Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide

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PubChem ID

CID: 447912

SID: 14932512

Canonical SMILES	OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F Show/Hide
Compound Formula	C17H12F9NO3S

Compound Structure

Protein Name

Protein Info

Oxysterols receptor LXR-beta

Protein Classification

Transcription factor

Nuclear receptor

Nuclear hormone receptor subfamily 1

Nuclear hormone receptor subfamily 1 group H

Nuclear hormone receptor subfamily 1 group H member 3

Uniprot ID

P55055

Gene Name

NR1H2

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	EC50 = 16 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	EC50 = 410 nM	TI LI LO TS
CL000053	COS-7 Cell Line Info	Chlorocebus aethiops (Green monkey)	1
1	EC50 = 11 nM	TI LI LO TS
CL000044	CV-1 Cell Line Info	Chlorocebus aethiops (Green monkey)	4
1	EC50 = 100 nM	TI LI LO TS
2	EC50 = 130 nM	TI LI LO TS
3	EC50 = 140 nM	TI LI LO TS
4	EC50 = 198 nM	TI LI LO TS
CL000008	H4 Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 20 nM	TI LI LO TS
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 260 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	6
1	EC50 = 19 nM	TI LI LO TS
2	EC50 = 21 nM	TI LI LO TS
3	EC50 = 66 nM	TI LI LO TS
4	EC50 = 85 nM	TI LI LO TS
5	EC50 = 90 nM	TI LI LO TS
6	EC50 = 120 nM	TI LI LO TS
CL000148	Huh-7 Cell Line Info	Homo sapiens (Human)	3
1	EC50 = 135 nM	TI LI LO TS
2	EC50 = 170 nM	TI LI LO TS
3	EC50 = 178 nM	TI LI LO TS
CL000004	SH-SY5Y Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 75 nM	TI LI LO TS

Biochemical Assays