General Information of the Protein
Protein ID
PT06135
Protein Name
Solute carrier organic anion transporter family member 1A1
Secondarily
Protein Name
Organic anion-transporting polypeptide 1
Sodium-independent organic anion transporter 1
Solute carrier family 21 member 1
Gene Name
SLCO1A1
Secondarily
Gene Name
Oatp1
Oatp1a1
Slc21a1
Sequence
MEETEKKIATQEGRLFSKMKVFLLSLTCACLTKSLSGVYMNSMLTQIERQFDISTSVAGLINGSFEIGNLFFIVFVSYFGTKLHRPVVIGIGCVIMGLGCLLMSLPHFFMGRYEYETTISPTGNLSSNSFLCMENRTQTLKPTQDPAECVKEMKSLMWICVMVGNIIRGIGETPIVPLGISYIEDFAKSENSPLYIGILEMGKVAGPIFGLLLGSYCAQIYVDIGSVNTDDLTITPSDTRWVGAWWIGFLVCAGVNILTSIPFFFLPKALPKKGQQENVAVTKDGKVEKYGGQAREENLGITKDFLTFMKRLFCNPIYMLFILTSVLQVNGFINKFTFLPKYLEQQYGKSTAEAIFLIGVYSLPPICLGYLIGGFIMKKFKITVKKAAYLAFCLSVFEYLLFLCHFMLTCDNAAVAGLTTSYKGVQHQLHVESKVLADCNTRCSCSTNTWDPVCGDNGVAYMSACLAGCKKFVGTGTNMVFQDCSCIQSLGNSSAVLGLCKKGPECANRLQYFLILTIIISFIYSLTAIPGYMVFLRCVKSEEKSLGVGLHTFCIRVFAGIPAPVYFGALIDRTCLHWGTLKCGQRGACRMYDINSFRHIYLGLPIALRGSSYLPAFFILILMRKFQFPGDIDSSATDHTEMMLGEKESEHTDVHGSPQVENDGELKTKL
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Organism
Rattus norvegicus, Rat
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC21/SLCO family of organic anion transporting polypeptides
Function
Mediates the Na(+)-independent transport of organic anions such as steroid sulfate conjugates (dehydroepiandrosterone sulfate (DHEAS), 17-beta-glucuronosyl estradiol, estrone-3-sulfate), conjugated (taurocholate) and unconjugated (cholate) bile acids, prostaglandin E2 (PGE2) and L-thyroxine T4 (PubMed:19129463). Also capable of transporting sulfobromophthalein (BSP), ouabain and gadoxetate (By similarity). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463).
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Uniprot ID
P46720
Subcellular Location
Basolateral cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL001012 , CHO-03
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0741284
 Compound Info 
bromosulphophthalein
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C20H8Br4Na2O10S2
  1
1
Km = 3000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0256501
 Compound Info 
17beta-Estradiol-17-(beta-D-glucuronide)
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C24H32O8
  1
1
Km = 4000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0253768
 Compound Info 
[(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-oxo-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-yl] hydrogen sulfate
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C19H28O5S
  1
1
Km = 5000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0286675
 Compound Info 
2-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid
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C26H45NO6S
  1
1
Km = 7000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0127632
 Compound Info 
ESTRONE
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C18H22O5S
  1
1
Km = 11000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0375715
 Compound Info 
2-((R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethanesulfonic acid
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C26H45NO6S
  1
1
Km = 13000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0077615
 Compound Info 
3R14S-OCHRATOXIN A
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C20H18ClNO6
  1
1
Km = 29000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0397440
 Compound Info 
2-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]acetic acid
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C26H43NO6
  1
1
Km = 54000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0870535
 Compound Info 
CRC-220
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C29H39N5O7S
  1
1
Km = 57000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0081887
 Compound Info 
4-((1R,3S,5S,8R,10R,11R,13R,14S,17R)-1,5,11,14-tetrahydroxy-10-(hydroxymethyl)-13-methyl-3-((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro-2H-pyran-2-yloxy)-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-one
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C29H44O12
  1
1
Km = 3000000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000017 , HeLa
 Cell Line Info 
Cell Line ID: CL000009 , LLC-PK1
 Cell Line Info 
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT06133 Solute carrier organic anion transporter family member 1A4 Rattus norvegicus, Rat
 Protein Info 
PT06139 Solute carrier organic anion transporter family member 1A5 Rattus norvegicus, Rat
 Protein Info 
PT06163 Solute carrier organic anion transporter family member 1A3 Rattus norvegicus, Rat
 Protein Info