Protein Information

General Information of the Protein

Protein ID	PT04406
Protein Name	Neuropeptide FF receptor 1
Secondarily Protein Name	G-protein coupled receptor 147 RFamide-related peptide receptor OT7T022
Gene Name	NPFFR1
Secondarily Gene Name	GPR147 NPFF1
Sequence	MEGEPSQPPNSSWPLSQNGTNTEATPATNLTFSSYYQHTSPVAAMFIVAYALIFLLCMVGNTLVCFIVLKNRHMHTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSVSASVFTLVAIAVERFRCIVHPFREKLTLRKALVTIAVIWALALLIMCPSAVTLTVTREEHHFMVDARNRSYPLYSCWEAWPEKGMRRVYTTVLFSHIYLAPLALIVVMYARIARKLCQAPGPAPGGEEAADPRASRRRARVVHMLVMVALFFTLSWLPLWALLLLIDYGQLSAPQLHLVTVYAFPFAHWLAFFNSSANPIIYGYFNENFRRGFQAAFRARLCPRPSGSHKEAYSERPGGLLHRRVFVVVRPSDSGLPSESGPSSGAPRPGRLPLRNGRVAHHGLPREGPGCSHLPLTIPAWDI Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Peptide receptor (family A GPCR) > Short peptide receptor (family A GPCR) > RF amide receptor
Function	Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Show/Hide
Uniprot ID	Primary ID: Q9GZQ6 Secondarily ID: A2RRF0 Q8NGR0 Q96RN3 Show/Hide
Ensembl ID	ENSG00000148734
HGNC ID	HGNC:17425
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000109 , COS-1

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0110442 Compound Info	L-Val-L-Pro-L-Asn-L-Leu-L-Pro-L-Gln-L-Arg-L-Phe-NH2 Show/Hide	C45H72N14O10	1
1	EC50 = 1.7 nM Bioactivity Info	TI LI LO TS
CP0179651 Compound Info	Adamantane-1-carboxylic acid [(S)-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-4-guanidino-butyl]-amide Show/Hide	C26H38N6O3	1
1	EC50 = 71 nM Bioactivity Info	TI LI LO TS
CP0874222 Compound Info	2-(3,4-dibromobenzylidene)hydrazinecarboximidamide Show/Hide	C8H8Br2N4	1
1	EC50 = 527 nM Bioactivity Info	TI LI LO TS
CP0860641 Compound Info	2-(4-chloro-3-(trifluoromethyl)benzylidene)hydrazinecarboximidamide Show/Hide	C9H8ClF3N4	1
1	EC50 = 2370 nM Bioactivity Info	TI LI LO TS
CP0877733 Compound Info	2-((5-(4-bromo-2-(trifluoromethyl)phenyl)furan-2-yl)methylene)hydrazinecarboximidamide Show/Hide	C13H10BrF3N4O	1
1	EC50 = 5624 nM Bioactivity Info	TI LI LO TS
CP0084655 Compound Info	(R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hydroxybenzyl)pentanamide Show/Hide	C27H31N5O3	1
1	Kd = 20.89 nM Bioactivity Info	TI LI LO TS
CP0860640 Compound Info	1-[1-adamantylmethyleneamino]guanidine Show/Hide	C12H20N4	1
1	Kd = 41.69 nM Bioactivity Info	TI LI LO TS

Cell Line Info

Cell Line Info

Cell Line Info

Cell Line Info

Cell Line Info

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0089248 Compound Info	(2S)-2-[[(2S)-1-[(2S)-5-amino-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-amino-3-(4-hydroxyphenyl)propanoyl]-methylamino]-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pentanediamide Show/Hide	C55H78N14O11	1
1	EC50 = 71 nM
CP0229463 Compound Info	2-[(E)-(3,4-dibromophenyl)methylideneamino]guanidine;hydrochloride Show/Hide	C8H9Br2ClN4	1
1	Ki = 100 nM

Clinical Information about the Protein

Target 1 ( Neuropeptide FF receptor 1 (NPFFR1) )

Target Type	Literature-reported Target

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT05783	Neuropeptide FF receptor 1	Rattus norvegicus, Rat	Protein Info