Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetic acid

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PubChem ID

CID: 9803963

SID: 14760044

Canonical SMILES	Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F Show/Hide
Compound Formula	C21H18F3NO3S2

Compound Structure

Protein Name

Protein Info

Peroxisome proliferator-activated receptor delta

Protein Classification

Transcription factor

Nuclear receptor

Nuclear hormone receptor subfamily 1

Nuclear hormone receptor subfamily 1 group C

Nuclear hormone receptor subfamily 1 group C member 2

Uniprot ID

Q03181

Gene Name

PPARD

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	EC50 = 9.5 nM	TI LI LO TS
CL000109	COS-1 Cell Line Info	Chlorocebus aethiops (Green monkey)	1
1	EC50 = 2.9 nM	TI LI LO TS
CL000053	COS-7 Cell Line Info	Chlorocebus aethiops (Green monkey)	2
1	EC50 = 1 nM	TI LI LO TS
2	EC50 = 1050 nM	TI LI LO TS
CL000044	CV-1 Cell Line Info	Chlorocebus aethiops (Green monkey)	7
1	EC50 = 1 nM	TI LI LO TS
2	EC50 = 1.2 nM	TI LI LO TS
3	EC50 = 1.7 nM	TI LI LO TS
4	EC50 = 2 nM	TI LI LO TS
5	EC50 = 2.5 nM	TI LI LO TS
6	EC50 = 3.162 nM	TI LI LO TS
7	IC50 = 125.89 nM	TI LI LO TS
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 5 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	7
1	EC50 = 0.18 nM	TI LI LO TS
2	EC50 = 1.8 nM	TI LI LO TS
3	EC50 = 2 nM	TI LI LO TS
4	EC50 = 4.4 nM	TI LI LO TS
5	EC50 = 5.9 nM	TI LI LO TS
6	EC50 = 7.9 nM	TI LI LO TS
7	EC50 = 85 nM	TI LI LO TS
CL000017	HeLa Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 8 nM	TI LI LO TS
CL000063	Hep-G2 Cell Line Info	Homo sapiens (Human)	2
1	EC50 = 1.2 nM	TI LI LO TS
2	EC50 = 4 nM	TI LI LO TS

Biochemical Assays