H24F3N3O3
|
1
|
| 1 |
IC50 = 3.162 nM
|
|
|
|
CP0348026
|
N-[(1R,3S)-3-hydroxycyclohexyl]-4-[[(3-hydroxy-2,2-dimethylpropyl)amino]methyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C23H30F3N3O4
|
1
|
| 1 |
IC50 = 3.162 nM
|
|
|
|
CP0396648
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C23H28F4N4O3S
|
4
|
| 1 |
IC50 = 4.5 nM
|
|
|
| 2 |
IC50 = 8.4 nM
|
|
|
| 3 |
Ki = 0.23 nM
|
|
|
| 4 |
Ki = 0.3 nM
|
|
|
|
CP0436396
|
N-[(1R,3S)-3-hydroxycyclohexyl]-4-[[methyl-[[(2S)-oxolan-2-yl]methyl]amino]methyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C24H30F3N3O4
|
1
|
| 1 |
IC50 = 5.012 nM
|
|
|
|
CP0515341
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[[(1R,2R)-2-methylcyclopropyl]methoxy]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C22H25F4N3O4S
|
2
|
| 1 |
IC50 = 5.1 nM
|
|
|
| 2 |
Ki = 0.3 nM
|
|
|
|
CP0219197
|
4-[(cyclopropylmethylamino)methyl]-N-[(1R,3S)-3-hydroxycyclohexyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
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|
C22H26F3N3O3
|
1
|
| 1 |
IC50 = 7.943 nM
|
|
|
|
CP0436394
|
N-[(1R,3S)-3-hydroxycyclohexyl]-4-[[2-methoxyethyl(methyl)amino]methyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C22H28F3N3O4
|
1
|
| 1 |
IC50 = 7.943 nM
|
|
|
|
CP0509098
|
N-[[2-(4,4-dimethylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H30F4N4O3S
|
2
|
| 1 |
IC50 = 8 nM
|
|
|
| 2 |
Ki = 0.3 nM
|
|
|
|
CP0390351
|
2-[3,5-difluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C23H27F5N4O3S
|
3
|
| 1 |
IC50 = 8.1 nM
|
|
|
| 2 |
IC50 = 8.7 nM
|
|
|
| 3 |
Ki = 0.2 nM
|
|
|
|
CP0494095
|
N-[(1R,3S)-3-hydroxycyclohexyl]-4-[[(3,3,3-trifluoro-2-hydroxypropyl)amino]methyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C21H23F6N3O4
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0503330
|
N-[(1R,3S)-3-hydroxycyclohexyl]-4-[[[(2S)-1-hydroxy-3-methylbutan-2-yl]amino]methyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C23H30F3N3O4
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0446017
|
N-[[2-(dibutylamino)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H34F4N4O3S
|
2
|
| 1 |
IC50 = 10.5 nM
|
|
|
| 2 |
Ki = 0.6 nM
|
|
|
|
CP0380645
|
N-[[2-(cyclopentylmethoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
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|
C23H27F4N3O4S
|
2
|
| 1 |
IC50 = 11.6 nM
|
|
|
| 2 |
Ki = 0.4 nM
|
|
|
|
CP0427763
|
N-[[2-(3,6-dihydro-2H-pyridin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C22H24F4N4O3S
|
2
|
| 1 |
IC50 = 12.1 nM
|
|
|
| 2 |
Ki = 0.3 nM
|
|
|
|
CP0527479
|
(2S)-2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-hexoxy-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
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|
C23H29F4N3O4S
|
2
|
| 1 |
IC50 = 12.3 nM
|
|
|
| 2 |
Ki = 0.4 nM
|
|
|
|
CP0473915
|
N-[(1R,3S)-3-hydroxycyclohexyl]-4-[[methyl-[(3R)-oxolan-3-yl]amino]methyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C23H28F3N3O4
|
1
|
| 1 |
IC50 = 12.59 nM
|
|
|
|
CP0386674
|
2-(4-amino-3,5-dichlorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide
Show/Hide
|
C21H23Cl2F3N4O
|
4
|
| 1 |
IC50 = 12.8 nM
|
|
|
| 2 |
IC50 = 158 nM
|
|
|
| 3 |
Ki = 0.1 nM
|
|
|
| 4 |
Ki = 0.3 nM
|
|
|
|
CP0482535
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[6-(trifluoromethyl)-2-[4-(trifluoromethyl)cyclohexyl]oxypyridin-3-yl]methyl]propanamide
Show/Hide
|
C24H26F7N3O4S
|
2
|
| 1 |
IC50 = 14 nM
|
|
|
| 2 |
Ki = 0.3 nM
|
|
|
|
CP0400486
|
N-[[2-(dipropylamino)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H30F4N4O3S
|
2
|
| 1 |
IC50 = 14.7 nM
|
|
|
| 2 |
Ki = 0.2 nM
|
|
|
|
CP0380275
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(3-methylbutoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C22H27F4N3O4S
|
2
|
| 1 |
IC50 = 15.1 nM
|
|
|
| 2 |
Ki = 0.8 nM
|
|
|
|
CP0498682
|
4-[(cyclobutylamino)methyl]-N-[(1R,3S)-3-hydroxycyclohexyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C22H26F3N3O3
|
1
|
| 1 |
IC50 = 15.85 nM
|
|
|
|
CP0396673
|
tert-butyl 2-[2-[3-[[2-[3-fluoro-4-(methanesulfonamido)phenyl]propanoylamino]methyl]-6-(trifluoromethyl)pyridin-2-yl]oxyethyl]piperidine-1-carboxylate
Show/Hide
|
C29H38F4N4O6S
|
2
|
| 1 |
IC50 = 16.6 nM
|
|
|
| 2 |
Ki = 0.3 nM
|
|
|
|
CP0540685
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[4-[(4-methylphenyl)methyl]piperidin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C30H34F4N4O3S
|
2
|
| 1 |
IC50 = 17 nM
|
|
|
| 2 |
Ki = 0.2 nM
|
|
|
|
CP0427762
|
(2S)-2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-phenylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C28H30F4N4O3S
|
2
|
| 1 |
IC50 = 17.4 nM
|
|
|
| 2 |
Ki = 0.3 nM
|
|
|
|
CP0394941
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-phenylmethoxy-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C24H23F4N3O4S
|
3
|
| 1 |
IC50 = 18.6 nM
|
|
|
| 2 |
IC50 = 52.3 nM
|
|
|
| 3 |
Ki = 0.5 nM
|
|
|
|
CP0122651
|
4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-tert-butyl-phenyl)-amide
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|
C20H25ClN4O
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0529630
|
N-[[2-(cyclohexylmethoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H29F4N3O4S
|
2
|
| 1 |
IC50 = 19.7 nM
|
|
|
| 2 |
Ki = 0.7 nM
|
|
|
|
CP0441780
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-fluoropiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C22H25F5N4O3S
|
2
|
| 1 |
IC50 = 19.8 nM
|
|
|
| 2 |
Ki = 0.5 nM
|
|
|
|
CP0427764
|
N-[[2-[butyl(methyl)amino]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C22H28F4N4O3S
|
2
|
| 1 |
IC50 = 21.3 nM
|
|
|
| 2 |
Ki = 0.8 nM
|
|
|
|
CP0471621
|
(2S)-N-[[2-cyclohexylsulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H27F4N3O3S2
|
4
|
| 1 |
IC50 = 22.3 nM
|
|
|
| 2 |
IC50 > 1000 nM
|
|
|
| 3 |
Ki = 0.05 nM
|
|
|
| 4 |
Ki = 0.4 nM
|
|
|
|
CP0486704
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[4-(4-fluorophenyl)piperazin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C27H28F5N5O3S
|
2
|
| 1 |
IC50 = 23.1 nM
|
|
|
| 2 |
Ki = 1.1 nM
|
|
|
|
CP0397712
|
N-[[2-(3,3-dimethylbutoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H29F4N3O4S
|
2
|
| 1 |
IC50 = 23.8 nM
|
|
|
| 2 |
Ki = 0.9 nM
|
|
|
|
CP0452160
|
N-[[2-[4-[(3,5-difluorophenyl)methyl]piperidin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C29H30F6N4O3S
|
2
|
| 1 |
IC50 = 24 nM
|
|
|
| 2 |
Ki = 0.4 nM
|
|
|
|
CP0856456
|
rac-2-(3-Fluoro-4-(methylsulfonamido)phenyl)-N-((2-(4-phenylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-propanamide
Show/Hide
|
C28H30F4N4O3S
|
2
|
| 1 |
IC50 = 25 nM
|
|
|
| 2 |
Ki = 0.6 nM
|
|
|
|
CP0449861
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[(4-fluorophenyl)methoxy]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C24H22F5N3O4S
|
2
|
| 1 |
IC50 = 25 nM
|
|
|
| 2 |
Ki = 2.5 nM
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|
|
|
CP0554813
|
N-[[2-(azepan-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H28F4N4O3S
|
2
|
| 1 |
IC50 = 25.1 nM
|
|
|
| 2 |
Ki = 0.8 nM
|
|
|
|
CP0441586
|
N-[(1R,3S)-3-hydroxycyclohexyl]-4-[[methyl(propan-2-yl)amino]methyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C22H28F3N3O3
|
1
|
| 1 |
IC50 = 25.12 nM
|
|
|
|
CP0441587
|
4-[[ethyl(propan-2-yl)amino]methyl]-N-[(1R,3S)-3-hydroxycyclohexyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C23H30F3N3O3
|
1
|
| 1 |
IC50 = 25.12 nM
|
|
|
|
CP0453715
|
N-[[2-(3,5-dimethylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H30F4N4O3S
|
2
|
| 1 |
IC50 = 25.6 nM
|
|
|
| 2 |
Ki = 0.7 nM
|
|
|
|
CP0394932
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-pentoxy-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C22H27F4N3O4S
|
2
|
| 1 |
IC50 = 27.3 nM
|
|
|
| 2 |
Ki = 0.7 nM
|
|
|
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CP0396324
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(2-phenylethoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C25H25F4N3O4S
|
2
|
| 1 |
IC50 = 27.6 nM
|
|
|
| 2 |
Ki = 0.5 nM
|
|
|
|
CP0452159
|
N-[[2-(azocan-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H30F4N4O3S
|
2
|
| 1 |
IC50 = 27.8 nM
|
|
|
| 2 |
Ki = 0.7 nM
|
|
|
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CP0428034
|
N-[[2-(4-butoxypiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C26H34F4N4O4S
|
2
|
| 1 |
IC50 = 28.2 nM
|
|
|
| 2 |
Ki = 3.5 nM
|
|
|
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CP0380648
|
N-[[2-cyclopentyloxy-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C22H25F4N3O4S
|
2
|
| 1 |
IC50 = 28.7 nM
|
|
|
| 2 |
Ki = 0.9 nM
|
|
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CP0886708
|
N-((2-Hexyloxy-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide
Show/Hide
|
C23H29F4N3O4S
|
2
|
| 1 |
IC50 = 29.9 nM
|
|
|
| 2 |
Ki = 0.5 nM
|
|
|
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CP0452161
|
N-[[2-[4-[(3,4-difluorophenyl)methyl]piperidin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C29H30F6N4O3S
|
2
|
| 1 |
IC50 = 30 nM
|
|
|
| 2 |
Ki = 0.2 nM
|
|
|
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CP0432992
|
N-[[2-butoxy-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C21H25F4N3O4S
|
2
|
| 1 |
IC50 = 30.5 nM
|
|
|
| 2 |
Ki = 0.3 nM
|
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|
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CP0499954
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-phenylpiperazin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C27H29F4N5O3S
|
2
|
| 1 |
IC50 = 30.7 nM
|
|
|
| 2 |
Ki = 0.7 nM
|
|
|
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CP0427728
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[4-(methoxymethyl)piperidin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C24H30F4N4O4S
|
2
|
| 1 |
IC50 = 31 nM
|
|
|
| 2 |
Ki = 1.4 nM
|
|
|
|
CP0441779
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[6-(trifluoromethyl)-2-[4-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl]methyl]propanamide
Show/Hide
|
C23H25F7N4O3S
|
2
|
| 1 |
IC50 = 31 nM
|
|
|
| 2 |
Ki = 0.6 nM
|
|
|
|
CP0385584
|
2-(4-tert-butylphenoxy)-N-[6-[2-hydroxyethyl(methyl)amino]pyridin-3-yl]acetamide
Show/Hide
|
C20H27N3O3
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0395657
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[4-(2-fluorophenyl)piperazin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C27H28F5N5O3S
|
2
|
| 1 |
IC50 = 34 nM
|
|
|
| 2 |
Ki = 2.4 nM
|
|
|
|
CP0480946
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[4-(4-methylphenyl)piperazin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C28H31F4N5O3S
|
2
|
| 1 |
IC50 = 38.3 nM
|
|
|
| 2 |
Ki = 3.3 nM
|
|
|
|
CP0452721
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[4-(3-methylphenyl)piperazin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C28H31F4N5O3S
|
2
|
| 1 |
IC50 = 39.2 nM
|
|
|
| 2 |
Ki = 3.4 nM
|
|
|
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CP0374736
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N-[[2-(4-benzylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C29H32F4N4O3S
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2
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| 1 |
IC50 = 40 nM
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| 2 |
Ki = 0.2 nM
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CP0461869
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N-[[2-butylsulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
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C21H25F4N3O3S2
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2
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| 1 |
IC50 = 40.4 nM
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| 2 |
Ki = 0.7 nM
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CP0396490
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N-[[2-(cyclobutylmethoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C22H25F4N3O4S
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2
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| 1 |
IC50 = 40.5 nM
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| 2 |
Ki = 0.3 nM
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CP0554814
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C28H28F4N4O3S
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2
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| 1 |
IC50 = 43 nM
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| 2 |
Ki = 1.7 nM
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CP0515344
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[(Z)-pent-2-enoxy]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
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C22H25F4N3O4S
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2
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| 1 |
IC50 = 43 nM
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| 2 |
Ki = 1 nM
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CP0396266
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylcyclohexyl)oxy-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C24H29F4N3O4S
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2
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| 1 |
IC50 = 43.1 nM
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| 2 |
Ki = 2.9 nM
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CP0380646
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N-[[2-cyclohexyloxy-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
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C23H27F4N3O4S
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2
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| 1 |
IC50 = 43.4 nM
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| 2 |
Ki = 1.3 nM
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CP0397709
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[(3-methoxyphenyl)methoxy]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C25H25F4N3O5S
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2
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| 1 |
IC50 = 43.7 nM
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| 2 |
Ki = 0.8 nM
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CP0491571
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2-(4-tert-butylphenoxy)-N-[5-chloro-6-[2-hydroxyethyl(methyl)amino]pyridin-3-yl]acetamide
Show/Hide
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C20H26ClN3O3
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1
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| 1 |
IC50 = 44 nM
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CP0394943
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[(4-methylcyclohexyl)methoxy]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C25H31F4N3O4S
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2
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| 1 |
IC50 = 44.4 nM
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| 2 |
Ki = 1 nM
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CP0428033
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[4-(4-methoxyphenyl)piperazin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C28H31F4N5O4S
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2
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| 1 |
IC50 = 44.5 nM
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| 2 |
Ki = 2.5 nM
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CP0509108
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[1-[3-[[2-[3-fluoro-4-(methanesulfonamido)phenyl]propanoylamino]methyl]-6-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl] 2,2-dimethylpropanoate
Show/Hide
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C27H34F4N4O5S
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2
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| 1 |
IC50 = 45.2 nM
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| 2 |
Ki = 2 nM
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CP0428036
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(2S)-2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-piperidin-1-yl-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C22H26F4N4O3S
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2
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| 1 |
IC50 = 46.7 nM
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| 2 |
Ki = 0.3 nM
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CP0395660
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(2S)-2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[(3R)-3-phenylmethoxypyrrolidin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C28H30F4N4O4S
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2
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| 1 |
IC50 = 50 nM
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| 2 |
Ki = 1.4 nM
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CP0397713
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(2-methylpropoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C21H25F4N3O4S
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4
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| 1 |
IC50 = 52.6 nM
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| 2 |
IC50 = 67.5 nM
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| 3 |
Ki = 0.29 nM
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| 4 |
Ki = 0.5 nM
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CP0515340
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[(4-methylphenyl)methoxy]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
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C25H25F4N3O4S
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2
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| 1 |
IC50 = 53 nM
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| 2 |
Ki = 1.5 nM
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CP0493678
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(N-methylanilino)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C24H24F4N4O3S
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2
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| 1 |
IC50 = 57.4 nM
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| 2 |
Ki = 0.9 nM
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CP0439141
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2-(4-tert-butylphenoxy)-N-[6-(dimethylamino)pyridin-3-yl]acetamide
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C19H25N3O2
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1
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| 1 |
IC50 = 59 nM
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CP0160739
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N-[(1R,3S)-3-hydroxycyclohexyl]-4-[(propan-2-ylamino)methyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
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C21H26F3N3O3
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1
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| 1 |
IC50 = 63.1 nM
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CP0408458
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[6-(trifluoromethyl)-2-[[4-(trifluoromethyl)phenyl]methoxy]pyridin-3-yl]methyl]propanamide
Show/Hide
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C25H22F7N3O4S
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2
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| 1 |
IC50 = 66.1 nM
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| 2 |
Ki = 3.2 nM
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CP0469185
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N-[[2-(3-bromopropylsulfanyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C20H22BrF4N3O3S2
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2
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| 1 |
IC50 = 68 nM
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| 2 |
Ki = 7 nM
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CP0515337
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[(3-fluorophenyl)methoxy]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C24H22F5N3O4S
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2
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| 1 |
IC50 = 69 nM
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| 2 |
Ki = 0.8 nM
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CP0396644
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N-[[2-cyclobutyloxy-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C21H23F4N3O4S
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2
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| 1 |
IC50 = 69.8 nM
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| 2 |
Ki = 1.4 nM
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CP0493749
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[6-(trifluoromethyl)-2-[[3-(trifluoromethyl)phenyl]methylsulfanyl]pyridin-3-yl]methyl]propanamide
Show/Hide
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C25H22F7N3O3S2
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2
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| 1 |
IC50 = 71 nM
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| 2 |
Ki = 3.9 nM
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CP0469715
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2-[[1-[2-(trifluoromethyl)phenyl]triazol-4-yl]methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
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C21H18F3N5
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1
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| 1 |
IC50 = 75 nM
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CP0482534
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N-[[2-[(3,5-dimethoxyphenyl)methoxy]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C26H27F4N3O6S
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2
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| 1 |
IC50 = 76 nM
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| 2 |
Ki = 0.7 nM
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CP0436302
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N-[(1R,3S)-3-hydroxycyclohexyl]-4-[[methyl(oxan-4-yl)amino]methyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
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C24H30F3N3O4
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1
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| 1 |
IC50 = 79.43 nM
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CP0395701
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[4-(4-fluorophenyl)piperidin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C28H29F5N4O3S
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2
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| 1 |
IC50 = 81 nM
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| 2 |
Ki = 4.2 nM
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CP0471637
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(3-methylbutylsulfanyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C22H27F4N3O3S2
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2
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| 1 |
IC50 = 82 nM
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| 2 |
Ki = 0.7 nM
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CP0484114
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2-(2-bromo-4-tert-butylphenoxy)-N-[6-[2-hydroxyethyl(methyl)amino]pyridin-3-yl]acetamide
Show/Hide
|
C20H26BrN3O3
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1
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| 1 |
IC50 = 86 nM
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CP0462467
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2-[[1-[3-(trifluoromethyl)phenyl]triazol-4-yl]methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
|
C21H18F3N5
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1
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| 1 |
IC50 = 89 nM
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CP0510470
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N-[[2-(4-tert-butylcyclohexyl)sulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C27H35F4N3O3S2
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2
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| 1 |
IC50 = 89.6 nM
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| 2 |
Ki = 2.6 nM
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CP0433865
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-propoxy-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C20H23F4N3O4S
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2
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| 1 |
IC50 = 90.1 nM
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| 2 |
Ki = 0.9 nM
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CP0396488
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N-[[2-[(3,5-difluorophenyl)methoxy]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H21F6N3O4S
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2
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| 1 |
IC50 = 93 nM
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| 2 |
Ki = 1 nM
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CP0387833
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-propan-2-yloxy-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C20H23F4N3O4S
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2
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| 1 |
IC50 = 93.4 nM
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| 2 |
Ki = 2.1 nM
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CP0396489
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N-[[2-[(3-chlorophenyl)methoxy]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H22ClF4N3O4S
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2
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| 1 |
IC50 = 95 nM
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| 2 |
Ki = 4.9 nM
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CP0510471
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-pentylsulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C22H27F4N3O3S2
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2
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| 1 |
IC50 = 95.6 nM
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| 2 |
Ki = 2.5 nM
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CP0441781
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N-[[2-(4-ethylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H30F4N4O3S
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2
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| 1 |
IC50 = 97.3 nM
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| 2 |
Ki = 1.5 nM
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CP0491691
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2-(2,4-ditert-butylphenoxy)-N-[6-[2-hydroxyethyl(methyl)amino]pyridin-3-yl]acetamide
Show/Hide
|
C24H35N3O3
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1
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| 1 |
IC50 = 107 nM
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CP0428032
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-pyridin-2-ylpiperazin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C26H28F4N6O3S
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2
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| 1 |
IC50 = 108 nM
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| 2 |
Ki = 1.4 nM
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CP0549560
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2-[[1-(2-nitrophenyl)triazol-4-yl]methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
|
C20H18N6O2
|
1
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| 1 |
IC50 = 108 nM
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CP0491692
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N-[6-[2-hydroxyethyl(methyl)amino]pyridin-3-yl]-2-(4-propan-2-ylphenoxy)acetamide
Show/Hide
|
C19H25N3O3
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1
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| 1 |
IC50 = 110 nM
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CP0493744
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(2-phenylethylsulfanyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C25H25F4N3O3S2
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2
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| 1 |
IC50 = 111 nM
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| 2 |
Ki = 1.9 nM
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CP0435450
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2-[[1-(2,5-dichlorophenyl)triazol-4-yl]methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
|
C20H17Cl2N5
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1
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| 1 |
IC50 = 112 nM
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CP0432991
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N-[[2-[(3,5-dichlorophenyl)methoxy]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H21Cl2F4N3O4S
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2
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| 1 |
IC50 = 114 nM
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| 2 |
Ki = 2.6 nM
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CP0397711
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N-[[2-(cyclopropylmethoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C21H23F4N3O4S
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2
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| 1 |
IC50 = 115 nM
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| 2 |
Ki = 1.1 nM
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CP0372650
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(E)-3-(2-Morpholin-4-yl-6-trifluoromethyl-pyridin-3-yl)-N-quinolin-7-yl-acrylamide
Show/Hide
|
C22H19F3N4O2
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2
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| 1 |
IC50 = 116 nM
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| 2 |
Ki = 1.2 nM
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CP0395700
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[6-(trifluoromethyl)-2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]pyridin-3-yl]methyl]propanamide
Show/Hide
|
C28H28F7N5O3S
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2
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| 1 |
IC50 = 117 nM
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| 2 |
Ki = 2.3 nM
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CP0486706
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N-[[2-[4-(3-chloropyridin-2-yl)piperazin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C26H27ClF4N6O3S
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2
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| 1 |
IC50 = 117 nM
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| 2 |
Ki = 2.1 nM
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CP0423129
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(2-phenoxyethylsulfanyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C25H25F4N3O4S2
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2
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| 1 |
IC50 = 118 nM
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| 2 |
Ki = 2.3 nM
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CP0491574
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1-(2-bromophenyl)-3-[(3S)-1-[5-(trifluoromethyl)pyridin-2-yl]pyrrolidin-3-yl]urea
Show/Hide
|
C17H16BrF3N4O
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1
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| 1 |
IC50 = 120 nM
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CP0535680
|
2-[[1-(4-nitrophenyl)triazol-4-yl]methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
|
C20H18N6O2
|
1
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| 1 |
IC50 = 121 nM
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CP0515338
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N-[[2-(4-ethylcyclohexyl)oxy-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H31F4N3O4S
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2
|
| 1 |
IC50 = 125 nM
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| 2 |
Ki = 4.8 nM
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CP0478588
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N-[(1R,3S)-3-hydroxycyclohexyl]-4-[(2-methoxyethylamino)methyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C21H26F3N3O4
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1
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| 1 |
IC50 = 125.89 nM
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CP0491572
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2-(4-tert-butylphenoxy)-N-[6-[2-hydroxyethyl(methyl)amino]-5-methylpyridin-3-yl]acetamide
Show/Hide
|
C21H29N3O3
|
1
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| 1 |
IC50 = 130 nM
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CP0394933
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N-[[2-[(4-chlorophenyl)methoxy]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H22ClF4N3O4S
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2
|
| 1 |
IC50 = 132 nM
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| 2 |
Ki = 2.5 nM
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CP0395668
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[1-[3-[[2-[3-fluoro-4-(methanesulfonamido)phenyl]propanoylamino]methyl]-6-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl] acetate
Show/Hide
|
C24H28F4N4O5S
|
2
|
| 1 |
IC50 = 139 nM
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| 2 |
Ki = 4 nM
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CP0455690
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N-[[2-(5-chloro-2-methylanilino)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H23ClF4N4O3S
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2
|
| 1 |
IC50 = 140 nM
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| 2 |
Ki = 14 nM
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CP0515342
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N-[[2-(4,4-dimethylcyclohexyl)oxy-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H31F4N3O4S
|
2
|
| 1 |
IC50 = 140 nM
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| 2 |
Ki = 0.9 nM
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CP0395663
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N-[[2-(diethylamino)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C21H26F4N4O3S
|
2
|
| 1 |
IC50 = 148 nM
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| 2 |
Ki = 3.5 nM
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CP0441783
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[4-(4-fluorophenyl)-3,6-dihydro-2H-pyridin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C28H27F5N4O3S
|
2
|
| 1 |
IC50 = 159 nM
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| 2 |
Ki = 2.4 nM
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CP0380653
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(3-phenoxypropoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C26H27F4N3O5S
|
2
|
| 1 |
IC50 = 161 nM
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| 2 |
Ki = 1.5 nM
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CP0397566
|
N-[[2-[(2,2-dimethylcyclopropyl)methoxy]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H27F4N3O4S
|
2
|
| 1 |
IC50 = 161 nM
|
|
|
| 2 |
Ki = 1.1 nM
|
|
|
|
CP0529628
|
N-[[2-[(4-ethylphenyl)methoxy]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C26H27F4N3O4S
|
2
|
| 1 |
IC50 = 165 nM
|
|
|
| 2 |
Ki = 3.7 nM
|
|
|
|
CP0395702
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-morpholin-4-yl-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C21H24F4N4O4S
|
2
|
| 1 |
IC50 = 169 nM
|
|
|
| 2 |
Ki = 1.3 nM
|
|
|
|
CP0409393
|
(2S)-N-[(4-tert-butylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C21H27FN2O3S
|
6
|
| 1 |
IC50 = 174 nM
|
|
|
| 2 |
IC50 = 1210 nM
|
|
|
| 3 |
IC50 = 1281 nM
|
|
|
| 4 |
Ki = 6.6 nM
|
|
|
| 5 |
Ki = 20 nM
|
|
|
| 6 |
Ki = 28 nM
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CP0396487
|
N-[[2-(3,5-dimethylcyclohexyl)oxy-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H31F4N3O4S
|
2
|
| 1 |
IC50 = 174 nM
|
|
|
| 2 |
Ki = 3 nM
|
|
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|
CP0423152
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylcyclohexyl)sulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C24H29F4N3O3S2
|
2
|
| 1 |
IC50 = 180 nM
|
|
|
| 2 |
Ki = 0.5 nM
|
|
|
|
CP0397710
|
N-[[2-[(4-tert-butylphenyl)methoxy]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C28H31F4N3O4S
|
2
|
| 1 |
IC50 = 182 nM
|
|
|
| 2 |
Ki = 2.1 nM
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|
CP0482536
|
N-[[2-[(Z)-but-2-enoxy]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C21H23F4N3O4S
|
2
|
| 1 |
IC50 = 183 nM
|
|
|
| 2 |
Ki = 1.6 nM
|
|
|
|
CP0521239
|
N-[[2-(1,3-dihydroisoindol-2-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H24F4N4O3S
|
2
|
| 1 |
IC50 = 192 nM
|
|
|
| 2 |
Ki = 5 nM
|
|
|
|
CP0540686
|
N-[[2-(benzylamino)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H24F4N4O3S
|
2
|
| 1 |
IC50 = 203 nM
|
|
|
| 2 |
Ki = 15.8 nM
|
|
|
|
CP0435452
|
2-[[1-[4-(trifluoromethyl)phenyl]triazol-4-yl]methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
|
C21H18F3N5
|
1
|
| 1 |
IC50 = 204 nM
|
|
|
|
CP0395662
|
tert-butyl (2S)-1-[3-[[[(2S)-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanoyl]amino]methyl]-6-(trifluoromethyl)pyridin-2-yl]pyrrolidine-2-carboxylate
Show/Hide
|
C26H32F4N4O5S
|
2
|
| 1 |
IC50 = 209 nM
|
|
|
| 2 |
Ki = 2.6 nM
|
|
|
|
CP0480948
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-pyrrolidin-1-yl-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C21H24F4N4O3S
|
2
|
| 1 |
IC50 = 211 nM
|
|
|
| 2 |
Ki = 0.6 nM
|
|
|
|
CP0471623
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[3-(4-methylpiperidin-1-yl)propylsulfanyl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C26H34F4N4O3S2
|
2
|
| 1 |
IC50 = 217 nM
|
|
|
| 2 |
Ki = 2.9 nM
|
|
|
|
CP0856457
|
rac-2-(3-Fluoro-4-(methylsulfonamido)phenyl)-N-((2-(piperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide
Show/Hide
|
C22H26F4N4O3S
|
2
|
| 1 |
IC50 = 218 nM
|
|
|
| 2 |
Ki = 0.43 nM
|
|
|
|
CP0382670
|
2-[[1-(2-fluorophenyl)triazol-4-yl]methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
|
C20H18FN5
|
1
|
| 1 |
IC50 = 232 nM
|
|
|
|
CP0433023
|
N-[[2-(4-tert-butylcyclohexyl)oxy-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C27H35F4N3O4S
|
2
|
| 1 |
IC50 = 242 nM
|
|
|
| 2 |
Ki = 7.7 nM
|
|
|
|
CP0462466
|
2-[[1-(2-chlorophenyl)triazol-4-yl]methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
|
C20H18ClN5
|
1
|
| 1 |
IC50 = 243 nM
|
|
|
|
CP0471619
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(3-piperidin-1-ylpropylsulfanyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C25H32F4N4O3S2
|
2
|
| 1 |
IC50 = 250 nM
|
|
|
| 2 |
Ki = 3 nM
|
|
|
|
CP0487992
|
(2R)-2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C23H28F4N4O3S
|
2
|
| 1 |
IC50 = 254 nM
|
|
|
| 2 |
Ki = 9.8 nM
|
|
|
|
CP0510468
|
N-[[2-(cyclohexylmethylsulfanyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H29F4N3O3S2
|
2
|
| 1 |
IC50 = 254 nM
|
|
|
| 2 |
Ki = 2.3 nM
|
|
|
|
CP0427730
|
N-[[2-(cyclohexylamino)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H28F4N4O3S
|
2
|
| 1 |
IC50 = 260 nM
|
|
|
| 2 |
Ki = 20.4 nM
|
|
|
|
CP0433867
|
N-[[2-ethoxy-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C19H21F4N3O4S
|
2
|
| 1 |
IC50 = 277 nM
|
|
|
| 2 |
Ki = 12.7 nM
|
|
|
|
CP0471620
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[(4-methoxyphenyl)methylsulfanyl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C25H25F4N3O4S2
|
2
|
| 1 |
IC50 = 279 nM
|
|
|
| 2 |
Ki = 2.3 nM
|
|
|
|
CP0428035
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methoxypiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C23H28F4N4O4S
|
2
|
| 1 |
IC50 = 280 nM
|
|
|
| 2 |
Ki = 2.4 nM
|
|
|
|
CP0452718
|
N-[[2-(3-tert-butyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C28H35F4N5O4S
|
2
|
| 1 |
IC50 = 281 nM
|
|
|
| 2 |
Ki = 3.8 nM
|
|
|
|
CP0427726
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C30H31F4N5O4S
|
2
|
| 1 |
IC50 = 289 nM
|
|
|
| 2 |
Ki = 6.1 nM
|
|
|
|
CP0427731
|
N-[[2-(butylamino)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C21H26F4N4O3S
|
2
|
| 1 |
IC50 = 293 nM
|
|
|
| 2 |
Ki = 9.1 nM
|
|
|
|
CP0418916
|
tert-butyl 4-[3-[[2-[3-fluoro-4-(methanesulfonamido)phenyl]propanoylamino]methyl]-6-(trifluoromethyl)pyridin-2-yl]oxypiperidine-1-carboxylate
Show/Hide
|
C27H34F4N4O6S
|
2
|
| 1 |
IC50 = 293 nM
|
|
|
| 2 |
Ki = 1.3 nM
|
|
|
|
CP0493746
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(3-pyrrolidin-1-ylpropylsulfanyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C24H30F4N4O3S2
|
2
|
| 1 |
IC50 = 312 nM
|
|
|
| 2 |
Ki = 3.3 nM
|
|
|
|
CP0435446
|
2-[(1-phenyltriazol-4-yl)methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
|
C20H19N5
|
1
|
| 1 |
IC50 = 314 nM
|
|
|
|
CP0515339
|
N-[[2-[(4-butylphenyl)methoxy]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C28H31F4N3O4S
|
2
|
| 1 |
IC50 = 337 nM
|
|
|
| 2 |
Ki = 16 nM
|
|
|
|
CP0459698
|
2-[[1-(3,4-dichlorophenyl)triazol-4-yl]methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
|
C20H17Cl2N5
|
1
|
| 1 |
IC50 = 341 nM
|
|
|
|
CP0394942
|
tert-butyl 4-[[3-[[2-[3-fluoro-4-(methanesulfonamido)phenyl]propanoylamino]methyl]-6-(trifluoromethyl)pyridin-2-yl]oxymethyl]piperidine-1-carboxylate
Show/Hide
|
C28H36F4N4O6S
|
2
|
| 1 |
IC50 = 342 nM
|
|
|
| 2 |
Ki = 3.4 nM
|
|
|
|
CP0402175
|
2-[[1-(3-fluorophenyl)triazol-4-yl]methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
|
C20H18FN5
|
1
|
| 1 |
IC50 = 385 nM
|
|
|
|
CP0435454
|
2-[[1-(4-chloro-2-nitrophenyl)triazol-4-yl]methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
|
C20H17ClN6O2
|
1
|
| 1 |
IC50 = 394 nM
|
|
|
|
CP0439143
|
2-(4-tert-butylphenoxy)-N-(6-pyrrolidin-1-ylpyridin-3-yl)acetamide
Show/Hide
|
C21H27N3O2
|
1
|
| 1 |
IC50 = 411 nM
|
|
|
|
CP0487987
|
N-[[2-[(4-chlorophenyl)methylamino]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H23ClF4N4O3S
|
2
|
| 1 |
IC50 = 414 nM
|
|
|
| 2 |
Ki = 65.7 nM
|
|
|
|
CP0472301
|
2-[[1-(3-chlorophenyl)triazol-4-yl]methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
|
C20H18ClN5
|
1
|
| 1 |
IC50 = 416 nM
|
|
|
|
CP0493675
|
N-[[2-[4-[(dimethylamino)methyl]piperidin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C25H33F4N5O3S
|
2
|
| 1 |
IC50 = 426 nM
|
|
|
| 2 |
Ki = 2.1 nM
|
|
|
|
CP0515343
|
N-[[2-(3-ethoxypropoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C22H27F4N3O5S
|
2
|
| 1 |
IC50 = 462 nM
|
|
|
| 2 |
Ki = 9.7 nM
|
|
|
|
CP0395666
|
N-[[2-(4-anilinopiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C28H31F4N5O3S
|
2
|
| 1 |
IC50 = 480 nM
|
|
|
| 2 |
Ki = 4.4 nM
|
|
|
|
CP0435447
|
2-[[1-(4-fluorophenyl)triazol-4-yl]methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
|
C20H18FN5
|
1
|
| 1 |
IC50 = 494 nM
|
|
|
|
CP0472302
|
2-[[1-(4-chlorophenyl)triazol-4-yl]methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
|
C20H18ClN5
|
1
|
| 1 |
IC50 = 495 nM
|
|
|
|
CP0439142
|
2-(4-tert-butylphenoxy)-N-[6-(3-hydroxypyrrolidin-1-yl)pyridin-3-yl]acetamide
Show/Hide
|
C21H27N3O3
|
1
|
| 1 |
IC50 = 516 nM
|
|
|
|
CP0432197
|
2-(4-tert-butylphenoxy)-N-[6-[ethyl(methyl)amino]pyridin-3-yl]acetamide
Show/Hide
|
C20H27N3O2
|
1
|
| 1 |
IC50 = 583 nM
|
|
|
|
CP0441798
|
N-[[2-(4-ethoxypiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H30F4N4O4S
|
2
|
| 1 |
IC50 = 612 nM
|
|
|
| 2 |
Ki = 1.3 nM
|
|
|
|
CP0505257
|
N-[[2-[(2-chlorophenyl)methylsulfanyl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H22ClF4N3O3S2
|
2
|
| 1 |
IC50 = 620 nM
|
|
|
| 2 |
Ki = 4.9 nM
|
|
|
|
CP0427722
|
N-[[2-(4-benzylpiperazin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C28H31F4N5O3S
|
2
|
| 1 |
IC50 = 634 nM
|
|
|
| 2 |
Ki = 8.8 nM
|
|
|
|
CP0529627
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[(4-methoxyphenyl)methoxy]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C25H25F4N3O5S
|
2
|
| 1 |
IC50 = 653 nM
|
|
|
| 2 |
Ki = 2.6 nM
|
|
|
|
CP0471618
|
N-[[2-[(4-chlorophenyl)methylsulfanyl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H22ClF4N3O3S2
|
2
|
| 1 |
IC50 = 674 nM
|
|
|
| 2 |
Ki = 8.7 nM
|
|
|
|
CP0493751
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-hexylsulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C23H29F4N3O3S2
|
2
|
| 1 |
IC50 = 719 nM
|
|
|
| 2 |
Ki = 5.6 nM
|
|
|
|
CP0493676
|
tert-butyl N-[(3S)-1-[3-[[[(2S)-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanoyl]amino]methyl]-6-(trifluoromethyl)pyridin-2-yl]pyrrolidin-3-yl]carbamate
Show/Hide
|
C26H33F4N5O5S
|
2
|
| 1 |
IC50 = 737 nM
|
|
|
| 2 |
Ki = 7.1 nM
|
|
|
|
CP0395659
|
tert-butyl N-[(3R)-1-[3-[[[(2S)-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanoyl]amino]methyl]-6-(trifluoromethyl)pyridin-2-yl]pyrrolidin-3-yl]carbamate
Show/Hide
|
C26H33F4N5O5S
|
2
|
| 1 |
IC50 = 757 nM
|
|
|
| 2 |
Ki = 11 nM
|
|
|
|
CP0391190
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[(4-methylphenyl)methylsulfanyl]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C25H25F4N3O3S2
|
2
|
| 1 |
IC50 = 764 nM
|
|
|
| 2 |
Ki = 3.2 nM
|
|
|
|
CP0435453
|
2-[[1-(4-bromophenyl)triazol-4-yl]methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
|
C20H18BrN5
|
1
|
| 1 |
IC50 = 788 nM
|
|
|
|
CP0525702
|
2-(2-tert-butylphenoxy)-N-[6-[2-hydroxyethyl(methyl)amino]pyridin-3-yl]acetamide
Show/Hide
|
C20H27N3O3
|
1
|
| 1 |
IC50 = 796 nM
|
|
|
|
CP0527608
|
2-(4-tert-butyl-2-piperidin-1-ylphenoxy)-N-[6-[2-hydroxyethyl(methyl)amino]pyridin-3-yl]acetamide
Show/Hide
|
C25H36N4O3
|
1
|
| 1 |
IC50 = 941 nM
|
|
|
|
CP0509097
|
N-[[2-[4-(4-fluorobenzoyl)piperidin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C29H29F5N4O4S
|
2
|
| 1 |
IC50 = 990 nM
|
|
|
| 2 |
Ki = 3.9 nM
|
|
|
|
CP0428031
|
N-[[2-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H28F4N4O4S
|
2
|
| 1 |
IC50 = 1090 nM
|
|
|
| 2 |
Ki = 1.43 nM
|
|
|
|
CP0517250
|
methyl 3-[3-[[2-[3-fluoro-4-(methanesulfonamido)phenyl]propanoylamino]methyl]-6-(trifluoromethyl)pyridin-2-yl]sulfanylpropanoate
Show/Hide
|
C21H23F4N3O5S2
|
2
|
| 1 |
IC50 = 1099 nM
|
|
|
| 2 |
Ki = 48.2 nM
|
|
|
|
CP0435449
|
2-[[1-(3,4-dimethoxyphenyl)triazol-4-yl]methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
|
C22H23N5O2
|
1
|
| 1 |
IC50 = 1122 nM
|
|
|
|
CP0446018
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-[(4-methylcyclohexyl)amino]-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C24H30F4N4O3S
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2
|
| 1 |
IC50 = 1130 nM
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| 2 |
Ki = 27.2 nM
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CP0493879
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tert-butyl 4-[[[3-[[2-[3-fluoro-4-(methanesulfonamido)phenyl]propanoylamino]methyl]-6-(trifluoromethyl)pyridin-2-yl]amino]methyl]piperidine-1-carboxylate
Show/Hide
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C28H37F4N5O5S
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2
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| 1 |
IC50 = 1140 nM
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| 2 |
Ki = 19.3 nM
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CP0428037
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N-[[2-(3,4-dimethylanilino)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
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C25H26F4N4O3S
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2
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| 1 |
IC50 = 1160 nM
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| 2 |
Ki = 39.3 nM
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CP0534240
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2-[[1-(4-methoxyphenyl)triazol-4-yl]methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
|
C21H21N5O
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1
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| 1 |
IC50 = 1195 nM
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CP0541591
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2-[[1-(4-tert-butylphenyl)triazol-4-yl]methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
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C24H27N5
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1
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| 1 |
IC50 = 1217 nM
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CP0503266
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N-[(1R,3S)-3-hydroxycyclohexyl]-4-[[methyl(2-methylsulfonylethyl)amino]methyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
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C22H28F3N3O5S
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1
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| 1 |
IC50 = 1258.93 nM
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CP0486596
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N-[[2-anilino-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C23H22F4N4O3S
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2
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| 1 |
IC50 = 1400 nM
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| 2 |
Ki = 59.6 nM
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CP0493748
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N-[[2-[3-(dimethylamino)propylsulfanyl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C22H28F4N4O3S2
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2
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| 1 |
IC50 = 1498 nM
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| 2 |
Ki = 27.4 nM
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CP0403168
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2-[[1-(2,5-dimethylphenyl)triazol-4-yl]methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
|
C22H23N5
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1
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| 1 |
IC50 = 1543 nM
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CP0535786
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2-[[1-(3-propan-2-ylphenyl)triazol-4-yl]methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
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C23H25N5
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1
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| 1 |
IC50 = 1674 nM
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CP0435448
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2-[[1-(2-methoxyphenyl)triazol-4-yl]methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
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C21H21N5O
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1
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| 1 |
IC50 = 1878 nM
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CP0394930
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N-[(4-tert-butylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C21H27FN2O3S
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2
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| 1 |
IC50 = 1990 nM
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| 2 |
Ki = 44.5 nM
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CP0462465
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2-[(1-isoquinolin-5-yltriazol-4-yl)methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
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C23H20N6
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1
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| 1 |
IC50 = 2156 nM
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CP0395669
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(2R)-2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-phenylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C28H30F4N4O3S
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2
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| 1 |
IC50 = 2350 nM
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| 2 |
Ki = 7.5 nM
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CP0455689
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N-[[2-(dimethylamino)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C19H22F4N4O3S
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2
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| 1 |
IC50 = 2390 nM
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| 2 |
Ki = 19.1 nM
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CP0462468
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2-[[1-(2-propan-2-ylphenyl)triazol-4-yl]methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
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C23H25N5
|
1
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| 1 |
IC50 = 2531 nM
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CP0385583
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2-(3-tert-butylphenoxy)-N-[6-[2-hydroxyethyl(methyl)amino]pyridin-3-yl]acetamide
Show/Hide
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C20H27N3O3
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1
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| 1 |
IC50 = 2620 nM
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CP0462939
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4-[(4-carbamoylpiperidin-1-yl)methyl]-N-[(1R,3S)-3-hydroxycyclohexyl]-5-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide
Show/Hide
|
C24H29F3N4O4
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1
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| 1 |
IC50 = 3162.28 nM
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CP0541590
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2-[[1-(2-chloropyridin-3-yl)triazol-4-yl]methyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
|
C19H17ClN6
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1
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| 1 |
IC50 = 3489 nM
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CP0435451
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1-[[1-[2-(trifluoromethyl)phenyl]triazol-4-yl]methyl]-2,3-dihydroindole
Show/Hide
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C18H15F3N4
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1
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| 1 |
IC50 = 4945 nM
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CP0395902
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6-methyl-5-[2-(trifluoromethyl)phenyl]-1H-indazole
Show/Hide
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C15H11F3N2
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1
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| 1 |
IC50 = 5100 nM
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CP0447248
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6-(cyclopropylmethoxy)-5-[2-(trifluoromethyl)phenyl]-1H-indazole
Show/Hide
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C18H15F3N2O
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1
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| 1 |
IC50 = 8100 nM
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CP0407450
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N-[6-[2-hydroxyethyl(methyl)amino]pyridin-3-yl]-2-[4-(trifluoromethyl)phenoxy]acetamide
Show/Hide
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C17H18F3N3O3
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1
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| 1 |
IC50 > 10000 nM
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CP0407451
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N-[6-[2-hydroxyethyl(methyl)amino]pyridin-3-yl]-2-phenoxyacetamide
Show/Hide
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C16H19N3O3
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1
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| 1 |
IC50 > 10000 nM
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CP0433933
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2-[4-(1-adamantyl)phenoxy]-N-[6-[2-hydroxyethyl(methyl)amino]pyridin-3-yl]acetamide
Show/Hide
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C26H33N3O3
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1
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| 1 |
IC50 > 10000 nM
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CP0380654
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(piperidin-4-ylmethoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C23H28F4N4O4S
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2
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| 1 |
IC50 > 10000 nM
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| 2 |
Ki < 1000 nM
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CP0394944
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-pentan-3-yloxy-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C22H27F4N3O4S
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2
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| 1 |
IC50 > 10000 nM
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| 2 |
Ki = 1.1 nM
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CP0529617
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-piperidin-4-yloxy-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C22H26F4N4O4S
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2
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| 1 |
IC50 > 10000 nM
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| 2 |
Ki < 1000 nM
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CP0395903
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6-(trifluoromethoxy)-5-[2-(trifluoromethyl)phenyl]-1H-indazole
Show/Hide
|
C15H8F6N2O
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1
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| 1 |
IC50 = 11500 nM
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CP0554723
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1-[[1-(4-chlorophenyl)triazol-4-yl]methyl]-2,3-dihydroindole
Show/Hide
|
C17H15ClN4
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1
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| 1 |
IC50 = 12572 nM
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CP0440771
|
6-chloro-5-[2-(trifluoromethyl)phenyl]-1H-indazole
Show/Hide
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C14H8ClF3N2
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1
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| 1 |
IC50 = 16700 nM
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CP0402174
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1-[[1-(3-fluorophenyl)triazol-4-yl]methyl]-2,3-dihydroindole
Show/Hide
|
C17H15FN4
|
1
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| 1 |
IC50 = 19416 nM
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CP0534241
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1-[[1-(4-tert-butylphenyl)triazol-4-yl]methyl]-2,3-dihydroindole
Show/Hide
|
C21H24N4
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1
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| 1 |
IC50 = 22573 nM
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CP0403169
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1-[[1-(4-tert-butylphenyl)triazol-4-yl]methyl]-5-chloro-2,3-dihydroindole
Show/Hide
|
C21H23ClN4
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1
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| 1 |
IC50 = 27071 nM
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CP0440768
|
5-[2-(trifluoromethyl)phenyl]-1H-indazole
Show/Hide
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C14H9F3N2
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1
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| 1 |
IC50 > 30000 nM
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CP0447265
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6-methoxy-5-[2-(trifluoromethyl)phenyl]-1H-indazole
Show/Hide
|
C15H11F3N2O
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1
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| 1 |
IC50 > 30000 nM
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CP0380650
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N-[[2-(2,6-dimethylheptan-4-yloxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C26H35F4N3O4S
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2
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| 1 |
IC50 < 10000 nM
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| 2 |
Ki = 0.7 nM
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CP0387830
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N-[[2-(2,3-dihydro-1H-inden-2-yloxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C26H25F4N3O4S
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2
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| 1 |
IC50 < 10000 nM
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| 2 |
Ki = 2.7 nM
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CP0387831
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-heptan-4-yloxy-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C24H31F4N3O4S
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2
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| 1 |
IC50 < 10000 nM
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| 2 |
Ki = 0.7 nM
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CP0394945
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-phenoxy-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C23H21F4N3O4S
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2
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| 1 |
IC50 < 10000 nM
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| 2 |
Ki = 6.4 nM
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CP0396494
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N-[[2-(2-ethoxyethoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C21H25F4N3O5S
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2
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| 1 |
IC50 < 10000 nM
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| 2 |
Ki = 50 nM
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CP0396645
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(pyridin-4-ylmethoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C23H22F4N4O4S
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2
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| 1 |
IC50 < 10000 nM
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| 2 |
Ki = 51 nM
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CP0396646
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylphenoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C24H23F4N3O4S
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2
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| 1 |
IC50 < 10000 nM
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| 2 |
Ki = 2.8 nM
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CP0396649
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(pyridin-2-ylmethoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C23H22F4N4O4S
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2
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| 1 |
IC50 < 10000 nM
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| 2 |
Ki = 29.5 nM
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CP0396650
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(3-methoxypropoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C21H25F4N3O5S
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2
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| 1 |
IC50 < 10000 nM
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| 2 |
Ki = 15.3 nM
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CP0408467
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-octan-4-yloxy-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C25H33F4N3O4S
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2
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| 1 |
IC50 < 10000 nM
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| 2 |
Ki = 0.5 nM
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CP0408482
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(pyridin-3-ylmethoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C23H22F4N4O4S
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2
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| 1 |
IC50 < 10000 nM
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| 2 |
Ki = 142 nM
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CP0433881
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-methoxy-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C18H19F4N3O4S
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2
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| 1 |
IC50 < 10000 nM
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| 2 |
Ki = 68.8 nM
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CP0515288
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(2-methoxyethoxy)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C20H23F4N3O5S
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2
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| 1 |
IC50 < 10000 nM
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| 2 |
Ki = 49 nM
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CP0876135
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(R)-N-((2-Hexyloxy-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamido)phenyl)propanamide
Show/Hide
|
C23H29F4N3O4S
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2
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| 1 |
IC50 < 10000 nM
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| 2 |
Ki < 1000 nM
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CP0566068
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N-[[6-tert-butyl-2-(4-ethylpiperidin-1-yl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C27H39FN4O3S
|
1
|
| 1 |
Ki = 0.1 nM
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CP0455688
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(2S)-2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(2-methylpyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C22H26F4N4O3S
|
1
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| 1 |
Ki = 0.3 nM
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CP0389473
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N-[[6-tert-butyl-2-(4-fluorophenyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C26H29F2N3O3S
|
1
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| 1 |
Ki = 0.3 nM
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CP0409017
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N-[[2-(4-benzylpiperidin-1-yl)-6-tert-butylpyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C32H41FN4O3S
|
1
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| 1 |
Ki = 0.3 nM
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CP0475358
|
2-[3-fluoro-4-(methanesulfonamido)-5-methoxyphenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C24H30F4N4O4S
|
1
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| 1 |
Ki = 0.3 nM
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CP0211580
|
(R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea
Show/Hide
|
C21H24N4O
|
1
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| 1 |
Ki = 0.3 nM
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CP0552181
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1-[[5-tert-butyl-2-[3-(trifluoromethyl)phenyl]pyrazol-3-yl]methyl]-3-(1H-indazol-4-yl)urea
Show/Hide
|
C23H23F3N6O
|
1
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| 1 |
Ki = 0.3 nM
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CP0560200
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1-[[5-tert-butyl-2-(3-chlorophenyl)pyrazol-3-yl]methyl]-3-(1-methylindazol-4-yl)urea
Show/Hide
|
C23H25ClN6O
|
1
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| 1 |
Ki = 0.4 nM
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CP0409011
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N-[(4-tert-butyl-2-hexoxyphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C27H39FN2O4S
|
1
|
| 1 |
Ki = 0.5 nM
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|
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CP0568154
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1-[[5-tert-butyl-2-(3-chloro-4-fluorophenyl)pyrazol-3-yl]methyl]-3-(1H-indazol-4-yl)urea
Show/Hide
|
C22H22ClFN6O
|
1
|
| 1 |
Ki = 0.5 nM
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|
|
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CP0576632
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1-[[5-tert-butyl-2-(3,4-difluorophenyl)pyrazol-3-yl]methyl]-3-(1H-indazol-4-yl)urea
Show/Hide
|
C22H22F2N6O
|
1
|
| 1 |
Ki = 0.5 nM
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CP0409016
|
N-[[6-tert-butyl-2-(2-methylpropoxy)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H34FN3O4S
|
1
|
| 1 |
Ki = 0.6 nM
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|
|
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CP0575585
|
N-[[4-tert-butyl-2-(3-methylbutoxy)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C26H37FN2O4S
|
1
|
| 1 |
Ki = 0.6 nM
|
|
|
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CP0566419
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2-[4-(methanesulfonamido)-3-methylphenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C24H31F3N4O3S
|
1
|
| 1 |
Ki = 0.6 nM
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|
|
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CP0507568
|
1-[[2-(3-chloro-4-fluorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-3-(1H-indazol-4-yl)urea
Show/Hide
|
C19H13ClF4N6O
|
1
|
| 1 |
Ki = 0.6 nM
|
|
|
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CP0552162
|
1-[[5-tert-butyl-2-(3-chloro-4-fluorophenyl)pyrazol-3-yl]methyl]-3-(1-methylindazol-4-yl)urea
Show/Hide
|
C23H24ClFN6O
|
1
|
| 1 |
Ki = 0.6 nM
|
|
|
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CP0552180
|
1-[[5-tert-butyl-2-(3-chlorophenyl)pyrazol-3-yl]methyl]-3-(1H-indazol-4-yl)urea
Show/Hide
|
C22H23ClN6O
|
1
|
| 1 |
Ki = 0.6 nM
|
|
|
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CP0568155
|
1-[[5-tert-butyl-2-[3-(trifluoromethyl)phenyl]pyrazol-3-yl]methyl]-3-(1-methylindazol-4-yl)urea
Show/Hide
|
C24H25F3N6O
|
1
|
| 1 |
Ki = 0.6 nM
|
|
|
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CP0472762
|
N-[[4-tert-butyl-2-(4-methylpiperidin-1-yl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C27H38FN3O3S
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
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CP0475357
|
2-[3-bromo-5-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C23H27BrF4N4O3S
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
|
CP0572725
|
US8791268, 22
Show/Hide
|
C21H23Br2F3N4O
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
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CP0554818
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(3-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
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C23H28F4N4O3S
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1
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| 1 |
Ki = 0.8 nM
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CP0519295
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N-[[4-tert-butyl-2-(4-phenylpiperazin-1-yl)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C31H39FN4O3S
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1
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| 1 |
Ki = 0.8 nM
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CP0519299
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N-[(6-tert-butyl-2-pentoxypyridin-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C25H36FN3O4S
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1
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| 1 |
Ki = 0.8 nM
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CP0521685
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N-[[6-tert-butyl-2-[(4-fluorophenyl)methoxy]pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C27H31F2N3O4S
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1
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| 1 |
Ki = 0.8 nM
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CP0566067
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N-[[6-tert-butyl-2-(3-methylbutoxy)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C25H36FN3O4S
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1
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| 1 |
Ki = 0.8 nM
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CP0575557
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2-[4-(methanesulfonamido)-3-methoxyphenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C24H31F3N4O4S
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1
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| 1 |
Ki = 0.8 nM
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CP0384886
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N-[[2-cyclohexylsulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C23H27F4N3O3S2
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1
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| 1 |
Ki = 0.9 nM
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CP0475122
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N-[(2-butoxy-6-tert-butylpyridin-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C24H34FN3O4S
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1
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| 1 |
Ki = 0.9 nM
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CP0558958
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N-[[2-(azepan-1-yl)-6-tert-butylpyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C26H37FN4O3S
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1
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| 1 |
Ki = 0.9 nM
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CP0561725
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US8791268, 20
Show/Hide
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C22H25Br2F3N4O
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1
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| 1 |
Ki = 0.9 nM
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CP0554922
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1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-3-(1H-indazol-4-yl)urea
Show/Hide
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C19H14ClF3N6O
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1
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| 1 |
Ki = 0.9 nM
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CP0510469
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N-[[2-(4-ethylcyclohexyl)sulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C25H31F4N3O3S2
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1
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| 1 |
Ki = 1 nM
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CP0558952
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N-[[4-tert-butyl-2-[butyl(methyl)amino]phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C26H38FN3O3S
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1
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| 1 |
Ki = 1 nM
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CP0553285
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1-[[5-tert-butyl-2-(3,4-difluorophenyl)pyrazol-3-yl]methyl]-3-(1-methylindazol-4-yl)urea
Show/Hide
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C23H24F2N6O
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1
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| 1 |
Ki = 1 nM
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CP0472765
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N-[(6-tert-butyl-2-piperidin-1-ylpyridin-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C25H35FN4O3S
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1
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| 1 |
Ki = 1.1 nM
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CP0468571
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N-[[2-cyclopentylsulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C22H25F4N3O3S2
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1
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| 1 |
Ki = 1.2 nM
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CP0566069
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N-[[6-tert-butyl-2-[butyl(methyl)amino]pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C25H37FN4O3S
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1
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| 1 |
Ki = 1.2 nM
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CP0575670
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N-[(6-tert-butyl-2-pyrrolidin-1-ylpyridin-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C24H33FN4O3S
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1
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| 1 |
Ki = 1.2 nM
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CP0546850
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2-[4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C23H29F3N4O3S
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1
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| 1 |
Ki = 1.2 nM
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CP0574634
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1-[[5-tert-butyl-2-(3-fluorophenyl)pyrazol-3-yl]methyl]-3-(1H-indazol-4-yl)urea
Show/Hide
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C22H23FN6O
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1
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| 1 |
Ki = 1.3 nM
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CP0574733
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1-(1H-indazol-4-yl)-3-[[5-(trifluoromethyl)-2-[3-(trifluoromethyl)phenyl]pyrazol-3-yl]methyl]urea
Show/Hide
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C20H14F6N6O
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1
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| 1 |
Ki = 1.3 nM
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CP0546303
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N-[(2-butoxy-4-tert-butylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C25H35FN2O4S
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1
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| 1 |
Ki = 1.4 nM
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CP0537162
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1-(1-methylindazol-4-yl)-3-[[5-(trifluoromethyl)-2-[3-(trifluoromethyl)phenyl]pyrazol-3-yl]methyl]urea
Show/Hide
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C21H16F6N6O
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1
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| 1 |
Ki = 1.4 nM
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CP0409015
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N-[(6-tert-butyl-2-cyclopentyloxypyridin-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C25H34FN3O4S
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1
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| 1 |
Ki = 1.5 nM
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CP0546307
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N-[(6-tert-butyl-2-hexylsulfanylpyridin-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C26H38FN3O3S2
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1
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| 1 |
Ki = 1.5 nM
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CP0569229
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2-[4-(methanesulfonamido)-3,5-dimethoxyphenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C25H33F3N4O5S
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1
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| 1 |
Ki = 1.6 nM
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CP0470599
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N-[(6-tert-butyl-2-propoxypyridin-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C23H32FN3O4S
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1
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| 1 |
Ki = 1.7 nM
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CP0409010
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N-[(4-tert-butyl-2-cyclopentyloxyphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C26H35FN2O4S
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1
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| 1 |
Ki = 1.8 nM
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CP0423214
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(2-methylcyclohexyl)sulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C24H29F4N3O3S2
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1
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| 1 |
Ki = 1.9 nM
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CP0470600
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N-[[6-tert-butyl-2-(4-methylpiperidin-1-yl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C26H37FN4O3S
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1
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| 1 |
Ki = 1.9 nM
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CP0558953
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N-[(6-tert-butyl-2-pentylpyridin-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C25H36FN3O3S
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1
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| 1 |
Ki = 1.9 nM
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CP0566544
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N-[(4-tert-butyl-2-piperidin-1-ylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C26H36FN3O3S
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1
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| 1 |
Ki = 1.9 nM
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CP0568153
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1-[[2-(3-chloro-4-fluorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-3-(1-methylindazol-4-yl)urea
Show/Hide
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C20H15ClF4N6O
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1
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| 1 |
Ki = 1.9 nM
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CP0575586
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N-[[4-tert-butyl-2-(2-methylpropoxy)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C25H35FN2O4S
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1
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| 1 |
Ki = 2.1 nM
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CP0575587
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N-[(4-tert-butyl-2-pentoxyphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C26H37FN2O4S
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1
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| 1 |
Ki = 2.2 nM
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CP0554901
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1-[[5-tert-butyl-2-(4-fluorophenyl)pyrazol-3-yl]methyl]-3-(1H-indazol-4-yl)urea
Show/Hide
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C22H23FN6O
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1
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| 1 |
Ki = 2.2 nM
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CP0558957
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N-[(6-tert-butyl-2-propan-2-yloxypyridin-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C23H32FN3O4S
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1
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| 1 |
Ki = 2.3 nM
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CP0566417
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2-[3-chloro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C23H28ClF3N4O3S
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1
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| 1 |
Ki = 2.3 nM
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CP0560199
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1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-3-(1-methylindazol-4-yl)urea
Show/Hide
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C20H16ClF3N6O
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1
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| 1 |
Ki = 2.3 nM
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CP0558923
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2-[3-fluoro-4-[methylsulfonyl(prop-2-enoyl)amino]phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C26H30F4N4O4S
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1
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| 1 |
Ki = 2.4 nM
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CP0572692
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2-(4-amino-3,5-dichlorophenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C22H25Cl2F3N4O
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1
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| 1 |
Ki = 2.4 nM
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CP0519301
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N-[[6-tert-butyl-2-(dipropylamino)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C26H39FN4O3S
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1
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| 1 |
Ki = 2.5 nM
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CP0546306
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N-[(6-tert-butyl-2-cyclopentylsulfanylpyridin-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C25H34FN3O3S2
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1
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| 1 |
Ki = 2.5 nM
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CP0558956
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N-[(6-tert-butyl-2-cyclohexyloxypyridin-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C26H36FN3O4S
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1
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| 1 |
Ki = 2.5 nM
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CP0571381
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1-[[2-(4-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-3-(1H-indazol-4-yl)urea
Show/Hide
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C19H14ClF3N6O
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1
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| 1 |
Ki = 2.5 nM
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CP0475121
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N-[(6-tert-butyl-2-hexoxypyridin-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C26H38FN3O4S
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1
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| 1 |
Ki = 2.7 nM
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CP0475359
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2-[3-fluoro-4-(sulfamoylamino)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C22H27F4N5O3S
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1
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| 1 |
Ki = 2.7 nM
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CP0520763
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1-[[2-(4-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-3-(1-methylindazol-4-yl)urea
Show/Hide
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C20H16ClF3N6O
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1
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| 1 |
Ki = 2.7 nM
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CP0543309
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[6-(trifluoromethyl)-2-[4-[3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]pyridin-3-yl]methyl]propanamide
Show/Hide
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C27H27F7N6O3S
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1
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| 1 |
Ki = 2.8 nM
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CP0558950
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N-[(4-tert-butyl-2-pentylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C26H37FN2O3S
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1
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| 1 |
Ki = 2.8 nM
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CP0576631
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1-[[2-(3,4-dimethylphenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-3-(1H-indazol-4-yl)urea
Show/Hide
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C21H19F3N6O
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1
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| 1 |
Ki = 2.8 nM
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CP0546462
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(2-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C23H28F4N4O3S
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1
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| 1 |
Ki = 2.9 nM
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CP0519294
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N-[(4-tert-butyl-2-phenylmethoxyphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C28H33FN2O4S
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1
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| 1 |
Ki = 2.9 nM
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CP0562214
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N-[[5-tert-butyl-2-(3-chlorophenyl)pyrazol-3-yl]methyl]-2-(2,3-dihydro-1H-inden-5-yl)acetamide
Show/Hide
|
C25H28ClN3O
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1
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| 1 |
Ki = 2.9 nM
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CP0427727
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-propan-2-yloxypiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C25H32F4N4O4S
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1
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| 1 |
Ki = 3 nM
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CP0519298
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N-[(6-tert-butyl-2-pentylsulfanylpyridin-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C25H36FN3O3S2
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1
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| 1 |
Ki = 3.1 nM
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CP0521684
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N-[(6-tert-butyl-2-cyclohexylpyridin-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C26H36FN3O3S
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1
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| 1 |
Ki = 3.1 nM
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CP0566546
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N-[(6-tert-butyl-2-butylsulfanylpyridin-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C24H34FN3O3S2
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1
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| 1 |
Ki = 3.2 nM
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CP0566418
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2-[3-bromo-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
|
C23H28BrF3N4O3S
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1
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| 1 |
Ki = 3.2 nM
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CP0475119
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(2S)-N-[(6-tert-butyl-2-cyclohexylsulfanylpyridin-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C26H36FN3O3S2
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1
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| 1 |
Ki = 3.4 nM
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CP0566545
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N-[[6-tert-butyl-2-[(4-chlorophenyl)methylsulfanyl]pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C27H31ClFN3O3S2
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1
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| 1 |
Ki = 3.4 nM
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CP0472763
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N-[[6-tert-butyl-2-[(4-methoxyphenyl)methylsulfanyl]pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C28H34FN3O4S2
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1
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| 1 |
Ki = 3.5 nM
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CP0554899
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1-[[2-(3,4-dimethylphenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-3-(1-methylindazol-4-yl)urea
Show/Hide
|
C22H21F3N6O
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1
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| 1 |
Ki = 3.5 nM
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CP0519293
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N-[[4-tert-butyl-2-[(4-fluorophenyl)methoxy]phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C28H32F2N2O4S
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1
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| 1 |
Ki = 3.8 nM
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CP0519296
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N-[[6-tert-butyl-2-[(2-chlorophenyl)methylsulfanyl]pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C27H31ClFN3O3S2
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1
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| 1 |
Ki = 3.8 nM
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CP0521683
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N-[[4-tert-butyl-2-(2,2-dimethylpropoxy)phenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C26H37FN2O4S
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1
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| 1 |
Ki = 3.8 nM
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CP0568152
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1-(1H-indazol-4-yl)-3-[[5-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]pyrazol-3-yl]methyl]urea
Show/Hide
|
C20H14F6N6O
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1
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| 1 |
Ki = 3.8 nM
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CP0537163
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1-(1-methylindazol-4-yl)-3-[[5-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]pyrazol-3-yl]methyl]urea
Show/Hide
|
C21H16F6N6O
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1
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| 1 |
Ki = 3.9 nM
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CP0575588
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N-[(2-benzylsulfanyl-6-tert-butylpyridin-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C27H32FN3O3S2
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1
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| 1 |
Ki = 4 nM
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CP0453711
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N-[[2-[4-(3-chloropyridin-2-yl)-2-methylpiperazin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C27H29ClF4N6O3S
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1
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| 1 |
Ki = 4.1 nM
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CP0575667
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N-[[6-tert-butyl-2-(2,2,2-trifluoroethylsulfanyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C22H27F4N3O3S2
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1
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| 1 |
Ki = 4.1 nM
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CP0409339
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N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-(2,3-dihydro-1H-inden-5-yl)propanamide
Show/Hide
|
C23H21ClF3N3O
|
1
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| 1 |
Ki = 4.1 nM
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CP0554898
|
1-(1H-indazol-4-yl)-3-[[2-(4-propan-2-ylphenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]urea
Show/Hide
|
C22H21F3N6O
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1
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| 1 |
Ki = 4.1 nM
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CP0505256
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(2,2,2-trifluoroethylsulfanyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C19H18F7N3O3S2
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1
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| 1 |
Ki = 4.3 nM
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CP0466955
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(2E)-3-[2-(piperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]-N-(quinolin-7-yl)prop-2-enamide
Show/Hide
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C23H21F3N4O
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1
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| 1 |
Ki = 4.4 nM
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CP0472761
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N-[(4-tert-butyl-2-propoxyphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C24H33FN2O4S
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1
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| 1 |
Ki = 4.4 nM
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CP0566547
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N-[(6-tert-butyl-2-phenylmethoxypyridin-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C27H32FN3O4S
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1
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| 1 |
Ki = 4.4 nM
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CP0563984
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2-[4-(ethylsulfonylamino)-3-fluorophenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
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C24H30F4N4O3S
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1
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| 1 |
Ki = 4.4 nM
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CP0527207
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US8791268, 3
Show/Hide
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C22H26BrF3N4O2
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1
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| 1 |
Ki = 4.4 nM
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CP0507569
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1-[[5-tert-butyl-2-(4-fluorophenyl)pyrazol-3-yl]methyl]-3-(1-methylindazol-4-yl)urea
Show/Hide
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C23H25FN6O
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1
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| 1 |
Ki = 4.5 nM
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CP0562787
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1-[[2-(3,4-difluorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-3-(1-methylindazol-4-yl)urea
Show/Hide
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C20H15F5N6O
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1
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| 1 |
Ki = 4.9 nM
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CP0554550
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N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-(2,3-dihydro-1H-inden-5-yl)acetamide
Show/Hide
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C22H19ClF3N3O
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1
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| 1 |
Ki = 5.2 nM
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CP0561726
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2-(4-amino-3-fluoro-5-hydroxyphenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C22H26F4N4O2
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1
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| 1 |
Ki = 5.3 nM
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CP0574561
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N-[[6-tert-butyl-2-(3-methoxypropoxy)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C24H34FN3O5S
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1
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| 1 |
Ki = 5.6 nM
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CP0520977
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2-(1,3-benzodioxol-5-yl)-N-[[5-(trifluoromethyl)-2-[3-(trifluoromethyl)phenyl]pyrazol-3-yl]methyl]propanamide
Show/Hide
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C22H17F6N3O3
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1
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| 1 |
Ki = 5.8 nM
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CP0575668
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N-[[6-tert-butyl-2-(3-methylbutylsulfanyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C25H36FN3O3S2
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1
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| 1 |
Ki = 5.9 nM
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CP0389471
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(2S)-N-[(4-tert-butyl-2-cyclohexylsulfanylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C27H37FN2O3S2
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1
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| 1 |
Ki = 6 nM
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CP0558954
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N-[[6-tert-butyl-2-[(3-methoxyphenyl)methoxy]pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C28H34FN3O5S
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1
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| 1 |
Ki = 6 nM
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CP0558951
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N-[[2-(azepan-1-yl)-4-tert-butylphenyl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C27H38FN3O3S
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1
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| 1 |
Ki = 6.2 nM
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CP0409009
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N-[(4-tert-butyl-2-butylsulfanylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C25H35FN2O3S2
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1
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| 1 |
Ki = 6.7 nM
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CP0553283
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1-[[2-(3-fluorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-3-(1-methylindazol-4-yl)urea
Show/Hide
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C20H16F4N6O
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1
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| 1 |
Ki = 7 nM
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CP0576153
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N-[[5-tert-butyl-2-[3-(trifluoromethyl)phenyl]pyrazol-3-yl]methyl]-2-(2,3-dihydro-1H-inden-5-yl)acetamide
Show/Hide
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C26H28F3N3O
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1
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| 1 |
Ki = 7.1 nM
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CP0575584
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N-[(4-tert-butyl-2-cyclohexylsulfanylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C27H37FN2O3S2
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1
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| 1 |
Ki = 7.4 nM
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CP0462129
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N-[2-fluoro-4-[1-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methylamino]-1-oxopropan-2-yl]phenyl]benzamide
Show/Hide
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C29H30F4N4O2
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1
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| 1 |
Ki = 7.4 nM
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CP0487605
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2-(1,3-benzodioxol-5-yl)-N-[[2-(3-chloro-4-fluorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]propanamide
Show/Hide
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C21H16ClF4N3O3
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1
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| 1 |
Ki = 7.5 nM
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CP0562712
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N-[[5-tert-butyl-2-(3-chloro-4-fluorophenyl)pyrazol-3-yl]methyl]-2-(2,3-dihydro-1H-inden-5-yl)acetamide
Show/Hide
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C25H27ClFN3O
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1
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| 1 |
Ki = 7.5 nM
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CP0574909
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2-(2,3-dihydro-1H-inden-5-yl)-N-[[5-(trifluoromethyl)-2-[3-(trifluoromethyl)phenyl]pyrazol-3-yl]methyl]propanamide
Show/Hide
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C24H21F6N3O
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1
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| 1 |
Ki = 7.5 nM
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CP0472760
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N-[(4-tert-butyl-2-cyclohexyloxyphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C27H37FN2O4S
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1
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| 1 |
Ki = 8.1 nM
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CP0546304
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N-[(4-tert-butyl-2-pyrrolidin-1-ylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C25H34FN3O3S
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1
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| 1 |
Ki = 8.1 nM
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CP0560201
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1-[[2-(4-fluorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-3-(1-methylindazol-4-yl)urea
Show/Hide
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C20H16F4N6O
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1
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| 1 |
Ki = 8.4 nM
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CP0546305
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N-[(6-tert-butyl-2-cyclohexylsulfanylpyridin-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C26H36FN3O3S2
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1
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| 1 |
Ki = 8.5 nM
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CP0390352
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2-[3-fluoro-4-(propan-2-ylsulfonylamino)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C25H32F4N4O3S
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1
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| 1 |
Ki = 8.7 nM
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CP0516649
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2-(1,3-benzodioxol-5-yl)-N-[[5-tert-butyl-2-(3-chlorophenyl)pyrazol-3-yl]methyl]acetamide
Show/Hide
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C23H24ClN3O3
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1
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| 1 |
Ki = 9.2 nM
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CP0576633
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1-[[5-tert-butyl-2-(4-chlorophenyl)pyrazol-3-yl]methyl]-3-(1-methylindazol-4-yl)urea
Show/Hide
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C23H25ClN6O
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1
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| 1 |
Ki = 9.5 nM
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CP0405011
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US8791268, 26
Show/Hide
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C22H25F5N4O
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1
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| 1 |
Ki = 9.6 nM
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CP0575583
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N-[(4-tert-butyl-2-cyclohexylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C27H37FN2O3S
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1
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| 1 |
Ki = 9.8 nM
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CP0539257
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2-(1,3-benzodioxol-5-yl)-N-[[5-tert-butyl-2-(3-chloro-4-fluorophenyl)pyrazol-3-yl]methyl]acetamide
Show/Hide
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C23H23ClFN3O3
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1
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| 1 |
Ki = 10.7 nM
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CP0516647
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N-[[5-tert-butyl-2-(4-chlorophenyl)pyrazol-3-yl]methyl]-2-(2,3-dihydro-1H-inden-5-yl)acetamide
Show/Hide
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C25H28ClN3O
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1
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| 1 |
Ki = 11.1 nM
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CP0473072
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N-[[5-tert-butyl-2-(3-fluorophenyl)pyrazol-3-yl]methyl]-2-(2,3-dihydro-1H-inden-5-yl)acetamide
Show/Hide
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C25H28FN3O
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1
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| 1 |
Ki = 11.2 nM
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CP0539258
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2-(1,3-benzodioxol-5-yl)-N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]propanamide
Show/Hide
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C21H17ClF3N3O3
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1
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| 1 |
Ki = 11.2 nM
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CP0558714
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2-(2,3-dihydro-1H-inden-5-yl)-N-[[2-(3,4-dimethylphenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]propanamide
Show/Hide
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C25H26F3N3O
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1
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| 1 |
Ki = 11.3 nM
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CP0475361
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2-[4-[acetyl(methylsulfonyl)amino]-3-fluorophenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C25H30F4N4O4S
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1
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| 1 |
Ki = 11.9 nM
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CP0562708
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2-(2,3-dihydro-1H-inden-5-yl)-N-[[2-(4-methylpiperidin-1-yl)-4-(trifluoromethyl)phenyl]methyl]acetamide
Show/Hide
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C25H29F3N2O
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1
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| 1 |
Ki = 12 nM
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CP0409338
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2-(1,3-benzodioxol-5-yl)-N-[[5-tert-butyl-2-[3-(trifluoromethyl)phenyl]pyrazol-3-yl]methyl]acetamide
Show/Hide
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C24H24F3N3O3
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1
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| 1 |
Ki = 12.2 nM
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CP0574734
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1-[[5-tert-butyl-2-[4-(trifluoromethyl)phenyl]pyrazol-3-yl]methyl]-3-(1-methylindazol-4-yl)urea
Show/Hide
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C24H25F3N6O
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1
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| 1 |
Ki = 12.4 nM
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CP0535086
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N-[[5-tert-butyl-2-(3,4-difluorophenyl)pyrazol-3-yl]methyl]-2-(2,3-dihydro-1H-inden-5-yl)acetamide
Show/Hide
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C25H27F2N3O
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1
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| 1 |
Ki = 12.8 nM
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CP0520764
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1-[[2-(4-tert-butylphenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-3-(1-methylindazol-4-yl)urea
Show/Hide
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C24H25F3N6O
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1
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| 1 |
Ki = 13.2 nM
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CP0574908
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2-(2,3-dihydro-1H-inden-5-yl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide
Show/Hide
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C24H28F3N3O
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1
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| 1 |
Ki = 13.3 nM
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CP0575669
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N-[(6-tert-butyl-2-methoxypyridin-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C21H28FN3O4S
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1
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| 1 |
Ki = 14.3 nM
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CP0423151
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(furan-2-ylmethylsulfanyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C22H21F4N3O4S2
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1
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| 1 |
Ki = 14.6 nM
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CP0562713
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N-[[2-(3-chloro-4-fluorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-(2,3-dihydro-1H-inden-5-yl)propanamide
Show/Hide
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C23H20ClF4N3O
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1
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| 1 |
Ki = 14.7 nM
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CP0472764
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N-[(6-tert-butyl-2-ethoxypyridin-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C22H30FN3O4S
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1
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| 1 |
Ki = 14.8 nM
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CP0493745
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(thiophen-2-ylmethylsulfanyl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C22H21F4N3O3S3
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1
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| 1 |
Ki = 15 nM
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CP0562216
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N-[[5-tert-butyl-2-(3,5-dichlorophenyl)pyrazol-3-yl]methyl]-2-(2,3-dihydro-1H-inden-5-yl)acetamide
Show/Hide
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C25H27Cl2N3O
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1
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| 1 |
Ki = 15.7 nM
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CP0562225
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2-(1,3-benzodioxol-5-yl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide
Show/Hide
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C22H24F3N3O3
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1
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| 1 |
Ki = 15.9 nM
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CP0519297
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N-[[6-tert-butyl-2-(3-pyrrolidin-1-ylpropylsulfanyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C27H39FN4O3S2
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1
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| 1 |
Ki = 17.1 nM
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CP0554549
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2-(1,3-benzodioxol-5-yl)-N-[[2-(4-methylpiperidin-1-yl)-4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
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C24H27F3N2O3
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1
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| 1 |
Ki = 17.3 nM
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CP0552751
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1-(1-acetylindazol-4-yl)-3-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]urea
Show/Hide
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C21H16ClF3N6O2
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1
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| 1 |
Ki = 17.4 nM
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CP0535025
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2-(1,3-benzodioxol-5-yl)-N-[[2-(3-fluorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]propanamide
Show/Hide
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C21H17F4N3O3
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1
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| 1 |
Ki = 17.5 nM
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CP0554902
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1-[[5-tert-butyl-2-[4-(trifluoromethyl)phenyl]pyrazol-3-yl]methyl]-3-(1H-indazol-4-yl)urea
Show/Hide
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C23H23F3N6O
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1
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| 1 |
Ki = 19.6 nM
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CP0572724
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N-[2-fluoro-4-[1-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methylamino]-1-oxopropan-2-yl]phenyl]cyclopropanecarboxamide
Show/Hide
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C26H30F4N4O2
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1
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| 1 |
Ki = 20 nM
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CP0487562
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2-(2,3-dihydro-1-benzofuran-5-yl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]acetamide
Show/Hide
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C23H26F3N3O2
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1
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| 1 |
Ki = 20.5 nM
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CP0546469
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2-(4-amino-3,5-dimethoxyphenyl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C24H31F3N4O3
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1
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| 1 |
Ki = 21 nM
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CP0427724
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N-[[2-(4-cyclohexylpiperazin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C27H35F4N5O3S
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1
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| 1 |
Ki = 21.6 nM
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CP0558922
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2-[4-[ethyl(methylsulfonyl)amino]-3-fluorophenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C25H32F4N4O3S
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1
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| 1 |
Ki = 22.7 nM
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CP0535022
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2-(1,3-benzodioxol-5-yl)-N-[[4-tert-butyl-2-(4-methylpiperidin-1-yl)phenyl]methyl]acetamide
Show/Hide
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C26H34N2O3
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1
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| 1 |
Ki = 22.7 nM
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CP0558955
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N-[[6-tert-butyl-2-(2-ethoxyethoxy)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C24H34FN3O5S
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1
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| 1 |
Ki = 23.9 nM
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CP0539254
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2-(2,3-dihydro-1H-inden-5-yl)-N-[[2-(4-fluorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]acetamide
Show/Hide
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C22H19F4N3O
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1
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| 1 |
Ki = 24 nM
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CP0386675
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US8791268, 18
Show/Hide
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C24H28F4N4O2
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1
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| 1 |
Ki = 25 nM
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CP0487565
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2-(1,3-benzodioxol-5-yl)-N-[[5-tert-butyl-2-(3,4-difluorophenyl)pyrazol-3-yl]methyl]acetamide
Show/Hide
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C23H23F2N3O3
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1
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| 1 |
Ki = 25.8 nM
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CP0407472
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3-[(4-tert-butylphenyl)methyl]-1-[(3-fluoro-4-methanesulfonamidophenyl)methyl]thiourea
Show/Hide
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C20H26FN3O2S2
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1
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| 1 |
Ki = 26 nM
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CP0561724
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N-[2-fluoro-4-[1-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methylamino]-1-oxopropan-2-yl]phenyl]-2-methylpropanamide
Show/Hide
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C26H32F4N4O2
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1
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| 1 |
Ki = 26.4 nM
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CP0562714
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2-(1,3-benzodioxol-5-yl)-N-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]acetamide
Show/Hide
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C20H15ClF3N3O3
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1
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| 1 |
Ki = 28.3 nM
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CP0551797
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1-(1-acetylindazol-4-yl)-3-[[5-tert-butyl-2-(3-chlorophenyl)pyrazol-3-yl]methyl]urea
Show/Hide
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C24H25ClN6O2
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1
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| 1 |
Ki = 29.5 nM
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CP0539253
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2-(2,3-dihydro-1-benzofuran-5-yl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C24H28F3N3O2
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1
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| 1 |
Ki = 29.7 nM
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CP0487564
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N-[[2-(3,4-difluorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-(2,3-dihydro-1H-inden-5-yl)propanamide
Show/Hide
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C23H20F5N3O
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1
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| 1 |
Ki = 30.5 nM
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CP0562709
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2-(1,3-benzodioxol-5-yl)-N-[[6-tert-butyl-2-(4-methylpiperidin-1-yl)pyridin-3-yl]methyl]propanamide
Show/Hide
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C26H35N3O3
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1
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| 1 |
Ki = 31.4 nM
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CP0526862
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2-(1,3-benzodioxol-5-yl)-N-[[2-(4-methylpiperidin-1-yl)-4-(trifluoromethyl)phenyl]methyl]acetamide
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C23H25F3N2O3
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1
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| 1 |
Ki = 32.4 nM
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CP0409013
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(2R)-N-[(6-tert-butyl-2-cyclohexylsulfanylpyridin-3-yl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
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C26H36FN3O3S2
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1
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| 1 |
Ki = 36.4 nM
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CP0487604
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2-(1,3-benzodioxol-5-yl)-N-[[4-tert-butyl-2-(4-methylpiperidin-1-yl)phenyl]methyl]propanamide
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C27H36N2O3
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1
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| 1 |
Ki = 37.2 nM
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CP0437479
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N-[[2-(4-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-(2,3-dihydro-1H-inden-5-yl)acetamide
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C22H19ClF3N3O
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1
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| 1 |
Ki = 37.8 nM
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CP0539255
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2-(1,3-benzodioxol-5-yl)-N-[[5-tert-butyl-2-(3-fluorophenyl)pyrazol-3-yl]methyl]acetamide
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C23H24FN3O3
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1
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| 1 |
Ki = 38.6 nM
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CP0499955
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N-[[2-(4-fluoroanilino)-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
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C23H21F5N4O3S
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1
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| 1 |
Ki = 39.2 nM
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CP0535018
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N-[[6-tert-butyl-2-(4-methylpiperidin-1-yl)pyridin-3-yl]methyl]-2-(2,3-dihydro-1H-inden-5-yl)acetamide
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C27H37N3O
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1
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| 1 |
Ki = 39.9 nM
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CP0571382
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1-[[5-tert-butyl-2-(4-tert-butylphenyl)pyrazol-3-yl]methyl]-3-(1H-indazol-4-yl)urea
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C26H32N6O
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1
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| 1 |
Ki = 40 nM
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CP0386956
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2-[4-(dimethylsulfamoylamino)-3-fluorophenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
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C24H31F4N5O3S
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1
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| 1 |
Ki = 42 nM
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CP0558705
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2-(1,3-benzodioxol-5-yl)-N-[[5-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]pyrazol-3-yl]methyl]propanamide
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C22H17F6N3O3
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1
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| 1 |
Ki = 42.5 nM
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CP0526224
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(2R)-N-[[2-cyclohexylsulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
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C23H27F4N3O3S2
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1
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| 1 |
Ki = 43.5 nM
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CP0558915
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2-[3-fluoro-4-(2,2,2-trifluoroethylsulfonylamino)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
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C24H27F7N4O3S
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1
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| 1 |
Ki = 43.7 nM
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CP0577195
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2-(1,3-benzodioxol-5-yl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
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C23H26F3N3O3
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1
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| 1 |
Ki = 43.8 nM
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CP0526861
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N-[[6-tert-butyl-2-(4-methylpiperidin-1-yl)pyridin-3-yl]methyl]-2-(2,3-dihydro-1H-inden-5-yl)propanamide
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C28H39N3O
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1
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| 1 |
Ki = 44 nM
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CP0540727
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N-[[2-(4-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-2-(2,3-dihydro-1H-inden-5-yl)propanamide
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C23H21ClF3N3O
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1
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| 1 |
Ki = 45 nM
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CP0568156
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1-[[5-tert-butyl-2-(4-tert-butylphenyl)pyrazol-3-yl]methyl]-3-(1-methylindazol-4-yl)urea
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C27H34N6O
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1
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| 1 |
Ki = 46.3 nM
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CP0562226
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N-[[4-tert-butyl-2-(4-methylpiperidin-1-yl)phenyl]methyl]-2-(2,3-dihydro-1H-inden-5-yl)acetamide
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C28H38N2O
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1
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| 1 |
Ki = 46.5 nM
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CP0516646
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N-[[5-tert-butyl-2-(4-fluorophenyl)pyrazol-3-yl]methyl]-2-(2,3-dihydro-1H-inden-5-yl)acetamide
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C25H28FN3O
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1
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| 1 |
Ki = 49.9 nM
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CP0526885
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2-(1,3-benzodioxol-5-yl)-N-[[6-tert-butyl-2-(4-methylpiperidin-1-yl)pyridin-3-yl]methyl]acetamide
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C25H33N3O3
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1
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| 1 |
Ki = 50.5 nM
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CP0540015
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2-(2,3-dihydro-1H-inden-5-yl)-N-[[5-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]pyrazol-3-yl]methyl]propanamide
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C24H21F6N3O
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1
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| 1 |
Ki = 51.3 nM
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CP0437480
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2-(2,3-dihydro-1H-inden-5-yl)-N-[[2-[4-(trifluoromethoxy)phenyl]-5-(trifluoromethyl)pyrazol-3-yl]methyl]propanamide
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C24H21F6N3O2
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1
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| 1 |
Ki = 51.6 nM
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CP0475120
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N-[[6-tert-butyl-2-[3-(dimethylamino)propylsulfanyl]pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
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C25H37FN4O3S2
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1
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| 1 |
Ki = 51.8 nM
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CP0555794
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N-[2-fluoro-4-[1-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methylamino]-1-oxopropan-2-yl]phenyl]-2,2-dimethylpropanamide
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C27H34F4N4O2
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1
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| 1 |
Ki = 51.9 nM
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CP0554551
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2-(1,3-benzodioxol-5-yl)-N-[[2-(4-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]acetamide
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C20H15ClF3N3O3
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1
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| 1 |
Ki = 53.9 nM
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CP0390353
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2-[3-fluoro-4-[methyl(methylsulfonyl)amino]phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
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C24H30F4N4O3S
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1
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| 1 |
Ki = 55.5 nM
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CP0526860
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2-(2,3-dihydro-1H-inden-5-yl)-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
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C25H30F3N3O
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1
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| 1 |
Ki = 57.4 nM
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CP0552706
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1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)pyrazol-3-yl]methyl]-3-(1-methylindazol-5-yl)urea
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C20H16ClF3N6O
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1
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| 1 |
Ki = 61 nM
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CP0575122
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N-[[4-tert-butyl-2-(4-methylpiperidin-1-yl)phenyl]methyl]-2-(2,3-dihydro-1H-inden-5-yl)propanamide
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C29H40N2O
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1
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| 1 |
Ki = 61.7 nM
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CP0437468
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N-[[5-tert-butyl-2-[4-(trifluoromethyl)phenyl]pyrazol-3-yl]methyl]-2-(2,3-dihydro-1H-inden-5-yl)propanamide
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C27H30F3N3O
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1
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| 1 |
Ki = 62.4 nM
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CP0562788
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1-[[5-tert-butyl-2-(4-methoxyphenyl)pyrazol-3-yl]methyl]-3-(1H-indazol-4-yl)urea
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C23H26N6O2
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1
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| 1 |
Ki = 62.9 nM
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CP0539256
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2-(1,3-benzodioxol-5-yl)-N-[[5-tert-butyl-2-[4-(trifluoromethyl)phenyl]pyrazol-3-yl]methyl]acetamide
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C24H24F3N3O3
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1
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| 1 |
Ki = 63.2 nM
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CP0516648
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N-[[5-tert-butyl-2-[4-(trifluoromethoxy)phenyl]pyrazol-3-yl]methyl]-2-(2,3-dihydro-1H-inden-5-yl)propanamide
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C27H30F3N3O2
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1
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| 1 |
Ki = 65.9 nM
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CP0471838
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2-[4-(4-chloroanilino)phenyl]-N-[[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
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C28H30ClF3N4O
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1
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| 1 |
Ki = 66.5 nM
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CP0535024
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2-(1,3-benzodioxol-5-yl)-N-[[5-tert-butyl-2-(3,5-dichlorophenyl)pyrazol-3-yl]methyl]acetamide
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C23H23Cl2N3O3
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1
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| 1 |
Ki = 71 nM
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CP0558713
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N-[[5-tert-butyl-2-[4-(trifluoromethyl)phenyl]pyrazol-3-yl]methyl]-2-(2,3-dihydro-1H-inden-5-yl)acetamide
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C26H28F3N3O
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1
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| 1 |
Ki = 78.6 nM
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CP0471622
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(3-oxo-3-pyrrolidin-1-ylpropyl)sulfanyl-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
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C24H28F4N4O4S2
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1
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| 1 |
Ki = 85 nM
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CP0519292
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(2R)-N-[(4-tert-butyl-2-cyclohexylsulfanylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
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C27H37FN2O3S2
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1
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| 1 |
Ki = 89.2 nM
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CP0500016
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-oxopiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
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C22H24F4N4O4S
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1
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| 1 |
Ki = 91 nM
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CP0535085
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2-(2,3-dihydro-1H-inden-5-yl)-N-[[2-(4-methylpiperidin-1-yl)-4-(trifluoromethyl)phenyl]methyl]propanamide
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C26H31F3N2O
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1
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| 1 |
Ki = 96.4 nM
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CP0493677
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(2S)-N-[[2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
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C23H29F4N5O3S
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1
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| 1 |
Ki = 101 nM
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CP0480947
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(2S)-N-[[2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
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C23H29F4N5O3S
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1
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| 1 |
Ki = 103 nM
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CP0409014
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N-[[6-tert-butyl-2-(3-morpholin-4-ylpropylsulfanyl)pyridin-3-yl]methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
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C27H39FN4O4S2
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1
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| 1 |
Ki = 112 nM
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CP0500028
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[2-(4-methylpiperazin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl]propanamide
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C22H27F4N5O3S
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1
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| 1 |
Ki = 146 nM
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