Brief Information of the Compound and Protein
Compound Name
3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one
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PubChem ID
CID: 86705695
Canonical SMILES
CCN1C(=O)N(Cc2cnc3[nH]c(CN4CCOCC4)cc3c12)c1c(F)c(OC)cc(OC)c1F
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Compound Formula C24H27F2N5O4
Compound Structure
Protein Name
Fibroblast growth factor receptor 3
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase FGFR family
Uniprot ID
P22607
Gene Name
FGFR3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 1.7 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.97 nM
2 IC50 = 1 nM
3 IC50 <= 1 nM
4 IC50 = 1.2 nM
5 IC50 = 6.87 nM
6 IC50 = 201 nM
7 IC50 = 776.3 nM