Brief Information of the Cell Line and Protein
Cell Line ID: CL000633 , TM3
Synonyms
TM-3
Category Spontaneously immortalized cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_4326
Protein ID: PT04787 , Protein-serine O-palmitoleoyltransferase porcupine
Gene Name PORCN
Organism Mus musculus, Mouse
Protein Classification Enzyme
Uniprot ID Q9JJJ7
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000633  Protein ID: PT04787
 
Compound ID Compound Name Compound Formula
CP0477312
US10251893, Cpd 166
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C25H28N6O3
 1
1
IC50 = 0.1 nM
   TI
   LI
   LO
   TS
CP0434388
US10251893, Cpd 50
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C26H22N2O
 1
1
IC50 = 0.2 nM
   TI
   LI
   LO
   TS
CP0537044
US10251893, Cpd 51
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C24H20N4O
 1
1
IC50 = 0.2 nM
   TI
   LI
   LO
   TS
CP0565072
2-(2'-fluoro-3-methyl-2,4'-bipyridin-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide
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C22H17FN6O
 1
1
IC50 = 0.2 nM
   TI
   LI
   LO
   TS
CP0414749
CHEBI:78030
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C23H20N6O
 1
1
IC50 = 0.4 nM
   TI
   LI
   LO
   TS
CP0469782
US10251893, Cpd 128
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C22H18N6O
 1
1
IC50 = 0.4 nM
   TI
   LI
   LO
   TS
CP0551174
N-(2,3'-bipyridin-6'-yl)-2-(2',3-dimethyl-2,4'-bipyridin-5-yl)acetamide
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C24H21N5O
 1
1
IC50 = 0.4 nM
   TI
   LI
   LO
   TS
CP0434386
US10251893, Cpd 126
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C23H19N5O
 1
1
IC50 = 0.5 nM
   TI
   LI
   LO
   TS
CP0551176
US10251893, Cpd 6
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C22H19N3O2S
 1
1
IC50 = 0.5 nM
   TI
   LI
   LO
   TS
CP0478528
N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(2',3-dimethyl-2,4'-bipyridin-5-yl)acetamide
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C25H28N6O2
 1
1
IC50 = 0.7 nM
   TI
   LI
   LO
   TS
CP0574616
2-(4-(2-methylpyridin-4-yl)phenyl)-N-(5-phenylpyridin-2-yl)acetamide
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C25H21N3O
 1
1
IC50 = 0.7 nM
   TI
   LI
   LO
   TS
CP0157632
N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(2'-fluoro-3-methyl-2,4'-bipyridin-5-yl)acetamide
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C24H25FN6O2
 1
1
IC50 = 0.8 nM
   TI
   LI
   LO
   TS
CP0575168
N-(6-methoxybenzo [d]thiazol-2-yl)-2-(4-(pyridin-4-yl)phenyl)acetamide
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C21H17N3O2S
 1
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
CP0551175
N-(4-phenyl-1,3-thiazol-2-yl)-2-(4-pyridin-4-ylphenyl)acetamide
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C22H17N3OS
 1
1
IC50 = 5.5 nM
   TI
   LI
   LO
   TS
CP0578966
N-(6-methoxy-1,3-benzothiazol-2-yl)-2-[(4-propyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide
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C20H20N6O2S2
 1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0434385
2-[6-(2-fluoropyridin-4-yl)-5-methylpyridin-3-yl]-N-(5-piperazin-1-ylpyridin-2-yl)acetamide
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C22H23FN6O
 1
1
IC50 = 24 nM
   TI
   LI
   LO
   TS
CP0549892
2-[6-[2-(hydroxymethyl)pyridin-4-yl]-5-methylpyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide
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C23H20N6O2
 1
1
IC50 = 26 nM
   TI
   LI
   LO
   TS
CP0477313
US10251893, Cpd 62
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C22H19N3O2S
 1
1
IC50 = 189 nM
   TI
   LI
   LO
   TS
CP0434390
6-methoxy-N-[(4-pyridin-4-ylphenyl)methyl]-1,3-benzothiazole-2-carboxamide
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C21H17N3O2S
 1
1
IC50 = 380 nM
   TI
   LI
   LO
   TS
CP0574617
N-(6-methoxy-1,3-benzothiazol-2-yl)-2-(4-pyridin-3-ylphenyl)acetamide
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C21H17N3O2S
 1
1
IC50 = 771 nM
   TI
   LI
   LO
   TS
CP0469783
[4-(2-methylpyridin-4-yl)phenyl] N-(4-phenylphenyl)carbamate
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C25H20N2O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0537046
1-[4-(2-methylpyridin-4-yl)phenyl]-3-(4-phenylphenyl)urea
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C25H21N3O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS