General Information of the Protein
Protein ID
PT04787
Protein Name
Protein-serine O-palmitoleoyltransferase porcupine
Gene Name
PORCN
Secondarily
Gene Name
Porc
Ppn
Sequence
MATFSRQEFFQQLLQGCLLPTVQQGLDQIWLLLTICFACRLLWRLGLPSYLKHASTVAGGFFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTWHKMRGAQMIVAMKAVSLGFDLDRGEVGAVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAVQGRPLSRRWLKKVARSLALALLCLVLSTCVGPYLFPYFIPLDGDRLLRNKKRKARGTMVRWLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSRPLNVELPRSMVEVVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYVEHVLRKRLAQILSACILSKRCLPDCSHRHRLGLGVRALNLLFGALAIFHLSYLGSLFDVDVDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
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Organism
Mus musculus, Mouse
Protein Classification
Enzyme
>
Transferase
Function
Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors.
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Uniprot ID
Primary ID:
Q9JJJ7

Secondarily ID:
A2AC30
A2AC32
A2AC33
Q9CWT0
Q9JJJ8
Q9JJJ9
Q9JJK0
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Ensembl ID
ENSG00000102312
Subcellular Location
Endoplasmic reticulum membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0429492
 Compound Info 
N-[[5-fluoro-6-(2-methylpyridin-4-yl)pyridin-3-yl]methyl]-9H-carbazole-2-carboxamide
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C25H19FN4O
  1
1
IC50 = 0.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0540691
 Compound Info 
N-[[5-cyano-6-(2-methylpyridin-4-yl)pyridin-3-yl]methyl]-9H-carbazole-2-carboxamide
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C26H19N5O
  1
1
IC50 = 0.72 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0414749
 Compound Info 
CHEBI:78030
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C23H20N6O
  1
1
IC50 = 0.9 nM
 Bioactivity Info 
   TI
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CP0465107
 Compound Info 
N-[[4-(2-methylpyridin-4-yl)phenyl]methyl]-4-phenylbenzamide
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C26H22N2O
  1
1
IC50 = 1 nM
 Bioactivity Info 
   TI
   LI
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CP0476085
 Compound Info 
N-[[5-methoxy-6-(2-methylpyridin-4-yl)pyridin-3-yl]methyl]-9H-carbazole-2-carboxamide
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C26H22N4O2
  1
1
IC50 = 1.9 nM
 Bioactivity Info 
   TI
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CP0516013
 Compound Info 
N-[[5-fluoro-6-(2-methylpyridin-4-yl)pyridin-3-yl]methyl]dibenzofuran-3-carboxamide
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C25H18FN3O2
  2
1
IC50 = 2.1 nM
 Bioactivity Info 
   TI
   LI
   LO
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2
IC50 = 3.1 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0562446
 Compound Info 
N-[[6-(2-methylpyridin-4-yl)pyridin-3-yl]methyl]-9H-carbazole-2-carboxamide
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C25H20N4O
  1
1
IC50 = 6.2 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0429494
 Compound Info 
N-[[5-fluoro-6-(2-methylpyridin-4-yl)pyridin-3-yl]methyl]-9H-fluorene-2-carboxamide
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C26H20FN3O
  2
1
IC50 = 6.5 nM
 Bioactivity Info 
   TI
   LI
   LO
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2
IC50 = 9.2 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0465105
 Compound Info 
N-[[4-(2-methylpyridin-4-yl)phenyl]methyl]-9H-carbazole-2-carboxamide
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C26H21N3O
  1
1
IC50 = 7.5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0516047
 Compound Info 
N-[[4-(2-methylpyridin-4-yl)phenyl]methyl]dibenzofuran-3-carboxamide
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C26H20N2O2
  1
1
IC50 = 9.1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0465106
 Compound Info 
N-[[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]methyl]-9H-carbazole-2-carboxamide
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C26H22N4O
  1
1
IC50 = 10 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0396365
 Compound Info 
N-[(6-cyanonaphthalen-2-yl)methyl]-9H-carbazole-2-carboxamide
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C25H17N3O
  1
1
IC50 = 13 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0519646
 Compound Info 
9,9-difluoro-N-[[5-fluoro-6-(2-methylpyridin-4-yl)pyridin-3-yl]methyl]fluorene-2-carboxamide
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C26H18F3N3O
  1
1
IC50 = 16 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0566604
 Compound Info 
N-[[5-(2-methylpyridin-4-yl)pyridin-2-yl]methyl]-9H-carbazole-2-carboxamide
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C25H20N4O
  1
1
IC50 = 18 nM
 Bioactivity Info 
   TI
   LI
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CP0566605
 Compound Info 
N-[(4-pyridin-4-ylphenyl)methyl]-9H-carbazole-2-carboxamide
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C25H19N3O
  1
1
IC50 = 18 nM
 Bioactivity Info 
   TI
   LI
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CP0529391
 Compound Info 
N-[[4-(2-methylpyridin-4-yl)phenyl]methyl]-9H-fluorene-2-carboxamide
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C27H22N2O
  1
1
IC50 = 35 nM
 Bioactivity Info 
   TI
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CP0538592
 Compound Info 
N-[[5-fluoro-6-(2-methylpyridin-4-yl)pyridin-3-yl]methyl]-9-oxofluorene-2-carboxamide
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C26H18FN3O2
  1
1
IC50 = 44 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0566606
 Compound Info 
9,9-difluoro-N-[[4-(2-methylpyridin-4-yl)phenyl]methyl]fluorene-2-carboxamide
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C27H20F2N2O
  1
1
IC50 = 60 nM
 Bioactivity Info 
   TI
   LI
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   TS
CP0530881
 Compound Info 
N-[[4-(2-methylpyridin-4-yl)phenyl]methyl]-9-oxofluorene-2-carboxamide
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C27H20N2O2
  1
1
IC50 = 85 nM
 Bioactivity Info 
   TI
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CP0511804
 Compound Info 
N-[[4-(4-methylimidazol-1-yl)phenyl]methyl]-9H-carbazole-2-carboxamide
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C24H20N4O
  1
1
IC50 = 119 nM
 Bioactivity Info 
   TI
   LI
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CP0396366
 Compound Info 
N-[[4-(2-methylpyrazol-3-yl)phenyl]methyl]-9H-carbazole-2-carboxamide
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C24H20N4O
  1
1
IC50 = 130 nM
 Bioactivity Info 
   TI
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CP0530880
 Compound Info 
N-[[5-fluoro-6-(2-methylpyridin-4-yl)pyridin-3-yl]methyl]-9-methylcarbazole-2-carboxamide
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C26H21FN4O
  1
1
IC50 = 175 nM
 Bioactivity Info 
   TI
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CP0562445
 Compound Info 
N-(isoquinolin-6-ylmethyl)-9H-carbazole-2-carboxamide
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C23H17N3O
  1
1
IC50 = 207 nM
 Bioactivity Info 
   TI
   LI
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CP0538593
 Compound Info 
N-[(4-imidazol-1-ylphenyl)methyl]-9H-carbazole-2-carboxamide
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C23H18N4O
  1
1
IC50 = 314 nM
 Bioactivity Info 
   TI
   LI
   LO
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CP0555807
 Compound Info 
N-(dibenzofuran-3-ylmethyl)-4-pyrazin-2-ylbenzamide
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C24H17N3O2
  1
1
IC50 = 701 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0396367
 Compound Info 
N-(9H-fluoren-2-ylmethyl)-4-phenylbenzamide
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C27H21NO
  1
1
IC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
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CP0514718
 Compound Info 
N-(9H-fluoren-2-ylmethyl)-4-pyrazin-2-ylbenzamide
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C25H19N3O
  1
1
IC50 > 1000 nM
 Bioactivity Info 
   TI
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CP0562447
 Compound Info 
9-methyl-N-[[4-(2-methylpyridin-4-yl)phenyl]methyl]carbazole-2-carboxamide
   Show/Hide
C27H23N3O
  1
1
IC50 > 1000 nM
 Bioactivity Info 
   TI
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   TS
Cell Line ID: CL000309 , NCTC clone 929
 Cell Line Info 
Cell Line ID: CL000633 , TM3
 Cell Line Info 
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT04895 Protein-serine O-palmitoleoyltransferase porcupine Homo sapiens, Human
 Protein Info