Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-2-[(2R)-2-methylmorpholin-4-yl]-1,6-naphthyridin-5-amine
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 PubChem ID
CID: 49840814
SID: 104167406
Canonical SMILES
C[C@@H]1CN(CCO1)c1ccc2c(Nc3ccc(Cl)c(c3)-c3nc(c[nH]3)-c3ccccc3)nccc2n1
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Compound Formula C28H25ClN6O
Compound Structure
Protein Name
 Protein Info 
Protein smoothened
Protein Classification
Membrane receptor
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Frizzled family G protein-coupled receptor
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Smoothened receptor (frizzled family GPCR)
Uniprot ID
P56726
Gene Name
SMO
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 1.6 nM
   TI
   LI
   LO
   TS
CL000633 TM3
 Cell Line Info 
Mus musculus (Mouse)  2
1
IC50 = 0.6 nM
   TI
   LI
   LO
   TS
2
IC50 = 11 nM
   TI
   LI
   LO
   TS