General Information of the Cell Line
Cell Line ID
CL000633
Cell Line Name
TM3
Synonyms
TM-3
Category
Spontaneously immortalized cell line
Organism
Mus musculus (Mouse)
Cellosaurus ID
CVCL_4326
Tissue Information
Testis
Disease None
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT02397, Protein smoothened
Compound ID Compound Name Compound Formula
CP0392338
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-6-[(2R)-2-methylmorpholin-4-yl]isoquinolin-1-amine
   Show/Hide
C29H26ClN5O
 2
1
IC50 = 0.1 nM
   TI
   LI
   LO
   TS
2
IC50 = 1.6 nM
   TI
   LI
   LO
   TS
CP0449700
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]isoquinolin-1-amine
   Show/Hide
C30H28ClN5O
 2
1
IC50 = 0.1 nM
   TI
   LI
   LO
   TS
2
IC50 = 3 nM
   TI
   LI
   LO
   TS
CP0486918
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-6-morpholin-4-ylisoquinolin-1-amine
   Show/Hide
C28H24ClN5O
 2
1
IC50 = 0.1 nM
   TI
   LI
   LO
   TS
2
IC50 = 2.6 nM
   TI
   LI
   LO
   TS
CP0392333
N-[4-methyl-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-4-morpholin-4-ylbenzamide
   Show/Hide
C27H26N4O2
 1
1
IC50 = 0.2 nM
   TI
   LI
   LO
   TS
CP0392341
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-1,6-naphthyridin-5-amine
   Show/Hide
C29H27ClN6O
 2
1
IC50 = 0.2 nM
   TI
   LI
   LO
   TS
2
IC50 = 6 nM
   TI
   LI
   LO
   TS
CP0449699
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]quinolin-5-amine
   Show/Hide
C30H28ClN5O
 2
1
IC50 = 0.3 nM
   TI
   LI
   LO
   TS
2
IC50 = 5 nM
   TI
   LI
   LO
   TS
CP0507774
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-7-[(2R,6S)-2,6-dimethylmorpholin-4-yl]quinolin-4-amine
   Show/Hide
C30H28ClN5O
 2
1
IC50 = 0.4 nM
   TI
   LI
   LO
   TS
2
IC50 = 8 nM
   TI
   LI
   LO
   TS
CP0392339
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-6-piperidin-1-ylisoquinolin-1-amine
   Show/Hide
C29H26ClN5
 2
1
IC50 = 0.6 nM
   TI
   LI
   LO
   TS
2
IC50 = 12 nM
   TI
   LI
   LO
   TS
CP0392340
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-2-[(2R)-2-methylmorpholin-4-yl]-1,6-naphthyridin-5-amine
   Show/Hide
C28H25ClN6O
 2
1
IC50 = 0.6 nM
   TI
   LI
   LO
   TS
2
IC50 = 11 nM
   TI
   LI
   LO
   TS
CP0544458
3,5-dimethoxy-N-[4-methyl-3-(5-phenyl-1H-imidazol-2-yl)phenyl]benzamide
   Show/Hide
C25H23N3O3
 1
1
IC50 = 0.6 nM
   TI
   LI
   LO
   TS
CP0455389
1-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]pyridin-3-yl}1-methylethylamine
   Show/Hide
C27H30N6
 2
1
IC50 = 1.3 nM
   TI
   LI
   LO
   TS
2
IC50 = 42 nM
   TI
   LI
   LO
   TS
CP0449701
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-6-(1,1-dioxo-1,4-thiazinan-4-yl)isoquinolin-1-amine
   Show/Hide
C28H24ClN5O2S
 2
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
2
IC50 = 31 nM
   TI
   LI
   LO
   TS
CP0472123
2-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]pyridin-3-yl}propan-2-ol
   Show/Hide
C27H29N5O
 2
1
IC50 = 2.7 nM
   TI
   LI
   LO
   TS
2
IC50 = 35 nM
   TI
   LI
   LO
   TS
CP0375008
N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide
   Show/Hide
C24H23ClN4O3
 1
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
CP0486916
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]quinoxalin-5-amine
   Show/Hide
C29H27ClN6O
 2
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
2
IC50 = 35 nM
   TI
   LI
   LO
   TS
CP0374378
1-[6-[4-(4-benzylphthalazin-1-yl)piperazin-1-yl]pyridin-3-yl]-N,N-dimethylmethanamine
   Show/Hide
C27H30N6
 2
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
2
IC50 = 246 nM
   TI
   LI
   LO
   TS
CP0452552
(+/-)-2-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]pyridin-3-yl}propane-1,2-diol
   Show/Hide
C27H29N5O2
 2
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
2
IC50 = 136 nM
   TI
   LI
   LO
   TS
CP0486917
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]isoquinolin-1-amine
   Show/Hide
C24H17ClN4
 2
1
IC50 = 19 nM
   TI
   LI
   LO
   TS
2
IC50 = 157 nM
   TI
   LI
   LO
   TS
CP0457490
6-{4-[4-(4-Cyanobenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile
   Show/Hide
C26H21N7
 2
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
2
IC50 = 256 nM
   TI
   LI
   LO
   TS
CP0455398
6-[(S)-4-(4-Benzylphthalazin-1-yl)-3-methylpiperazin-1-yl]nicotinonitrile
   Show/Hide
C26H24N6
 2
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
2
IC50 = 210 nM
   TI
   LI
   LO
   TS
CP0498345
6-[(R)-4-(4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitrile
   Show/Hide
C26H24N6
 2
1
IC50 = 30 nM
   TI
   LI
   LO
   TS
2
IC50 = 244 nM
   TI
   LI
   LO
   TS
CP0452554
N-[[6-[4-(4-benzylphthalazin-1-yl)piperazin-1-yl]pyridin-3-yl]methyl]acetamide
   Show/Hide
C27H28N6O
 2
1
IC50 = 35 nM
   TI
   LI
   LO
   TS
2
IC50 = 327 nM
   TI
   LI
   LO
   TS
CP0397016
1-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]pyridin-3-yl}ethanol
   Show/Hide
C26H27N5O
 2
1
IC50 = 38 nM
   TI
   LI
   LO
   TS
2
IC50 = 222 nM
   TI
   LI
   LO
   TS
CP0497373
6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]nicotinamide
   Show/Hide
C25H24N6O
 2
1
IC50 = 46 nM
   TI
   LI
   LO
   TS
2
IC50 = 149 nM
   TI
   LI
   LO
   TS
CP0502393
6-{4-[4-(4-Chlorobenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile
   Show/Hide
C25H21ClN6
 2
1
IC50 = 48 nM
   TI
   LI
   LO
   TS
2
IC50 = 498 nM
   TI
   LI
   LO
   TS
CP0497372
1-{6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]pyridin-3-yl}cyclopropanol
   Show/Hide
C27H27N5O
 2
1
IC50 = 55 nM
   TI
   LI
   LO
   TS
2
IC50 = 345 nM
   TI
   LI
   LO
   TS
CP0457488
6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]nicotinonitrile
   Show/Hide
C25H22N6
 2
1
IC50 = 69 nM
   TI
   LI
   LO
   TS
2
IC50 = 821 nM
   TI
   LI
   LO
   TS
CP0422210
6-[(S)-4-(4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitrile
   Show/Hide
C26H24N6
 2
1
IC50 = 79 nM
   TI
   LI
   LO
   TS
2
IC50 = 735 nM
   TI
   LI
   LO
   TS
CP0387837
6-[(R)-4-(4-Benzylphthalazin-1-yl)-3-methylpiperazin-1-yl]nicotinonitrile
   Show/Hide
C26H24N6
 2
1
IC50 = 86 nM
   TI
   LI
   LO
   TS
2
IC50 = 738 nM
   TI
   LI
   LO
   TS
CP0457489
6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]pyridine-3-sulfonicAcid Amide
   Show/Hide
C24H24N6O2S
 2
1
IC50 = 104 nM
   TI
   LI
   LO
   TS
2
IC50 = 919 nM
   TI
   LI
   LO
   TS
CP0422211
6-{4-[4-(4-Fluorobenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile
   Show/Hide
C25H21FN6
 2
1
IC50 = 112 nM
   TI
   LI
   LO
   TS
2
IC50 = 975 nM
   TI
   LI
   LO
   TS
CP0452558
6-{4-[4-(3-Chlorobenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile
   Show/Hide
C25H21ClN6
 2
1
IC50 = 112 nM
   TI
   LI
   LO
   TS
2
IC50 = 693 nM
   TI
   LI
   LO
   TS
CP0387836
1-Benzyl-4-[4-(5-trifluoromethylpyridin-2-yl)piperazin-1-yl]phthalazine
   Show/Hide
C25H22F3N5
 2
1
IC50 = 134 nM
   TI
   LI
   LO
   TS
2
IC50 = 1327 nM
   TI
   LI
   LO
   TS
CP0474046
6-[4-(4-Benzylphthalazin-1-yl)[1,4]diazepan-1-yl]nicotinonitrile
   Show/Hide
C26H24N6
 2
1
IC50 = 210 nM
   TI
   LI
   LO
   TS
2
IC50 = 1632 nM
   TI
   LI
   LO
   TS
CP0374376
7-Benzyl-4-[4-(5-trifluoromethylpyridin-2-yl)piperazin-1-yl]furo[2,3-d]pyridazine
   Show/Hide
C23H20F3N5O
 2
1
IC50 = 212 nM
   TI
   LI
   LO
   TS
2
IC50 = 2560 nM
   TI
   LI
   LO
   TS
CP0452555
1-Benzyl-4-(4-pyridin-2-yl-piperazin-1-yl)phthalazine
   Show/Hide
C24H23N5
 2
1
IC50 = 258 nM
   TI
   LI
   LO
   TS
2
IC50 = 772 nM
   TI
   LI
   LO
   TS
CP0407677
4-{4-[4-(5-Cyanopyridin-2-yl)piperazin-1-yl]phthalazin-1-ylmethyl}benzoic Acid Methyl Ester
   Show/Hide
C27H24N6O2
 2
1
IC50 = 265 nM
   TI
   LI
   LO
   TS
2
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0374377
6-{4-[4-(4-Trifluoromethylbenzyl)phthalazin-1-yl]piperazin-1-yl}nicotinonitrile
   Show/Hide
C26H21F3N6
 2
1
IC50 = 366 nM
   TI
   LI
   LO
   TS
2
IC50 = 1239 nM
   TI
   LI
   LO
   TS
CP0457491
[6-[4-(4-benzylphthalazin-1-yl)piperazin-1-yl]pyridin-3-yl]methanol
   Show/Hide
C25H25N5O
 2
1
IC50 = 374 nM
   TI
   LI
   LO
   TS
2
IC50 = 2448 nM
   TI
   LI
   LO
   TS
CP0498346
4-(1-Benzyl-1H-indol-3-yl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-carbonitrile
   Show/Hide
C26H24N4
 2
1
IC50 = 382 nM
   TI
   LI
   LO
   TS
2
IC50 = 1507 nM
   TI
   LI
   LO
   TS
CP0428583
1-Benzyl-4-(4-phenylpiperazin-1-yl)phthalazine
   Show/Hide
C25H24N4
 2
1
IC50 = 414 nM
   TI
   LI
   LO
   TS
2
IC50 = 2246 nM
   TI
   LI
   LO
   TS
CP0428584
1-Pyridin-4-ylmethyl-4-(4-pyridin-2-ylpiperazin-1-yl)phthalazine
   Show/Hide
C23H22N6
 2
1
IC50 = 690 nM
   TI
   LI
   LO
   TS
2
IC50 = 4493 nM
   TI
   LI
   LO
   TS
CP0397039
7-Benzyl-4-[4-(5-trifluoromethylpyridin-2-yl)piperazin-1-yl]-1Himidazo[4,5-d]pyridazine
   Show/Hide
C22H20F3N7
 2
1
IC50 = 724 nM
   TI
   LI
   LO
   TS
2
IC50 = 1549 nM
   TI
   LI
   LO
   TS
CP0455276
6-[4-(1-Benzylisoquinolin-4-yl)piperazin-1-yl]nicotinonitrile
   Show/Hide
C26H23N5
 2
1
IC50 = 910 nM
   TI
   LI
   LO
   TS
2
IC50 = 2500 nM
   TI
   LI
   LO
   TS
CP0431427
6-[4-(4-Benzylisoquinolin-1-yl)piperazin-1-yl]nicotinonitrile
   Show/Hide
C26H23N5
 2
1
IC50 = 1427 nM
   TI
   LI
   LO
   TS
2
IC50 = 2987 nM
   TI
   LI
   LO
   TS
CP0387801
4-Benzyl-7-[4-(5-trifluoromethylpyridin-2-yl)piperazin-1-yl]furo[2,3-d]pyridazine
   Show/Hide
C23H20F3N5O
 2
1
IC50 = 1798 nM
   TI
   LI
   LO
   TS
2
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0387803
6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]nicotinic Acid
   Show/Hide
C25H23N5O2
 2
1
IC50 = 2665 nM
   TI
   LI
   LO
   TS
2
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0397036
4-[1-(4-Benzylphthalazin-1-yl)piperidin-4-yl]benzonitrile
   Show/Hide
C27H24N4
 2
1
IC50 = 3776 nM
   TI
   LI
   LO
   TS
2
IC50 > 5000 nM
   TI
   LI
   LO
   TS
CP0387805
4-{4-[4-(5-Cyanopyridin-2-yl)piperazin-1-yl]phthalazin-1-ylmethyl}benzoic Acid
   Show/Hide
C26H22N6O2
 1
1
IC50 > 5000 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Testis)
Cell Line Name Organism Disease
MA-10 Mus musculus (Mouse) Mouse Leydig cell tumor
MLTC-1 Mus musculus (Mouse) Mouse Leydig cell tumor
HEP Homo sapiens (Human) -
HepTAT Homo sapiens (Human) -