General Information of the Protein
Protein ID
PT02591
Protein Name
Major prion protein
Secondarily
Protein Name
ASCR
PrP27-30
PrP33-35C
Gene Name
PRNP
Secondarily
Gene Name
ALTPRP
PRIP
PRP
Sequence
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
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Organism
Homo sapiens, Human
Protein Classification
Surface antigen
Function
Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
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Uniprot ID
Primary ID:
P04156

Secondarily ID:
O60489
P78446
Q15216
Q15221
Q27H91
Q5QPB4
Q8TBG0
Q96E70
Q9UP19
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Ensembl ID
ENSG00000171867
HGNC ID
HGNC:9449
Subcellular Location
Cell membrane
Golgi apparatus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000235 , ScN2a
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0016322
 Compound Info 
6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-methylbutyl)amine
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C23H30ClN3O
  1
1
EC50 = 300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0033479
 Compound Info 
(chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine
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C17H19ClN2S
  1
1
EC50 = 2000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0029912
 Compound Info 
Aralen
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C18H26ClN3
  1
1
EC50 = 4000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0084343
 Compound Info 
N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;hydrochloride
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C17H20N2S
  1
1
EC50 = 5000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0329262
 Compound Info 
1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]ethanone
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C19H22N2OS
  1
1
EC50 = 5000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0066128
 Compound Info 
(2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine
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C17H20N2S
  1
1
EC50 = 8000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0008601
 Compound Info 
4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl)
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C21H23ClFNO2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0036757
 Compound Info 
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
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C19H24N2
  1
1
EC50 = 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0071077
 Compound Info 
5H-dibenzo[b,f]azepine-5-carboxamide
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C15H12N2O
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0188268
 Compound Info 
9,10-diazaanthracene
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C12H8N2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( Major prion protein (PRNP) )
Target Type Literature-reported Target
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT06141 Major prion protein Ovis aries, Sheep
 Protein Info