General Information of the Compound
Compound ID
CP0071077
Compound Name
5H-dibenzo[b,f]azepine-5-carboxamide
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Synonyms
Carbamazepine
Carbamazepine (iv, epilepsy)
Carbamazepine (iv, epilepsy), Lundbeck
Carbamazepine (iv, epilepsy), Ovation Pharmaceuticals
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Structure
Formula
C15H12N2O
Molecular Weight
236.274
Canonical SMILES
NC(=O)N1c2ccccc2C=Cc2ccccc12
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InChI
InChI=1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)
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InChIKey
FFGPTBGBLSHEPO-UHFFFAOYSA-N
CAS
298-46-4
Physicochemical Property
logP
3.3872
Rotatable Bonds
0
Heavy Atom Count
18
Polar Areas
46.33
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
1
Complexity
18

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 2554
SID: 57304372
ChEMBL ID
CHEMBL108
DrugBank ID
DB00564
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02997, Isocitrate dehydrogenase [NADP] cytoplasmic
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000156 HT-1080 Homo sapiens (Human)  1
1
Potency ~ 1032.3 nM
   TI
   LI
   LO
   TS
Protein ID: PT02591, Major prion protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000235 ScN2a Mus musculus (Mouse)  1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT02908, P2X purinoceptor 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000094 1321N1 Homo sapiens (Human)  1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
Protein ID: PT03043, Sodium channel protein type 4 subunit alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 52000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01000, Sodium channel protein type 9 subunit alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 22000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 32700 nM
Clinical Information about the Compound
Drug 1 ( Carbamazepine )
Drug Name Carbamazepine
Company Lundbeck Inc
Indication
Epilepsy
Approved
Type-1 diabetes
NDA filed
Gastric adenocarcinoma
Phase 3