Brief Information of the Cell Line and Protein
Cell Line ID: CL000011 , CHO
Synonyms
Chinese Hamster Ovary
CHO-ori
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0213
Protein ID: PT01307 , 5-hydroxytryptamine receptor 4
Gene Name HTR4
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID Q13639
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000011  Protein ID: PT01307
 
Compound ID Compound Name Compound Formula
CP0545822
N-[[1-(oxan-4-ylmethyl)piperidin-4-yl]methyl]-2-propan-2-ylpyrazolo[1,5-a]pyridine-7-carboxamide
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C23H34N4O2
 1
1
EC50 = 0.1 nM
   TI
   LI
   LO
   TS
CP0409231
N-[[1-(3-methoxypropyl)piperidin-4-yl]methyl]-2-propan-2-ylpyrazolo[1,5-a]pyridine-7-carboxamide
   Show/Hide
C21H32N4O2
 1
1
EC50 = 0.3 nM
   TI
   LI
   LO
   TS
CP0538685
N-[[1-[(1-hydroxycyclohexyl)methyl]piperidin-4-yl]methyl]-2-propan-2-ylimidazo[1,2-a]pyridine-8-carboxamide
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C24H36N4O2
 1
1
EC50 = 0.3 nM
   TI
   LI
   LO
   TS
CP0549075
N-[[1-[(4-hydroxyoxan-4-yl)methyl]piperidin-4-yl]methyl]-2-propan-2-ylimidazo[1,2-a]pyridine-8-carboxamide
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C23H34N4O3
 1
1
EC50 = 0.4 nM
   TI
   LI
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   TS
CP0204174
N-[[1-[(4-hydroxyoxan-4-yl)methyl]piperidin-4-yl]methyl]-2-oxo-3-propan-2-ylbenzimidazole-1-carboxamide
   Show/Hide
C23H34N4O4
 1
1
EC50 = 0.5 nM
   TI
   LI
   LO
   TS
CP0414039
N-[[1-(oxan-4-ylmethyl)piperidin-4-yl]methyl]-2-propan-2-ylimidazo[1,2-a]pyridine-8-carboxamide
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C23H34N4O2
 1
1
EC50 = 0.6 nM
   TI
   LI
   LO
   TS
CP0462167
methyl 4-[[4-[[(2-propan-2-ylimidazo[1,2-a]pyridine-8-carbonyl)amino]methyl]piperidin-1-yl]methyl]piperidine-1-carboxylate
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C25H37N5O3
 1
1
EC50 = 0.6 nM
   TI
   LI
   LO
   TS
CP0538686
N-[[1-(2-hydroxy-2-methylpropyl)piperidin-4-yl]methyl]-2-propan-2-ylimidazo[1,2-a]pyridine-8-carboxamide
   Show/Hide
C21H32N4O2
 1
1
EC50 = 0.7 nM
   TI
   LI
   LO
   TS
CP0148502
4-[[4-[[4-[(3R)-oxolan-3-yl]oxy-1,2-benzoxazol-3-yl]oxymethyl]piperidin-1-yl]methyl]oxan-4-ol
   Show/Hide
C23H32N2O6
 3
1
EC50 = 1.3 nM
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2
EC50 = 1.5 nM
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3
Ki = 0.32 nM
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CP0043344
methyl 4-[[4-[[(2-propan-2-yl-1H-benzimidazole-4-carbonyl)amino]methyl]piperidin-1-yl]methyl]piperidine-1-carboxylate
   Show/Hide
C25H37N5O3
 1
1
EC50 = 1.5 nM
   TI
   LI
   LO
   TS
CP0409229
N-[[1-(3-methoxypropyl)piperidin-4-yl]methyl]-2-propan-2-ylimidazo[1,2-a]pyridine-8-carboxamide
   Show/Hide
C21H32N4O2
 1
1
EC50 = 1.5 nM
   TI
   LI
   LO
   TS
CP0097781
CAS_183782
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C19H29ClN2O2
 1
1
EC50 = 2 nM
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   LI
   LO
   TS
CP0290551
2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoate
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C15H21ClN2O3
 3
1
EC50 = 2.5 nM
   TI
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2
Ki = 3.5 nM
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3
Ki = 5.7 nM
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CP0540782
3-propan-2-yl-N-(1-propan-2-ylpiperidin-4-yl)imidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C19H28N4O
 1
1
EC50 = 3.4 nM
   TI
   LI
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   TS
CP0429690
N-[1-(2-fluoroethyl)piperidin-4-yl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
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C18H25FN4O
 1
1
EC50 = 3.9 nM
   TI
   LI
   LO
   TS
CP0429686
N-[[1-(3-methoxypropyl)piperidin-4-yl]methyl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C21H32N4O2
 1
1
EC50 = 4.8 nM
   TI
   LI
   LO
   TS
CP0409232
methyl 4-[[4-[[(1-propan-2-ylimidazo[1,5-a]pyridine-3-carbonyl)amino]methyl]piperidin-1-yl]methyl]piperidine-1-carboxylate
   Show/Hide
C25H37N5O3
 1
1
EC50 = 4.9 nM
   TI
   LI
   LO
   TS
CP0106868
4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxylic acid [1-(3-methoxy-propyl)-piperidin-4-yl]-amide
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C18H26ClN3O3
 1
1
EC50 = 5.2 nM
   TI
   LI
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   TS
CP0388931
N-[[(1R,5S)-3-(3-hydroxy-2,2-dimethylpropyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C22H32N4O2
 1
1
EC50 = 5.7 nM
   TI
   LI
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   TS
CP0462169
2-[1-(3-methoxypropyl)piperidin-4-yl]-5-(2-propan-2-ylpyrazolo[1,5-a]pyridin-7-yl)-1,3,4-oxadiazole
   Show/Hide
C21H29N5O2
 2
1
EC50 = 6 nM
   TI
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2
EC50 = 62 nM
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   TS
CP0532800
2-[1-(oxan-4-ylmethyl)piperidin-4-yl]-5-(2-propan-2-ylpyrazolo[1,5-a]pyridin-7-yl)-1,3,4-oxadiazole
   Show/Hide
C23H31N5O2
 2
1
EC50 = 6 nM
   TI
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2
EC50 = 21 nM
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   LI
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   TS
CP0390034
N-[[3-(3-methoxypropyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-2-propan-2-ylpyrazolo[1,5-a]pyridine-7-carboxamide
   Show/Hide
C21H30N4O2
 1
1
EC50 = 7.3 nM
   TI
   LI
   LO
   TS
CP0409234
methyl 4-[[6-[[(2-propan-2-ylpyrazolo[1,5-a]pyridine-7-carbonyl)amino]methyl]-3-azabicyclo[3.1.0]hexan-3-yl]methyl]piperidine-1-carboxylate
   Show/Hide
C25H35N5O3
 1
1
EC50 = 8.4 nM
   TI
   LI
   LO
   TS
CP0540512
methyl 4-[4-[[(2-propan-2-ylimidazo[1,2-a]pyridine-8-carbonyl)amino]methyl]piperidin-1-yl]piperidine-1-carboxylate
   Show/Hide
C24H35N5O3
 1
1
EC50 = 8.4 nM
   TI
   LI
   LO
   TS
CP0435278
methyl 4-[[(1S,5R)-6-[[(3-propan-2-ylimidazo[1,5-a]pyridine-1-carbonyl)amino]methyl]-3-azabicyclo[3.1.0]hexan-3-yl]methyl]piperidine-1-carboxylate
   Show/Hide
C25H35N5O3
 1
1
EC50 = 8.7 nM
   TI
   LI
   LO
   TS
CP0564792
N-[[3-(oxan-4-ylmethyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-2-propan-2-ylpyrazolo[1,5-a]pyridine-7-carboxamide
   Show/Hide
C23H32N4O2
 1
1
EC50 = 8.7 nM
   TI
   LI
   LO
   TS
CP0390001
N-[[1-(oxan-4-ylmethyl)piperidin-4-yl]methyl]-1-propan-2-ylimidazo[1,5-a]pyridine-3-carboxamide
   Show/Hide
C23H34N4O2
 1
1
EC50 = 8.8 nM
   TI
   LI
   LO
   TS
CP0415573
2-propan-2-yl-N-[(1-propan-2-ylpiperidin-4-yl)methyl]imidazo[1,2-a]pyridine-8-carboxamide
   Show/Hide
C20H30N4O
 1
1
EC50 = 9 nM
   TI
   LI
   LO
   TS
CP0380218
methyl 4-[(1R,5S)-6-[[(3-propan-2-ylimidazo[1,5-a]pyridine-1-carbonyl)amino]methyl]-3-azabicyclo[3.1.0]hexan-3-yl]piperidine-1-carboxylate
   Show/Hide
C24H33N5O3
 1
1
EC50 = 9.7 nM
   TI
   LI
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   TS
CP0380209
N-[(1-cyclobutylpiperidin-4-yl)methyl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C21H30N4O
 1
1
EC50 = 9.8 nM
   TI
   LI
   LO
   TS
CP0380210
N-[[1-(oxan-4-ylmethyl)piperidin-4-yl]methyl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C23H34N4O2
 1
1
EC50 = 10 nM
   TI
   LI
   LO
   TS
CP0462168
N-[[3-(oxan-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-1-propan-2-ylimidazo[1,5-a]pyridine-3-carboxamide
   Show/Hide
C22H30N4O2
 1
1
EC50 = 10.4 nM
   TI
   LI
   LO
   TS
CP0429634
N-[[1-(oxan-4-yl)piperidin-4-yl]methyl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C22H32N4O2
 1
1
EC50 = 11 nM
   TI
   LI
   LO
   TS
CP0395412
N-[[(1S,5R)-3-(cyclobutylmethyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C22H30N4O
 1
1
EC50 = 13.2 nM
   TI
   LI
   LO
   TS
CP0546973
N-[[3-(3-methoxypropyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-1-propan-2-ylimidazo[1,5-a]pyridine-3-carboxamide
   Show/Hide
C21H30N4O2
 1
1
EC50 = 13.6 nM
   TI
   LI
   LO
   TS
CP0545823
N-[[3-(3-methoxypropyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-2-propan-2-ylimidazo[1,2-a]pyridine-8-carboxamide
   Show/Hide
C21H30N4O2
 1
1
EC50 = 13.8 nM
   TI
   LI
   LO
   TS
CP0385052
N-[1-(cyclobutylmethyl)piperidin-4-yl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C21H30N4O
 1
1
EC50 = 15.5 nM
   TI
   LI
   LO
   TS
CP0414038
N-[[3-(2-hydroxy-2-methylpropyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-2-propan-2-ylimidazo[1,2-a]pyridine-8-carboxamide
   Show/Hide
C21H30N4O2
 1
1
EC50 = 17 nM
   TI
   LI
   LO
   TS
CP0406997
N-[[(1S,5R)-3-cyclobutyl-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C21H28N4O
 1
1
EC50 = 18 nM
   TI
   LI
   LO
   TS
CP0429687
N-[[(1S,5R)-3-(2-fluoro-2-methylpropyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C21H29FN4O
 1
1
EC50 = 18 nM
   TI
   LI
   LO
   TS
CP0538418
3-propan-2-yl-N-[[(1S,5R)-3-propan-2-yl-3-azabicyclo[3.1.0]hexan-6-yl]methyl]imidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C20H28N4O
 1
1
EC50 = 18.3 nM
   TI
   LI
   LO
   TS
CP0380293
N-[[(1R,5S)-3-(3-methoxy-2,2-dimethylpropyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C23H34N4O2
 1
1
EC50 = 19.8 nM
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   TS
CP0429688
N-[[(1S,5R)-3-(oxan-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C22H30N4O2
 1
1
EC50 = 20.7 nM
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CP0120561
N-[[(1R,5S)-3-(3-methoxypropyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C21H30N4O2
 1
1
EC50 = 22 nM
   TI
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CP0462777
N-[1-(oxolan-3-ylmethyl)piperidin-4-yl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C21H30N4O2
 1
1
EC50 = 25 nM
   TI
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CP0456851
N-[[(1S,5R)-3-(oxan-4-ylmethyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C23H32N4O2
 1
1
EC50 = 31 nM
   TI
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   TS
CP0385050
N-[[(1S,5R)-3-(2-hydroxy-2-methylpropyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C21H30N4O2
 1
1
EC50 = 34 nM
   TI
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CP0414036
2-propan-2-yl-N-[(3-propan-2-yl-3-azabicyclo[3.1.0]hexan-6-yl)methyl]imidazo[1,2-a]pyridine-8-carboxamide
   Show/Hide
C20H28N4O
 1
1
EC50 = 34.2 nM
   TI
   LI
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CP0542700
N-[[3-(oxan-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-2-propan-2-ylimidazo[1,2-a]pyridine-8-carboxamide
   Show/Hide
C22H30N4O2
 1
1
EC50 = 36 nM
   TI
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CP0429689
N-[8-(2-hydroxy-2-methylpropyl)-8-azabicyclo[3.2.1]octan-3-yl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C22H32N4O2
 1
1
EC50 = 39 nM
   TI
   LI
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CP0385053
N-[1-(2-hydroxy-2-methylpropyl)piperidin-4-yl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C20H30N4O2
 1
1
EC50 = 40 nM
   TI
   LI
   LO
   TS
CP0429649
N-[1-(3-methoxypropyl)piperidin-4-yl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C20H30N4O2
 1
1
EC50 = 40 nM
   TI
   LI
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   TS
CP0542703
N-[[1-(oxan-4-yl)piperidin-4-yl]methyl]-1-propan-2-ylimidazo[1,5-a]pyridine-3-carboxamide
   Show/Hide
C22H32N4O2
 1
1
EC50 = 42 nM
   TI
   LI
   LO
   TS
CP0385049
N-[1-(3-methoxy-2,2-dimethylpropyl)piperidin-4-yl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C22H34N4O2
 1
1
EC50 = 47 nM
   TI
   LI
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   TS
CP0545825
1-propan-2-yl-N-[(1-propan-2-ylpiperidin-4-yl)methyl]imidazo[1,5-a]pyridine-3-carboxamide
   Show/Hide
C20H30N4O
 1
1
EC50 = 48 nM
   TI
   LI
   LO
   TS
CP0380219
N-[1-(oxan-4-yl)piperidin-4-yl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C21H30N4O2
 1
1
EC50 = 49 nM
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CP0486594
N-[1-(cyclopropylmethyl)piperidin-4-yl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C20H28N4O
 1
1
EC50 = 49 nM
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CP0575191
N-(1-ethylpiperidin-4-yl)-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C18H26N4O
 1
1
EC50 = 50 nM
   TI
   LI
   LO
   TS
CP0456854
N-[[4-methyl-1-(oxan-4-ylmethyl)piperidin-4-yl]methyl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C24H36N4O2
 1
1
EC50 = 53 nM
   TI
   LI
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   TS
CP0469612
2-(1-propan-2-ylpiperidin-4-yl)-5-(2-propan-2-ylpyrazolo[1,5-a]pyridin-7-yl)-1,3,4-oxadiazole
   Show/Hide
C20H27N5O
 1
1
EC50 = 54 nM
   TI
   LI
   LO
   TS
CP0385054
N-[[4-hydroxy-1-(oxan-4-ylmethyl)piperidin-4-yl]methyl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C23H34N4O3
 1
1
EC50 = 56.7 nM
   TI
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CP0240582
Prx-03140
   Show/Hide
C19H27N3O3S
 1
1
EC50 = 58 nM
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CP0538687
N-[[1-(3-methoxypropyl)piperidin-4-yl]methyl]-1-propan-2-ylimidazo[1,5-a]pyridine-3-carboxamide
   Show/Hide
C21H32N4O2
 1
1
EC50 = 65 nM
   TI
   LI
   LO
   TS
CP0456855
N-[[4-hydroxy-1-(2-hydroxy-2-methylpropyl)piperidin-4-yl]methyl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C21H32N4O3
 1
1
EC50 = 72.3 nM
   TI
   LI
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   TS
CP0410418
N-[[1-(oxan-4-ylmethyl)piperidin-4-yl]methyl]-2-propan-2-yl-[1,2,4]triazolo[1,5-a]pyridine-8-carboxamide
   Show/Hide
C22H33N5O2
 1
1
EC50 = 79 nM
   TI
   LI
   LO
   TS
CP0380212
N-[8-[(4-hydroxyoxan-4-yl)methyl]-8-azabicyclo[3.2.1]octan-3-yl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C24H34N4O3
 1
1
EC50 = 88 nM
   TI
   LI
   LO
   TS
CP0549058
2-propan-2-yl-N-[(1-propan-2-ylpiperidin-4-yl)methyl]pyrazolo[1,5-a]pyridine-7-carboxamide
   Show/Hide
C20H30N4O
 1
1
EC50 = 98 nM
   TI
   LI
   LO
   TS
CP0526732
N-[[3-(oxan-4-ylmethyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-2-propan-2-ylimidazo[1,2-a]pyridine-8-carboxamide
   Show/Hide
C23H32N4O2
 1
1
EC50 = 114 nM
   TI
   LI
   LO
   TS
CP0407003
N-[1-(2-fluoro-2-methylpropyl)piperidin-4-yl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C20H29FN4O
 1
1
EC50 = 132 nM
   TI
   LI
   LO
   TS
CP0407004
N-[1-[(4-hydroxyoxan-4-yl)methyl]piperidin-4-yl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
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C22H32N4O3
 1
1
EC50 = 144 nM
   TI
   LI
   LO
   TS
CP0486595
N-[1-(2-methoxyethyl)piperidin-4-yl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
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C19H28N4O2
 1
1
EC50 = 144 nM
   TI
   LI
   LO
   TS
CP0429648
N-[1-[(4-fluorooxan-4-yl)methyl]piperidin-4-yl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
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C22H31FN4O2
 1
1
EC50 = 196 nM
   TI
   LI
   LO
   TS
CP0390035
3-chloro-N-[[3-(oxan-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-2-propan-2-ylpyrazolo[1,5-a]pyridine-7-carboxamide
   Show/Hide
C22H29ClN4O2
 1
1
EC50 = 291 nM
   TI
   LI
   LO
   TS
CP0385055
N-[[4-hydroxy-1-(3-methoxypropyl)piperidin-4-yl]methyl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
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C21H32N4O3
 1
1
EC50 = 315.7 nM
   TI
   LI
   LO
   TS
CP0406492
N-[[4-(oxan-4-yl)morpholin-2-yl]methyl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
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C21H30N4O3
 1
1
EC50 = 467 nM
   TI
   LI
   LO
   TS
CP0525751
2-[1-(oxan-4-ylmethyl)piperidin-4-yl]-5-(1-propan-2-ylimidazo[1,5-a]pyridin-3-yl)-1,3,4-oxadiazole
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C23H31N5O2
 1
1
EC50 = 484 nM
   TI
   LI
   LO
   TS
CP0429632
2-(3-propan-2-ylimidazo[1,5-a]pyridin-1-yl)-5-(1-propan-2-ylpiperidin-4-yl)-1,3,4-oxadiazole
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C20H27N5O
 1
1
EC50 = 500 nM
   TI
   LI
   LO
   TS
CP0417322
2-[1-(cyclobutylmethyl)piperidin-4-yl]-5-(3-propan-2-ylimidazo[1,5-a]pyridin-1-yl)-1,3,4-oxadiazole
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C22H29N5O
 1
1
EC50 = 520 nM
   TI
   LI
   LO
   TS
CP0466629
2-[1-(oxan-4-ylmethyl)piperidin-4-yl]-5-(2-propan-2-ylimidazo[1,2-a]pyridin-8-yl)-1,3,4-oxadiazole
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C23H31N5O2
 1
1
EC50 = 598 nM
   TI
   LI
   LO
   TS
CP0395413
N-[[4-fluoro-1-(3-methoxypropyl)piperidin-4-yl]methyl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
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C21H31FN4O2
 1
1
EC50 = 633 nM
   TI
   LI
   LO
   TS
CP0410447
2-[1-(3-methoxypropyl)piperidin-4-yl]-5-(2-propan-2-ylimidazo[1,2-a]pyridin-8-yl)-1,3,4-oxadiazole
   Show/Hide
C21H29N5O2
 1
1
EC50 = 687 nM
   TI
   LI
   LO
   TS
CP0429631
2-[1-(3-methoxypropyl)piperidin-4-yl]-5-(3-propan-2-ylimidazo[1,5-a]pyridin-1-yl)-1,3,4-oxadiazole
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C21H29N5O2
 1
1
EC50 = 736 nM
   TI
   LI
   LO
   TS
CP0390899
2-(1-propan-2-ylimidazo[1,5-a]pyridin-3-yl)-5-(1-propan-2-ylpiperidin-4-yl)-1,3,4-oxadiazole
   Show/Hide
C20H27N5O
 1
1
EC50 = 758 nM
   TI
   LI
   LO
   TS
CP0542702
2-[1-(3-methoxypropyl)piperidin-4-yl]-5-(1-propan-2-ylimidazo[1,5-a]pyridin-3-yl)-1,3,4-oxadiazole
   Show/Hide
C21H29N5O2
 1
1
EC50 = 796 nM
   TI
   LI
   LO
   TS
CP0429633
2-(1-cyclobutylpiperidin-4-yl)-5-(3-propan-2-ylimidazo[1,5-a]pyridin-1-yl)-1,3,4-oxadiazole
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C21H27N5O
 1
1
EC50 = 840 nM
   TI
   LI
   LO
   TS
CP0417320
2-[1-(cyclopropylmethyl)piperidin-4-yl]-5-(3-propan-2-ylimidazo[1,5-a]pyridin-1-yl)-1,3,4-oxadiazole
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C21H27N5O
 1
1
EC50 = 857 nM
   TI
   LI
   LO
   TS
CP0385051
N-[3-(oxan-4-ylmethyl)-3-azabicyclo[3.1.0]hexan-6-yl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
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C22H30N4O2
 1
1
EC50 = 1061 nM
   TI
   LI
   LO
   TS
CP0545899
3-chloro-N-[[1-(3-methoxypropyl)piperidin-4-yl]methyl]-2-propan-2-ylimidazo[1,2-a]pyridine-8-carboxamide
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C21H31ClN4O2
 1
1
EC50 = 1090 nM
   TI
   LI
   LO
   TS
CP0564099
N-[[4-fluoro-1-(oxan-4-ylmethyl)piperidin-4-yl]methyl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
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C23H33FN4O2
 1
1
EC50 = 1358 nM
   TI
   LI
   LO
   TS
CP0467812
N-[[1-(3-methoxypropyl)piperidin-4-yl]methyl]-2-propan-2-yl-[1,2,4]triazolo[1,5-a]pyridine-8-carboxamide
   Show/Hide
C20H31N5O2
 1
1
EC50 = 1941 nM
   TI
   LI
   LO
   TS
CP0538688
N-[[1-(3-methoxypropyl)piperidin-4-yl]methyl]-2-propan-2-yl-[1,2,4]triazolo[1,5-a]pyridine-5-carboxamide
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C20H31N5O2
 1
1
EC50 = 1941 nM
   TI
   LI
   LO
   TS
CP0462774
N-[(4-cyclobutylmorpholin-2-yl)methyl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
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C20H28N4O2
 1
1
EC50 = 2247 nM
   TI
   LI
   LO
   TS
CP0395410
N-[3-(3-methoxypropyl)-3-azabicyclo[3.1.0]hexan-6-yl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C20H28N4O2
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0406999
N-[3-(2-hydroxy-2-methylpropyl)-3-azabicyclo[3.1.0]hexan-6-yl]-3-propan-2-ylimidazo[1,5-a]pyridine-1-carboxamide
   Show/Hide
C20H28N4O2
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0390002
3-chloro-N-[[1-(3-methoxypropyl)piperidin-4-yl]methyl]-2-propan-2-ylpyrazolo[1,5-a]pyridine-7-carboxamide
   Show/Hide
C21H31ClN4O2
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0545909
3-chloro-N-[[3-(3-methoxypropyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-2-propan-2-ylimidazo[1,2-a]pyridine-8-carboxamide
   Show/Hide
C21H29ClN4O2
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0549489
N-[[1-(oxan-4-ylmethyl)piperidin-4-yl]methyl]-2-propan-2-yl-[1,2,4]triazolo[1,5-a]pyridine-5-carboxamide
   Show/Hide
C22H33N5O2
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0559962
2-propan-2-yl-N-[(1-propan-2-ylpiperidin-4-yl)methyl]-[1,2,4]triazolo[1,5-a]pyridine-5-carboxamide
   Show/Hide
C19H29N5O
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0559963
3-chloro-N-[[3-(3-methoxypropyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-2-propan-2-ylpyrazolo[1,5-a]pyridine-7-carboxamide
   Show/Hide
C21H29ClN4O2
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0123097
3H-GR113808
   Show/Hide
C19H27N3O4S
 3
1
IC50 = 0.21 nM
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   LI
   LO
   TS
2
Ki = 0.5 nM
   TI
   LI
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   TS
3
Ki = 0.7 nM
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   TS
CP0046314
4-[2-[4-[(2-methylpyrrolo[3,4-c]quinolin-4-yl)oxymethyl]piperidin-1-yl]ethyl]benzoic acid
   Show/Hide
C27H29N3O3
 1
1
IC50 = 2.8 nM
   TI
   LI
   LO
   TS
CP0046312
4-[2-[4-[[(1-propan-2-ylindazole-3-carbonyl)amino]methyl]piperidin-1-yl]ethyl]benzoic acid
   Show/Hide
C26H32N4O3
 1
1
IC50 = 9.8 nM
   TI
   LI
   LO
   TS
CP0170456
3-chloro-1-(4-fluoro benzenesulfonyl)-5-(4-methylpiperazin-1-yl-methyl)-1H-indole
   Show/Hide
C20H21ClFN3O2S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0212171
1-(2-Bromo benzenesulfonyl)-5-(4-ethylpiperazin-1-yl-methyl)-1H-indole
   Show/Hide
C21H24BrN3O2S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0376851
6-fluoro-N-[[1-[(4-hydroxyoxan-4-yl)methyl]piperidin-4-yl]methyl]-2-oxo-3-propan-2-ylbenzimidazole-1-carboxamide
   Show/Hide
C23H33FN4O4
 1
1
Ki = 4.9 nM
   TI
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   LO
   TS
CP0395625
6-fluoro-N-[[1-[(4-hydroxyoxan-4-yl)methyl]piperidin-4-yl]methyl]-3,3-dimethyl-2-oxoindole-1-carboxamide
   Show/Hide
C23H32FN3O4
 1
1
Ki = 6.3 nM
   TI
   LI
   LO
   TS
CP0913714
2-(4-{4-[N-(3-{4-[3-(N-{3-[(1-{2-[(4-amino-5-chloro-2-methoxyphenyl)carbonyloxy]ethyl}piperidin-4-yl)carbamoyl]propyl}-2,2-dimethylpropanamido)propyl]phenyl}propyl)-2,2-dimethylpropanamido]butanamido}piperidin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate
   Show/Hide
C60H88Cl2N8O12
 1
1
Ki = 10 nM
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   TS