Brief Information of the Compound and Protein
Compound Name
 Compound Info 
Clobenpropit
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 PubChem ID
CID: 2790
SID: 14825609
Canonical SMILES
NC(SCCCc1cnc[nH]1)=NCc1ccc(Cl)cc1
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Compound Formula C14H17ClN4S
Compound Structure
Protein Name
 Protein Info 
Histamine H3 receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Histamine receptor
Uniprot ID
Q9Y5N1
Gene Name
HRH3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  5
1
IC50 = 0.7943 nM
   TI
   LI
   LO
   TS
2
Kd = 0.1 nM
   TI
   LI
   LO
   TS
3
Ki = 0.3388 nM
   TI
   LI
   LO
   TS
4
Ki = 0.58 nM
   TI
   LI
   LO
   TS
5
Ki = 2.4 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
Ki = 2.4 nM
   TI
   LI
   LO
   TS
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  3
1
Ki = 0.2512 nM
   TI
   LI
   LO
   TS
2
Ki = 0.3388 nM
   TI
   LI
   LO
   TS
3
Ki = 2.512 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  4
1
IC50 = 1.15 nM
   TI
   LI
   LO
   TS
2
Ki = 0.5012 nM
   TI
   LI
   LO
   TS
3
Ki = 2.4 nM
   TI
   LI
   LO
   TS
4
Ki = 2.818 nM
   TI
   LI
   LO
   TS
CL000156 HT-1080
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
Ki = 0.5012 nM
   TI
   LI
   LO
   TS
CL000074 SK-N-MC
 Cell Line Info 
Homo sapiens (Human)  2
1
Ki = 2.512 nM
   TI
   LI
   LO
   TS
2
Ki = 3.162 nM
   TI
   LI
   LO
   TS