Brief Information of the Compound and Protein
Compound Name
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-6-(1,1-dioxo-1,4-thiazinan-4-yl)isoquinolin-1-amine
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PubChem ID
CID: 71451512
Canonical SMILES
Clc1ccc(Nc2nccc3cc(ccc23)N2CCS(=O)(=O)CC2)cc1-c1nc(c[nH]1)-c1ccccc1
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Compound Formula C28H24ClN5O2S
Compound Structure
Protein Name
Protein smoothened
Protein Classification
Membrane receptor
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Frizzled family G protein-coupled receptor
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Smoothened receptor (frizzled family GPCR)
Uniprot ID
P56726
Gene Name
SMO
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000633 TM3 Mus musculus (Mouse)  2
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
2
IC50 = 31 nM
   TI
   LI
   LO
   TS