| Compound ID |
Compound Name |
Compound Formula |
|
CP0375072
|
8-(1-methylimidazol-4-yl)-2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazole
Show/Hide
|
C20H20N6OS
|
1
|
| 1 |
IC50 = 0.6 nM
|
|
|
|
CP0380703
|
2-(2-propan-2-yl-1,2,4-triazol-3-yl)-8-(1H-pyrazol-4-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazole
Show/Hide
|
C19H18N6OS
|
1
|
| 1 |
IC50 = 0.7 nM
|
|
|
|
CP0013679
|
4-[2-amino-5-[2-[(1S)-1-cyclopropylethyl]-1-oxo-7-(trifluoromethyl)-3H-isoindol-5-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-2-propan-2-ylbenzoic acid
Show/Hide
|
C30H28F3N5O3
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0013153
|
N-[5-[2-[(1S)-1-cyclopropylethyl]-7-(methanesulfonamido)-1-oxo-3H-isoindol-5-yl]pyrazolo[1,5-a]pyrimidin-2-yl]acetamide
Show/Hide
|
C22H24N6O4S
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0376487
|
2-methyl-1-[4-[2-[2-(2,2,2-trifluoroethyl)-1,2,4-triazol-3-yl]-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]pyrazol-1-yl]propan-2-ol
Show/Hide
|
C22H21F3N6O2S
|
1
|
| 1 |
IC50 = 1.4 nM
|
|
|
|
CP0375073
|
8-(1H-imidazol-2-yl)-2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazole
Show/Hide
|
C19H18N6OS
|
1
|
| 1 |
IC50 = 1.5 nM
|
|
|
|
CP0012178
|
5-[2-amino-3-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-2-[(1S)-1-cyclopropylethyl]-7-(trifluoromethyl)-3H-isoindol-1-one
Show/Hide
|
C24H22F3N7O
|
1
|
| 1 |
IC50 = 1.9 nM
|
|
|
|
CP0012177
|
4-[5-[2-[(1S)-1-cyclopropylethyl]-1-oxo-7-(trifluoromethyl)-3H-isoindol-5-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-2-propan-2-ylbenzoic acid
Show/Hide
|
C30H27F3N4O3
|
1
|
| 1 |
IC50 = 2.1 nM
|
|
|
|
CP0014372
|
2-[4-[2-amino-5-[2-[(1S)-1-cyclopropylethyl]-7-methyl-1-oxo-3H-isoindol-5-yl]pyrazolo[1,5-a]pyrimidin-3-yl]phenyl]acetic acid
Show/Hide
|
C28H27N5O3
|
1
|
| 1 |
IC50 = 2.1 nM
|
|
|
|
CP0333717
|
2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydrothieno[3,2-d][1]benzoxepine-8-carboxamide
Show/Hide
|
C18H18N4O2S
|
1
|
| 1 |
IC50 = 2.2 nM
|
|
|
|
CP0012414
|
N-[5-[2-[(1S)-1-cyclopropylethyl]-1-oxo-7-(trifluoromethyl)-3H-isoindol-5-yl]pyrazolo[1,5-a]pyrimidin-2-yl]acetamide
Show/Hide
|
C22H20F3N5O2
|
1
|
| 1 |
IC50 = 2.2 nM
|
|
|
|
CP0012642
|
4-[2-amino-5-[2-[(1S)-1-cyclopropylethyl]-7-methyl-1-oxo-3H-isoindol-5-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-2-methylbenzoic acid
Show/Hide
|
C28H27N5O3
|
1
|
| 1 |
IC50 = 2.2 nM
|
|
|
|
CP0090561
|
N-[2-chloro-5-(3-morpholin-4-ylquinoxalin-6-yl)pyridin-3-yl]-4-fluorobenzenesulfonamide
Show/Hide
|
C23H19ClFN5O3S
|
1
|
| 1 |
IC50 = 2.4 nM
|
|
|
|
CP0012928
|
N-[5-[2-[(1S)-1-cyclopropylethyl]-7-(methylsulfamoyl)-1-oxo-3H-isoindol-5-yl]pyrazolo[1,5-a]pyrimidin-2-yl]acetamide
Show/Hide
|
C22H24N6O4S
|
1
|
| 1 |
IC50 = 2.7 nM
|
|
|
|
CP0010400
|
5-[2-amino-3-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-2-[(1S)-1-cyclopropylethyl]-7-methyl-3H-isoindol-1-one
Show/Hide
|
C24H25N7O
|
1
|
| 1 |
IC50 = 2.9 nM
|
|
|
|
CP0012927
|
(2S)-1-N-[6-[2-[(1S)-1-cyclopropylethyl]-7-methyl-1-oxo-3H-isoindol-5-yl]imidazo[1,2-b]pyridazin-2-yl]pyrrolidine-1,2-dicarboxamide
Show/Hide
|
C26H29N7O3
|
1
|
| 1 |
IC50 = 2.9 nM
|
|
|
|
CP0456044
|
2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazole
Show/Hide
|
C16H16N4OS
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0380704
|
8-(azetidin-3-yl)-2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazole
Show/Hide
|
C19H21N5OS
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0012179
|
N-[5-[2-[(1S)-1-cyclopropylethyl]-7-methyl-1-oxo-3H-isoindol-5-yl]-4-methyl-1,3-thiazol-2-yl]acetamide
Show/Hide
|
C20H23N3O2S
|
1
|
| 1 |
IC50 = 3.6 nM
|
|
|
|
CP0404178
|
5-[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]pyridin-2-amine
Show/Hide
|
C21H20N6OS
|
1
|
| 1 |
IC50 = 3.7 nM
|
|
|
|
CP0231521
|
1-[4-(3,3-dimethylpiperazine-1-carbonyl)phenyl]-3-[4-(4-methoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea
Show/Hide
|
C28H34N8O4
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0468673
|
2-(2-propan-2-yl-1,2,4-triazol-3-yl)-8-pyrrolidin-3-yl-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazole
Show/Hide
|
C20H23N5OS
|
1
|
| 1 |
IC50 = 4.3 nM
|
|
|
|
CP0013201
|
N-[5-[2-[(1S)-1-cyclopropylethyl]-7-methyl-1-oxo-3H-isoindol-5-yl]pyrazolo[1,5-a]pyrimidin-2-yl]acetamide
Show/Hide
|
C22H23N5O2
|
1
|
| 1 |
IC50 = 4.4 nM
|
|
|
|
CP0160666
|
N-[2-(dimethylamino)ethyl]-N-methyl-4-[[4-[4-morpholin-4-yl-6-[(3S)-oxolan-3-yl]oxy-1,3,5-triazin-2-yl]phenyl]carbamoylamino]benzamide
Show/Hide
|
C30H38N8O5
|
1
|
| 1 |
IC50 = 4.8 nM
|
|
|
|
CP0456951
|
3-amino-6-[4-chloro-3-[(2-chloro-4-fluorophenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C18H14Cl2FN5O3S
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0012830
|
N-[6-[2-[(1S)-1-cyclopropylethyl]-7-methyl-1-oxo-3H-isoindol-5-yl]imidazo[1,2-b]pyridazin-2-yl]acetamide
Show/Hide
|
C22H23N5O2
|
1
|
| 1 |
IC50 = 5.5 nM
|
|
|
|
CP0010401
|
5-[2-amino-3-(2-methyl-1,3-oxazol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-2-[(1S)-1-cyclopropylethyl]-7-methyl-3H-isoindol-1-one
Show/Hide
|
C24H24N6O2
|
1
|
| 1 |
IC50 = 5.9 nM
|
|
|
|
CP0341850
|
4-[[4-[4-morpholin-4-yl-6-[(3S)-oxolan-3-yl]oxy-1,3,5-triazin-2-yl]phenyl]carbamoylamino]-N-(2-pyrrolidin-1-ylethyl)benzamide
Show/Hide
|
C31H38N8O5
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0533679
|
5-[2-amino-4-(2,2,2-trifluoroethoxy)pyrimidin-5-yl]-2-chloro-N-(2,3-difluorophenyl)benzenesulfonamide
Show/Hide
|
C18H12ClF5N4O3S
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0010601
|
5-[2-amino-3-[1-(2-hydroxyethyl)pyrazol-4-yl]pyrazolo[1,5-a]pyrimidin-5-yl]-2-[(1S)-1-cyclopropylethyl]-7-methyl-3H-isoindol-1-one
Show/Hide
|
C25H27N7O2
|
1
|
| 1 |
IC50 = 6.4 nM
|
|
|
|
CP0044692
|
1-[4-[4-(dimethylamino)piperidine-1-carbonyl]phenyl]-3-[4-[4-morpholin-4-yl-6-[(3S)-oxolan-3-yl]oxy-1,3,5-triazin-2-yl]phenyl]urea
Show/Hide
|
C32H40N8O5
|
1
|
| 1 |
IC50 = 6.5 nM
|
|
|
|
CP0090562
|
N-[2-chloro-5-[4-[4-(pyridin-4-ylmethyl)piperazin-1-yl]quinolin-6-yl]pyridin-3-yl]-4-fluorobenzenesulfonamide
Show/Hide
|
C30H26ClFN6O2S
|
1
|
| 1 |
IC50 = 6.5 nM
|
|
|
|
CP0012929
|
5-[2-amino-3-(1,5-dimethylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-2-[(1S)-1-cyclopropylethyl]-7-(trifluoromethyl)-3H-isoindol-1-one
Show/Hide
|
C25H24F3N7O
|
1
|
| 1 |
IC50 = 6.6 nM
|
|
|
|
CP0341848
|
N-[2-(dimethylamino)ethyl]-4-[[4-(4-methoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoylamino]-N-methylbenzamide
Show/Hide
|
C27H34N8O4
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0010602
|
N-[6-[2-[(1S)-1-cyclopropylethyl]-7-methyl-1-oxo-3H-isoindol-5-yl]imidazo[1,2-b]pyridazin-2-yl]propanamide
Show/Hide
|
C23H25N5O2
|
1
|
| 1 |
IC50 = 7.3 nM
|
|
|
|
CP0012828
|
5-(2-amino-3-pyrimidin-4-ylpyrazolo[1,5-a]pyrimidin-5-yl)-2-[(1S)-1-cyclopropylethyl]-7-methyl-3H-isoindol-1-one
Show/Hide
|
C24H23N7O
|
1
|
| 1 |
IC50 = 7.5 nM
|
|
|
|
CP0210324
|
N-[2-chloro-5-(4-pyridin-3-ylquinolin-6-yl)pyridin-3-yl]-4-fluorobenzenesulfonamide
Show/Hide
|
C25H16ClFN4O2S
|
1
|
| 1 |
IC50 = 7.7 nM
|
|
|
|
CP0303113
|
4-[[4-[4-morpholin-4-yl-6-[(3S)-oxolan-3-yl]oxy-1,3,5-triazin-2-yl]phenyl]carbamoylamino]-N-(2-piperidin-1-ylethyl)benzamide
Show/Hide
|
C32H40N8O5
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0381347
|
3-amino-6-[4-chloro-3-[(2,4-dichlorophenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C18H14Cl3N5O3S
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0008417
|
5-[2-amino-3-(1,3-dimethylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-2-[(1S)-1-cyclopropylethyl]-7-(trifluoromethyl)-3H-isoindol-1-one
Show/Hide
|
C25H24F3N7O
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0252844
|
N-[2-chloro-5-(4-morpholin-4-ylquinolin-6-yl)pyridin-3-yl]-4-fluorobenzenesulfonamide
Show/Hide
|
C24H20ClFN4O3S
|
1
|
| 1 |
IC50 = 8.1 nM
|
|
|
|
CP0376489
|
8-piperidin-4-yl-2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazole
Show/Hide
|
C21H25N5OS
|
1
|
| 1 |
IC50 = 8.4 nM
|
|
|
|
CP0404180
|
[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]methanol
Show/Hide
|
C17H18N4O2S
|
1
|
| 1 |
IC50 = 8.4 nM
|
|
|
|
CP0095286
|
1-[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3]triazolo-[4,5-d]pyrimidin-5-yl)phenyl]-3-{4-[(4-methylpiperazin-1-yl)carbonyl]-phenyl}urea
Show/Hide
|
C29H34N10O3
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0008794
|
2-[(1S)-1-cyclopropylethyl]-7-methyl-5-[3-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-3H-isoindol-1-one
Show/Hide
|
C24H24N6O
|
1
|
| 1 |
IC50 = 9.1 nM
|
|
|
|
CP0282348
|
1-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3-[4-[4-morpholin-4-yl-6-(oxetan-3-yloxy)-1,3,5-triazin-2-yl]phenyl]urea
Show/Hide
|
C29H34N8O5
|
1
|
| 1 |
IC50 = 9.5 nM
|
|
|
|
CP0341849
|
4-[[4-(4-methoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoylamino]-N-methyl-N-[2-(methylamino)ethyl]benzamide
Show/Hide
|
C26H32N8O4
|
1
|
| 1 |
IC50 = 9.5 nM
|
|
|
|
CP0453880
|
5-[3-[4-[3-(4-methoxyphenyl)pyrazin-2-yl]piperazin-1-yl]sulfonylphenyl]pyrimidin-2-amine
Show/Hide
|
C25H25N7O3S
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0231518
|
N-[2-(dimethylamino)ethyl]-4-[[4-(4-methoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoylamino]benzamide
Show/Hide
|
C26H32N8O4
|
1
|
| 1 |
IC50 = 10.5 nM
|
|
|
|
CP0108539
|
1-(4-{[4-(Dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea
Show/Hide
|
C32H41N9O4
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0456950
|
3-amino-6-[4-chloro-3-[(3-chlorophenyl)sulfonylamino]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C18H15Cl2N5O3S
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0376488
|
3-[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]-1H-pyridin-2-one
Show/Hide
|
C21H19N5O2S
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0152367
|
N-[2-chloro-5-(4-pyridin-4-ylquinolin-6-yl)pyridin-3-yl]-4-fluorobenzenesulfonamide
Show/Hide
|
C25H16ClFN4O2S
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0298054
|
N-[2-chloro-5-[3-(4-propan-2-ylpiperazin-1-yl)quinoxalin-6-yl]pyridin-3-yl]-4-fluorobenzenesulfonamide
Show/Hide
|
C26H26ClFN6O2S
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0231504
|
1-[4-(4-methoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[4-(4-methylpiperazine-1-carbonyl)phenyl]urea
Show/Hide
|
C27H32N8O4
|
1
|
| 1 |
IC50 = 13.5 nM
|
|
|
|
CP0011320
|
2-amino-N-[(1S)-1-(8-ethynyl-1-oxo-2-phenylisoquinolin-3-yl)ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C26H20N6O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0013202
|
N-[6-[2-[(1S)-1-cyclopropylethyl]-7-methyl-1-oxo-3H-isoindol-5-yl]imidazo[1,2-b]pyridazin-2-yl]-2-methoxyacetamide
Show/Hide
|
C23H25N5O3
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0281944
|
1-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3-[4-[4-morpholin-4-yl-6-[(3S)-oxolan-3-yl]oxy-1,3,5-triazin-2-yl]phenyl]urea
Show/Hide
|
C30H36N8O5
|
1
|
| 1 |
IC50 = 14.3 nM
|
|
|
|
CP0012827
|
2-[(1S)-1-cyclopropylethyl]-7-methyl-5-[3-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazin-6-yl]-3H-isoindol-1-one
Show/Hide
|
C24H24N6O
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0252843
|
N-[2-chloro-5-[3-(2-morpholin-4-ylethylamino)quinoxalin-6-yl]pyridin-3-yl]-4-fluorobenzenesulfonamide
Show/Hide
|
C25H24ClFN6O3S
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0006058
|
2-amino-N-[(1S)-1-[8-[2-(1-methylpyrazol-4-yl)ethynyl]-1-oxo-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C30H24N8O2
|
2
|
| 1 |
IC50 = 16 nM
|
|
|
| 2 |
Kd = 0.29 nM
|
|
|
|
CP0525817
|
3-amino-6-[4-chloro-3-(methylsulfamoyl)phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C13H14ClN5O3S
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0008792
|
5-[2-amino-3-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazin-6-yl]-2-[(1S)-1-cyclopropylethyl]-7-methyl-3H-isoindol-1-one
Show/Hide
|
C24H25N7O
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0044691
|
N-[2-(dimethylamino)ethyl]-N-methyl-4-[[4-(4-morpholin-4-yl-6-propan-2-yloxy-1,3,5-triazin-2-yl)phenyl]carbamoylamino]benzamide
Show/Hide
|
C29H38N8O4
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0027760
|
3-amino-6-[4-chloro-3-[(2,3-difluorophenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C18H14ClF2N5O3S
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0381346
|
5-[3-[4-[3-(4-propan-2-ylphenyl)pyrazin-2-yl]piperazin-1-yl]sulfonylphenyl]pyrimidin-2-amine
Show/Hide
|
C27H29N7O2S
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0433674
|
3-amino-6-[4-chloro-3-[(3-chlorophenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C18H15Cl2N5O3S
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0456948
|
3-amino-6-[4-chloro-3-[(2,3-dichlorophenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C18H14Cl3N5O3S
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
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CP0481681
|
5-[3-[4-[2-(4-propan-2-ylphenyl)pyridin-3-yl]piperazin-1-yl]sulfonylphenyl]pyrimidin-2-amine
Show/Hide
|
C28H30N6O2S
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0380436
|
1-[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]ethane-1,2-diol
Show/Hide
|
C18H20N4O3S
|
1
|
| 1 |
IC50 = 19.1 nM
|
|
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CP0413762
|
3-amino-6-[4-chloro-3-[(2-chlorophenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C18H15Cl2N5O3S
|
1
|
| 1 |
IC50 = 20 nM
|
|
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CP0455221
|
5-(2-amino-4-methoxypyrimidin-5-yl)-2-chloro-N-(2,3-difluorophenyl)benzenesulfonamide
Show/Hide
|
C17H13ClF2N4O3S
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0313931
|
4-[[4-(4-methoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoylamino]-N-(2-piperidin-1-ylethyl)benzamide
Show/Hide
|
C29H36N8O4
|
1
|
| 1 |
IC50 = 20.5 nM
|
|
|
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CP0456945
|
3-amino-N-methyl-6-[3-(2H-tetrazol-5-yl)phenyl]pyrazine-2-carboxamide
Show/Hide
|
C13H12N8O
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
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CP0484883
|
3-amino-6-[4-chloro-3-[(2-chloro-3-fluorophenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C18H14Cl2FN5O3S
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0345631
|
N-[2-(dimethylamino)ethyl]-4-[[4-(4-morpholin-4-yl-6-propan-2-yloxy-1,3,5-triazin-2-yl)phenyl]carbamoylamino]benzamide
Show/Hide
|
C28H36N8O4
|
1
|
| 1 |
IC50 = 24.5 nM
|
|
|
|
CP0002783
|
2-amino-N-[(1S)-1-(1-oxo-2-phenyl-8-prop-1-ynylisoquinolin-3-yl)ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C27H22N6O2
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0413763
|
3-amino-6-[4-chloro-3-[(4-chlorophenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C18H15Cl2N5O3S
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0488589
|
3-amino-6-(4-chloro-3-sulfamoylphenyl)-N-methylpyrazine-2-carboxamide
Show/Hide
|
C12H12ClN5O3S
|
1
|
| 1 |
IC50 = 26 nM
|
|
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|
CP0413761
|
3-amino-6-[4-chloro-3-[(3-methoxyphenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C19H18ClN5O4S
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0637312
|
5-[2-Amino-3-(1H-1,2,4-triazol-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-2-[(1S)-1-cyclopropylethyl]-7-methyl-2,3-dihydro-1H-isoindol-1-one
Show/Hide
|
C22H22N8O
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0020253
|
3-amino-6-[4-chloro-3-[(3-fluoro-2-methylphenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C19H17ClFN5O3S
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0380434
|
2-(2-propan-2-yl-1,2,4-triazol-3-yl)-8-pyrrolidin-2-yl-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazole
Show/Hide
|
C20H23N5OS
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0455223
|
3-amino-6-[4-chloro-3-(phenylsulfamoyl)phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C18H16ClN5O3S
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0845652
|
PIK-75
Show/Hide
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C16H15BrClN5O4S
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0012605
|
2-amino-N-[(1S)-1-(8-chloro-1-oxo-2-phenylisoquinolin-3-yl)ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C24H19ClN6O2
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0007893
|
4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine
Show/Hide
|
C23H27N7O3S2
|
2
|
| 1 |
IC50 = 42 nM
|
|
|
| 2 |
Ki = 1.4 nM
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|
|
|
CP0381386
|
3-amino-6-[3-[(3-chlorophenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C18H16ClN5O3S
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0456942
|
3-amino-6-[4-chloro-3-[(3-fluorophenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C18H15ClFN5O3S
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0638347
|
5-[2-Amino-3-(1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-2-[(1S)-1-cyclopropylethyl]-7-methyl-2,3-dihydro-1H-isoindol-1-one
Show/Hide
|
C23H23N7O
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0413764
|
3-amino-6-[4-chloro-3-[(3-methylphenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C19H18ClN5O3S
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
|
CP0484882
|
3-amino-6-[4-chloro-3-[[3-(trifluoromethyl)phenyl]sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C19H15ClF3N5O3S
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0303112
|
1-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3-[4-(4-morpholin-4-yl-6-propan-2-yloxy-1,3,5-triazin-2-yl)phenyl]urea
Show/Hide
|
C29H36N8O4
|
1
|
| 1 |
IC50 = 49.5 nM
|
|
|
|
CP0006062
|
2-amino-N-[(1S)-1-(8-fluoro-1-oxo-2-phenylisoquinolin-3-yl)ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C24H19FN6O2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0010399
|
5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-[(1S)-1-cyclopropylethyl]-7-methyl-3H-isoindol-1-one
Show/Hide
|
C20H21N5O
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0433670
|
3-amino-6-[6-amino-5-(phenylsulfamoyl)pyridin-3-yl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C17H17N7O3S
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0012829
|
5-(2-amino-3-pyrimidin-2-ylpyrazolo[1,5-a]pyrimidin-5-yl)-2-[(1S)-1-cyclopropylethyl]-7-(trifluoromethyl)-3H-isoindol-1-one
Show/Hide
|
C24H20F3N7O
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0409919
|
N-[[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]methyl]acetamide
Show/Hide
|
C19H21N5O2S
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0453878
|
5-(2-aminopyrimidin-5-yl)-2-chloro-N-(2,3-difluorophenyl)benzenesulfonamide
Show/Hide
|
C16H11ClF2N4O2S
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0456949
|
3-amino-N-methyl-6-[3-(phenylsulfamoyl)phenyl]pyrazine-2-carboxamide
Show/Hide
|
C18H17N5O3S
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0002785
|
7-amino-N-[(1S)-1-(8-chloro-1-oxo-2-phenylisoquinolin-3-yl)ethyl]-1,6-naphthyridine-8-carboxamide
Show/Hide
|
C26H20ClN5O2
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0008793
|
5-(2-aminopyrazolo[1,5-a]pyrimidin-5-yl)-2-[(1S)-1-cyclopropylethyl]-7-methyl-3H-isoindol-1-one
Show/Hide
|
C20H21N5O
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0012180
|
5-(2-amino-3-pyridin-2-ylpyrazolo[1,5-a]pyrimidin-5-yl)-2-[(1S)-1-cyclopropylethyl]-7-methyl-3H-isoindol-1-one
Show/Hide
|
C25H24N6O
|
1
|
| 1 |
IC50 = 64 nM
|
|
|
|
CP0455222
|
3-amino-6-[4-chloro-3-(2,2,2-trifluoroethylsulfamoyl)phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C14H13ClF3N5O3S
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0012641
|
N-[6-[2-[(1S)-1-cyclopropylethyl]-7-methyl-1-oxo-3H-isoindol-5-yl]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropanamide
Show/Hide
|
C24H27N5O2
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0272045
|
4-[[4-[4-[(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)oxy]-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl]carbamoylamino]benzamide
Show/Hide
|
C29H34N8O4
|
1
|
| 1 |
IC50 = 72.5 nM
|
|
|
|
CP0006928
|
2-amino-N-[(1S)-1-[1-oxo-2-phenyl-8-[2-(1,3-thiazol-4-yl)ethynyl]isoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C29H21N7O2S
|
1
|
| 1 |
IC50 = 75 nM
|
|
|
|
CP0008416
|
N-[6-[2-[(1S)-1-cyclopropylethyl]-7-methyl-1-oxo-3H-isoindol-5-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
Show/Hide
|
C22H23N5O2
|
1
|
| 1 |
IC50 = 76 nM
|
|
|
|
CP0380449
|
2-[[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]methylamino]ethanol
Show/Hide
|
C19H23N5O2S
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0014252
|
N-[7-[2-[(1S)-1-cyclopropylethyl]-7-methyl-1-oxo-3H-isoindol-5-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
Show/Hide
|
C22H23N5O2
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0008795
|
N-[6-[2-[(1S)-1-cyclopropylethyl]-7-methyl-1-oxo-3H-isoindol-5-yl]imidazo[1,2-b]pyridazin-2-yl]benzamide
Show/Hide
|
C27H25N5O2
|
1
|
| 1 |
IC50 = 93 nM
|
|
|
|
CP0303297
|
1-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3-[4-(4-morpholin-4-yl-6-oxo-1H-1,3,5-triazin-2-yl)phenyl]urea
Show/Hide
|
C26H30N8O4
|
1
|
| 1 |
IC50 = 96.5 nM
|
|
|
|
CP0007857
|
2-amino-N-[(1S)-1-[8-[2-(1-methylpyrazol-3-yl)ethynyl]-1-oxo-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C30H24N8O2
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0453882
|
3-amino-6-[3-[(2,3-difluorophenyl)sulfamoyl]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C18H15F2N5O3S
|
1
|
| 1 |
IC50 = 102 nM
|
|
|
|
CP0005858
|
2-amino-N-[(1S)-1-[1-oxo-2-phenyl-8-[2-(1,3-thiazol-5-yl)ethynyl]isoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C29H21N7O2S
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0006060
|
2-amino-N-[(1S)-1-[1-oxo-2-phenyl-8-(2-pyridin-3-ylethynyl)isoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C31H23N7O2
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0007858
|
2-amino-N-[(1S)-1-(8-methyl-1-oxo-2-phenylisoquinolin-3-yl)ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C25H22N6O2
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0005794
|
2-amino-N-[(1S)-1-(8-chloro-1-oxo-2-phenylisoquinolin-3-yl)propyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C25H21ClN6O2
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0456946
|
3-amino-6-[4-fluoro-3-(phenylsulfamoyl)phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C18H16FN5O3S
|
1
|
| 1 |
IC50 = 152 nM
|
|
|
|
CP0413759
|
3-amino-6-[3-[(3-chlorophenyl)sulfonylamino]phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C18H16ClN5O3S
|
1
|
| 1 |
IC50 = 161 nM
|
|
|
|
CP0455220
|
3-amino-6-[3-(benzenesulfonamido)phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C18H17N5O3S
|
1
|
| 1 |
IC50 = 167 nM
|
|
|
|
CP0005859
|
2-amino-N-[(1S)-1-[1-oxo-2-phenyl-8-(2-pyridin-2-ylethynyl)isoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C31H23N7O2
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0013382
|
2-amino-N-[(1S)-1-(8-cyano-1-oxo-2-phenylisoquinolin-3-yl)ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C25H19N7O2
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0642162
|
3-(4-morpholin-4-yl-pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)-phenol
Show/Hide
|
C19H17ClN4O3
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0003941
|
2-amino-N-[(1S)-1-[1-oxo-2-phenyl-8-(2-phenylethynyl)isoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C32H24N6O2
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0014371
|
5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-[(1S)-1-cyclopropylethyl]-7-methyl-3H-isoindol-1-one
Show/Hide
|
C20H21N5O
|
1
|
| 1 |
IC50 = 291 nM
|
|
|
|
CP0003942
|
2-amino-N-[(1S)-1-(8-chloro-1-oxo-2-phenylisoquinolin-3-yl)ethyl]pyrazolo[1,5-a]pyridine-3-carboxamide
Show/Hide
|
C25H20ClN5O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0006061
|
2-amino-N-[(1S)-1-[1-oxo-2-phenyl-8-[(E)-prop-1-enyl]isoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C27H24N6O2
|
1
|
| 1 |
IC50 = 330 nM
|
|
|
|
CP0002782
|
2-amino-N-[(1S)-1-[1-oxo-2-phenyl-8-(2-pyridin-4-ylethynyl)isoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C31H23N7O2
|
1
|
| 1 |
IC50 = 350 nM
|
|
|
|
CP0011319
|
2-amino-N-[(1S)-1-[1-oxo-2-phenyl-8-[2-(1,3-thiazol-2-yl)ethynyl]isoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C29H21N7O2S
|
1
|
| 1 |
IC50 = 360 nM
|
|
|
|
CP0010248
|
N-[(1S)-1-(8-chloro-1-oxo-2-phenylisoquinolin-3-yl)ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C24H18ClN5O2
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0012831
|
5-(2-aminoimidazo[1,2-b]pyridazin-6-yl)-2-[(1S)-1-cyclopropylethyl]-7-methyl-3H-isoindol-1-one
Show/Hide
|
C20H21N5O
|
1
|
| 1 |
IC50 = 425 nM
|
|
|
|
CP0013154
|
N-[5-[2-[(1S)-1-cyclopropylethyl]-7-methyl-1-oxo-3H-isoindol-5-yl]-3-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-2-yl]acetamide
Show/Hide
|
C26H27N7O2
|
1
|
| 1 |
IC50 = 429 nM
|
|
|
|
CP0453879
|
2-(4-methoxyphenyl)-3-[4-[3-(4-methoxyphenyl)phenyl]sulfonylpiperazin-1-yl]pyrazine
Show/Hide
|
C28H28N4O4S
|
1
|
| 1 |
IC50 = 441 nM
|
|
|
|
CP0639090
|
(+/-)-N-{5-[2-(1-Cyclopropylethyl)-7-methyl-1-oxo-2,3-dihydro-1H-isoindol-5-yl]-1H-1,3-benzodiazol-2-yl}-acetamide
Show/Hide
|
C23H24N4O2
|
1
|
| 1 |
IC50 = 482 nM
|
|
|
|
CP0456944
|
5-(5-aminopyrazin-2-yl)-2-chloro-N-(2,3-difluorophenyl)benzenesulfonamide
Show/Hide
|
C16H11ClF2N4O2S
|
1
|
| 1 |
IC50 = 497 nM
|
|
|
|
CP0456947
|
3-amino-6-[4-methoxy-3-(phenylsulfamoyl)phenyl]-N-methylpyrazine-2-carboxamide
Show/Hide
|
C19H19N5O4S
|
1
|
| 1 |
IC50 = 507 nM
|
|
|
|
CP0640938
|
3-(4-morpholinothieno[3,2-d]pyrimidin-2-yl)phenol
Show/Hide
|
C16H16ClN3O2S
|
1
|
| 1 |
IC50 = 660 nM
|
|
|
|
CP0433672
|
3-amino-N-methyl-6-[3-(trifluoromethyl)phenyl]pyrazine-2-carboxamide
Show/Hide
|
C13H11F3N4O
|
1
|
| 1 |
IC50 = 777 nM
|
|
|
|
CP0265356
|
(4aS,7R,12cS)-10,11-Dihydroxy-4,4,7,12c-tetramethyl-2,3,4,4a,5,6,7,12c-octahydro-1H-8-oxa-dibenzo[a,h]azulene-9-carbaldehyde
Show/Hide
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C22H28O4
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
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CP0147576
|
4-morpholin-4-yl-2-[2-oxo-2-(4-pyridin-4-yl-2,3-dihydroindol-1-yl)ethyl]-1H-pyrimidin-6-one
Show/Hide
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C23H23N5O3
|
1
|
| 1 |
IC50 = 1000 nM
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|
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CP0006296
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2-amino-N-[(1S)-1-(8-methoxy-1-oxo-2-phenylisoquinolin-3-yl)ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C25H22N6O3
|
1
|
| 1 |
IC50 = 1000 nM
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|
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CP0006929
|
N-[(1S)-1-(8-chloro-1-oxo-2-phenylisoquinolin-3-yl)ethyl]-1,6-naphthyridine-8-carboxamide
Show/Hide
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C26H19ClN4O2
|
1
|
| 1 |
IC50 = 1000 nM
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CP0006295
|
2-amino-N-[(1S)-1-[8-(dimethylamino)-1-oxo-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C26H25N7O2
|
1
|
| 1 |
IC50 = 1100 nM
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|
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CP0011778
|
2-amino-N-[(1S)-1-[8-(methylamino)-1-oxo-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C25H23N7O2
|
1
|
| 1 |
IC50 = 1100 nM
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|
|
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CP0134138
|
2-[2-(4-chloro-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C18H19ClN4O3
|
1
|
| 1 |
IC50 = 1131 nM
|
|
|
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CP0869038
|
5-Phenyl-3-(1'-morpholinoethyl)-6-thioxo-5,6,8,9,10,10ahexahydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidin-1(2H)-one
Show/Hide
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C21H25N5O2S
|
1
|
| 1 |
IC50 = 1340 nM
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|
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CP0529072
|
(4aS,11cS)-9,10-Dihydroxy-4,4,11c-trimethyl-1,2,3,4,4a,5,6,11c-octahydro-benzo[b]naphtho[1,2-d]furan-8-carboxylic acid amide
Show/Hide
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C20H25NO4
|
1
|
| 1 |
IC50 = 1400 nM
|
|
|
|
CP0134137
|
4-morpholin-4-yl-2-[2-oxo-2-(4-phenyl-2,3-dihydroindol-1-yl)ethyl]-1H-pyrimidin-6-one
Show/Hide
|
C24H24N4O3
|
1
|
| 1 |
IC50 = 1532 nM
|
|
|
|
CP0155508
|
2-[2-(5-fluoro-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C18H19FN4O3
|
1
|
| 1 |
IC50 = 1590 nM
|
|
|
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CP0002420
|
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
Show/Hide
|
C19H17NO3
|
1
|
| 1 |
IC50 = 1600 nM
|
|
|
|
CP0431538
|
2-[2-(4-methyl-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C19H22N4O3
|
1
|
| 1 |
IC50 = 1780 nM
|
|
|
|
CP0522306
|
(4aS,11cS)-9,10-Dihydroxy-4,4,11c-trimethyl-1,2,3,4,4a,5,6,11c-octahydro-benzo[b]naphtho[1,2-d]furan-8-carbaldehyde
Show/Hide
|
C20H24O4
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0494841
|
(4aS,7R,12cS)-4,4,7,12c-Tetramethyl-2,3,4,4a,5,6,7,12c-octahydro-1H-8-oxa-dibenzo[a,h]azulen-11-ol
Show/Hide
|
C21H28O2
|
1
|
| 1 |
IC50 = 1900 nM
|
|
|
|
CP0508773
|
(4aS,7S,12cS)-4,4,7,12c-Tetramethyl-2,3,4,4a,5,6,7,12c-octahydro-1H-8-oxa-dibenzo[a,h]azulen-10-ol
Show/Hide
|
C21H28O2
|
1
|
| 1 |
IC50 = 2200 nM
|
|
|
|
CP0338973
|
4-morpholin-4-yl-2-[2-oxo-2-(4-pyridin-3-yl-2,3-dihydroindol-1-yl)ethyl]-1H-pyrimidin-6-one
Show/Hide
|
C23H23N5O3
|
1
|
| 1 |
IC50 = 2461 nM
|
|
|
|
CP0472463
|
(4aS,11cS)-9,10-Dimethoxy-4,4,11c-trimethyl-1,2,3,4,4a,5,6,11c-octahydro-benzo[b]naphtho[1,2-d]furan-8-carbaldehyde
Show/Hide
|
C22H28O4
|
1
|
| 1 |
IC50 = 2640 nM
|
|
|
|
CP0704953
|
2-{2-[(2R)-2-Methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)-pyrimidin-4(3H)-one
Show/Hide
|
C19H22N4O3
|
1
|
| 1 |
IC50 = 3315 nM
|
|
|
|
CP0237639
|
2-[(4-methyl-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C17H18N4O3
|
1
|
| 1 |
IC50 = 3333 nM
|
|
|
|
CP0426527
|
2-[2-(4-bromo-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C18H19BrN4O3
|
1
|
| 1 |
IC50 = 3975 nM
|
|
|
|
CP0891722
|
5-Ethyl-3-(10-morpholinoethyl)-6-thioxo-5,6,8,9,10,10ahexahydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidin-1(2H)-one
Show/Hide
|
C17H25N5O2S
|
1
|
| 1 |
IC50 = 4560 nM
|
|
|
|
CP0508774
|
(4aS,11cS)-9-Hydroxy-10-methoxy-4,4,11c-trimethyl-1,2,3,4,4a,5,6,11c-octahydro-benzo[b]naphtho[1,2-d]furan-8-carbaldehyde
Show/Hide
|
C21H26O4
|
1
|
| 1 |
IC50 = 5150 nM
|
|
|
|
CP0508770
|
(4'S,6R)-6'-bromo-2,2,4',6-tetramethyl-3',4'-dihydro-2'H-spiro[cyclohexane-1,1'-dibenzo[b,d]furan]-7',8'-diol
Show/Hide
|
C21H27BrO3
|
1
|
| 1 |
IC50 = 5300 nM
|
|
|
|
CP0013452
|
N-[6-[2-[(1S)-1-cyclopropylethyl]-7-methyl-1-oxo-3H-isoindol-5-yl]imidazo[1,2-b]pyridazin-2-yl]methanesulfonamide
Show/Hide
|
C21H23N5O3S
|
1
|
| 1 |
IC50 = 5300 nM
|
|
|
|
CP0508772
|
(4aS,7R,12cS)-9-Bromo-4,4,7,12c-tetramethyl-2,3,4,4a,5,6,7,12c-octahydro-1H-8-oxa-dibenzo[a,h]azulen-10-ol
Show/Hide
|
C21H27BrO2
|
1
|
| 1 |
IC50 = 5700 nM
|
|
|
|
CP0169941
|
4-morpholin-4-yl-2-[(4-thiophen-2-yl-1,3-benzoxazol-2-yl)methyl]-1H-pyrimidin-6-one
Show/Hide
|
C20H18N4O3S
|
1
|
| 1 |
IC50 = 5742 nM
|
|
|
|
CP0849535
|
5-Phenyl-3-(morpholinomethyl)-6-thioxo-5,6,8,9,10,10a-hexahydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidin-1(2H)-one
Show/Hide
|
C20H23N5O2S
|
1
|
| 1 |
IC50 = 5780 nM
|
|
|
|
CP0362492
|
BDBM50447090
Show/Hide
|
C18H19FN4O3
|
1
|
| 1 |
IC50 = 6215 nM
|
|
|
|
CP0308575
|
4-morpholin-4-yl-2-[2-oxo-2-[4-(trifluoromethoxy)-2,3-dihydroindol-1-yl]ethyl]-1H-pyrimidin-6-one
Show/Hide
|
C19H19F3N4O4
|
1
|
| 1 |
IC50 = 7418 nM
|
|
|
|
CP0867448
|
5-Ethyl-3-(morpholinomethyl)-6-thioxo-5,6,8,9,10,10ahexahydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidin-1(2H)-one
Show/Hide
|
C16H23N5O2S
|
1
|
| 1 |
IC50 = 7640 nM
|
|
|
|
CP0362462
|
2-[(1-ethylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C18H21N5O2
|
1
|
| 1 |
IC50 = 8270 nM
|
|
|
|
CP0308576
|
4-morpholin-4-yl-2-[2-oxo-2-[4-(trifluoromethyl)-2,3-dihydroindol-1-yl]ethyl]-1H-pyrimidin-6-one
Show/Hide
|
C19H19F3N4O3
|
1
|
| 1 |
IC50 = 8400 nM
|
|
|
|
CP0347349
|
4-morpholin-4-yl-2-[2-oxo-2-(4-pyridin-2-yl-2,3-dihydroindol-1-yl)ethyl]-1H-pyrimidin-6-one
Show/Hide
|
C23H23N5O3
|
1
|
| 1 |
IC50 = 8966 nM
|
|
|
|
CP0450213
|
2-[2-(2-methyl-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C19H22N4O3
|
1
|
| 1 |
IC50 = 9149 nM
|
|
|
|
CP0847737
|
(4aS,11cS)-6a,10-Dihydroxy-4,4,11c-trimethyl-1,3,4,4a,5,6,6a,11c-octahydro-2H-benzo[b]naphtho[1,2-d]furan-9-one
Show/Hide
|
C19H24O4
|
1
|
| 1 |
IC50 = 9570 nM
|
|
|
|
CP0508771
|
(4aS,7R,12cS)-9-Bromo-10-methoxy-4,4,7,12c-tetramethyl-2,3,4,4a,5,6,7,12c-octahydro-1H-8-oxa-dibenzo[a,h]azulene
Show/Hide
|
C22H29BrO2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0524644
|
(4aS,7R,12cS)-4,4,7,12c-Tetramethyl-2,3,4,4a,5,6,7,12c-octahydro-1H-8-oxa-dibenzo[a,h]azulen-10-ol
Show/Hide
|
C21H28O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0921262
|
(4aS,7R,12cS)-9-Bromo-7a,11-dihydroxy-4,4,7,12c-tetramethyl-1,2,3,4,4a,5,6,7,7a,12c-decahydro-8-oxa-dibenzo[a,h]azulen-10-one
Show/Hide
|
C21H27BrO4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0003061
|
9-(1-anilinoethyl)-7-methyl-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one
Show/Hide
|
C21H24N4O2
|
2
|
| 1 |
IC50 > 10000 nM
|
|
|
| 2 |
IC50 = 10000 nM
|
|
|
|
CP0084873
|
8-(1-anilinoethyl)-6-methyl-2-morpholin-4-ylchromen-4-one
Show/Hide
|
C22H24N2O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0111428
|
2-[(1-methylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C17H19N5O2
|
2
|
| 1 |
IC50 > 10000 nM
|
|
|
| 2 |
IC50 = 10000 nM
|
|
|
|
CP0147436
|
2-[(1-benzylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C23H23N5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0169943
|
4-morpholin-4-yl-2-[(7-phenyl-1,3-benzoxazol-2-yl)methyl]-1H-pyrimidin-6-one
Show/Hide
|
C22H20N4O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0169944
|
4-morpholin-4-yl-2-[(4-phenyl-1,3-benzoxazol-2-yl)methyl]-1H-pyrimidin-6-one
Show/Hide
|
C22H20N4O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0169945
|
2-[(1-methyl-7-phenylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C23H23N5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0169946
|
2-[(6-bromo-1H-benzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C16H16BrN5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0169947
|
2-[(6-fluoro-1H-benzimidazol-2-yl)methyl]-3-methyl-6-morpholin-4-ylpyrimidin-4-one
Show/Hide
|
C17H18FN5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0186648
|
2-(4-morpholin-4-yl-6-oxo-1H-pyrimidin-2-yl)-N-phenylacetamide
Show/Hide
|
C16H18N4O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0188427
|
4-morpholin-4-yl-2-[(1-phenylbenzimidazol-2-yl)methyl]-1H-pyrimidin-6-one
Show/Hide
|
C22H21N5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0204632
|
2-[(5-fluoro-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C16H15FN4O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0204633
|
2-[(1-cyclohexylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C22H27N5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0210357
|
2-[(1-methyl-6-phenylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C23H23N5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0210358
|
2-[(1-methyl-5-phenylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C23H23N5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0238398
|
4-morpholin-4-yl-2-[(4-pyridin-4-yl-1,3-benzoxazol-2-yl)methyl]-1H-pyrimidin-6-one
Show/Hide
|
C21H19N5O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0248363
|
2-[(5-fluoro-4-phenyl-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C22H19FN4O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0248388
|
4-morpholin-4-yl-2-[(4-pyridin-2-yl-1,3-benzoxazol-2-yl)methyl]-1H-pyrimidin-6-one
Show/Hide
|
C21H19N5O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0248389
|
2-[(6-methoxy-1H-benzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C17H19N5O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0253245
|
4-morpholin-4-yl-2-[(4-phenyl-1H-benzimidazol-2-yl)methyl]-1H-pyrimidin-6-one
Show/Hide
|
C22H21N5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0261386
|
2-[(5-fluoro-1-methylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C17H18FN5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0262695
|
2-[(1-methyl-4-phenylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C23H23N5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0295019
|
2-(1,3-benzoxazol-2-ylmethyl)-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C16H16N4O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0295157
|
2-[(7-fluoro-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C16H15FN4O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0295159
|
2-[[5-fluoro-1-(2-methoxyethyl)benzimidazol-2-yl]methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C19H22FN5O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0298910
|
2-[(6-chloro-1H-benzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C16H16ClN5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0303999
|
2-[(7-methyl-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C17H18N4O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0322764
|
4-morpholin-4-yl-2-[(4-pyridin-3-yl-1,3-benzoxazol-2-yl)methyl]-1H-pyrimidin-6-one
Show/Hide
|
C21H19N5O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0322765
|
2-[(6-methyl-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C17H18N4O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0322766
|
2-[(6-fluoro-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C16H15FN4O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0322767
|
2-[(4-fluoro-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C16H15FN4O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0322768
|
2-[(1-cyclopropyl-5-fluorobenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C19H20FN5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0322769
|
2-[(6-fluoro-1H-benzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C16H16FN5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0341818
|
2-[(4-bromo-1,3-benzoxazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C16H15BrN4O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0341819
|
4-morpholin-4-yl-2-[[6-(trifluoromethyl)-1H-benzimidazol-2-yl]methyl]-1H-pyrimidin-6-one
Show/Hide
|
C17H16F3N5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0341820
|
2-[(6-methyl-1H-benzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C17H19N5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0341821
|
2-[(6-fluoro-1-methylbenzimidazol-2-yl)methyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C17H18FN5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0362464
|
2-(1H-benzimidazol-2-ylmethyl)-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C16H17N5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0439702
|
8-(4-fluoro-2-methylphenoxy)-2-morpholin-4-yl-1H-quinolin-4-one
Show/Hide
|
C20H19FN2O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0134136
|
BDBM50447097
Show/Hide
|
C20H24N4O3
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0147577
|
2-[2-(4-methoxy-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C19H22N4O4
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0176436
|
2-[2-(2,3-dihydroindol-1-yl)-2-oxoethyl]-3-methyl-6-morpholin-4-ylpyrimidin-4-one
Show/Hide
|
C19H22N4O3
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0180687
|
2-[2-(2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C18H20N4O3
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0308574
|
2-[2-(3-methyl-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C19H22N4O3
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0308577
|
2-[2-(5-chloro-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C18H19ClN4O3
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0379786
|
2-[2-(2,2-dimethyl-3H-indol-1-yl)-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C20H24N4O3
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0379787
|
2-[2-[4-[(4-methylpiperazin-1-yl)methyl]-2,3-dihydroindol-1-yl]-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C24H32N6O3
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0402567
|
2-[2-[4-(4-methylpiperazin-1-yl)-2,3-dihydroindol-1-yl]-2-oxoethyl]-4-morpholin-4-yl-1H-pyrimidin-6-one
Show/Hide
|
C23H30N6O3
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0698887
|
2-{2-[(2S)-2-Methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one
Show/Hide
|
C19H22N4O3
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0000805
|
3-amino-N-[(1S)-1-(8-chloro-1-oxo-2-phenylisoquinolin-3-yl)ethyl]isoquinoline-4-carboxamide
Show/Hide
|
C27H21ClN4O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0636743
|
(+/-)-5-(2-Amino-1H-1,3-benzodiazol-5-yl)-2-(1-cyclopropylethyl)-7-methyl-2,3-dihydro-1H-isoindol-1-one
Show/Hide
|
C21H22N4O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0864151
|
3-(4-Methoxyphenyl)-5-ethyl-1-morpholino-6-thioxo-5,6,8,9,10,10a-hexahydropyrido[3,2-e]pyrrolo[1,2-c]pyrimidine-2-carbonitrile
Show/Hide
|
C24H27N5O2S
|
1
|
| 1 |
IC50 = 12570 nM
|
|
|
|
CP0886055
|
3-(3,4-Dimethoxyphenyl)-5-ethyl-1-morpholino-6-thioxo-5,6,8,9,10,10a-hexahydropyrido[3,2-e]pyrrolo[1,2-c]pyrimidine-2-carbonitrile
Show/Hide
|
C25H29N5O3S
|
1
|
| 1 |
IC50 = 15560 nM
|
|
|
|
CP0869037
|
3-(3-Methoxyphenyl)-5-ethyl-1-morpholino-6-thioxo-5,6,8,9,10,10a-hexahydropyrido[3,2-e]pyrrolo[1,2-c]pyrimidine-2-carbonitrile
Show/Hide
|
C24H27N5O2S
|
1
|
| 1 |
IC50 = 18480 nM
|
|
|
|
CP0869039
|
3-(3-Hydroxyphenyl)-5-ethyl-1-morpholino-6-thioxo-5,6,8,9,10,10a-hexahydropyrido[3,2-e]pyrrolo[1,2-c]pyrimidine-2-carbonitrile
Show/Hide
|
C23H25N5O2S
|
1
|
| 1 |
IC50 = 23640 nM
|
|
|
|
CP0382537
|
8-ethyl-11-(3-hydroxy-4-methoxyphenyl)-13-morpholin-4-yl-7-sulfanylidene-6,8,10-triazatricyclo[7.4.0.02,6]trideca-1(9),10,12-triene-12-carbonitrile
Show/Hide
|
C24H27N5O3S
|
1
|
| 1 |
IC50 = 26870 nM
|
|
|
|
CP0865022
|
5-Ethyl-3-(3-methoxyphenyl)-1-morpholino-8,9,10,10a-tetrahydropyrimido[5,4-e]pyrrolo[1,2-c]pyrimidine-6(5H)-thione
Show/Hide
|
C22H27N5O2S
|
1
|
| 1 |
IC50 = 91560 nM
|
|
|
|
CP0002784
|
2-amino-N-[(8-chloro-1-oxo-2-phenylisoquinolin-3-yl)methyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Show/Hide
|
C23H17ClN6O2
|
1
|
| 1 |
IC50 > 7000 nM
|
|
|
|
CP0085320
|
2-[4-[2-(2-propan-2-yl-1,2,4-triazol-3-yl)-4,5-dihydro-[1]benzoxepino[5,4-d][1,3]thiazol-8-yl]pyrazol-1-yl]ethanol
Show/Hide
|
C21H22N6O2S
|
1
|
| 1 |
Ki = 0.55 nM
|
|
|
|
CP0064487
|
N-[6-[6-chloro-5-[(4-fluorophenyl)sulfonylamino]pyridin-3-yl]imidazo[1,2-b]pyridazin-2-yl]acetamide
Show/Hide
|
C19H14ClFN6O3S
|
1
|
| 1 |
Ki = 1.9 nM
|
|
|
|
CP0172054
|
4-[5-(3,6-dihydro-2H-pyran-4-yl)-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C20H21N7O2
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0009370
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C21H27N9O3S
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0191328
|
3-[[1-(4-methyl-1,3,5-triazin-2-yl)benzimidazol-2-yl]amino]phenol
Show/Hide
|
C17H14N6O
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0397436
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-morpholin-4-ylpyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C19H22N8O2
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0199338
|
N-[6-[6-chloro-5-[(4-fluorophenyl)sulfonylamino]pyridin-3-yl]-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C20H14ClFN4O3S2
|
1
|
| 1 |
Ki = 4.7 nM
|
|
|
|
CP0087633
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-[(3-methylsulfonylpyrrolidin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C21H26N8O3S
|
1
|
| 1 |
Ki = 5 nM
|
|
|
|
CP0192152
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-(1-methylpyrazol-4-yl)pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C19H19N9O
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0330594
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylphenyl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C23H23N7O3S
|
1
|
| 1 |
Ki = 7 nM
|
|
|
|
CP0087634
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-[(1-methylsulfonylpiperidin-4-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C22H28N8O3S
|
1
|
| 1 |
Ki = 8 nM
|
|
|
|
CP0191321
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-(6-methylpyridin-3-yl)pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C21H20N8O
|
1
|
| 1 |
Ki = 8 nM
|
|
|
|
CP0335114
|
4-[[5-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]methyl]-N,N-dimethylpiperazine-1-carboxamide
Show/Hide
|
C23H30N10O2
|
1
|
| 1 |
Ki = 8 nM
|
|
|
|
CP0174686
|
4-[[5-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]methyl]-N,N-dimethylpiperazine-1-sulfonamide
Show/Hide
|
C22H30N10O3S
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0191323
|
4-[5-(methoxymethyl)-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C17H19N7O2
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0192153
|
4-[5-methoxy-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C16H17N7O2
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0338291
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-[(4-methylsulfonylpiperidin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C22H28N8O3S
|
1
|
| 1 |
Ki = 9 nM
|
|
|
|
CP0282688
|
4-[5-benzyl-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C22H21N7O
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0188464
|
N-(6-methoxypyridin-3-yl)-3-(2-methyl-7H-purin-6-yl)pyridin-2-amine
Show/Hide
|
C17H15N7O
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0282689
|
N-[3-(2-methyl-7H-purin-6-yl)pyridin-2-yl]-1H-indazol-4-amine
Show/Hide
|
C18H14N8
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0284307
|
3-[[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)pyridin-2-yl]amino]phenol
Show/Hide
|
C15H14N6O
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0192151
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-(morpholin-4-ylmethyl)pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C20H24N8O2
|
1
|
| 1 |
Ki = 17 nM
|
|
|
|
CP0452207
|
methyl 4-[[5-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]methyl]piperazine-1-carboxylate
Show/Hide
|
C22H27N9O3
|
1
|
| 1 |
Ki = 18 nM
|
|
|
|
CP0391258
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-(4-methylpiperazin-1-yl)pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C20H25N9O
|
1
|
| 1 |
Ki = 21 nM
|
|
|
|
CP0292692
|
4-[5-bromo-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C15H14BrN7O
|
1
|
| 1 |
Ki = 22 nM
|
|
|
|
CP0302072
|
N-[3-(2-methyl-7H-purin-6-yl)pyridin-2-yl]-1H-indol-4-amine
Show/Hide
|
C19H15N7
|
1
|
| 1 |
Ki = 23 nM
|
|
|
|
CP0172047
|
[5-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]methanol
Show/Hide
|
C16H17N7O2
|
1
|
| 1 |
Ki = 24 nM
|
|
|
|
CP0349679
|
4-[2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C15H15N7O
|
1
|
| 1 |
Ki = 29 nM
|
|
|
|
CP0191320
|
4-[5-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C20H24N8O3S
|
1
|
| 1 |
Ki = 30 nM
|
|
|
|
CP0369237
|
4-[5-chloro-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C15H14ClN7O
|
1
|
| 1 |
Ki = 40 nM
|
|
|
|
CP0142948
|
N-[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)pyridin-2-yl]-1H-indol-4-amine
Show/Hide
|
C17H15N7
|
1
|
| 1 |
Ki = 45 nM
|
|
|
|
CP0397437
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-[(4-methylsulfonyl-1,4-diazepan-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C22H29N9O3S
|
1
|
| 1 |
Ki = 46 nM
|
|
|
|
CP0087590
|
3-[[3-(6-amino-2-methylpyrimidin-4-yl)pyridin-2-yl]amino]phenol
Show/Hide
|
C16H15N5O
|
1
|
| 1 |
Ki = 51 nM
|
|
|
|
CP0131195
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-methylpyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C16H17N7O
|
1
|
| 1 |
Ki = 54 nM
|
|
|
|
CP0139562
|
6-[3-[(6-methoxypyridin-3-yl)amino]pyrazin-2-yl]-2-methylpyrimidin-4-amine
Show/Hide
|
C15H15N7O
|
1
|
| 1 |
Ki = 58 nM
|
|
|
|
CP0076062
|
4-[4-[(6-methoxypyridin-3-yl)amino]pyrimidin-5-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C14H14N8O
|
1
|
| 1 |
Ki = 59 nM
|
|
|
|
CP0142914
|
2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol-1-yl)-6-methyl-1,3,5-triazin-2-ylamino)acetonitrile
Show/Hide
|
C19H16N8O
|
1
|
| 1 |
Ki = 69 nM
|
|
|
|
CP0339164
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-(piperidin-1-ylmethyl)pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C21H26N8O
|
1
|
| 1 |
Ki = 80 nM
|
|
|
|
CP0143583
|
N-[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)pyridin-2-yl]-1H-indazol-4-amine
Show/Hide
|
C16H14N8
|
1
|
| 1 |
Ki = 88 nM
|
|
|
|
CP0064828
|
4-[3-[(6-methoxypyridin-3-yl)amino]pyrazin-2-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C14H14N8O
|
1
|
| 1 |
Ki = 90 nM
|
|
|
|
CP0143584
|
N-[3-(6-amino-2-methylpyrimidin-4-yl)pyridin-2-yl]-1H-indazol-4-amine
Show/Hide
|
C17H15N7
|
1
|
| 1 |
Ki = 91 nM
|
|
|
|
CP0191322
|
4-[5-[(2-methoxyethylamino)methyl]-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C19H24N8O2
|
1
|
| 1 |
Ki = 99 nM
|
|
|
|
CP0087587
|
[(3R)-1-[[5-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]methyl]pyrrolidin-3-yl]methanol
Show/Hide
|
C21H26N8O2
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0087588
|
1-[[5-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]methyl]piperidin-4-ol
Show/Hide
|
C21H26N8O2
|
1
|
| 1 |
Ki = 110 nM
|
|
|
|
CP0050326
|
2-(4-(2-(3-hydroxyphenylamino)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazin-2-ylamino)acetonitrile
Show/Hide
|
C18H14N8O
|
1
|
| 1 |
Ki = 120 nM
|
|
|
|
CP0172042
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-[(4-methylpiperazin-1-yl)methyl]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C21H27N9O
|
1
|
| 1 |
Ki = 130 nM
|
|
|
|
CP0343352
|
4-[5-(azetidin-1-ylmethyl)-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C19H22N8O
|
1
|
| 1 |
Ki = 140 nM
|
|
|
|
CP0192150
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-(piperazin-1-ylmethyl)pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
|
C20H25N9O
|
1
|
| 1 |
Ki = 200 nM
|
|
|
|
CP0313976
|
4-[2-[(6-methoxypyridin-3-yl)amino]-5-(pyrrolidin-1-ylmethyl)pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
Show/Hide
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C20H24N8O
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1
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| 1 |
Ki = 210 nM
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CP0346280
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N-[3-(6-amino-5-fluoro-2-methylpyrimidin-4-yl)pyridin-2-yl]-1H-indazol-4-amine
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C17H14FN7
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1
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| 1 |
Ki = 330 nM
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CP0330553
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4-[2-[(6-methoxypyridin-3-yl)amino]phenyl]-6-methyl-1,3,5-triazin-2-amine
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C16H16N6O
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1
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| 1 |
Ki = 380 nM
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CP0191327
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N-[3-(6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)pyridin-2-yl]-1H-indazol-4-amine
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C18H14N8
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1
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| 1 |
Ki = 450 nM
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CP0391261
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4-[3-[(6-methoxypyridin-3-yl)amino]pyridin-2-yl]-6-methyl-1,3,5-triazin-2-amine
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C15H15N7O
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1
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| 1 |
Ki = 480 nM
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CP0328888
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4-[3-[(6-methoxypyridin-3-yl)amino]pyridin-4-yl]-6-methyl-1,3,5-triazin-2-amine
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C15H15N7O
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1
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| 1 |
Ki = 690 nM
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CP0087589
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N-[3-(7H-purin-6-yl)pyridin-2-yl]-1H-indazol-4-amine
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C17H12N8
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1
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| 1 |
Ki = 750 nM
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CP0229154
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N-(6-methoxypyridin-3-yl)-3-(7H-purin-6-yl)pyridin-2-amine
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C16H13N7O
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1
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| 1 |
Ki = 1100 nM
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CP0335115
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3-[[3-(2-amino-6-methylpyrimidin-4-yl)pyridin-2-yl]amino]phenol
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C16H15N5O
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1
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| 1 |
Ki = 2600 nM
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CP0174742
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N-[3-[6-amino-2-(trifluoromethyl)pyrimidin-4-yl]pyridin-2-yl]-1H-indazol-4-amine
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C17H12F3N7
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1
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| 1 |
Ki = 3600 nM
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CP0356738
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4-[2-[(6-methoxypyridin-3-yl)-methylamino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
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C16H17N7O
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1
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| 1 |
Ki > 10000 nM
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CP0356739
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4-[2-(1H-indol-4-yloxy)pyridin-3-yl]-6-methylpyrimidin-2-amine
Show/Hide
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C18H15N5O
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1
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| 1 |
Ki > 10000 nM
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