General Information of the Protein
Protein ID
PT06163
Protein Name
Solute carrier organic anion transporter family member 1A3
Secondarily
Protein Name
OAT-K2
Sodium-independent organic anion transporter K1
Solute carrier family 21 member 4
rOAT-K
Gene Name
SLCO1A3
Secondarily
Gene Name
Oatp1a3
Slc21a4
Sequence
MGDLEKGAATHGAGCFAKIKVFLMALTCAYVSKSLSGTFMSSMLTQIERQFGIPTAIVGFINGSFEIGNLLLIIFVSYFGMKLHRPIVIGVGCAVMGLGCFIISLPHFLMGRYEYETTILPTSNLSSNSFLCMENQTQTLNPAQDPAECVKEVKSLMWIYVLVGNIIRGIGETPIMPLGVSYIENFAKSENSPLYIGILETGKMIGPIFGLLLGSFCASIYVDTGSVNTDDLTITPTDIRWVGAWWIGFLVCAGVNILISIPFFFFPKTLPKEGLQENVDGTENAKEESTEKRPRKKNRGITKDFFPFLKSPVLQPDLHAVHPYKVLQVNAFNIYFSFLPKYLENQYGKSTAEVIFLMGVYNLPAICIGYLIAGFMMKKFKITVKTAAFLAFCLSLSEYSFGFCNFLITCDNVPVAGLTNSYERDQKPLYLENNVLADCNTRCSCLTKTWDPVCGDNGLAYMSACLAGCEKSVGTGTNMVFHNCSCIQSPGNSSAVLGLCNKGPECTNKLQYLLILSGFLSILYSFAAIPGYMVFLRCIKSEEKSLGIGIHAFCIRVFAGIPAPIYFGALIDRTCLHWGTQKCGAPGACRMYDINSFRRIYLGMSAALRGSSYLPAFVIVILTRKFSLPGKINSSEMEIAEMKLTEKESQCTDVHRNPKFKNDGELKTKL
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Organism
Rattus norvegicus, Rat
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC21/SLCO family of organic anion transporting polypeptides
Function
Mediates the Na(+)-independent transport of organic anions such as methotrexate, taurocholate, folate and prostaglandin E2. May contribute to renal secretion and/or reabsorption of hydrophobic anionic compounds. Mediates renal clearance of methotrexate from the blood.
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Uniprot ID
Primary ID:
P70502

Secondarily ID:
Q8R008
Q8R4J0
Q8R4J1
Q8R4J2
Q8R4J3
Q8R4J4
Q8R4J5
Q8R4J6
Q8R4J7
Q8R4J8
Q8R4J9
Q8R4K0
Q8R4K1
Q9WTM0
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Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000031 , MDCK
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0053031
 Compound Info 
4-Aminofolic acid
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C19H20N8O5
  1
1
Ki = 500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0527008
 Compound Info 
LEVOMEFOLIC ACID
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C20H25N7O6
  1
1
Ki = 1200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0069691
 Compound Info 
CHEBI:15640
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C20H23N7O7
  1
1
Ki = 8200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0068879
 Compound Info 
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
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C19H19N7O6
  1
1
Ki = 14100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0741284
 Compound Info 
bromosulphophthalein
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C20H8Br4Na2O10S2
  1
1
Ki = 21000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0036197
 Compound Info 
2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid
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C20H22N8O5
  1
1
Km = 1800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0253768
 Compound Info 
[(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-oxo-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-yl] hydrogen sulfate
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C19H28O5S
  1
1
Km = 7600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0041554
 Compound Info 
Thyroxine
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C15H11I4NO4
  1
1
Km = 12000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0077615
 Compound Info 
3R14S-OCHRATOXIN A
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C20H18ClNO6
  1
1
Km = 16600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0026502
 Compound Info 
(2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid
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C15H12I3NO4
  1
1
Km = 24800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0216351
 Compound Info 
TAUROCHOLATE
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C26H45NO7S
  1
1
Km = 31100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0256501
 Compound Info 
17beta-Estradiol-17-(beta-D-glucuronide)
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C24H32O8
  1
1
Km = 44900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0041607
 Compound Info 
(AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
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C10H13N5O4
  1
1
Km = 76300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT06133 Solute carrier organic anion transporter family member 1A4 Rattus norvegicus, Rat
 Protein Info 
PT06135 Solute carrier organic anion transporter family member 1A1 Rattus norvegicus, Rat
 Protein Info 
PT06139 Solute carrier organic anion transporter family member 1A5 Rattus norvegicus, Rat
 Protein Info