| Compound ID |
Compound Name |
Compound Formula |
|
CP0315991
|
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(3-ethyl tetrahydro-2H-pyran-4-ylamino)-1-isopropylcyclopentanecarboxamide
Show/Hide
|
C25H34F6N2O2
|
1
|
| 1 |
IC50 = 0.3 nM
|
|
|
|
CP0053417
|
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(3-(trifluoromethyl)tetrahydro-2H-pyran-4-ylamino)cyclopentanecarboxamide
Show/Hide
|
C24H29F9N2O2
|
2
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
IC50 = 5.5 nM
|
|
|
|
CP0425145
|
(1S,3R)-1-cyclopropyl-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
Show/Hide
|
C31H34F4N2O
|
1
|
| 1 |
IC50 = 1.9 nM
|
|
|
|
CP0390911
|
(2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-(cyclopropylmethyl)-4-[(1R,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]butanamide
Show/Hide
|
C31H34F6N2O
|
2
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
IC50 = 25 nM
|
|
|
|
CP0444505
|
(1S,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-(propan-2-yl)cyclopentane-1-carboxamide
Show/Hide
|
C31H36F4N2O
|
1
|
| 1 |
IC50 = 3.1 nM
|
|
|
|
CP0437369
|
1-ethyl-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
Show/Hide
|
C30H34F4N2O
|
1
|
| 1 |
IC50 = 3.3 nM
|
|
|
|
CP0900717
|
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(oxetan-3-ylamino)cyclopentanecarboxamide trifluoroacetate salt
Show/Hide
|
C23H27F9N2O4
|
1
|
| 1 |
IC50 = 3.3 nM
|
|
|
|
CP0525772
|
(1R,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-[(methylsulfanyl)methyl]cyclopentane-1-carboxamide
Show/Hide
|
C30H34F4N2OS
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0428650
|
(1R,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-1-(2-methylpropyl)-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
Show/Hide
|
C32H38F4N2O
|
1
|
| 1 |
IC50 = 3.9 nM
|
|
|
|
CP0373631
|
(1S,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-1-methyl-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
Show/Hide
|
C29H32F4N2O
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0041927
|
(2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-cyclopropyl-4-[(1R,3R')-3'methyl-1'H-spiro[indene-1,4'-piperidin]-1'yl]butanamide
Show/Hide
|
C30H32F6N2O
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 14 nM
|
|
|
|
CP0165577
|
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(tetrahydro-2H-pyran-4-ylamino)cyclopentanecarboxamide
Show/Hide
|
C23H30F6N2O2
|
1
|
| 1 |
IC50 = 4.6 nM
|
|
|
|
CP0522581
|
N-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-3-[(1S,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-propylcyclopentane-1-carboxamide
Show/Hide
|
C31H36F4N2O
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0522786
|
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(3-propyltetrahydro-2H-pyran-4-ylamino)cyclopentanecarboxamide
Show/Hide
|
C26H36F6N2O2
|
2
|
| 1 |
IC50 = 5.1 nM
|
|
|
| 2 |
IC50 = 7.8 nM
|
|
|
|
CP0425146
|
1-(cyclopropylmethyl)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
Show/Hide
|
C32H36F4N2O
|
1
|
| 1 |
IC50 = 5.5 nM
|
|
|
|
CP0871032
|
CENICRIVIROC MESYLATE
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|
C42H56N4O7S2
|
1
|
| 1 |
IC50 = 5.9 nM
|
|
|
|
CP0535185
|
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1-cyclopropyl-3-[(1S,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
Show/Hide
|
C32H34F6N2O
|
1
|
| 1 |
IC50 = 6.5 nM
|
|
|
|
CP0053416
|
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(3,5-dimethyltetrahydro-2H-pyran-4-ylamino)-1-isopropylcyclopentanecarboxamide
Show/Hide
|
C25H34F6N2O2
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0442366
|
(1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-(propan-2-yl)cyclopentane-1-carboxamide
Show/Hide
|
C32H36F6N2O
|
1
|
| 1 |
IC50 = 7.6 nM
|
|
|
|
CP0496763
|
(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-((3-(dimethylamino)propyl)(methyl)amino)-2-phenylacetamide
Show/Hide
|
C23H27F6N3O
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0437367
|
(1R,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-1-(2-methylpropyl)-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
Show/Hide
|
C33H38F6N2O
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0522580
|
N-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-1-(methoxymethyl)-3-[(1S,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
Show/Hide
|
C30H34F4N2O2
|
1
|
| 1 |
IC50 = 8.5 nM
|
|
|
|
CP0437368
|
(1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-1-methyl-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
Show/Hide
|
C30H32F6N2O
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0920191
|
(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(3-(dimethylamino)propylideneamino)-2-phenylacetamide
Show/Hide
|
C22H23F6N3O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0428649
|
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1-ethyl-3-[(1S,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
Show/Hide
|
C31H34F6N2O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0395332
|
(2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-cyclobutyl-4-[(1R,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]butanamide
Show/Hide
|
C31H34F6N2O
|
2
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
IC50 = 28 nM
|
|
|
|
CP0428042
|
(S)-N-(3,5-bis(trifluoromethyl)benzyl)-5-(dimethylamino)-2-phenylpentanamide
Show/Hide
|
C22H24F6N2O
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0428698
|
(1R,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-[(methylsulfanyl)methyl]cyclopentane-1-carboxamide
Show/Hide
|
C31H34F6N2OS
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0535186
|
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1-(methoxymethyl)-3-[(1S,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
Show/Hide
|
C31H34F6N2O2
|
1
|
| 1 |
IC50 = 15.5 nM
|
|
|
|
CP0420176
|
(1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-propylcyclopentane-1-carboxamide
Show/Hide
|
C32H36F6N2O
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0507891
|
US8906911, 64
Show/Hide
|
C26H35F3N4O2
|
2
|
| 1 |
IC50 = 16.5 nM
|
|
|
| 2 |
Ki = 12 nM
|
|
|
|
CP0565604
|
US8906911, 46
Show/Hide
|
C27H35ClF3N3O3
|
2
|
| 1 |
IC50 = 17.6 nM
|
|
|
| 2 |
Ki = 17 nM
|
|
|
|
CP0428169
|
US8906911, 63
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|
C26H35F3N4O2
|
2
|
| 1 |
IC50 = 17.9 nM
|
|
|
| 2 |
Ki = 10 nM
|
|
|
|
CP0428648
|
(1R,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-1-(cyclobutylmethyl)-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
Show/Hide
|
C34H38F6N2O
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0518546
|
US8906911, 28
Show/Hide
|
C28H35F3N4O3
|
2
|
| 1 |
IC50 = 19.8 nM
|
|
|
| 2 |
Ki = 32 nM
|
|
|
|
CP0427178
|
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1-(cyclopropylmethyl)-3-[(1S,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
Show/Hide
|
C33H36F6N2O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0440375
|
(1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
Show/Hide
|
C29H30F6N2O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0238399
|
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(tetrahydro-2H-thiopyran-4-ylamino)cyclopentanecarboxamide
Show/Hide
|
C23H30F6N2OS
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0496758
|
(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(dimethylamino)ethylthio)-2-phenylacetamide
Show/Hide
|
C21H22F6N2OS
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0562154
|
US8906911, 50
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|
C28H35F6N3O3
|
2
|
| 1 |
IC50 = 25.9 nM
|
|
|
| 2 |
Ki = 78 nM
|
|
|
|
CP0373628
|
N-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-1-hexyl-3-[(1S,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
Show/Hide
|
C34H42F4N2O
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0666580
|
Dimethyl-(tetrahydro-pyran-4-yl)-{4-[(3-p-tolyl-8,9-dihydro-7H-benzocycloheptene-6-carbonyl)-amino]-benzyl}-ammonium chloride(TAK-779)
Show/Hide
|
C33H39ClN2O2
|
3
|
| 1 |
IC50 = 27 nM
|
|
|
| 2 |
IC50 = 28 nM
|
|
|
| 3 |
Ki = 4.169 nM
|
|
|
|
CP0433968
|
(1R,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-(methylsulfanyl)cyclopentane-1-carboxamide
Show/Hide
|
C30H32F6N2OS
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0467606
|
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(2-methyltetrahydro-2H-pyran-4-ylamino)cyclopentanecarboxamide
Show/Hide
|
C24H32F6N2O2
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0468216
|
US8906911, 65
Show/Hide
|
C27H37F3N4O2
|
2
|
| 1 |
IC50 = 28 nM
|
|
|
| 2 |
Ki = 6 nM
|
|
|
|
CP0302119
|
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(oxepan-4-ylamino)cyclopentanecarboxamide
Show/Hide
|
C24H32F6N2O2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0532438
|
1'-{2-[2-(4-fluorophenyl)-1,3-oxazol-4-yl]ethyl}-6-methyl-1,2-dihydrospiro[3,1-benzoxazine-4,4'-piperidine]-2-one
Show/Hide
|
C24H24FN3O3
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0515439
|
US8906911, 6
Show/Hide
|
C25H34F3N5O3
|
2
|
| 1 |
IC50 = 32.8 nM
|
|
|
| 2 |
Ki = 28 nM
|
|
|
|
CP0562153
|
US8906911, 15
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|
C27H35F4N3O3
|
2
|
| 1 |
IC50 = 34.7 nM
|
|
|
| 2 |
Ki = 29 nM
|
|
|
|
CP0315992
|
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(tetrahydrothiophen-3-ylamino)cyclopentanecarboxamide
Show/Hide
|
C22H28F6N2OS
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0557635
|
US8906911, 49
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|
C31H37F3N4O
|
2
|
| 1 |
IC50 = 37 nM
|
|
|
| 2 |
Ki = 15 nM
|
|
|
|
CP0145835
|
(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(piperidin-1-yl)ethylamino)-2-(thiophen-3-yl)acetamide
Show/Hide
|
C22H25F6N3OS
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0400725
|
US8906911, 40
Show/Hide
|
C26H35Cl2N3O3
|
2
|
| 1 |
IC50 = 41.5 nM
|
|
|
| 2 |
Ki = 38 nM
|
|
|
|
CP0468205
|
US8906911, 14
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|
C27H35F4N3O3
|
2
|
| 1 |
IC50 = 43 nM
|
|
|
| 2 |
Ki = 31 nM
|
|
|
|
CP0563848
|
US8906911, 51
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|
C28H37ClF3N3O3
|
2
|
| 1 |
IC50 = 43.3 nM
|
|
|
| 2 |
Ki = 21 nM
|
|
|
|
CP0538110
|
(2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-(4-fluorophenyl)-4-{5'-methylspiro[indene-1,4'-piperidine]-1'-yl}butanamide
Show/Hide
|
C33H31F7N2O
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0561490
|
US8906911, 66
Show/Hide
|
C27H37F3N4O2
|
2
|
| 1 |
IC50 = 45.8 nM
|
|
|
| 2 |
Ki = 13 nM
|
|
|
|
CP0507889
|
US8906911, 56
Show/Hide
|
C29H37F3N4O3
|
2
|
| 1 |
IC50 = 46 nM
|
|
|
| 2 |
Ki = 32 nM
|
|
|
|
CP0516781
|
US8906911, 53
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|
C29H37F3N4O3
|
2
|
| 1 |
IC50 = 47.9 nM
|
|
|
| 2 |
Ki = 16 nM
|
|
|
|
CP0507888
|
US8906911, 47
Show/Hide
|
C27H35ClN4O3
|
2
|
| 1 |
IC50 = 49.8 nM
|
|
|
| 2 |
Ki = 77 nM
|
|
|
|
CP0165576
|
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(3-hydroxytetrahydro-2H-pyran-4-ylamino)-1-isopropylcyclopentanecarboxamide
Show/Hide
|
C23H30F6N2O3
|
1
|
| 1 |
IC50 = 51 nM
|
|
|
|
CP0516780
|
US8906911, 48
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|
C33H37F3N4O
|
2
|
| 1 |
IC50 = 51.8 nM
|
|
|
| 2 |
Ki = 8 nM
|
|
|
|
CP0518544
|
US8906911, 1
Show/Hide
|
C26H35F3N4O3
|
2
|
| 1 |
IC50 = 54.9 nM
|
|
|
| 2 |
Ki = 32 nM
|
|
|
|
CP0517169
|
US8906911, 39
Show/Hide
|
C28H35F3N4O3
|
2
|
| 1 |
IC50 = 55.3 nM
|
|
|
| 2 |
Ki = 66 nM
|
|
|
|
CP0514673
|
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(tetrahydro-2H-pyran-3-ylamino)cyclopentanecarboxamide
Show/Hide
|
C23H30F6N2O2
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
|
CP0285420
|
(2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-(4-fluorophenyl)-4-[(1R,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]butanamide
Show/Hide
|
C33H31F7N2O
|
2
|
| 1 |
IC50 = 59 nM
|
|
|
| 2 |
IC50 = 67 nM
|
|
|
|
CP0165578
|
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(cyclohexylamino)-1-isopropylcyclopentanecarboxamide
Show/Hide
|
C24H32F6N2O
|
1
|
| 1 |
IC50 = 64 nM
|
|
|
|
CP0561511
|
US8906911, 7
Show/Hide
|
C27H37F3N4O3
|
2
|
| 1 |
IC50 = 65.7 nM
|
|
|
| 2 |
Ki = 30 nM
|
|
|
|
CP0505434
|
(1R,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-(methylsulfanyl)cyclopentane-1-carboxamide
Show/Hide
|
C29H32F4N2OS
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
|
CP0390625
|
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-cyclopropyl-4-spiro[indene-1,4'-piperidine]-1'-ylbutanamide
Show/Hide
|
C29H30F6N2O
|
1
|
| 1 |
IC50 = 69 nM
|
|
|
|
CP0419277
|
US8906911, 18
Show/Hide
|
C27H36F3N3O3
|
2
|
| 1 |
IC50 = 76.4 nM
|
|
|
| 2 |
Ki = 207 nM
|
|
|
|
CP0562152
|
US8906911, 2
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C26H35F3N4O3
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2
|
| 1 |
IC50 = 76.7 nM
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| 2 |
Ki = 60 nM
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CP0331716
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(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(2,3-dihydro-1H-inden-1-ylamino)-1-isopropylcyclopentanecarboxamide
Show/Hide
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C27H30F6N2O
|
1
|
| 1 |
IC50 = 77 nM
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CP0277808
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(2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-(4-fluorophenyl)-4-(1'H-spiro[indene-1,4'-piperidin]-1'yl)butanamide
Show/Hide
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C32H29F7N2O
|
1
|
| 1 |
IC50 = 80 nM
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CP0467334
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(2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-cyclopropyl-4-[(1R,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]butanamide
Show/Hide
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C30H32F6N2O
|
1
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| 1 |
IC50 = 80 nM
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CP0428168
|
US8906911, 52
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C29H37F6N3O3
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2
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| 1 |
IC50 = 83.9 nM
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| 2 |
Ki = 49 nM
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CP0315993
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(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(tetrahydrofuran-3-ylamino)cyclopentanecarboxamide
Show/Hide
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C22H28F6N2O2
|
1
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| 1 |
IC50 = 85 nM
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CP0532188
|
US8906911, 25
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C27H35F4N3O3
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2
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| 1 |
IC50 = 92.2 nM
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| 2 |
Ki = 271 nM
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CP0513407
|
US8906911, 30
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C24H33F3N4O3S
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2
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| 1 |
IC50 = 95.5 nM
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| 2 |
Ki = 831 nM
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CP0485249
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(2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-cyclopropyl-4-{spiro[indene-1,4'-piperidine]-1'-yl}butanamide
Show/Hide
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C29H30F6N2O
|
1
|
| 1 |
IC50 = 98 nM
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CP0517482
|
US8906911, 61
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C26H35F3N4O2
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2
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| 1 |
IC50 = 100 nM
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| 2 |
Ki = 69 nM
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CP0468206
|
US8906911, 16
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C28H38F3N3O3
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2
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| 1 |
IC50 = 106 nM
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| 2 |
Ki = 199 nM
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CP0527600
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(2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-(4-fluorophenyl)-4-[(1S,5'S)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]butanamide
Show/Hide
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C33H31F7N2O
|
1
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| 1 |
IC50 = 120 nM
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CP0388120
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(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(3-cyclopropyltetrahydro-2H-pyran-4-ylamino)-1-isopropylcyclopentanecarboxamide
Show/Hide
|
C26H34F6N2O2
|
1
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| 1 |
IC50 = 123 nM
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CP0443065
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N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-4-spiro[indene-1,4'-piperidine]-1'-yl-2-(trifluoromethylsulfonylamino)butanamide
Show/Hide
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C27H26F9N3O3S
|
1
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| 1 |
IC50 = 125 nM
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CP0386030
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(R)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(4-phenylpiperidin-1-yl)ethyl)pentanamide
Show/Hide
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C27H32F6N2O
|
1
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| 1 |
IC50 = 126 nM
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CP0522378
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(2S)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-(4-fluorophenyl)-4-[(3R,4S)-3-methyl-4-phenylpiperidin-1-yl]butan-1-amine
Show/Hide
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C31H33F7N2
|
1
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| 1 |
IC50 = 140 nM
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CP0513440
|
US8906911, 5
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C25H34F3N5O3
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2
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| 1 |
IC50 = 140 nM
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| 2 |
Ki = 104 nM
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CP0468208
|
US8906911, 29
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C27H36F3N3O4
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2
|
| 1 |
IC50 = 148 nM
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| 2 |
Ki = 473 nM
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CP0171015
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(2S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluorophenyl)-4-(4-phenylpiperidin-1-yl)butanamide
Show/Hide
|
C30H29F7N2O
|
1
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| 1 |
IC50 = 150 nM
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CP0532187
|
US8906911, 22
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C26H35F3N4O3
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2
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| 1 |
IC50 = 153 nM
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| 2 |
Ki = 120 nM
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CP0340173
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(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(cyclopentylamino)-1-isopropylcyclopentanecarboxamide
Show/Hide
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C23H30F6N2O
|
1
|
| 1 |
IC50 = 156 nM
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CP0441645
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(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluorophenyl)-4-(4-(thiophen-3-yl)piperidin-1-yl)butanamide
Show/Hide
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C28H27F7N2OS
|
1
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| 1 |
IC50 = 160 nM
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CP0376674
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N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-cyclohexyl-4-spiro[indene-1,4'-piperidine]-1'-ylbutanamide
Show/Hide
|
C32H36F6N2O
|
1
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| 1 |
IC50 = 160 nM
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CP0428073
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N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-4-[(1R,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]butanamide
Show/Hide
|
C27H28F6N2O
|
1
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| 1 |
IC50 = 173 nM
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CP0512376
|
(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluorophenyl)-2-(2-(piperidin-1-yl)ethylamino)acetamide
Show/Hide
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C24H26F7N3O
|
2
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| 1 |
IC50 = 175 nM
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| 2 |
IC50 = 180 nM
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CP0481537
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(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(cycloheptylamino)-1-isopropylcyclopentanecarboxamide
Show/Hide
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C25H34F6N2O
|
1
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| 1 |
IC50 = 175 nM
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CP0555435
|
US8906911, 20
Show/Hide
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C26H35ClFN3O3
|
2
|
| 1 |
IC50 = 182 nM
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| 2 |
Ki = 112 nM
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CP0468412
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(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(2,3-dihydro-1H-inden-2-ylamino)-1-isopropylcyclopentanecarboxamide
Show/Hide
|
C27H30F6N2O
|
1
|
| 1 |
IC50 = 187 nM
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CP0467333
|
(2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-(2-{spiro[indene-1,4'-piperidine]-1'-yl}ethyl)pent-4-enamide
Show/Hide
|
C29H30F6N2O
|
1
|
| 1 |
IC50 = 193 nM
|
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CP0282451
|
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(cyclobutylamino)-1-isopropylcyclopentanecarboxamide
Show/Hide
|
C22H28F6N2O
|
1
|
| 1 |
IC50 = 193 nM
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|
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CP0565014
|
US8906911, 12
Show/Hide
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C25H34F3N5O3
|
2
|
| 1 |
IC50 = 194 nM
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| 2 |
Ki = 261 nM
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CP0505625
|
2-amino-N-[2-[[1-[(4-chlorophenyl)methyl]piperidin-4-yl]methylamino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Show/Hide
|
C23H26ClF3N4O2
|
1
|
| 1 |
IC50 = 200 nM
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|
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CP0536582
|
(2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-methyl-2-(2-{spiro[indene-1,4'-piperidine]-1'-yl}ethyl)butanamide
Show/Hide
|
C29H32F6N2O
|
1
|
| 1 |
IC50 = 204 nM
|
|
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CP0522282
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(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-phenyl-2-(2-(piperidin-1-yl)ethylamino)acetamide
Show/Hide
|
C24H27F6N3O
|
2
|
| 1 |
IC50 = 219 nM
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|
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| 2 |
IC50 = 220 nM
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CP0493802
|
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(3,3-dimethyltetrahydro-2H-pyran-4-ylamino)-1-isopropylcyclopentanecarboxamide
Show/Hide
|
C25H34F6N2O2
|
1
|
| 1 |
IC50 = 230 nM
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CP0433969
|
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1-hexyl-3-[(1S,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
Show/Hide
|
C35H42F6N2O
|
1
|
| 1 |
IC50 = 231 nM
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|
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CP0536581
|
(2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-methyl-4-{spiro[indene-1,4'-piperidine]-1'-yl}butanamide
Show/Hide
|
C27H28F6N2O
|
1
|
| 1 |
IC50 = 231 nM
|
|
|
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CP0518545
|
US8906911, 19
Show/Hide
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C28H38F3N3O3
|
2
|
| 1 |
IC50 = 233 nM
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|
|
| 2 |
Ki = 306 nM
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CP0459575
|
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-(1,2,3,4-tetrahydronaphthalen-2-ylamino)cyclopentanecarboxamide
Show/Hide
|
C28H32F6N2O
|
1
|
| 1 |
IC50 = 239 nM
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CP0541313
|
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-(methanesulfonamido)-4-spiro[indene-1,4'-piperidine]-1'-ylbutanamide
Show/Hide
|
C27H29F6N3O3S
|
1
|
| 1 |
IC50 = 244 nM
|
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CP0453043
|
(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-cyclopropyl-4-(4-(4-fluorophenyl)piperidin-1-yl)butanamide
Show/Hide
|
C27H29F7N2O
|
1
|
| 1 |
IC50 = 280 nM
|
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CP0456460
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(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-cyclopropyl-4-(4-phenylpiperidin-1-yl)butanamide
Show/Hide
|
C27H30F6N2O
|
1
|
| 1 |
IC50 = 285 nM
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|
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CP0439634
|
2-benzyl-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-4-{spiro[indene-1,4'-piperidine]-1'-yl}butanamide
Show/Hide
|
C33H32F6N2O
|
1
|
| 1 |
IC50 = 298 nM
|
|
|
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CP0518547
|
US8906911, 36
Show/Hide
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C28H35F3N4O3
|
2
|
| 1 |
IC50 = 305 nM
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| 2 |
Ki = 1060 nM
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CP0468210
|
US8906911, 32
Show/Hide
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C26H34ClF3N4O3
|
2
|
| 1 |
IC50 = 314 nM
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|
|
| 2 |
Ki = 1060 nM
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CP0496914
|
(2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-4-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}-2-(4-fluorophenyl)butanamide
Show/Hide
|
C32H31F7N2O
|
1
|
| 1 |
IC50 = 320 nM
|
|
|
|
CP0468214
|
US8906911, 60
Show/Hide
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C25H41N3O5
|
2
|
| 1 |
IC50 = 328 nM
|
|
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| 2 |
Ki = 552 nM
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CP0428041
|
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-phenyl-2-(2-piperidin-1-ylethylamino)acetamide
Show/Hide
|
C24H27F6N3O
|
1
|
| 1 |
IC50 = 342 nM
|
|
|
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CP0394052
|
(2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-methyl-2-(2-{spiro[indene-1,4'-piperidine]-1'-yl}ethyl)butanamide
Show/Hide
|
C29H32F6N2O
|
1
|
| 1 |
IC50 = 349 nM
|
|
|
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CP0119832
|
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopropyl-3-((tetrahydro-2H-pyran-4-yl)methylamino)cyclopentanecarboxamide
Show/Hide
|
C24H32F6N2O2
|
1
|
| 1 |
IC50 = 362 nM
|
|
|
|
CP0466639
|
US8906911, 27
Show/Hide
|
C25H34F3N5O3
|
2
|
| 1 |
IC50 = 391 nM
|
|
|
| 2 |
Ki = 444 nM
|
|
|
|
CP0464513
|
(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(azepan-1-yl)ethylamino)-2-phenylacetamide
Show/Hide
|
C25H29F6N3O
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0262145
|
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(chroman-4-ylamino)-1-isopropylcyclopentanecarboxamide
Show/Hide
|
C27H30F6N2O2
|
1
|
| 1 |
IC50 = 419 nM
|
|
|
|
CP0449525
|
(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(dimethylamino)ethylamino)-2-(thiophen-3-yl)acetamide
Show/Hide
|
C19H21F6N3OS
|
1
|
| 1 |
IC50 = 424 nM
|
|
|
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CP0390994
|
(2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-4-[(1R,3'R)-3'-ethylspiro[indene-1,4'-piperidine]-1'-yl]-2-(4-fluorophenyl)butanamide
Show/Hide
|
C34H33F7N2O
|
1
|
| 1 |
IC50 = 437 nM
|
|
|
|
CP0422297
|
(2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-4-{5'-ethylspiro[indene-1,4'-piperidine]-1'-yl}-2-(4-fluorophenyl)butanamide
Show/Hide
|
C34H33F7N2O
|
1
|
| 1 |
IC50 = 440 nM
|
|
|
|
CP0468215
|
US8906911, 62
Show/Hide
|
C26H35F3N4O2
|
1
|
| 1 |
IC50 = 445 nM
|
|
|
|
CP0556819
|
US8906911, 9
Show/Hide
|
C32H37F3N4O3
|
1
|
| 1 |
IC50 = 470 nM
|
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|
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CP0532437
|
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-phenyl-2-(2-pyrrolidin-1-ylethylamino)acetamide
Show/Hide
|
C23H25F6N3O
|
1
|
| 1 |
IC50 = 521 nM
|
|
|
|
CP0507890
|
US8906911, 57
Show/Hide
|
C29H37F3N4O3
|
1
|
| 1 |
IC50 = 521 nM
|
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CP0528177
|
N-[1-[[3,5-bis(trifluoromethyl)phenyl]methylamino]-1-oxo-4-spiro[indene-1,4'-piperidine]-1'-ylbutan-2-yl]-2-oxoimidazolidine-4-carboxamide
Show/Hide
|
C30H31F6N5O3
|
1
|
| 1 |
IC50 = 525 nM
|
|
|
|
CP0563261
|
US8906911, 13
Show/Hide
|
C25H34F3N5O3
|
2
|
| 1 |
IC50 = 525 nM
|
|
|
| 2 |
Ki = 593 nM
|
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CP0480387
|
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-4-spiro[indene-1,4'-piperidine]-1'-ylbutanamide
Show/Hide
|
C26H26F6N2O
|
1
|
| 1 |
IC50 = 570 nM
|
|
|
|
CP0542432
|
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-(2-morpholin-4-ylethylamino)-2-phenylacetamide
Show/Hide
|
C23H25F6N3O2
|
1
|
| 1 |
IC50 = 575 nM
|
|
|
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CP0511038
|
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-[2-(dimethylamino)ethylamino]-2-(furan-2-yl)acetamide
Show/Hide
|
C19H21F6N3O2
|
1
|
| 1 |
IC50 = 592 nM
|
|
|
|
CP0468207
|
US8906911, 26
Show/Hide
|
C26H35F3N4O3
|
2
|
| 1 |
IC50 = 598 nM
|
|
|
| 2 |
Ki = 792 nM
|
|
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CP0501984
|
(2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-methyl-4-{spiro[indene-1,4'-piperidine]-1'-yl}butanamide
Show/Hide
|
C27H28F6N2O
|
1
|
| 1 |
IC50 = 605 nM
|
|
|
|
CP0388118
|
(1S,3R)-3-(1,1-Dioxo-hexahydro-1lambda*6*-thiopyran-4-ylamino)-1-isopropyl-cyclopentanecarboxylic acid 3,5-bis-trifluoromethyl-benzylamide
Show/Hide
|
C23H30F6N2O3S
|
1
|
| 1 |
IC50 = 631 nM
|
|
|
|
CP0390923
|
(R)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(4-phenylpiperidin-1-yl)ethyl)pent-4-enamide
Show/Hide
|
C27H30F6N2O
|
1
|
| 1 |
IC50 = 642 nM
|
|
|
|
CP0500007
|
2-(1-acetylpiperidin-3-yl)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-4-{spiro[indene-1,4'-piperidine]-1'-yl}butanamide
Show/Hide
|
C33H37F6N3O2
|
1
|
| 1 |
IC50 = 660 nM
|
|
|
|
CP0464560
|
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-[2-(diethylamino)ethylamino]-2-phenylacetamide
Show/Hide
|
C23H27F6N3O
|
1
|
| 1 |
IC50 = 678 nM
|
|
|
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CP0496915
|
(2S)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-(4-fluorophenyl)-4-[(3S,4S)-3-methyl-4-phenylpiperidin-1-yl]butan-1-amine
Show/Hide
|
C31H33F7N2
|
1
|
| 1 |
IC50 = 700 nM
|
|
|
|
CP0167324
|
(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(dimethylamino)ethylamino)-2-(4-fluorophenyl)acetamide
Show/Hide
|
C21H22F7N3O
|
2
|
| 1 |
IC50 = 720 nM
|
|
|
| 2 |
IC50 = 770 nM
|
|
|
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CP0464512
|
(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(4-methylpiperidin-1-yl)ethylamino)-2-phenylacetamide
Show/Hide
|
C25H29F6N3O
|
1
|
| 1 |
IC50 = 756 nM
|
|
|
|
CP0204218
|
(1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(3-hydroxy-3-(trifluoromethyl)tetrahydro-2H-pyran-4-ylamino)-1-isopropylcyclopentanecarboxamide
Show/Hide
|
C24H29F9N2O3
|
1
|
| 1 |
IC50 = 765 nM
|
|
|
|
CP0515959
|
(2S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluorophenyl)-4-(3-methyl-4-phenylpiperazin-1-yl)butanamide
Show/Hide
|
C30H30F7N3O
|
1
|
| 1 |
IC50 = 780 nM
|
|
|
|
CP0536583
|
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-(1-methylsulfonylpiperidin-3-yl)-4-spiro[indene-1,4'-piperidine]-1'-ylbutanamide
Show/Hide
|
C32H37F6N3O3S
|
1
|
| 1 |
IC50 = 783 nM
|
|
|
|
CP0541314
|
methyl N-[1-[[3,5-bis(trifluoromethyl)phenyl]methylamino]-1-oxo-4-spiro[indene-1,4'-piperidine]-1'-ylbutan-2-yl]carbamate
Show/Hide
|
C28H29F6N3O3
|
1
|
| 1 |
IC50 = 805 nM
|
|
|
|
CP0564955
|
US8906911, 42
Show/Hide
|
C28H35F3N4O3
|
1
|
| 1 |
IC50 = 812 nM
|
|
|
|
CP0461573
|
US8906911, 21
Show/Hide
|
C26H34F4N4O3
|
1
|
| 1 |
IC50 = 821 nM
|
|
|
|
CP0501138
|
(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-phenyl-2-(2-(4-phenylpiperidin-1-yl)ethylamino)acetamide
Show/Hide
|
C30H31F6N3O
|
2
|
| 1 |
IC50 = 822 nM
|
|
|
| 2 |
IC50 = 830 nM
|
|
|
|
CP0516783
|
US8906911, 59
Show/Hide
|
C24H31F3N4O2
|
1
|
| 1 |
IC50 = 830 nM
|
|
|
|
CP0542431
|
(2S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(2-methylpiperidin-1-yl)ethylamino)-2-phenylacetamide
Show/Hide
|
C25H29F6N3O
|
1
|
| 1 |
IC50 = 838 nM
|
|
|
|
CP0524406
|
(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(dimethylamino)ethylamino)-2-(thiophen-2-yl)acetamide
Show/Hide
|
C19H21F6N3OS
|
1
|
| 1 |
IC50 = 865 nM
|
|
|
|
CP0441644
|
(R)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluorophenyl)-4-(4-phenylpiperidin-1-yl)butanamide
Show/Hide
|
C30H29F7N2O
|
1
|
| 1 |
IC50 = 930 nM
|
|
|
|
CP0442885
|
(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(dimethylamino)ethylamino)-2-phenylacetamide
Show/Hide
|
C21H23F6N3O
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0464517
|
(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluorophenyl)-5-(piperidin-1-yl)pentanamide
Show/Hide
|
C25H27F7N2O
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0468209
|
US8906911, 31
Show/Hide
|
C28H38F3N3O4
|
1
|
| 1 |
IC50 = 1020 nM
|
|
|
|
CP0522377
|
(R)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluorophenyl)-2-methyl-4-(4-phenylpiperidin-1-yl)butan-1-amine
Show/Hide
|
C31H33F7N2
|
1
|
| 1 |
IC50 = 1070 nM
|
|
|
|
CP0464518
|
(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluorophenyl)-5-(4-phenylpiperidin-1-yl)pentanamide
Show/Hide
|
C31H31F7N2O
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0501957
|
(S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluorophenyl)-4-(piperidin-1-yl)butanamide
Show/Hide
|
C24H25F7N2O
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0563074
|
US8906911, 23
Show/Hide
|
C28H38F3N3O3
|
1
|
| 1 |
IC50 = 1110 nM
|
|
|
|
CP0565601
|
US8906911, 17
Show/Hide
|
C27H35F4N3O3
|
1
|
| 1 |
IC50 = 1290 nM
|
|
|
|
CP0563855
|
US8906911, 24
Show/Hide
|
C28H38F3N3O3
|
1
|
| 1 |
IC50 = 1390 nM
|
|
|
|
CP0466641
|
US8906911, 55
Show/Hide
|
C29H37F6N3O3
|
1
|
| 1 |
IC50 = 1410 nM
|
|
|
|
CP0555433
|
US8906911, 11
Show/Hide
|
C27H37F3N4O3
|
1
|
| 1 |
IC50 = 1470 nM
|
|
|
|
CP0464561
|
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-[2-(dimethylamino)ethylamino]-2-phenylacetamide
Show/Hide
|
C21H23F6N3O
|
1
|
| 1 |
IC50 = 1477 nM
|
|
|
|
CP0551302
|
(2S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluorophenyl)-4-(4-phenylpiperidin-1-yl)pentan-1-amine
Show/Hide
|
C31H33F7N2
|
1
|
| 1 |
IC50 = 1500 nM
|
|
|
|
CP0466640
|
US8906911, 43
Show/Hide
|
C28H35F6N3O3
|
1
|
| 1 |
IC50 = 1520 nM
|
|
|
|
CP0419276
|
US8906911, 10
Show/Hide
|
C32H37F3N4O3
|
1
|
| 1 |
IC50 = 1600 nM
|
|
|
|
CP0468211
|
US8906911, 37
Show/Hide
|
C28H35F3N4O3
|
1
|
| 1 |
IC50 = 1600 nM
|
|
|
|
CP0468212
|
US8906911, 38
Show/Hide
|
C27H37F3N4O3
|
1
|
| 1 |
IC50 = 1600 nM
|
|
|
|
CP0468213
|
US8906911, 44
Show/Hide
|
C27H35ClN4O3
|
1
|
| 1 |
IC50 = 1600 nM
|
|
|
|
CP0565603
|
US8906911, 45
Show/Hide
|
C28H35F3N4O3
|
1
|
| 1 |
IC50 = 2200 nM
|
|
|
|
CP0555431
|
US8906911, 3
Show/Hide
|
C26H35F3N4O3
|
1
|
| 1 |
IC50 = 2500 nM
|
|
|
|
CP0428167
|
US8906911, 34
Show/Hide
|
C26H35F3N4O3
|
1
|
| 1 |
IC50 = 2780 nM
|
|
|
|
CP0516782
|
US8906911, 54
Show/Hide
|
C29H37F3N4O3
|
1
|
| 1 |
IC50 = 2780 nM
|
|
|
|
CP0556910
|
US8906911, 58
Show/Hide
|
C28H37ClN4O3
|
1
|
| 1 |
IC50 = 2780 nM
|
|
|
|
CP0563856
|
US8906911, 35
Show/Hide
|
C25H35ClN4O3
|
1
|
| 1 |
IC50 = 2780 nM
|
|
|
|
CP0649585
|
1-butyl-3-(2-methylpropyl)-9-(6-phenylhexyl)-1,4,9-triazaspiro-[5.5]undeca-2,5-dione hydrochloride
Show/Hide
|
C28H46ClN3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0662025
|
(3R)-3-cyclohexylmethyl-9-(6-phenylhexyl)-1-propyl-1,4,9-triazaspiro[5.5]undeca-2,5-dione hydrochloride
Show/Hide
|
C30H48ClN3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0878092
|
(3S)-3-(2-methylpropyl)-9-(6-phenylhexyl)-1-propyl-1,4,9-triazaspiro[5.5]undeca-2,5-dione hydrochloride
Show/Hide
|
C27H44ClN3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0651200
|
9-(1,4-benzodioxane-6-yl)-1-butyl-3-(2-methylpropyl)-1,4,9-triazaspiro[5.5]undeca-2,5-dione hydrochloride
Show/Hide
|
C25H38ClN3O4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0657856
|
(+/-)-1-butyl-3-(cyclohexylmethyl)-9-(4-phenoxybenzyl)-1,4,9-triazaspiro[5.5]undecane-2,5-dione hydrochloride
Show/Hide
|
C32H44ClN3O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0662064
|
9-(1,4-benzodioxane-6-yl)-1-butyl-3-cyclohexyl-1,4,9-triazaspiro-[5.5]undeca-2,5-dione hydrochloride
Show/Hide
|
C28H42ClN3O4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0662079
|
(3S)-3-cyclohexylmethyl-9-(6-phenylhexyl)-1-propyl-1,4,9-triazaspiro[5.5]undeca-2,5-dione hydrochloride
Show/Hide
|
C30H48ClN3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0720738
|
(+/-)-1-butyl-3-isobutyl-9-(4-phenoxybenzyl)-1,4,9-triazaspiro[5.5]undecane-2,5-dione hydrochloride
Show/Hide
|
C29H40ClN3O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0837909
|
9-(4-allyloxyphenylmethyl)-1-butyl-3-cyclohexyl-1,4,9-triazaspiro[5.5]undeca-2,5-dione hydrochloride
Show/Hide
|
C29H44ClN3O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0878091
|
(3R)-3-(2-methylpropyl)-9-(6-phenylhexyl)-1-propyl-1,4,9-triazaspiro[5.5]undeca-2,5-dione hydrochloride
Show/Hide
|
C27H44ClN3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0449524
|
4-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)-N-methyl-N-(2-(piperidin-1-yl)ethyl)benzenamine
Show/Hide
|
C21H24Cl2N4
|
1
|
| 1 |
IC50 = 13400 nM
|
|
|
|
CP0419274
|
US8906911, 8
Show/Hide
|
C27H37F3N4O3
|
1
|
| 1 |
IC50 = 14430 nM
|
|
|
|
CP0400726
|
US8906911, 41
Show/Hide
|
C27H37F3N4O3
|
1
|
| 1 |
IC50 = 25000 nM
|
|
|
|
CP0428166
|
US8906911, 33
Show/Hide
|
C26H35F3N4O3
|
1
|
| 1 |
IC50 = 25000 nM
|
|
|
|
CP0515438
|
US8906911, 4
Show/Hide
|
C26H35F3N4O3
|
1
|
| 1 |
IC50 = 25000 nM
|
|
|
|
CP0466642
|
US8906911, Compound B
Show/Hide
|
C25H34F3N3O2
|
1
|
| 1 |
IC50 = 28000 nM
|
|
|
|
CP0651215
|
9-benzyl-1-butyl-3-(2-methylpropyl)-1,4,9-triazaspiro[5.5]-undeca-2,5-dione hydrochloride
Show/Hide
|
C23H36ClN3O2
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0856132
|
(3S)-1,9-dibenzyl-3-(2-methylpropyl)-1,4,9-triazaspiro[5.5]-undeca-2,5-dione hydrochloride
Show/Hide
|
C26H34ClN3O2
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0651202
|
1-butyl-3-cyclohexylmethyl-9-(4-methoxyphenylmethyl)-1,4,9-triazaspiro[5.5]undeca-2,5-dione hydrochloride
Show/Hide
|
C27H42ClN3O3
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0699196
|
3-(2-methylpropyl)-9-(4-phenoxyphenylmethyl)-1-propyl-1,4,9-triazaspiro[5.5]undeca-2,5-dione hydrochloride
Show/Hide
|
C28H38ClN3O3
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0850182
|
(3R)-1,9-dibenzyl-3-(2-methylpropyl)-1,4,9-triazaspiro[5.5]-undeca-2,5-dione hydrochloride
Show/Hide
|
C26H34ClN3O2
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0462820
|
US8906911, Compound A
Show/Hide
|
C26H36F3N3O2
|
1
|
| 1 |
IC50 > 50000 nM
|
|
|
|
CP0129722
|
2-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxybenzoic acid
Show/Hide
|
C18H11Cl3N2O5S
|
1
|
| 1 |
Ki = 1.259 nM
|
|
|
|
CP0497113
|
3-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxybenzoic acid
Show/Hide
|
C18H11Cl3N2O5S
|
1
|
| 1 |
Ki = 1.585 nM
|
|
|
|
CP0502322
|
2-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxy-6-fluorobenzoic acid
Show/Hide
|
C18H10Cl3FN2O5S
|
1
|
| 1 |
Ki = 1.995 nM
|
|
|
|
CP0496030
|
4-[4-chloro-2-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonylamino]phenoxy]-N-(2-pyrrolidin-1-ylethyl)benzamide
Show/Hide
|
C26H24Cl2F3N3O4S
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0221913
|
4-[5-chloro-3-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonylamino]pyridin-2-yl]oxy-N-(2-piperidin-1-ylethyl)benzamide
Show/Hide
|
C26H25Cl2F3N4O4S
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0116928
|
2-[4-chloro-2-[(3,4-dichlorophenyl)sulfonylamino]phenoxy]benzoic acid
Show/Hide
|
C19H12Cl3NO5S
|
1
|
| 1 |
Ki = 3.162 nM
|
|
|
|
CP0427754
|
4-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxybenzoic acid
Show/Hide
|
C18H11Cl3N2O5S
|
1
|
| 1 |
Ki = 3.162 nM
|
|
|
|
CP0391753
|
4-[4-chloro-2-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonylamino]-5-methoxyphenoxy]-N-(2-pyrrolidin-1-ylethyl)benzamide
Show/Hide
|
C27H26Cl2F3N3O5S
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0502323
|
2-[4-chloro-2-[(5-chlorothiophen-2-yl)sulfonylamino]phenoxy]benzoic acid
Show/Hide
|
C17H11Cl2NO5S2
|
1
|
| 1 |
Ki = 5.012 nM
|
|
|
|
CP0094565
|
4-[4-chloro-2-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonylamino]phenoxy]-3-methoxy-N-(2-pyrrolidin-1-ylethyl)benzamide
Show/Hide
|
C27H26Cl2F3N3O5S
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0430764
|
2-[4-chloro-2-[(3-chlorophenyl)sulfonylamino]phenoxy]benzoic acid
Show/Hide
|
C19H13Cl2NO5S
|
1
|
| 1 |
Ki = 7.943 nM
|
|
|
|
CP0401059
|
4-[4-chloro-2-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonylamino]phenoxy]-3-methyl-N-(2-pyrrolidin-1-ylethyl)benzamide
Show/Hide
|
C27H26Cl2F3N3O4S
|
1
|
| 1 |
Ki = 8 nM
|
|
|
|
CP0461434
|
4-[4-chloro-2-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonylamino]-5-methylphenoxy]-N-(2-pyrrolidin-1-ylethyl)benzamide
Show/Hide
|
C27H26Cl2F3N3O4S
|
1
|
| 1 |
Ki = 8 nM
|
|
|
|
CP0039269
|
3,4-dichloro-N-[5-chloro-2-(2-methylpyridin-3-yl)oxypyridin-3-yl]benzenesulfonamide
Show/Hide
|
C17H12Cl3N3O3S
|
2
|
| 1 |
Ki = 10 nM
|
|
|
| 2 |
Ki = 1259 nM
|
|
|
|
CP0373790
|
5-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxypyridine-3-carboxylic acid
Show/Hide
|
C17H10Cl3N3O5S
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0461432
|
4-[4-chloro-2-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonylamino]-5-methoxyphenoxy]-N-(2-piperidin-1-ylethyl)benzamide
Show/Hide
|
C28H28Cl2F3N3O5S
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0517819
|
4-[4-chloro-2-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonylamino]phenoxy]-N-(2-piperidin-1-ylethyl)benzamide
Show/Hide
|
C27H26Cl2F3N3O4S
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0228770
|
3,4-dichloro-N-[5-chloro-2-(5-chloropyridin-3-yl)oxypyridin-3-yl]benzenesulfonamide
Show/Hide
|
C16H9Cl4N3O3S
|
1
|
| 1 |
Ki = 12.59 nM
|
|
|
|
CP0273839
|
4-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxy-N-(2-piperidin-1-ylethyl)benzamide
Show/Hide
|
C25H25Cl3N4O4S
|
2
|
| 1 |
Ki = 13 nM
|
|
|
| 2 |
Ki = 20 nM
|
|
|
|
CP0298012
|
4-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxy-N-(2-pyrrolidin-1-ylethyl)benzamide
Show/Hide
|
C24H23Cl3N4O4S
|
2
|
| 1 |
Ki = 13 nM
|
|
|
| 2 |
Ki = 63 nM
|
|
|
|
CP0401900
|
3,4-dichloro-N-[5-chloro-2-(6-cyanopyridin-3-yl)oxypyridin-3-yl]benzenesulfonamide
Show/Hide
|
C17H9Cl3N4O3S
|
1
|
| 1 |
Ki = 15.85 nM
|
|
|
|
CP0390963
|
4-[4-chloro-2-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonylamino]-5-methylphenoxy]-N-(2-piperidin-1-ylethyl)benzamide
Show/Hide
|
C28H28Cl2F3N3O4S
|
1
|
| 1 |
Ki = 16 nM
|
|
|
|
CP0226249
|
3,4-dichloro-N-(5-chloro-2-pyridin-3-yloxypyridin-3-yl)benzenesulfonamide
Show/Hide
|
C16H10Cl3N3O3S
|
1
|
| 1 |
Ki = 19.95 nM
|
|
|
|
CP0387732
|
2-[4-chloro-2-[(4-chlorophenyl)sulfonylamino]phenoxy]benzoic acid
Show/Hide
|
C19H13Cl2NO5S
|
1
|
| 1 |
Ki = 19.95 nM
|
|
|
|
CP0400865
|
4-[4-chloro-2-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonylamino]phenoxy]-3-methyl-N-(2-piperidin-1-ylethyl)benzamide
Show/Hide
|
C28H28Cl2F3N3O4S
|
1
|
| 1 |
Ki = 25 nM
|
|
|
|
CP0400866
|
4-[4-chloro-2-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonylamino]phenoxy]-3-methoxy-N-(2-piperidin-1-ylethyl)benzamide
Show/Hide
|
C28H28Cl2F3N3O5S
|
1
|
| 1 |
Ki = 25 nM
|
|
|
|
CP0125371
|
2-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxy-N-(2-hydroxyethyl)benzamide
Show/Hide
|
C20H16Cl3N3O5S
|
1
|
| 1 |
Ki = 25.12 nM
|
|
|
|
CP0863194
|
3-p-Tolyl-8,9-dihydro-7H-benzocycloheptene-6-carboxylic acid (4-{[methyl-(tetrahydro-pyran-4-yl)-amino]-methyl}-phenyl)-amide
Show/Hide
|
C32H36N2O2
|
1
|
| 1 |
Ki = 28.84 nM
|
|
|
|
CP0390615
|
1-(3,4-dichlorobenzyl)-5-hydroxy-1H-indole-2-carboxylic acid
Show/Hide
|
C16H11Cl2NO3
|
1
|
| 1 |
Ki = 29 nM
|
|
|
|
CP0416381
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2-[3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxybenzoic acid
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C18H12Cl2N2O5S
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1
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| 1 |
Ki = 31.62 nM
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CP0506133
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2-[2-[(4-chlorophenyl)sulfonylamino]-6-fluoro-4-(trifluoromethyl)phenoxy]benzoic acid
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C20H12ClF4NO5S
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1
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| 1 |
Ki = 31.62 nM
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CP0430766
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2-[2-[(4-chlorophenyl)sulfonylamino]-4-fluorophenoxy]benzoic acid
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C19H13ClFNO5S
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1
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| 1 |
Ki = 39.81 nM
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CP0275299
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4-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxy-N-(2-piperazin-1-ylethyl)benzamide
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C24H24Cl3N5O4S
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2
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| 1 |
Ki = 40 nM
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| 2 |
Ki = 251 nM
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CP0104462
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(E)-3-(3,4-Dichloro-phenyl)-N-{5-[4-(5-hydroxy-1H-indol-3-yl)-piperidin-1-yl]-pentyl}-acrylamide
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C27H31Cl2N3O2
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2
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| 1 |
Ki = 50 nM
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| 2 |
Ki = 50.12 nM
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CP0471020
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2-[4-[(3,4-dichlorophenyl)sulfonylamino]pyridin-3-yl]oxybenzoic acid
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C18H12Cl2N2O5S
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1
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| 1 |
Ki = 50.12 nM
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CP0488745
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3,4-dichloro-N-[5-cyano-2-(2-methylpyridin-3-yl)oxypyridin-3-yl]benzenesulfonamide
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C18H12Cl2N4O3S
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1
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| 1 |
Ki = 50.12 nM
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CP0387506
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4-[4-chloro-2-[(3,4-dichlorophenyl)sulfonylamino]phenoxy]-N-(2-piperidin-1-ylethyl)benzamide
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C26H26Cl3N3O4S
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1
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| 1 |
Ki = 63 nM
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CP0390739
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4-[4-chloro-2-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonylamino]phenoxy]-N-[2-(3,3-difluoropyrrolidin-1-yl)ethyl]benzamide
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C26H22Cl2F5N3O4S
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1
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| 1 |
Ki = 63 nM
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CP0516419
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2-[2-[(4-chlorophenyl)sulfonylamino]-4-cyanophenoxy]benzoic acid
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C20H13ClN2O5S
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1
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| 1 |
Ki = 63.1 nM
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CP0323451
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3-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxy-N-(2-piperidin-1-ylethyl)benzamide
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C25H25Cl3N4O4S
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2
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| 1 |
Ki = 79 nM
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| 2 |
Ki = 1259 nM
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CP0314740
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3-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxy-N-(2-pyrrolidin-1-ylethyl)benzamide
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C24H23Cl3N4O4S
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2
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| 1 |
Ki = 100 nM
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| 2 |
Ki = 1000 nM
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CP0387734
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2-[2-[(4-chlorophenyl)sulfonylamino]-4-(trifluoromethyl)phenoxy]-6-fluorobenzoic acid
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C20H12ClF4NO5S
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1
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| 1 |
Ki = 125.89 nM
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CP0473576
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2-[2-(benzenesulfonamido)-4-chlorophenoxy]benzoic acid
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C19H14ClNO5S
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1
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| 1 |
Ki = 158.49 nM
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CP0493533
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3,4-dichloro-N-(5-chloro-2-pyridazin-3-yloxypyridin-3-yl)benzenesulfonamide
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C15H9Cl3N4O3S
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1
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| 1 |
Ki = 199.53 nM
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CP0209406
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3-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxy-N-(2-piperazin-1-ylethyl)benzamide
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C24H24Cl3N5O4S
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2
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| 1 |
Ki = 200 nM
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| 2 |
Ki = 2511 nM
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CP0250469
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6-methyl-1'-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethyl]spiro[1,4-dihydro-2H-benzo[d][1,3]oxazine-4,4'-(hexahydropyridine)]-2-one
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C25H27N3O3
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1
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| 1 |
Ki = 208.93 nM
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CP0416380
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2-[2-[(4-chlorophenyl)sulfonylamino]phenoxy]benzoic acid
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C19H14ClNO5S
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1
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| 1 |
Ki = 251.19 nM
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CP0185499
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(R)-N-(2-(1-(2,4-dimethylbenzyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
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C23H26F3N3O2
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1
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| 1 |
Ki = 288.4 nM
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CP0416382
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2-[4-chloro-2-(methanesulfonamido)phenoxy]benzoic acid
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C14H12ClNO5S
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1
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| 1 |
Ki = 398.11 nM
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CP0438745
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2-[2-chloro-6-[(4-chlorophenyl)sulfonylamino]phenoxy]benzoic acid
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C19H13Cl2NO5S
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1
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| 1 |
Ki = 398.11 nM
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CP0499946
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2-[5-[(3,4-dichlorophenyl)sulfonylamino]pyrimidin-4-yl]oxybenzoic acid
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C17H11Cl2N3O5S
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1
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| 1 |
Ki = 398.11 nM
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CP0464608
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2-[2-[(4-chlorophenyl)sulfonylamino]-5-methylphenoxy]benzoic acid
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C20H16ClNO5S
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1
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| 1 |
Ki = 630.96 nM
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CP0209407
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2-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxy-N-(2-pyrrolidin-1-ylethyl)benzamide
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C24H23Cl3N4O4S
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2
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| 1 |
Ki = 631 nM
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| 2 |
Ki = 2512 nM
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CP0298013
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2-[5-chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxy-N-(2-piperidin-1-ylethyl)benzamide
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C25H25Cl3N4O4S
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2
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| 1 |
Ki = 794 nM
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| 2 |
Ki = 1585 nM
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CP0502324
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2-[2-[(4-chlorophenyl)sulfonylamino]-4-(trifluoromethyl)phenoxy]benzoic acid
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C20H13ClF3NO5S
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1
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| 1 |
Ki = 794.33 nM
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CP0514942
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2-[3-[(3,4-dichlorophenyl)sulfonylamino]pyrazin-2-yl]oxybenzoic acid
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C17H11Cl2N3O5S
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1
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| 1 |
Ki = 794.33 nM
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CP0471061
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2-[2-[(4-chlorophenyl)sulfonylamino]-4-methylsulfonylphenoxy]benzoic acid
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C20H16ClNO7S2
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1
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| 1 |
Ki > 3162.28 nM
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CP0516417
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2-[2-[(4-chlorophenyl)sulfonylamino]-3-fluorophenoxy]benzoic acid
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C19H13ClFNO5S
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1
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| 1 |
Ki > 3162.28 nM
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CP0516418
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2-[2-[(4-chlorophenyl)sulfonylamino]-6-methylphenoxy]benzoic acid
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C20H16ClNO5S
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1
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| 1 |
Ki > 3162.28 nM
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