Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

(1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-one

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PubChem ID

CID: 10635

SID: 14751321

Canonical SMILES	C[C@]12CC[C@H]3[C@@H](CC[C@H]4CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O Show/Hide
Compound Formula	C19H30O2

Compound Structure

Protein Name

Protein Info

Androgen receptor

Protein Classification

Transcription factor

Nuclear receptor

Nuclear hormone receptor subfamily 3

Nuclear hormone receptor subfamily 3 group C

Nuclear hormone receptor subfamily 3 group C member 4

Uniprot ID

P10275

Gene Name

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000361	C2C12 Cell Line Info	Mus musculus (Mouse)	1
1	EC50 = 0.13 nM	TI LI LO TS
CL000880	COS Cell Line Info	Chlorocebus aethiops (Green monkey)	2
1	IC50 = 4 nM	TI LI LO TS
2	Ki = 2 nM	TI LI LO TS
CL000053	COS-7 Cell Line Info	Chlorocebus aethiops (Green monkey)	7
1	EC50 = 3 nM	TI LI LO TS
2	EC50 = 6.2 nM	TI LI LO TS
3	EC50 = 12 nM	TI LI LO TS
4	EC50 = 15 nM	TI LI LO TS
5	EC50 = 20 nM	TI LI LO TS
6	IC50 > 10000 nM	TI LI LO TS
7	Ki = 0.2 nM	TI LI LO TS
CL000044	CV-1 Cell Line Info	Chlorocebus aethiops (Green monkey)	5
1	EC50 = 5.1 nM	TI LI LO TS
2	EC50 = 5.7 nM	TI LI LO TS
3	EC50 = 6 nM	TI LI LO TS
4	IC50 > 10000 nM	TI LI LO TS
5	Ki = 0.2 nM	TI LI LO TS
CL000742	FreeStyle 293-F Cell Line Info	Homo sapiens (Human)	2
1	IC50 = 2.1 nM	TI LI LO TS
2	IC50 = 2.6 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	3
1	EC50 = 0.18 nM	TI LI LO TS
2	IC50 = 2.1 nM	TI LI LO TS
3	IC50 = 2.6 nM	TI LI LO TS
CL000017	HeLa Cell Line Info	Homo sapiens (Human)	1
1	Activity = 8 nM	TI LI LO TS
CL000888	LNCaP-hr Cell Line Info	Homo sapiens (Human)	2
1	EC50 = 6.2 nM	TI LI LO TS
2	EC50 = 15 nM	TI LI LO TS
CL000284	MDA-MB-453 Cell Line Info	Homo sapiens (Human)	5
1	EC50 = 2 nM	TI LI LO TS
2	IC50 = 1 nM	TI LI LO TS
3	Ki = 0.2 nM	TI LI LO TS
4	Ki = 0.3 nM	TI LI LO TS
5	Ki = 0.9 nM	TI LI LO TS
CL000099	SaOS-2 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 0.05 nM	TI LI LO TS

Biochemical Assays

1	EC50 = 0.1 nM
2	EC50 = 0.14 nM
3	IC50 = 0.67 nM
4	IC50 = 10 nM
5	IC50 = 13.1 nM
6	IC50 = 18 nM
7	Kd = 0.25 nM
8	Ki = 0.2 nM
9	Ki = 2 nM
10	Ki = 4.7 nM
11	Ki = 10 nM

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han