Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT02392 , B2 bradykinin receptor
Gene Name BDKRB2
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P30411
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT02392
 
Compound ID Compound Name Compound Formula
CP0921884
FASITIBANT CHLORIDE
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C36H49Cl3N6O6S
 1
1
IC50 = 0.05 nM
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CP0515213
(S)-4-carbamimidoyl-N-(4-(1-(2,4-dichloro-3-((2,4-dimethylquinolin-8-yloxy)methyl)phenylsulfonyl)pyrrolidin-2-yl)-4-oxobutyl)benzamide
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C34H35Cl2N5O5S
 1
1
IC50 = 0.67 nM
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CP0373173
(E)-3-(6-Acetylamino-pyridin-3-yl)-N-({[2,4-dichloro-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-methyl-carbamoyl}-methyl)-acrylamide
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C30H27Cl2N5O4
 1
1
IC50 = 1.4 nM
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CP0470376
1-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinolin-8-yloxymethyl]-pyridin-3-ylmethyl}-3-trifluoromethyl-1H-pyridin-2-one
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C27H21ClF3N5O2
 1
1
IC50 = 4 nM
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CP0495393
1-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinolin-8-yloxymethyl]-pyridin-3-ylmethyl}-1H-pyridin-2-one
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C26H22ClN5O2
 1
1
IC50 = 5.1 nM
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CP0108866
2-methyl-N-[[4-methyl-3-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-2-yl]methyl]propanamide
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C26H29N5O2
 1
1
IC50 = 5.4 nM
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CP0510563
[5-chloro-4-[2-methyl-4-(2-methylpyrazol-3-yl)quinoline-8-carbonyl]pyridin-3-yl]methyl acetate
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C23H19ClN4O3
 1
1
IC50 = 6 nM
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CP0375764
2-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinolin-8-yloxymethyl]-pyridin-3-yloxy}-N,N-dimethyl-acetamide
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C24H24ClN5O3
 1
1
IC50 = 6.5 nM
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CP0510957
3-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinolin-8-yloxymethyl]-pyridin-3-ylmethyl}-1,1-dimethyl-urea
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C24H25ClN6O2
 1
1
IC50 = 6.6 nM
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CP0452630
2-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinolin-8-yloxymethyl]-pyridin-3-ylsulfanyl}-N,N-dimethyl-acetamide
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C24H24ClN5O2S
 1
1
IC50 = 7.5 nM
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CP0510561
N-[[5-chloro-4-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-3-yl]methyl]-2-methylpropanamide
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C25H26ClN5O2
 1
1
IC50 = 7.8 nM
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CP0510132
[5-chloro-4-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-3-yl]methyl N,N-dimethylcarbamate
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C24H24ClN5O3
 1
1
IC50 = 8.3 nM
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CP0043909
1-((4-methyl-3-((2-methyl-4-(4-methyl-1H-pyrazol-5-yl)quinolin-8-yloxy)methyl)pyridin-2-yl)methyl)-3-(trifluoromethyl)pyridin-2(1H)-one
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C28H24F3N5O2
 1
1
IC50 = 8.7 nM
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CP0191974
1-{4-methyl-3-[2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinolin-8-yloxymethyl]-pyridin-2-ylmethyl}-3-trifluoromethyl-1H-pyridin-2-one
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C28H24F3N5O2
 1
1
IC50 = 8.8 nM
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CP0247675
1-((3-((4-(5-chlorothiazol-4-yl)-2-methylquinolin-8-yloxy)methyl)-4-methylpyridin-2-yl)methyl)-3-(trifluoromethyl)pyridin-2(1H)-one
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C27H20ClF3N4O2S
 1
1
IC50 = 10 nM
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CP0259619
N-[[4-methyl-3-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-2-yl]methyl]cyclohexanecarboxamide
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C29H33N5O2
 1
1
IC50 = 10 nM
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CP0510562
N-[[5-chloro-4-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-3-yl]methyl]acetamide
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C23H22ClN5O2
 1
1
IC50 = 12 nM
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CP0375767
N-[[5-chloro-4-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-3-yl]methyl]methanesulfonamide
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C22H22ClN5O3S
 1
1
IC50 = 14 nM
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CP0510560
8-((3-chloro-5-(1-methyl-1H-imidazol-2-ylthio)pyridin-4-yl)methoxy)-2-methyl-4-(1-methyl-1H-pyrazol-5-yl)quinoline
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C24H21ClN6OS
 1
1
IC50 = 18 nM
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CP0431489
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(4-methyl-isothiazol-3-yl)-quinoline
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C20H15Cl2N3OS
 1
1
IC50 = 20 nM
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CP0452629
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-pyrazol-1-yl-quinoline
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C19H14Cl2N4O
 1
1
IC50 = 32 nM
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CP0481662
3-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinolin-8-yloxymethyl]-pyridin-3-yl}-propionamide
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C23H22ClN5O2
 1
1
IC50 = 33 nM
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CP0495392
3-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinolin-8-yloxymethyl]-pyridin-3-yl}-N,N-dimethyl-propionamide
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C25H26ClN5O2
 1
1
IC50 = 36 nM
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CP0470375
2-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinolin-8-yloxymethyl]-pyridine-3-sulfinyl}-N,N-dimethyl-acetamide
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C24H24ClN5O3S
 1
1
IC50 = 37 nM
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CP0309352
8-[3-chloro-5-(thiazol-2-ylsulfanyl)-pyridin-4-ylmethoxy]-2-methyl-4-(2-methyl-2Hpyrazol-3-yl)-quinoline
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C23H18ClN5OS2
 1
1
IC50 = 50 nM
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CP0375766
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinoline
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C20H16Cl2N4O
 1
1
IC50 = 50 nM
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CP0514707
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(5-methyl-thiazol-4-yl)-quinoline
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C20H15Cl2N3OS
 1
1
IC50 = 64 nM
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CP0374397
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(2-methyl-2H-[1,2,4]triazol-3-yl)-quinoline
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C19H15Cl2N5O
 1
1
IC50 = 68 nM
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CP0481659
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-thiazol-4-yl-quinoline
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C19H13Cl2N3OS
 1
1
IC50 = 80 nM
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CP0507985
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(1-methyl-1H-imidazol-2-yl)-quinoline
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C20H16Cl2N4O
 1
1
IC50 = 90 nM
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CP0510559
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(4-methyl-thiazol-5-yl)-quinoline
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C20H15Cl2N3OS
 1
1
IC50 = 110 nM
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CP0515212
8-((3,5-dichloropyridin-4-yl)methoxy)-2-methyl-4-(4-methyl-1H-pyrazol-3-yl)quinoline
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C20H16Cl2N4O
 1
1
IC50 = 110 nM
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CP0470377
5-(8-((3,5-dichloropyridin-4-yl)methoxy)-2-methylquinolin-4-yl)thiazole
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C19H13Cl2N3OS
 1
1
IC50 = 135 nM
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CP0452631
8-[3-chloro-5-(pyridin-2-yloxymethyl)-pyridin-4-ylmethoxy]-2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinoline
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C26H22ClN5O2
 1
1
IC50 = 140 nM
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CP0407669
8-(3,5-dichloro-pyridin-4-ylmethoxy)-4-(1,5-dimethyl-1H-imidazol-2-yl)-2-methylquinoline
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C21H18Cl2N4O
 1
1
IC50 = 200 nM
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CP0481660
4-(8-((3,5-dichloropyridin-4-yl)methoxy)-2-methylquinolin-4-yl)-3-methylisothiazole
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C20H15Cl2N3OS
 1
1
IC50 = 200 nM
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CP0510131
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(2-methyl-imidazol-1-yl)-quinoline
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C20H16Cl2N4O
 1
1
IC50 = 200 nM
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CP0447916
4-(5-chloro-thiazol-4-yl)-8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-quinoline
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C19H12Cl3N3OS
 1
1
IC50 = 210 nM
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CP0495390
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(2H-pyrazol-3-yl)-quinoline
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C19H14Cl2N4O
 1
1
IC50 = 310 nM
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CP0443527
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-thiazol-2-yl-quinoline
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C19H13Cl2N3OS
 1
1
IC50 = 420 nM
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CP0407670
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(3-methyl-isoxazol-4-yl)-quinoline
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C20H15Cl2N3O2
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1
IC50 = 430 nM
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CP0375763
8-((3-chloropyridin-4-yl)methoxy)-2-methyl-4-(1-methyl-1H-pyrazol-5-yl)quinoline
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C20H17ClN4O
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1
IC50 = 517 nM
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CP0375765
8-(3,5-Dichloro-pyridin-4-ylmethoxy)-4-imidazol-1-yl-2-methyl-quinoline
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C19H14Cl2N4O
 1
1
IC50 = 580 nM
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CP0447915
4-(4-chloro-thiazol-5-yl)-8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-quinoline
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C19H12Cl3N3OS
 1
1
IC50 = 980 nM
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CP0495395
8-((3,5-dichloropyridin-4-yl)methoxy)-2-methyl-4-(5-methyl-1H-pyrazol-4-yl)quinoline
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C20H16Cl2N4O
 1
1
IC50 = 3600 nM
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CP0459192
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(3-methyl-3H-imidazol-4-yl)-quinoline
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C20H16Cl2N4O
 1
1
IC50 = 4400 nM
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CP0507984
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-quinoline
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C16H12Cl2N2O
 1
1
IC50 = 5300 nM
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CP0506446
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(4-methyl-oxazol-5-yl)-quinoline
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C20H15Cl2N3O2
 1
1
IC50 = 6050 nM
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CP0510558
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(4-methyl-4H-[1,2,4]triazol-3-yl)-quinoline
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C19H15Cl2N5O
 1
1
IC50 = 7100 nM
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