| Compound ID |
Compound Name |
Compound Formula |
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CP0543601
|
5-[5-[[(3S)-oxolan-3-yl]amino]-6-(1-propan-2-ylpyrazol-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-N-(trideuteriomethyl)pyridine-3-carboxamide
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C23H26N8O2
|
1
|
| 1 |
IC50 = 0.2 nM
|
|
|
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CP0573520
|
US11566028, Example 63
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C23H25N7O3
|
1
|
| 1 |
IC50 = 0.4 nM
|
|
|
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CP0952841
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(S)-5-(6-(1-Isopropyl-1H-pyrazol-4-yl)-5-((tetrahydrofuran-3-yl)oxy)pyrazolo[1,5-a]pyrimidin-3-yl)-N-(methyl-d3)nicotinamide
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|
C23H25N7O3
|
1
|
| 1 |
IC50 = 0.5 nM
|
|
|
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CP0547194
|
N'-(3,5-dimethoxyphenyl)-N'-[2-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-N-propan-2-ylethane-1,2-diamine
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C25H30N6O2
|
1
|
| 1 |
IC50 = 0.6 nM
|
|
|
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CP0577915
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3,4-difluoro-N-methyl-5-[7-(1-methylpyrazol-4-yl)-6-[(3S)-oxolan-3-yl]oxyimidazo[1,2-b]pyridazin-3-yl]benzamide
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|
C22H20F2N6O3
|
1
|
| 1 |
IC50 = 0.6 nM
|
|
|
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CP0543600
|
4-fluoro-N,3-dimethyl-5-[7-(1-methylpyrazol-4-yl)-6-[(3S)-oxolan-3-yl]oxyimidazo[1,2-b]pyridazin-3-yl]benzamide
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|
C23H23FN6O3
|
1
|
| 1 |
IC50 = 0.7 nM
|
|
|
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CP0546171
|
3-(difluoromethyl)-4-fluoro-N-methyl-5-[7-(1-methylpyrazol-4-yl)-6-[(3S)-oxolan-3-yl]oxyimidazo[1,2-b]pyridazin-3-yl]benzamide
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|
C23H21F3N6O3
|
1
|
| 1 |
IC50 = 0.9 nM
|
|
|
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CP0576753
|
N-methyl-3-[7-(1-methylpyrazol-4-yl)-6-[(3S)-oxolan-3-yl]oxyimidazo[1,2-b]pyridazin-3-yl]benzamide
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|
C22H22N6O3
|
1
|
| 1 |
IC50 = 0.9 nM
|
|
|
|
CP0551969
|
US11566028, Example 3
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|
C21H21N7O3
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
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CP0575345
|
N-methyl-3-[7-(1-methylpyrazol-4-yl)-6-(oxetan-3-yloxy)imidazo[1,2-b]pyridazin-3-yl]benzamide
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|
C21H20N6O3
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
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CP0572894
|
N,3-dimethyl-5-[6-[(3S)-oxolan-3-yl]oxy-7-(1-propan-2-ylpyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]benzamide
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|
C25H28N6O3
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
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CP0033516
|
3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one
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|
C24H27F2N5O4
|
1
|
| 1 |
IC50 = 1.7 nM
|
|
|
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CP0575346
|
N-methyl-5-[7-(1-methylpyrazol-4-yl)-6-(oxolan-3-yloxy)imidazo[1,2-b]pyridazin-3-yl]pyridine-3-carboxamide
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|
C21H21N7O3
|
1
|
| 1 |
IC50 = 2.2 nM
|
|
|
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CP0550308
|
N-methyl-3-[7-(1-methylpyrazol-4-yl)-6-(oxolan-3-yloxy)imidazo[1,2-b]pyridazin-3-yl]benzamide
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|
C22H22N6O3
|
1
|
| 1 |
IC50 = 2.4 nM
|
|
|
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CP0546221
|
4-fluoro-3-[6-methoxy-7-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]-N-methylbenzamide
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|
C19H17FN6O2
|
1
|
| 1 |
IC50 = 2.6 nM
|
|
|
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CP0575470
|
N-ethyl-5-[6-(1-ethylpyrazol-4-yl)-5-[(3S)-oxolan-3-yl]oxypyrazolo[1,5-a]pyrimidin-3-yl]pyridine-3-carboxamide
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|
C23H25N7O3
|
1
|
| 1 |
IC50 = 2.6 nM
|
|
|
|
CP0083239
|
BGJ398
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|
C26H31Cl2N7O3
|
1
|
| 1 |
IC50 = 2.7 nM
|
|
|
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CP0572978
|
3-[6-methoxy-7-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]-N-methylbenzamide
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|
C19H18N6O2
|
1
|
| 1 |
IC50 = 4.6 nM
|
|
|
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CP0576281
|
5-[6-methoxy-7-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]-N-methylpyridine-3-carboxamide
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|
C18H17N7O2
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
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CP0575771
|
N-methyl-3-[6-(1-methyl-2-oxopyrrolidin-3-yl)oxy-7-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]benzamide
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|
C23H23N7O3
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
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CP0579986
|
N-methyl-5-[6-(methylamino)-7-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]pyridine-3-carboxamide
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|
C18H18N8O
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
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CP0577256
|
N-methyl-3-[7-(1-methylpyrazol-4-yl)-6-[(3R)-oxolan-3-yl]oxyimidazo[1,2-b]pyridazin-3-yl]benzamide
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|
C22H22N6O3
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
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CP0571050
|
N-methyl-5-[7-(1-methylpyrazol-4-yl)-6-propan-2-yloxyimidazo[1,2-b]pyridazin-3-yl]pyridine-3-carboxamide
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|
C20H21N7O2
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
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CP0567794
|
5-[6-ethoxy-7-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]-N-methylpyridine-3-carboxamide
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|
C19H19N7O2
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
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CP0546169
|
N-methyl-3-[7-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]benzamide
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|
C18H16N6O
|
1
|
| 1 |
IC50 = 68 nM
|
|
|
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CP0576283
|
N-methyl-3-[7-(1-methylpyrazol-4-yl)-6-(oxan-4-yloxy)imidazo[1,2-b]pyridazin-3-yl]benzamide
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|
C23H24N6O3
|
1
|
| 1 |
IC50 = 167 nM
|
|
|
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CP0576444
|
5-[6-[2-(dimethylamino)ethoxy]-7-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]-N-methylpyridine-3-carboxamide
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|
C21H24N8O2
|
1
|
| 1 |
IC50 = 247 nM
|
|
|
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CP0577508
|
N-methyl-5-[7-(1-methylpyrazol-4-yl)-6-phenylmethoxyimidazo[1,2-b]pyridazin-3-yl]pyridine-3-carboxamide
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|
C24H21N7O2
|
1
|
| 1 |
IC50 = 441 nM
|
|
|
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CP0546170
|
3-[6-(1-acetylazetidin-3-yl)oxy-7-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]-N-methylbenzamide
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|
C23H23N7O3
|
1
|
| 1 |
IC50 = 515 nM
|
|
|
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CP0576282
|
N-methyl-5-[7-(1-methylpyrazol-4-yl)-6-phenoxyimidazo[1,2-b]pyridazin-3-yl]pyridine-3-carboxamide
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|
C23H19N7O2
|
1
|
| 1 |
IC50 = 1177 nM
|
|
|
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CP0139001
|
N-(4-fluorophenyl)-1-methyl-3-[[methyl-[2-(4-phenylphenyl)ethyl]amino]methyl]indole-5-carboxamide
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|
C32H30FN3O
|
1
|
| 1 |
IC50 = 6300 nM
|
|
|
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CP0382724
|
3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)-N-[2-[2-[2-[2-[[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]propanamide
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|
C49H54BF2N7O7
|
1
|
| 1 |
Kd = 409 nM
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CP0382649
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3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)-N-[2-[2-[2-[2-[[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-methylamino]ethoxy]ethoxy]ethoxy]ethyl]propanamide
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C50H56BF2N7O7
|
1
|
| 1 |
Kd = 848 nM
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