General Information of the Compound
Compound ID
CP0452629
Compound Name
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-pyrazol-1-yl-quinoline
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Structure
Formula
C19H14Cl2N4O
Molecular Weight
385.254
Canonical SMILES
Cc1cc(-n2cccn2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1
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InChI
InChI=1S/C19H14Cl2N4O/c1-12-8-17(25-7-3-6-23-25)13-4-2-5-18(19(13)24-12)26-11-14-15(20)9-22-10-16(14)21/h2-10H,11H2,1H3
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InChIKey
XRBNKLGCMWYERW-UHFFFAOYSA-N
Physicochemical Property
logP
5.00972
Rotatable Bonds
4
Heavy Atom Count
26
Polar Areas
52.83
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44191225
SID: 85186943
ChEMBL ID
CHEMBL562747
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02392, B2 bradykinin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 32 nM
   TI
   LI
   LO
   TS
CL000837 HF1-5 Rattus norvegicus (Rat)  1
1
IC50 = 920 nM
   TI
   LI
   LO
   TS