| Compound ID |
Compound Name |
Compound Formula |
|
CP0191974
|
1-{4-methyl-3-[2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinolin-8-yloxymethyl]-pyridin-2-ylmethyl}-3-trifluoromethyl-1H-pyridin-2-one
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|
C28H24F3N5O2
|
1
|
| 1 |
IC50 = 0.54 nM
|
|
|
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CP0043909
|
1-((4-methyl-3-((2-methyl-4-(4-methyl-1H-pyrazol-5-yl)quinolin-8-yloxy)methyl)pyridin-2-yl)methyl)-3-(trifluoromethyl)pyridin-2(1H)-one
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|
C28H24F3N5O2
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
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CP0247675
|
1-((3-((4-(5-chlorothiazol-4-yl)-2-methylquinolin-8-yloxy)methyl)-4-methylpyridin-2-yl)methyl)-3-(trifluoromethyl)pyridin-2(1H)-one
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|
C27H20ClF3N4O2S
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
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CP0470376
|
1-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinolin-8-yloxymethyl]-pyridin-3-ylmethyl}-3-trifluoromethyl-1H-pyridin-2-one
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|
C27H21ClF3N5O2
|
1
|
| 1 |
IC50 = 1.4 nM
|
|
|
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CP0259619
|
N-[[4-methyl-3-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-2-yl]methyl]cyclohexanecarboxamide
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|
C29H33N5O2
|
1
|
| 1 |
IC50 = 1.8 nM
|
|
|
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CP0510561
|
N-[[5-chloro-4-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-3-yl]methyl]-2-methylpropanamide
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|
C25H26ClN5O2
|
1
|
| 1 |
IC50 = 2.3 nM
|
|
|
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CP0510957
|
3-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinolin-8-yloxymethyl]-pyridin-3-ylmethyl}-1,1-dimethyl-urea
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|
C24H25ClN6O2
|
1
|
| 1 |
IC50 = 2.8 nM
|
|
|
|
CP0495393
|
1-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinolin-8-yloxymethyl]-pyridin-3-ylmethyl}-1H-pyridin-2-one
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|
C26H22ClN5O2
|
1
|
| 1 |
IC50 = 3.6 nM
|
|
|
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CP0108866
|
2-methyl-N-[[4-methyl-3-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-2-yl]methyl]propanamide
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|
C26H29N5O2
|
1
|
| 1 |
IC50 = 3.8 nM
|
|
|
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CP0510132
|
[5-chloro-4-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-3-yl]methyl N,N-dimethylcarbamate
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|
C24H24ClN5O3
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0452630
|
2-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinolin-8-yloxymethyl]-pyridin-3-ylsulfanyl}-N,N-dimethyl-acetamide
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|
C24H24ClN5O2S
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0510562
|
N-[[5-chloro-4-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-3-yl]methyl]acetamide
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|
C23H22ClN5O2
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
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CP0309352
|
8-[3-chloro-5-(thiazol-2-ylsulfanyl)-pyridin-4-ylmethoxy]-2-methyl-4-(2-methyl-2Hpyrazol-3-yl)-quinoline
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|
C23H18ClN5OS2
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0510560
|
8-((3-chloro-5-(1-methyl-1H-imidazol-2-ylthio)pyridin-4-yl)methoxy)-2-methyl-4-(1-methyl-1H-pyrazol-5-yl)quinoline
Show/Hide
|
C24H21ClN6OS
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0510559
|
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(4-methyl-thiazol-5-yl)-quinoline
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|
C20H15Cl2N3OS
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
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CP0431489
|
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(4-methyl-isothiazol-3-yl)-quinoline
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|
C20H15Cl2N3OS
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
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CP0495392
|
3-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinolin-8-yloxymethyl]-pyridin-3-yl}-N,N-dimethyl-propionamide
Show/Hide
|
C25H26ClN5O2
|
1
|
| 1 |
IC50 = 73 nM
|
|
|
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CP0470375
|
2-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinolin-8-yloxymethyl]-pyridine-3-sulfinyl}-N,N-dimethyl-acetamide
Show/Hide
|
C24H24ClN5O3S
|
1
|
| 1 |
IC50 = 76 nM
|
|
|
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CP0375764
|
2-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinolin-8-yloxymethyl]-pyridin-3-yloxy}-N,N-dimethyl-acetamide
Show/Hide
|
C24H24ClN5O3
|
1
|
| 1 |
IC50 = 91 nM
|
|
|
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CP0375767
|
N-[[5-chloro-4-[[2-methyl-4-(2-methylpyrazol-3-yl)quinolin-8-yl]oxymethyl]pyridin-3-yl]methyl]methanesulfonamide
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|
C22H22ClN5O3S
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
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CP0375766
|
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinoline
Show/Hide
|
C20H16Cl2N4O
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0481662
|
3-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinolin-8-yloxymethyl]-pyridin-3-yl}-propionamide
Show/Hide
|
C23H22ClN5O2
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
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CP0452631
|
8-[3-chloro-5-(pyridin-2-yloxymethyl)-pyridin-4-ylmethoxy]-2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinoline
Show/Hide
|
C26H22ClN5O2
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
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CP0510563
|
[5-chloro-4-[2-methyl-4-(2-methylpyrazol-3-yl)quinoline-8-carbonyl]pyridin-3-yl]methyl acetate
Show/Hide
|
C23H19ClN4O3
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0481659
|
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-thiazol-4-yl-quinoline
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|
C19H13Cl2N3OS
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
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CP0481660
|
4-(8-((3,5-dichloropyridin-4-yl)methoxy)-2-methylquinolin-4-yl)-3-methylisothiazole
Show/Hide
|
C20H15Cl2N3OS
|
1
|
| 1 |
IC50 = 330 nM
|
|
|
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CP0495390
|
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(2H-pyrazol-3-yl)-quinoline
Show/Hide
|
C19H14Cl2N4O
|
1
|
| 1 |
IC50 = 350 nM
|
|
|
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CP0515212
|
8-((3,5-dichloropyridin-4-yl)methoxy)-2-methyl-4-(4-methyl-1H-pyrazol-3-yl)quinoline
Show/Hide
|
C20H16Cl2N4O
|
1
|
| 1 |
IC50 = 390 nM
|
|
|
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CP0514707
|
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(5-methyl-thiazol-4-yl)-quinoline
Show/Hide
|
C20H15Cl2N3OS
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
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CP0470377
|
5-(8-((3,5-dichloropyridin-4-yl)methoxy)-2-methylquinolin-4-yl)thiazole
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|
C19H13Cl2N3OS
|
1
|
| 1 |
IC50 = 420 nM
|
|
|
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CP0443527
|
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-thiazol-2-yl-quinoline
Show/Hide
|
C19H13Cl2N3OS
|
1
|
| 1 |
IC50 = 480 nM
|
|
|
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CP0447916
|
4-(5-chloro-thiazol-4-yl)-8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-quinoline
Show/Hide
|
C19H12Cl3N3OS
|
1
|
| 1 |
IC50 = 730 nM
|
|
|
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CP0507985
|
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(1-methyl-1H-imidazol-2-yl)-quinoline
Show/Hide
|
C20H16Cl2N4O
|
1
|
| 1 |
IC50 = 760 nM
|
|
|
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CP0452629
|
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-pyrazol-1-yl-quinoline
Show/Hide
|
C19H14Cl2N4O
|
1
|
| 1 |
IC50 = 920 nM
|
|
|
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CP0510131
|
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(2-methyl-imidazol-1-yl)-quinoline
Show/Hide
|
C20H16Cl2N4O
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
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CP0375763
|
8-((3-chloropyridin-4-yl)methoxy)-2-methyl-4-(1-methyl-1H-pyrazol-5-yl)quinoline
Show/Hide
|
C20H17ClN4O
|
1
|
| 1 |
IC50 = 1600 nM
|
|
|
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CP0374397
|
8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(2-methyl-2H-[1,2,4]triazol-3-yl)-quinoline
Show/Hide
|
C19H15Cl2N5O
|
1
|
| 1 |
IC50 = 2400 nM
|
|
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CP0375765
|
8-(3,5-Dichloro-pyridin-4-ylmethoxy)-4-imidazol-1-yl-2-methyl-quinoline
Show/Hide
|
C19H14Cl2N4O
|
1
|
| 1 |
IC50 = 2500 nM
|
|
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CP0447915
|
4-(4-chloro-thiazol-5-yl)-8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-quinoline
Show/Hide
|
C19H12Cl3N3OS
|
1
|
| 1 |
IC50 = 2500 nM
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|
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CP0407669
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8-(3,5-dichloro-pyridin-4-ylmethoxy)-4-(1,5-dimethyl-1H-imidazol-2-yl)-2-methylquinoline
Show/Hide
|
C21H18Cl2N4O
|
1
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| 1 |
IC50 = 3400 nM
|
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CP0407670
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8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(3-methyl-isoxazol-4-yl)-quinoline
Show/Hide
|
C20H15Cl2N3O2
|
1
|
| 1 |
IC50 = 3800 nM
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CP0495395
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8-((3,5-dichloropyridin-4-yl)methoxy)-2-methyl-4-(5-methyl-1H-pyrazol-4-yl)quinoline
Show/Hide
|
C20H16Cl2N4O
|
1
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| 1 |
IC50 = 6300 nM
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CP0506446
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8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(4-methyl-oxazol-5-yl)-quinoline
Show/Hide
|
C20H15Cl2N3O2
|
1
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| 1 |
IC50 > 5000 nM
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