Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-[[4-[[4-[(3R)-oxolan-3-yl]oxy-1,2-benzoxazol-3-yl]oxymethyl]piperidin-1-yl]methyl]oxan-4-ol
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 PubChem ID
CID: 53354764
SID: 125239007
Canonical SMILES
OC1(CN2CCC(COc3noc4cccc(O[C@@H]5CCOC5)c34)CC2)CCOCC1
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Compound Formula C23H32N2O6
Compound Structure
Protein Name
 Protein Info 
5-hydroxytryptamine receptor 4
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Uniprot ID
Q13639
Gene Name
HTR4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  3
1
EC50 = 1.3 nM
   TI
   LI
   LO
   TS
2
EC50 = 1.5 nM
   TI
   LI
   LO
   TS
3
Ki = 0.32 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  7
1
EC50 = 0.2 nM
   TI
   LI
   LO
   TS
2
EC50 = 0.26 nM
   TI
   LI
   LO
   TS
3
EC50 = 0.36 nM
   TI
   LI
   LO
   TS
4
EC50 = 0.47 nM
   TI
   LI
   LO
   TS
5
Ki = 0.15 nM
   TI
   LI
   LO
   TS
6
Ki = 0.36 nM
   TI
   LI
   LO
   TS
7
Ki = 0.46 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 0.26 nM