Protein Information

General Information of the Protein

Protein ID	PT03075
Protein Name	Signal transducer and activator of transcription 1-alpha/beta
Gene Name	PDE9A
Sequence	MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Phosphodiesterase > Phosphodiesterase 9 > Phosphodiesterase 9A
Function	Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity). Show/Hide
Uniprot ID	Primary ID: O76083 Secondarily ID: B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 Show/Hide
Ensembl ID	ENSG00000160191
HGNC ID	HGNC:8795
Subcellular Location	Cell projection Ruffle membrane Cytoplasm Perinuclear region Golgi apparatus Endoplasmic reticulum Cell membrane Sarcolemma

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000013 , Sf9

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0398541 Compound Info	6-benzyl-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C17H18N4O	1
1	IC50 = 0.8 nM Bioactivity Info	TI LI LO TS
CP0271210 Compound Info	6-[(3S,4S)-1-[(4-fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C22H26FN5O2	1
1	IC50 = 0.9 nM Bioactivity Info	TI LI LO TS
CP0487996 Compound Info	6-benzyl-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C17H18N4O2	1
1	IC50 = 1 nM Bioactivity Info	TI LI LO TS
CP0486716 Compound Info	6-[(3S,4S)-1-[(3-fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C22H26FN5O2	1
1	IC50 = 1.2 nM Bioactivity Info	TI LI LO TS
CP0487995 Compound Info	6-[(3S,4S)-1-benzyl-4-ethylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C23H29N5O2	1
1	IC50 = 1.7 nM Bioactivity Info	TI LI LO TS
CP0958208 Compound Info	6-{1-[3-(quinoxalin-2-yloxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C23H25N7O3	1
1	IC50 = 2.94 nM Bioactivity Info	TI LI LO TS
CP0578902 Compound Info	6-[2-(2,3-dihydroindol-1-yl)-2-oxoethyl]-4-(4-methylphenyl)-2-oxo-8-propyl-1,5,7,8-tetrahydro-1,6-naphthyridine-3-carbonitrile Show/Hide	C29H30N4O2	1
1	IC50 = 3 nM Bioactivity Info	TI LI LO TS
CP0486714 Compound Info	6-[(3S,4S)-1-[(4-methoxyphenyl)methyl]-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C23H29N5O3	1
1	IC50 = 3.4 nM Bioactivity Info	TI LI LO TS
CP0441922 Compound Info	6-[(3S,4S)-4-methyl-1-[(6-methylpyridin-3-yl)methyl]pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C22H28N6O2	1
1	IC50 = 3.8 nM Bioactivity Info	TI LI LO TS
CP0958209 Compound Info	1-cyclopentyl-6-(1-{3-[(4,6-dimethylpyrimidin-2-yl)oxy]azetidin-1-yl}ethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C21H27N7O2	1
1	IC50 = 3.81 nM Bioactivity Info	TI LI LO TS
CP0875593 Compound Info	6-(1-{3-[(3-methylquinoxalin-2-yl)oxy]azetidin-1-yl}ethyl)-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-, 4-one Show/Hide	C24H27N7O3	1
1	IC50 = 4.56 nM Bioactivity Info	TI LI LO TS
CP0078267 Compound Info	6-[(3S,4S)-4-methyl-1-[(2-methylpyrimidin-5-yl)methyl]pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C21H27N7O2	1
1	IC50 = 4.6 nM Bioactivity Info	TI LI LO TS
CP0543310 Compound Info	6-[(3S,4S)-1-[(2-fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C22H26FN5O2	1
1	IC50 = 4.6 nM Bioactivity Info	TI LI LO TS
CP0841616 Compound Info	6-{1-[3-(phthalazin-1-yloxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C23H25N7O3	1
1	IC50 = 4.63 nM Bioactivity Info	TI LI LO TS
CP0476999 Compound Info	6-[(3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C22H27N5O2	1
1	IC50 = 4.9 nM Bioactivity Info	TI LI LO TS
CP0910086 Compound Info	US9328120, 16 Show/Hide	C20H22F2N6O	1
1	IC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0928194 Compound Info	US9328120, 2 Show/Hide	C19H23N5O3	1
1	IC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0954007 Compound Info	US9328120, 18 (enantiomer 1) Show/Hide	C18H20F2N6OS	1
1	IC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0688414 Compound Info	1-cyclopentyl-6-{(1S)-1-[3-(4-methylphenoxy)azetidin-1-yl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C22H27N5O2	1
1	IC50 = 5.37 nM Bioactivity Info	TI LI LO TS
CP0851630 Compound Info	6-{1-[3-(1,8-naphthyridin-2-yloxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C23H25N7O3	1
1	IC50 = 5.41 nM Bioactivity Info	TI LI LO TS
CP0578680 Compound Info	4-(2-oxa-7-azaspiro[3.5]nonan-7-yl)-2-oxo-8-propyl-5,6,7,8-tetrahydro-1H-1,6-naphthyridine-3-carbonitrile;2,2,2-trifluoroacetic acid Show/Hide	C21H27F3N4O4	1
1	IC50 = 6 nM Bioactivity Info	TI LI LO TS
CP0523690 Compound Info	6-[(3S,4S)-4-methyl-1-(pyridin-2-ylmethyl)pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C21H26N6O2	1
1	IC50 = 6.3 nM Bioactivity Info	TI LI LO TS
CP0037251 Compound Info	(-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl}amino)-4-(trifluoromethyl)pyrimidine-5-carboxylic acid Show/Hide	C21H24F3N7O3	1
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0862910 Compound Info	US9328120, 32 Show/Hide	C20H21F2N5O	1
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0928196 Compound Info	US9328120, 13 Show/Hide	C19H20F2N6O	1
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0804184 Compound Info	6-(1-{3-[(4,6-dimethylpyrimidin-2-yl)oxy]azetidin-1-yl}ethyl)-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C21H27N7O3	1
1	IC50 = 7.45 nM Bioactivity Info	TI LI LO TS
CP0243948 Compound Info	6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C20H25N7O2	1
1	IC50 = 8.3 nM Bioactivity Info	TI LI LO TS
CP0955029 Compound Info	1-Cyclopentyl-6-{(1R)-1-[3-(pyrimidin-2-yloxy)azetidin-1-yl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C19H23N7O2	1
1	IC50 = 9.49 nM Bioactivity Info	TI LI LO TS
CP0037249 Compound Info	US8829000, Referential Example 1 Show/Hide	C15H15ClN4O	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0578896 Compound Info	4-(4-methylphenyl)-2-oxo-8-propyl-5,6,7,8-tetrahydro-1H-quinoline-3-carbonitrile Show/Hide	C20H22N2O	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0368880 Compound Info	1-cyclopentyl-6-[(1S)-1-(3-phenoxyazetidin-1-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C21H25N5O2	1
1	IC50 = 10.5 nM Bioactivity Info	TI LI LO TS
CP0686512 Compound Info	6-{(1R)-1-[3-(4-Fluorophenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C21H24FN5O3	1
1	IC50 = 10.7 nM Bioactivity Info	TI LI LO TS
CP0920695 Compound Info	US9328120, 29 Show/Hide	C19H21N5O2	1
1	IC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0243949 Compound Info	6-[(3S,4S)-4-methyl-1-[(5-methylpyrazin-2-yl)methyl]pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C21H27N7O2	1
1	IC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0122342 Compound Info	1-(oxan-4-yl)-6-[(1R)-1-(3-phenoxyazetidin-1-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C21H25N5O3	1
1	IC50 = 12.5 nM Bioactivity Info	TI LI LO TS
CP0920693 Compound Info	US9328120, 10 Show/Hide	C18H21N5O2S	1
1	IC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0578901 Compound Info	4-(2-oxa-8-azaspiro[4.5]decan-8-yl)-2-oxo-8-propyl-5,6,7,8-tetrahydro-1H-1,6-naphthyridine-3-carbonitrile;hydrochloride Show/Hide	C20H29ClN4O2	1
1	IC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0579267 Compound Info	4-(7-azaspiro[3.5]nonan-7-yl)-2-oxo-8-propyl-5,6,7,8-tetrahydro-1H-1,6-naphthyridine-3-carbonitrile;hydrochloride Show/Hide	C20H29ClN4O	1
1	IC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0069183 Compound Info	2-chloro-4-[1-[1-[1-(oxan-4-yl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]ethyl]azetidin-3-yl]oxybenzonitrile Show/Hide	C22H23ClN6O3	1
1	IC50 = 13.2 nM Bioactivity Info	TI LI LO TS
CP0576481 Compound Info	4-(4-methylphenyl)-8-propyl-5,6,7,8-tetrahydro-1H-quinazolin-2-one Show/Hide	C18H22N2O	1
1	IC50 = 13.4 nM Bioactivity Info	TI LI LO TS
CP0942946 Compound Info	6-{1-[3-(quinazolin-2-yloxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C23H25N7O3	1
1	IC50 = 13.8 nM Bioactivity Info	TI LI LO TS
CP0955027 Compound Info	6-{1-[3-(2-chloro-4-methylphenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C24H27ClF3N5O5	1
1	IC50 = 14.2 nM Bioactivity Info	TI LI LO TS
CP0773276 Compound Info	6-{1-[3-(3-chlorophenoxy)azetidin-1-yl]ethyl}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C21H24ClN5O2	1
1	IC50 = 15.6 nM Bioactivity Info	TI LI LO TS
CP0875594 Compound Info	6-{1-[3-(isoquinolin-5-yloxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C26H27F3N6O5	1
1	IC50 = 15.6 nM Bioactivity Info	TI LI LO TS
CP0863066 Compound Info	6-{1-[3-(4-methylphenoxy)azetidin-1-yl]propyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C23H29N5O3	1
1	IC50 = 16.5 nM Bioactivity Info	TI LI LO TS
CP0128879 Compound Info	2-(oxan-4-yl)-N-[(1R,2S)-2-[(7-oxo-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl]acetamide Show/Hide	C22H33N5O3	1
1	IC50 = 19 nM Bioactivity Info	TI LI LO TS
CP0954006 Compound Info	US9328120, 9 Show/Hide	C19H21F2N5OS	1
1	IC50 = 19 nM Bioactivity Info	TI LI LO TS
CP0090870 Compound Info	2-fluoro-5-[1-[1-[1-(oxan-4-yl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]ethyl]azetidin-3-yl]oxybenzonitrile Show/Hide	C22H23FN6O3	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0578737 Compound Info	4-(4-methylphenyl)-2-oxo-8-propyl-5,6,7,8-tetrahydro-1H-1,6-naphthyridine-3-carbonitrile;hydrochloride Show/Hide	C19H22ClN3O	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0955057 Compound Info	6-{1-[3-(pyrido[2,3-d]pyrimidin-2-yloxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C22H24N8O3	1
1	IC50 = 20.2 nM Bioactivity Info	TI LI LO TS
CP0959843 Compound Info	US9328120, 22 Show/Hide	C18H18ClF2N5OS	1
1	IC50 = 21 nM Bioactivity Info	TI LI LO TS
CP0955055 Compound Info	4-({1-[1-(1-cyclopentyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)ethyl]azetidin-3-yl}oxy)benzonitrile Show/Hide	C22H24N6O2	1
1	IC50 = 21.1 nM Bioactivity Info	TI LI LO TS
CP0864903 Compound Info	6-{1-[3-(quinolin-7-yloxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C26H27F3N6O5	1
1	IC50 = 21.4 nM Bioactivity Info	TI LI LO TS
CP0883342 Compound Info	6-{1-[3-(2,3-dichlorophenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C23H24Cl2F3N5O5	1
1	IC50 = 22.3 nM Bioactivity Info	TI LI LO TS
CP0947353 Compound Info	6-{1-[3-(4-methylphenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C22H27N5O3	1
1	IC50 = 22.5 nM Bioactivity Info	TI LI LO TS
CP0773280 Compound Info	6-(1-{3-[(6-methylpyridazin-3-yl)oxy]azetidin-1-yl}ethyl)-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C20H25N7O3	1
1	IC50 = 22.8 nM Bioactivity Info	TI LI LO TS
CP0092375 Compound Info	3-isopropyl-5-(((1S, 2R)-2-(6-methylpyridazin-3-ylamino)cyclohexyl)methyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one Show/Hide	C20H27N7O	1
1	IC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0862909 Compound Info	US9328120, 23 Show/Hide	C18H20N6O2	1
1	IC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0928195 Compound Info	US9328120, 3 Show/Hide	C17H19N5O3	1
1	IC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0580070 Compound Info	4-(8-azaspiro[4.5]decan-8-yl)-2-oxo-8-propyl-5,6,7,8-tetrahydro-1H-1,6-naphthyridine-3-carbonitrile;hydrochloride Show/Hide	C21H31ClN4O	1
1	IC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0787449 Compound Info	6-{1-[3-(4-chloro-3-methylphenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C24H27ClF3N5O5	1
1	IC50 = 23.3 nM Bioactivity Info	TI LI LO TS
CP0688416 Compound Info	3-[(1-{1-[4-oxo-1-(tetrahydro-2H-pyran-4-yl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]ethyl}azetidin-3-yl)oxy]benzonitrile Show/Hide	C22H24N6O3	1
1	IC50 = 24.1 nM Bioactivity Info	TI LI LO TS
CP0773279 Compound Info	6-[1-(3-phenoxyazetldin-1-yl)propyl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C22H27N5O3	1
1	IC50 = 24.5 nM Bioactivity Info	TI LI LO TS
CP0576757 Compound Info	4-(4-methylphenyl)-8-(2-methylpropyl)-2-oxo-5,6,7,8-tetrahydro-1H-quinoline-3-carbonitrile Show/Hide	C21H24N2O	1
1	IC50 = 25 nM Bioactivity Info	TI LI LO TS
CP0875592 Compound Info	6-{(1R)-1-[3-(pyridin-2-yloxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C20H24N6O3	1
1	IC50 = 27.2 nM Bioactivity Info	TI LI LO TS
CP0804186 Compound Info	2-[(1-{1-[4-oxo-1-(tetrahydro-2H-pyran-4-yl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]ethyl}azetidin-3-yl)oxy]benzonitrile, trifluoroacetate salt Show/Hide	C24H25F3N6O5	1
1	IC50 = 28.3 nM Bioactivity Info	TI LI LO TS
CP0883424 Compound Info	2-chloro-3-fluoro-6-[(1-{1-[4-oxo-1-(tetrahydro-2H-pyran-4-yl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]ethyl}azetidin-3-yl)oxy]benzonitrile, trifluoroacetate salt Show/Hide	C24H23ClF4N6O5	1
1	IC50 = 30.1 nM Bioactivity Info	TI LI LO TS
CP0962541 Compound Info	6-{1-[3-(2,5-dichlorophenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C23H24Cl2F3N5O5	1
1	IC50 = 30.9 nM Bioactivity Info	TI LI LO TS
CP0906396 Compound Info	US9328120, 20 Show/Hide	C20H20N6OS	1
1	IC50 = 31 nM Bioactivity Info	TI LI LO TS
CP0920692 Compound Info	US9328120, 7 Show/Hide	C19H21F2N5O2	1
1	IC50 = 31 nM Bioactivity Info	TI LI LO TS
CP0688415 Compound Info	6-[(1R)-1-(3-benzylazetidin-1-yl)ethyl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C22H27N5O2	1
1	IC50 = 31.4 nM Bioactivity Info	TI LI LO TS
CP0841612 Compound Info	6-[(3-phenoxyazetidin-1-yl)(phenyl)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C26H27N5O3	1
1	IC50 = 32 nM Bioactivity Info	TI LI LO TS
CP0959846 Compound Info	US9328120, 26 Show/Hide	C19H17N7O	1
1	IC50 = 32 nM Bioactivity Info	TI LI LO TS
CP0942950 Compound Info	6-{1-[3-(3-fluoro-5-methoxyphenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C24H27F4N5O6	1
1	IC50 = 32.4 nM Bioactivity Info	TI LI LO TS
CP0851632 Compound Info	3-fluoro-4-[(1-{1-[4-oxo-1-(tetrahydro-2H-pyran-4-yl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]ethyl}azetidin-3-yl)oxy]benzonitrile, trifluoroacetate salt Show/Hide	C24H24F4N6O5	1
1	IC50 = 33.2 nM Bioactivity Info	TI LI LO TS
CP0851633 Compound Info	6-[1-[3-(2-chloro-5-methoxyphenoxy)azetidin-1-yl]ethyl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C24H27ClF3N5O6	1
1	IC50 = 34.4 nM Bioactivity Info	TI LI LO TS
CP0147026 Compound Info	2-fluoro-4-[1-[1-[1-(oxan-4-yl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]ethyl]azetidin-3-yl]oxybenzonitrile Show/Hide	C22H23FN6O3	1
1	IC50 = 34.8 nM Bioactivity Info	TI LI LO TS
CP0037255 Compound Info	(-)3-Isopropyl-5-{[(trans)-2-(pyrimidin-2-ylamino)cyclohexyl]methyl}-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one Show/Hide	C19H25N7O	1
1	IC50 = 35 nM Bioactivity Info	TI LI LO TS
CP0568847 Compound Info	8-butyl-4-(4-methylphenyl)-2-oxo-5,6,7,8-tetrahydro-1H-quinoline-3-carbonitrile Show/Hide	C21H24N2O	1
1	IC50 = 35 nM Bioactivity Info	TI LI LO TS
CP0256873 Compound Info	N-[(1R,2S)-2-[(7-oxo-3-propan-2-yl-2,6-dihydropyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl]-2-pyrrolidin-1-ylacetamide Show/Hide	C21H32N6O2	1
1	IC50 = 36 nM Bioactivity Info	TI LI LO TS
CP0864904 Compound Info	2-chloro-6-fluoro-3-[(1-{1-[4-oxo-1-(tetrahydro-2H-pyran-4-yl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]ethyl}azetidin-3-yl)oxy]benzonitrile, trifluoroacetate salt Show/Hide	C24H23ClF4N6O5	1
1	IC50 = 36.2 nM Bioactivity Info	TI LI LO TS
CP0816866 Compound Info	1-Cyclobutyl-6-{(1R)-1-[3-(pyrimidin-2-yloxy)azetidin-1-yl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C18H21N7O2	1
1	IC50 = 37.3 nM Bioactivity Info	TI LI LO TS
CP0686515 Compound Info	6-{1-[3-(pyrazin-2-yloxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C19H23N7O3	1
1	IC50 = 39.9 nM Bioactivity Info	TI LI LO TS
CP0708063 Compound Info	6-(1-{3-[(7-chloroquinolin-4-yl)oxy]azetldin-1-yl}ethyl)-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C26H26ClF3N6O5	1
1	IC50 = 40.4 nM Bioactivity Info	TI LI LO TS
CP0773283 Compound Info	6-{1-[3-(3,5-difluorophenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C23H24F5N5O5	1
1	IC50 = 40.4 nM Bioactivity Info	TI LI LO TS
CP0037254 Compound Info	3-isopropyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one Show/Hide	C21H27N5O3	1
1	IC50 = 41 nM Bioactivity Info	TI LI LO TS
CP0942948 Compound Info	3-chloro-4-[(1-{1-[4-oxo-1-(tetrahydro-2H-pyran-4-yl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]ethyl}azetidin-3-yl)oxy]benzonitrile, trifluoroacetate salt Show/Hide	C24H24ClF3N6O5	1
1	IC50 = 42.6 nM Bioactivity Info	TI LI LO TS
CP0914444 Compound Info	1-isopropyl-6-{1-[3-(4-methylphenoxy)azetidin-1-yl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C20H25N5O2	1
1	IC50 = 42.9 nM Bioactivity Info	TI LI LO TS
CP0967405 Compound Info	1-(tetrahydro-2H-pyran-4-yl)-6-(1-{3-[3-(trifluoromethyl)phenoxy]azetidin-1-yl}ethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C24H25F6N5O5	1
1	IC50 = 43.6 nM Bioactivity Info	TI LI LO TS
CP0914447 Compound Info	5-chloro-2-[(1-{1-[4-oxo-1-(tetrahydro-2H-pyran-4-yl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]ethyl}azetidin-3-yl)oxy]benzonitrile, trifluoroacetate salt Show/Hide	C24H24ClF3N6O5	1
1	IC50 = 44.7 nM Bioactivity Info	TI LI LO TS
CP0688418 Compound Info	6-{1-[3-(3-chloro-2-fluorophenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C23H24ClF4N5O5	1
1	IC50 = 44.9 nM Bioactivity Info	TI LI LO TS
CP0545563 Compound Info	4-(4,4-dimethylpiperidin-1-yl)-2-oxo-8-propyl-5,6,7,8-tetrahydro-1H-1,6-naphthyridine-3-carbonitrile;hydrochloride Show/Hide	C19H29ClN4O	1
1	IC50 = 45 nM Bioactivity Info	TI LI LO TS
CP0675505 Compound Info	6-{1-[3-(Pyrimidin-2-yloxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C19H23N7O3	1
1	IC50 = 45.3 nM Bioactivity Info	TI LI LO TS
CP0071234 Compound Info	1-{(1R,2S)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl}-3-(3-morpholin-4-ylpropyl)urea Show/Hide	C23H37N7O3	1
1	IC50 = 46 nM Bioactivity Info	TI LI LO TS
CP0957847 Compound Info	1-cyclopentyl-6-(1-{3-[4-(trifluoromethyl)phenoxy]azetidin-1-yl}ethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C22H24F3N5O2	1
1	IC50 = 47 nM Bioactivity Info	TI LI LO TS
CP0686518 Compound Info	6-{1-[3-(2,3-difluoro-4-methylphenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C24H26F5N5O5	1
1	IC50 = 47.2 nM Bioactivity Info	TI LI LO TS
CP0871236 Compound Info	6-{1-[3-(2-chloro-3,4-difluorophenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C23H23ClF5N5O5	1
1	IC50 = 48.8 nM Bioactivity Info	TI LI LO TS
CP0921110 Compound Info	1-(tetrahydro-2H-pyran-4-yl)-6-(1-{3-[3-(trifluoromethoxy)phenoxy]azetidin-1-yl}ethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C24H25F6N5O6	1
1	IC50 = 48.9 nM Bioactivity Info	TI LI LO TS
CP0883340 Compound Info	6-[(1R)-1-(3-benzyl-3-fluoroazetidin-1-yl)ethyl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C22H26FN5O2	1
1	IC50 = 50.3 nM Bioactivity Info	TI LI LO TS
CP0831183 Compound Info	1-(tetrahydro-2H-pyran-4-yl)-6-(1-{3-[3,4,5-trifluorophenoxy]azetidin-1-yl}ethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C23H23F6N5O5	1
1	IC50 = 51.4 nM Bioactivity Info	TI LI LO TS
CP0838686 Compound Info	6-{1-[3-(2-chlorophenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C23H25ClF3N5O5	1
1	IC50 = 52.1 nM Bioactivity Info	TI LI LO TS
CP0042235 Compound Info	3-isopropyl-5-(2-(trifluoromethoxy)benzyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one Show/Hide	C16H15F3N4O2	1
1	IC50 = 56 nM Bioactivity Info	TI LI LO TS
CP0796482 Compound Info	6-{1-[3-(quinolin-2-yloxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C24H26N6O3	1
1	IC50 = 57.2 nM Bioactivity Info	TI LI LO TS
CP0942949 Compound Info	6-{1-[3-(2,5-difluorophenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C23H24F5N5O5	1
1	IC50 = 57.4 nM Bioactivity Info	TI LI LO TS
CP0941862 Compound Info	US9328120, 6 Show/Hide	C19H21F2N5O2	1
1	IC50 = 58 nM Bioactivity Info	TI LI LO TS
CP0851634 Compound Info	6-{1-[3-(isoquinolin-7-yloxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C26H27F3N6O5	1
1	IC50 = 58.3 nM Bioactivity Info	TI LI LO TS
CP0955056 Compound Info	6-{1-[3-(pyrimidin-4-yloxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C19H23N7O3	1
1	IC50 = 59.4 nM Bioactivity Info	TI LI LO TS
CP0862907 Compound Info	US9328120, 5 Show/Hide	C20H23F2N5O2	1
1	IC50 = 60 nM Bioactivity Info	TI LI LO TS
CP0578775 Compound Info	8-ethyl-4-(4-methylphenyl)-2-oxo-5,6,7,8-tetrahydro-1H-quinoline-3-carbonitrile Show/Hide	C19H20N2O	1
1	IC50 = 60 nM Bioactivity Info	TI LI LO TS
CP0705291 Compound Info	6-{1-[3-(3-chloro-4-fluorophenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C23H24ClF4N5O5	1
1	IC50 = 63.8 nM Bioactivity Info	TI LI LO TS
CP0957496 Compound Info	6-[1-[3-(2-chloro-4,5-difluorophenoxy)azetidin-1-yl]ethyl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C23H23ClF5N5O5	1
1	IC50 = 64.6 nM Bioactivity Info	TI LI LO TS
CP0942947 Compound Info	5-fluoro-2-[(1-{1-[4-oxo-1-(tetrahydro-2H-pyran-4-yl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]ethyl}azetidin-3-yl)oxy]benzonitrile, trifluoroacetate salt Show/Hide	C24H24F4N6O5	1
1	IC50 = 69.4 nM Bioactivity Info	TI LI LO TS
CP0955058 Compound Info	6-(1-{3-[(4-fluoro-2,3-dihydro-1-benzofuran-7-yl)oxy]azetidin-1-yl}ethyl)-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C25H27F4N5O6	1
1	IC50 = 70.1 nM Bioactivity Info	TI LI LO TS
CP0169565 Compound Info	4-[1-[1-[1-(oxan-4-yl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]ethyl]azetidin-3-yl]oxybenzonitrile Show/Hide	C22H24N6O3	1
1	IC50 = 70.2 nM Bioactivity Info	TI LI LO TS
CP0883341 Compound Info	6-{1-[3-(2-chloro-4-fluorophenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C23H24ClF4N5O5	1
1	IC50 = 74.5 nM Bioactivity Info	TI LI LO TS
CP0831870 Compound Info	6-{1-[3-(3,4-difluoro-2-methylphenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C24H26F5N5O5	1
1	IC50 = 78.7 nM Bioactivity Info	TI LI LO TS
CP0910085 Compound Info	US9328120, 12 Show/Hide	C18H20F2N6OS	1
1	IC50 = 80 nM Bioactivity Info	TI LI LO TS
CP0914441 Compound Info	1-Isopropyl-6-[1-(3-phenoxyazetidin-1-yl)ethyl]-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C19H23N5O2	1
1	IC50 = 81.7 nM Bioactivity Info	TI LI LO TS
CP0039447 Compound Info	5-(2-(benzyloxy)benzyl)-3-isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one Show/Hide	C22H22N4O2	1
1	IC50 = 82 nM Bioactivity Info	TI LI LO TS
CP0914442 Compound Info	6-[(1R)-1-(3-Phenylazetidin-1-yl)ethyl]-1-tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C21H25N5O2	1
1	IC50 = 82.4 nM Bioactivity Info	TI LI LO TS
CP0957511 Compound Info	6-{1-[3-(4-chloro-2-methylphenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C24H27ClF3N5O5	1
1	IC50 = 84.5 nM Bioactivity Info	TI LI LO TS
CP0910084 Compound Info	US9328120, 8 Show/Hide	C20H20N6O2	1
1	IC50 = 85 nM Bioactivity Info	TI LI LO TS
CP0576476 Compound Info	8-ethoxy-4-(4-methylphenyl)-2-oxo-5,6,7,8-tetrahydro-1H-quinoline-3-carbonitrile Show/Hide	C19H20N2O2	1
1	IC50 = 85 nM Bioactivity Info	TI LI LO TS
CP0665654 Compound Info	6-{1-[3-(3-chlorophenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C23H25ClF3N5O5	1
1	IC50 = 85.6 nM Bioactivity Info	TI LI LO TS
CP0154317 Compound Info	3-isopropyl-5-{[(1S,2R)-2-(2-morpholin-4-ylethoxy)cyclohexyl]methyl}-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one Show/Hide	C21H33N5O3	1
1	IC50 = 87 nM Bioactivity Info	TI LI LO TS
CP0838687 Compound Info	6-{1-[3-(4-chlorophenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C23H25ClF3N5O5	1
1	IC50 = 88.2 nM Bioactivity Info	TI LI LO TS
CP0487994 Compound Info	6-[(3S,4S)-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C15H21N5O2	1
1	IC50 = 89 nM Bioactivity Info	TI LI LO TS
CP0578900 Compound Info	4-(2,2-difluoro-6-azaspiro[2.5]octan-6-yl)-2-oxo-8-propyl-5,6,7,8-tetrahydro-1H-1,6-naphthyridine-3-carbonitrile;hydrochloride Show/Hide	C19H25ClF2N4O	1
1	IC50 = 89 nM Bioactivity Info	TI LI LO TS
CP0864902 Compound Info	6-[(1R)-1-(3-benzyl-3-hydroxyazetidin-1-yl)ethyl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C22H27N5O3	1
1	IC50 = 89.2 nM Bioactivity Info	TI LI LO TS
CP0688417 Compound Info	6-{1-[3-(2-fluoro-5-methylphenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C24H27F4N5O5	1
1	IC50 = 90.8 nM Bioactivity Info	TI LI LO TS
CP0967404 Compound Info	6-{1-[3-(2-chloro-6-fluorophenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dlhydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C23H24ClF4N5O5	1
1	IC50 = 91.1 nM Bioactivity Info	TI LI LO TS
CP0580147 Compound Info	4-(4-cyanopiperidin-1-yl)-2-oxo-8-propyl-5,6,7,8-tetrahydro-1H-1,6-naphthyridine-3-carbonitrile;hydrochloride Show/Hide	C18H24ClN5O	1
1	IC50 = 92 nM Bioactivity Info	TI LI LO TS
CP0688860 Compound Info	6-{1-[3-(4-chloro-2-fluorophenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C23H24ClF4N5O5	1
1	IC50 = 99.1 nM Bioactivity Info	TI LI LO TS
CP0576485 Compound Info	4-(8,8-difluoro-6-azaspiro[2.5]octan-6-yl)-2-oxo-8-propyl-5,6,7,8-tetrahydro-1H-1,6-naphthyridine-3-carbonitrile;hydrochloride Show/Hide	C19H25ClF2N4O	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0708064 Compound Info	1-(tetrahydro-2H-pyran-4-yl)-6-{1-[3-(2,4,5-trifluorophenoxy)azetidin-1-yl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C23H23F6N5O5	1
1	IC50 = 102 nM Bioactivity Info	TI LI LO TS
CP0688419 Compound Info	1-(tetrahydro-2H-pyran-4-yl)-6-(1-{3-[4-(trifluoromethyl)phenoxy]azetidin-1-yl}ethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C24H25F6N5O5	1
1	IC50 = 107 nM Bioactivity Info	TI LI LO TS
CP0773284 Compound Info	1-(tetrahydro-2H-pyran-4-yl)-6-{1-[3-(2,3,4-trifluorophenoxy)azetidin-1-yl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C23H23F6N5O5	1
1	IC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0838685 Compound Info	6-{1-[3-(2,6-difluorophenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C23H24F5N5O5	1
1	IC50 = 112 nM Bioactivity Info	TI LI LO TS
CP0831869 Compound Info	6-{1-[3-(5-fluoro-2-methylphenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C24H27F4N5O5	1
1	IC50 = 119 nM Bioactivity Info	TI LI LO TS
CP0543875 Compound Info	4-(4-methylphenyl)-2-oxo-8-propan-2-yl-5,6,7,8-tetrahydro-1H-quinoline-3-carbonitrile Show/Hide	C20H22N2O	1
1	IC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0942924 Compound Info	1-cyclopentyl-6-{(1R)-1-[(3R)-3-phenylpyrrolidin-1-yl]propyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C23H29N5O	1
1	IC50 = 136 nM Bioactivity Info	TI LI LO TS
CP0579265 Compound Info	4-(4-methylphenyl)-2-oxo-8-(2,2,2-trifluoroethyl)-5,6,7,8-tetrahydro-1H-quinoline-3-carbonitrile Show/Hide	C19H17F3N2O	1
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0705290 Compound Info	6-{1-[3-(2-chlorophenyl)pyrrolidin-1-yl]ethyl}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C24H27ClF3N5O3	1
1	IC50 = 148 nM Bioactivity Info	TI LI LO TS
CP0967403 Compound Info	6-{1-[3-(2-fluorophenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4Hpyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C23H25F4N5O5	1
1	IC50 = 148 nM Bioactivity Info	TI LI LO TS
CP0486715 Compound Info	6-[(3R,4R)-1-benzyl-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C22H27N5O2	1
1	IC50 = 152 nM Bioactivity Info	TI LI LO TS
CP0579266 Compound Info	4-(4-methylpiperidin-1-yl)-2-oxo-8-propyl-5,6,7,8-tetrahydro-1H-1,6-naphthyridine-3-carbonitrile Show/Hide	C18H26N4O	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0773282 Compound Info	1-cyclopentyl-6-{1-[(3R)-3-(2-methoxyphenoxy)pyrrolidin-1-yl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C25H30F3N5O5	1
1	IC50 = 211 nM Bioactivity Info	TI LI LO TS
CP0787422 Compound Info	1-cyclopentyl-6-{(1R)-1-[(3R)-3-phenylpyrrolidin-1-yl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C22H27N5O	1
1	IC50 = 211 nM Bioactivity Info	TI LI LO TS
CP0914446 Compound Info	6-{1-[3-(2,4-difluorophenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C23H24F5N5O5	1
1	IC50 = 211 nM Bioactivity Info	TI LI LO TS
CP0957653 Compound Info	6-{1-[3-(2-chloro-6-methylphenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C24H27ClF3N5O5	1
1	IC50 = 215 nM Bioactivity Info	TI LI LO TS
CP0787448 Compound Info	1-isopropyl-6-{1-[3-(4-methylphenoxy)azetidin-1-yl]propyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C21H27N5O2	1
1	IC50 = 216 nM Bioactivity Info	TI LI LO TS
CP0919514 Compound Info	1-cyclopentyl-6-{(1R)-1-[3-(4-methylphenoxy)azetidin-1-yl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C22H27N5O2	1
1	IC50 = 222 nM Bioactivity Info	TI LI LO TS
CP0773281 Compound Info	1-cyclopentyl-6-[1-(3-phenylpyrrolidin-1-yl)ethyl]-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C24H28F3N5O3	1
1	IC50 = 230 nM Bioactivity Info	TI LI LO TS
CP0941863 Compound Info	US9328120, 11 Show/Hide	C20H24F2N6OS	1
1	IC50 = 233 nM Bioactivity Info	TI LI LO TS
CP0686519 Compound Info	6-{1-[3-(4-tert-butylphenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dlhydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C27H34F3N5O5	1
1	IC50 = 234 nM Bioactivity Info	TI LI LO TS
CP0913595 Compound Info	US9328120, 4 Show/Hide	C18H20F2N6O2	1
1	IC50 = 242 nM Bioactivity Info	TI LI LO TS
CP0883338 Compound Info	6-{1-[3-(pyridin-2-yloxy)azetidin-1-yl]propyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C21H26N6O3	1
1	IC50 = 245 nM Bioactivity Info	TI LI LO TS
CP0952682 Compound Info	1-isopropyl-6-[1-(3-phenoxyazetidin-1-yl)propyl]-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C20H25N5O2	1
1	IC50 = 256 nM Bioactivity Info	TI LI LO TS
CP0914445 Compound Info	6-{1-[3-(pyridin-3-yloxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4Hpyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C22H25F3N6O5	1
1	IC50 = 310 nM Bioactivity Info	TI LI LO TS
CP0576482 Compound Info	4-(4,4-dimethylpiperidin-1-yl)-2-oxo-1H-1,5-naphthyridine-3-carbonitrile Show/Hide	C16H18N4O	1
1	IC50 = 330 nM Bioactivity Info	TI LI LO TS
CP0851631 Compound Info	1-cyclopentyl-6-[1-(3-pyridin-4-ylpyrrolidin-1-yl)ethyl]-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C23H27F3N6O3	1
1	IC50 = 382 nM Bioactivity Info	TI LI LO TS
CP0578899 Compound Info	4-(3-ethyl-1,2-oxazol-5-yl)-2-oxo-8-propyl-5,6,7,8-tetrahydro-1H-1,6-naphthyridine-3-carbonitrile;hydrochloride Show/Hide	C17H21ClN4O2	1
1	IC50 = 410 nM Bioactivity Info	TI LI LO TS
CP0578504 Compound Info	4-(4-cyanophenyl)-2-oxo-8-propyl-5,6,7,8-tetrahydro-1H-1,6-naphthyridine-3-carbonitrile;hydrochloride Show/Hide	C19H19ClN4O	1
1	IC50 = 430 nM Bioactivity Info	TI LI LO TS
CP0926809 Compound Info	US9328120, 21 Show/Hide	C17H18F2N6O2	1
1	IC50 = 433 nM Bioactivity Info	TI LI LO TS
CP0953088 Compound Info	US9328120, 1 Show/Hide	C19H21F2N5O2	1
1	IC50 = 450 nM Bioactivity Info	TI LI LO TS
CP0163475 Compound Info	3-isopropyl-1-methyl-5-(2-(2-morpholinoethoxy)benzyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one Show/Hide	C22H29N5O3	1
1	IC50 = 530 nM Bioactivity Info	TI LI LO TS
CP0572328 Compound Info	4-(4-methylphenyl)-2-oxo-5,6,7,8-tetrahydro-1H-quinoline-3-carbonitrile Show/Hide	C17H16N2O	1
1	IC50 = 530 nM Bioactivity Info	TI LI LO TS
CP0568057 Compound Info	4-(5-ethylpyridin-2-yl)-2-oxo-8-propyl-5,6,7,8-tetrahydro-1H-1,6-naphthyridine-3-carbonitrile;hydrochloride Show/Hide	C19H23ClN4O	1
1	IC50 = 570 nM Bioactivity Info	TI LI LO TS
CP0946221 Compound Info	6-(1-azetidin-1-ylethyl)-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Show/Hide	C17H22F3N5O3	1
1	IC50 = 593 nM Bioactivity Info	TI LI LO TS
CP0580236 Compound Info	4-(5-ethyl-1,3-thiazol-2-yl)-2-oxo-8-propyl-5,6,7,8-tetrahydro-1H-1,6-naphthyridine-3-carbonitrile;hydrochloride Show/Hide	C17H21ClN4OS	1
1	IC50 = 600 nM Bioactivity Info	TI LI LO TS
CP0577383 Compound Info	4-(4,4-dimethylpiperidin-1-yl)-8-ethyl-2-oxo-1H-1,5-naphthyridine-3-carbonitrile Show/Hide	C18H22N4O	1
1	IC50 = 610 nM Bioactivity Info	TI LI LO TS
CP0578898 Compound Info	4-(6-methylpyridin-3-yl)-2-oxo-8-propyl-5,6,7,8-tetrahydro-1H-1,6-naphthyridine-3-carbonitrile;hydrochloride Show/Hide	C18H21ClN4O	1
1	IC50 = 630 nM Bioactivity Info	TI LI LO TS
CP0580145 Compound Info	2-oxo-8-propyl-4-pyridin-4-yl-5,6,7,8-tetrahydro-1H-1,6-naphthyridine-3-carbonitrile;dihydrochloride Show/Hide	C17H20Cl2N4O	1
1	IC50 = 640 nM Bioactivity Info	TI LI LO TS
CP0580146 Compound Info	4-(4-methylphenyl)-2-oxo-1H-1,5-naphthyridine-3-carbonitrile Show/Hide	C16H11N3O	1
1	IC50 = 725 nM Bioactivity Info	TI LI LO TS
CP0579563 Compound Info	8-methyl-4-(4-methylphenyl)-2-oxo-5,6,7,8-tetrahydro-1H-1,5-naphthyridine-3-carbonitrile;hydrochloride Show/Hide	C17H18ClN3O	1
1	IC50 = 1500 nM Bioactivity Info	TI LI LO TS
CP0385143 Compound Info	2-[4-[4-ethoxy-3-(3-ethyl-1-methyl-7-oxo-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenoxy]piperidin-1-yl]-N-hydroxypyrimidine-5-carboxamide Show/Hide	C26H30N8O5	1
1	IC50 = 4800 nM Bioactivity Info	TI LI LO TS
CP0578897 Compound Info	8-methyl-4-(4-methylphenyl)-2-oxo-5,6,7,8-tetrahydro-1H-1,7-naphthyridine-3-carbonitrile;hydrochloride Show/Hide	C17H18ClN3O	1
1	IC50 = 7000 nM Bioactivity Info	TI LI LO TS
CP0414199 Compound Info	4-[[1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine Show/Hide	C21H20ClN5O	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0090153 Compound Info	4-[[1-(5-butoxypyridin-3-yl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]morpholine Show/Hide	C24H28N6O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0147040 Compound Info	US11419874, Example 28 Show/Hide	C15H10ClN5	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0006487 Compound Info	2-oxo-N-[1-[4-(trifluoromethoxy)phenyl]propyl]-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide Show/Hide	C18H17F3N4O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0248670 Compound Info	5,8-dimethyl-2-(2-phenylimidazo[1,2-a]pyrimidin-7-yl)-[1,2,4]triazolo[1,5-a]pyrazine Show/Hide	C19H15N7	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0366792 Compound Info	5,8-Dimethyl-2-(2-phenyl-1H-benzimidazol-5-yl)[1,2,4]triazolo[1,5-a]pyrazine Show/Hide	C20H16N6	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0389044 Compound Info	5,8-dimethyl-2-(2-pyridin-3-yl-3H-benzimidazol-5-yl)-[1,2,4]triazolo[1,5-a]pyrazine Show/Hide	C19H15N7	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0389045 Compound Info	2-[2-(5-chlorothiophen-2-yl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine Show/Hide	C18H13ClN6S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0396021 Compound Info	5,8-dimethyl-2-(2-thiophen-2-yl-3H-benzimidazol-5-yl)-[1,2,4]triazolo[1,5-a]pyrazine Show/Hide	C18H14N6S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0396022 Compound Info	5-[6-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-1H-benzimidazol-2-yl]-1,3-thiazole Show/Hide	C17H13N7S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0396025 Compound Info	2-[2-(2-methoxyphenyl)imidazo[1,2-a]pyrimidin-7-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine Show/Hide	C20H17N7O	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0408074 Compound Info	2-[2-(3-bromophenyl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine Show/Hide	C20H15BrN6	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0408075 Compound Info	2-[2-(4-fluorophenyl)imidazo[1,2-a]pyrimidin-7-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine Show/Hide	C19H14FN7	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0408076 Compound Info	2-[2-(3-chlorophenyl)imidazo[1,2-a]pyrimidin-7-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine Show/Hide	C19H14ClN7	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0412213 Compound Info	2-[6-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-1H-benzimidazol-2-yl]-5-methyl-1,3-thiazole Show/Hide	C18H15N7S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0412218 Compound Info	US10138245, Example 56 Show/Hide	C19H15N7	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0412219 Compound Info	US10138245, Example 2 Show/Hide	C20H15FN6	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0412220 Compound Info	2-[2-(2-Methoxyphenyl)-1H-benzimidazol-5-yl]-5,8-dimethyl[1,2,4]triazolo[1,5-a]pyrazine Show/Hide	C21H18N6O	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0482326 Compound Info	5,7-Dimethyl-2-(2-phenyl-1H-benzo[d]imidazol-5-yl)-[1,2,4]triazolo-[1,5-a]pyrimidine Show/Hide	C20H16N6	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0482327 Compound Info	5,8-Dimethyl-2-[2-(1,3-thiazol-2-yl)-1H-benz-imidazol-5-yl][1,2,4]triazolo[1,5-a]pyrazine Show/Hide	C17H13N7S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0482328 Compound Info	2-[2-(4-FLuorophenyl)-1H-benzimidazol-5-yl]-5,8-dimethyl[1,2,4]triazolo[1,5-a]pyrazine Show/Hide	C20H15FN6	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0482329 Compound Info	2-[6-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-1H-benzimidazol-2-yl]-4-methyl-1,3-thiazole Show/Hide	C18H15N7S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0513387 Compound Info	5,8-Dimethyl-2-[2-(pyridin-2-yl)-1H-benzimidazol-5-yl][1,2,4]triazolo[1,5-a]pyrazine Show/Hide	C19H15N7	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0513391 Compound Info	2-[2-(3-methoxypyridin-2-yl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine Show/Hide	C20H17N7O	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0555893 Compound Info	2-[2-(furan-2-yl)-3H-benzimidazol-5-yl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine Show/Hide	C18H14N6O	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0862252 Compound Info	2-(2-Bromophenyl)-7-{5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl}imidazo[1,2-a]pyrimidine Show/Hide	C19H14BrN7	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0865138 Compound Info	2-(7-{5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl}imidazo[1,2-a]pyrimidin-2-yl)pyridine Show/Hide	C18H14N8	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0865140 Compound Info	6-{5,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl}-2-(3-fluoropyridin-2-yl)-1H-1,3-benzodiazole Show/Hide	C19H14FN7	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0905292 Compound Info	2-(7-{5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl}imidazo[1,2-a]pyrimidin-2-yl)-1,3-thiazole Show/Hide	C16H12N8S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0012519 Compound Info	5-[[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]-N-hydroxythiophene-2-carboxamide Show/Hide	C23H25N5O4S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0000847 Compound Info	(2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11(16),12,14-tetraene-4,7-dione Show/Hide	C22H19N3O4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0010658 Compound Info	5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one Show/Hide	C22H30N6O4S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0384486 Compound Info	N-[3-(4,5-diethyl-6-oxo-1H-pyrimidin-2-yl)-4-propoxyphenyl]-2-(4-methylpiperazin-1-yl)acetamide Show/Hide	C24H35N5O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0486657 Compound Info	[3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]-(3,4,5-trimethoxyphenyl)methanone Show/Hide	C20H23N5O4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0176508 Compound Info	[4-[3-(3-fluoro-4-methoxyphenyl)-5-(2-methylphenyl)-3,4-dihydropyrazol-2-yl]phenyl]-(4-methylpiperazin-1-yl)methanone Show/Hide	C29H31FN4O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0365459 Compound Info	[4-[5-tert-butyl-3-(3,5-difluoro-4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]phenyl]-(4-methylpiperazin-1-yl)methanone Show/Hide	C26H32F2N4O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0419692 Compound Info	N-(2-hydroxyethyl)-4-[3-(4-methoxyphenyl)-5-(2-methylphenyl)-3,4-dihydropyrazol-2-yl]benzamide Show/Hide	C26H27N3O3	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0419693 Compound Info	[4-[5-tert-butyl-3-(2,3-difluoro-4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]phenyl]-(4-methylpiperazin-1-yl)methanone Show/Hide	C26H32F2N4O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0444327 Compound Info	[4-[3-(4-methoxyphenyl)-5-(2-methylphenyl)-3,4-dihydropyrazol-2-yl]phenyl]-(4-methylpiperazin-1-yl)methanone Show/Hide	C29H32N4O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0013428 Compound Info	N-[(1S)-1-[3-fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl]-7-methoxy-2-oxo-1,3-dihydropyrido[2,3-b]pyrazine-4-carboxamide Show/Hide	C19H18F4N4O5	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0580144 Compound Info	1-methyl-4-(4-methylphenyl)-2-oxo-8-propyl-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carbonitrile Show/Hide	C20H23N3O	1
1	IC50 > 10 nM Bioactivity Info	TI LI LO TS
CP0257911 Compound Info	(10S,15S)-13-ethyl-10-(5-ethylfuran-2-yl)-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione Show/Hide	C21H21N3O3	1
1	IC50 > 3000 nM Bioactivity Info	TI LI LO TS
CP0268684 Compound Info	(2S,8R)-2-(5-ethylthiophen-2-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione Show/Hide	C21H21N3O2S	1
1	IC50 > 4000 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0037249 Compound Info	US8829000, Referential Example 1 Show/Hide	C15H15ClN4O	1
1	IC50 = 8 nM
CP0243948 Compound Info	6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C20H25N7O2	3
1	IC50 = 8 nM
2	IC50 = 8.3 nM
3	IC50 = 49 nM
CP0958208 Compound Info	6-{1-[3-(quinoxalin-2-yloxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C23H25N7O3	1
1	IC50 = 8.47 nM
CP0686512 Compound Info	6-{(1R)-1-[3-(4-Fluorophenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C21H24FN5O3	1
1	IC50 = 12.18 nM
CP0688415 Compound Info	6-[(1R)-1-(3-benzylazetidin-1-yl)ethyl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C22H27N5O2	1
1	IC50 = 13.2 nM
CP0523690 Compound Info	6-[(3S,4S)-4-methyl-1-(pyridin-2-ylmethyl)pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C21H26N6O2	1
1	IC50 = 14 nM
CP0271210 Compound Info	6-[(3S,4S)-1-[(4-fluorophenyl)methyl]-4-methylpyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C22H26FN5O2	1
1	IC50 = 17 nM
CP0069183 Compound Info	2-chloro-4-[1-[1-[1-(oxan-4-yl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]ethyl]azetidin-3-yl]oxybenzonitrile Show/Hide	C22H23ClN6O3	1
1	IC50 = 19 nM
CP0122342 Compound Info	1-(oxan-4-yl)-6-[(1R)-1-(3-phenoxyazetidin-1-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C21H25N5O3	2
1	IC50 = 22 nM
2	IC50 = 22.5 nM
CP0914442 Compound Info	6-[(1R)-1-(3-Phenylazetidin-1-yl)ethyl]-1-tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C21H25N5O2	1
1	IC50 = 25.4 nM
CP0078267 Compound Info	6-[(3S,4S)-4-methyl-1-[(2-methylpyrimidin-5-yl)methyl]pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C21H27N7O2	1
1	IC50 = 36 nM
CP0147026 Compound Info	2-fluoro-4-[1-[1-[1-(oxan-4-yl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]ethyl]azetidin-3-yl]oxybenzonitrile Show/Hide	C22H23FN6O3	1
1	IC50 = 43 nM
CP0090870 Compound Info	2-fluoro-5-[1-[1-[1-(oxan-4-yl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]ethyl]azetidin-3-yl]oxybenzonitrile Show/Hide	C22H23FN6O3	1
1	IC50 = 47 nM
CP0243949 Compound Info	6-[(3S,4S)-4-methyl-1-[(5-methylpyrazin-2-yl)methyl]pyrrolidin-3-yl]-1-(oxan-4-yl)-5H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C21H27N7O2	1
1	IC50 = 59 nM
CP0675505 Compound Info	6-{1-[3-(Pyrimidin-2-yloxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C19H23N7O3	1
1	IC50 = 63 nM
CP0919514 Compound Info	1-cyclopentyl-6-{(1R)-1-[3-(4-methylphenoxy)azetidin-1-yl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C22H27N5O2	1
1	IC50 = 67.1 nM
CP0169565 Compound Info	4-[1-[1-[1-(oxan-4-yl)-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl]ethyl]azetidin-3-yl]oxybenzonitrile Show/Hide	C22H24N6O3	1
1	IC50 = 70 nM
CP0686515 Compound Info	6-{1-[3-(pyrazin-2-yloxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C19H23N7O3	1
1	IC50 = 73.5 nM
CP0952932 Compound Info	4-[[(3S,4S)-3-(1-cyclopentyl-4-oxo-5H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-methyl-pyrrolidin-1-yl]methyl]benzenecarbohydroxamic acid Show/Hide	C23H28N6O3	1
1	IC50 = 107 nM
CP0368880 Compound Info	1-cyclopentyl-6-[(1S)-1-(3-phenoxyazetidin-1-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-one Show/Hide	C21H25N5O2	1
1	IC50 = 986 nM
CP0010658 Compound Info	5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one Show/Hide	C22H30N6O4S	4
1	IC50 = 3400 nM
2	IC50 = 3600 nM
3	IC50 = 5600 nM
4	IC50 > 10000 nM
CP0000847 Compound Info	(2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11(16),12,14-tetraene-4,7-dione Show/Hide	C22H19N3O4	1
1	IC50 > 10000 nM

Clinical Information about the Protein

Target 1 ( Phosphodiesterase 9 (PDE9) )

Target Type	Clinical trial Target
Disease	4 Target-related Diseases				4
1	Psychiatric disorder [ICD-11: 6E8Z]
2	Sickle-cell disorder [ICD-11: 3A51]
3	Alzheimer disease [ICD-11: 8A20]
4	Cognitive impairment [ICD-11: 6D71]
Clinical Trial Drug(s)	3 Clinical Trial Drugs				3
1	BI-409306	Drug Info	Phase 2	Psychiatric disorder
2	IMR-687	Drug Info	Phase 2	Sickle-cell disorder
3	PF-4447943	Drug Info	Phase 2	Alzheimer disease
Investigative Drug(s)	1 Investigative Drug				1
1	PF-4181366	Drug Info	Investigative	Cognitive impairment

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han